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"Nonparametric" A' and other modern misconceptions about signal detection theory.

Many modern descriptions of signal detection theory (SDT) are, at best, distorted caricatures of the Gaussian equal-variance model of SDT (G-SDT). The distortions have sometimes led to important, but unwarranted, conclusions about the nature of cognitive processes. Some researchers reject using d' and beta because of concerns about the validity of explicit underlying assumptions (that are shared with most inferential statistics), instead using either the supposedly "nonparametric" measures of A' and B" or measures known to confound ability and bias. The origins, development, and underlying assumptions of SDT are summarized, then contrasted with modern distortions and misconceptions. The nature and interpretation of common descriptive statistics for sensitivity and bias are described along with important pragmatic considerations about use. A deeper understanding of SDT provides researchers with tools that better evaluate both their own findings and the validity of conclusions drawn by others who have utilized SDT measures and analyses.

Decision Making↗

[Causality and disease].

The interpretation of the causal relations in the beginning of a disease offers a central problem in medicine. It obtains a special interest with the increasing significance of the chronic diseases. The handling of this problem cannot depend on the experience of the every day life. It must take in consideration the general aspects of the causality as they are the topic of modern physics and biology as well as of philosophy. In the principle acknowledgement of the principle of causality a change from a deterministic monocausal to a more complex thinking takes place considering a complex of conditions followed by a field of possibilities of effects. Special interest needs the differentiation between the description and the interpretation of causal relations that means between ontological and epistemological thinking. The causal relation in medicine depends on the same principles as in physics and in biology.

Chronic Disease↗

[Not Available].

This text is the description of an investigation. At the same time it is an interpretative essay and detailed description of still unexplored archival material, currently being catalogued. It also describes photographs, scientific instruments and books, all belonging to one of the oldest and most important institutions for childhood. The focus is on the nineteenth and twentieth centuries, a decisive and yet too little studied period at the origins of pediatrics. During this period the Istituto degli Innocenti experienced an extraordinary transformation from being a place of charity to being a centre for maternity and infant care in the modern sense, where pioneering activities took place relating to scientific research, sanitary care, medical experimentation and training, as well as to specialised nursing, prevention and divulgation.

Academies and Institutes↗

Counts, scales, and scores. Levels of observation.

Description, analysis, and interpretation of biomedical information are guided, in part, by the nature of the observations. Objects or events in categories, ie, nominal data, are simply counted. At a somewhat higher level, observations may have a "more than" character, so they can be ordered or ranked; the increments between the elements may be unknown or not measurable. Interval data have known and fixed increments, but no true zero; ratio scales are interval observations with a true zero. Some relationships between the levels of observation and the presentation and interpretation of biomedical information are discussed.

Epidemiologic Methods↗

Positional behavior and vertebral morphology in atelines and cebines.

Atelines are of particular interest to primate evolutionary studies because they converge with hominoids in postcranial anatomy, including the vertebral column. Currently, our understanding of ateline vertebral morphology is limited to mainly qualitative descriptions and functional interpretations based on general categories of positional behavior. Even less is known about the vertebrae of other platyrrhines. This study more closely examines vertebral form and function in atelines and cebines by combining direct field observations of axial postures and movements, assessments of spinal loading regimes, and a detailed vertebral morphometric analysis. Field observations (Corcovado, Costa Rica) on Ateles geoffroyi, Alouatta palliata, Cebus capucinus, and Saimiri oerstedii were quantified in conjunction with a morphometric analysis of ateline and cebine lumbar vertebrae. Hylobates was also included for comparison. Compared to Cebus and Saimiri, atelines engage more frequently in postures and locomotor behaviors that induce pronounced bending loads on the spine. All atelines share lumbar adaptations for resisting bending, including ventrodorsally elongated vertebral bodies and perpendicularly oriented transverse processes. Among atelines, lumbar region lengths and vertebral bodies are shortest in Ateles and Brachyteles, longest in Alouatta (resembling Cebus), and intermediate in Lagothrix. Compared to Cebus and all atelines, Saimiri has a relatively longer lumbar region, longer and less ventrodorsally expanded vertebral bodies, and more ventrally oriented transverse processes. These features accentuate bending loads, but increase the sagittal flexibility required for leaping. Vertebral convergence between hylobatids and atelines is more readily interpretable as a product of shared spinal loading patterns than shared positional behaviors.

Animals↗

Writing a good read: strategies for re-presenting qualitative data.

One key element in the successful dissemination and utilization of qualitative findings is the well-written research report. In contrast to quantitative research, there is no one style for reporting the findings from qualitative research. Qualitative researchers must select from an array of representational styles and formats those that best fit their research purposes, methods, and data. Qualitative researchers must attend to the balance among description, analysis, and interpretation, choose whether to emphasize character, setting, or plot, determine whose perspectives or voices will prevail, and treat metaphors seriously. Strategies for re-presenting qualitative data include using time, theme, sensitizing concepts, and coding families.

Humans↗

[Validity of computer-generated MMPI reports in psychiatric patients (author's transl)].

Lachar's (1974) completely documented, automated MMPI interpretational system was transplated into German and analyzed regarding validity and generalizability in 1190 German psychiatric inpatients. The 114 paragraphs of the text library, each interpreting independent aspects of the MMPI profile, were rated for their accuracy in each individual report by the psychiatrist in charge for the respective patient. As an average, 83 of every 100 printed paragraphs were rated as 'accurate.' Further analysis revealed that the accuracy of paragraphs describing elevated MMPI profiles was substatially higher than in those describing profiles within the normal range. Accuracy rates of individual paragraphs correlated significantly (r = 0.61) with those reported by Lachar, thus confirming the specific accuracy of each paragraph. It is concluded that the present MMPI interpretational system offers descriptive clinical reports that have shown a high accuracy in culturally diverse psychiatric settings.

Adult↗

Oculomotor mechanisms activated by imagery and memory: eye movements to absent objects.

It is hypothesized that eye movements are used to coordinate elements of a mental model with elements of the visual field. In two experiments, eye movements were recorded while observers imagined or recalled objects that were not present in the visual display. In both cases, observers spontaneously looked at particular blank regions of space in a systematic fashion, to manipulate and organize spatial relationships between mental and/or retinal images. These results contribute to evidence that interpreting a linguistic description of a visual scene requires a spatial (mental model) representation, and they support claims regarding the allocation of position markers in visual space for the manipulation of visual attention. More broadly, our results point to a concrete embodiment of cognition, in that a construction of a mental image is almost "acted out" by the eye movements, and a mental search of internal memory is accompanied by an ocolumotor search of external space.

Adult↗

Global transcriptomic analysis of Desulfovibrio vulgaris on different electron donors.

Whole-genome microarrays of Desulfovibrio vulgaris were used to determine relative transcript levels in cells grown to exponential or stationary phase on a medium containing either lactate or formate as electron donor. The results showed that 158 and 477 genes were differentially expressed when comparing exponential to stationary phase in lactate- or formate-based media, respectively; and 505 and 355 genes were responsive to the electron donor used at exponential or stationary phase, respectively. Functional analyses suggested that the differentially regulated genes were involved in almost every aspect of cellular metabolism, with genes involved in protein synthesis, carbon, and energy metabolism being the most regulated. The results suggested that HynBA-1 might function as a primary periplasmic hydrogenase responsible for oxidation of H2 linked to the proton gradient in lactate-based medium, while several periplasmic hydrogenases including HynBA-1 and Hyd might carry out this role in formate-based medium. The results also indicated that the alcohol dehydrogenase and heterodisulfide reductase catalyzed pathway for proton gradient formation might be actively functioning for ATP synthesis in D. vulgaris. In addition, hierarchical clustering analysis using expression data across different electron donors and growth phases allowed the identification of the common electron donor independent changes in gene expression specifically associated with the exponential to stationary phase transition, and those specifically associated with the different electron donors independent of growth phase. The study provides the first global description and functional interpretation of transcriptomic response to growth phase and electron donor in D. vulgaris.

Bacterial Proteins↗

Radiographic and MR imaging of the athletic hip.

Imaging of the athletic hip has changed significantly over the past 10 years to address clinical concerns of intra-articular pathology and femoroacetabular impingement. Currently, high-resolution direct MR arthrography of the hip provides the best means for evaluating intra-articular pathology. However, radiography remains important for the diagnosis of subtle bony irregularities associated with femoroacetabular impingement. Therefore, a comprehensive imaging strategy requires conventional radiographs and MRI to evaluate intra- and extra-articular sources of pain. Because of newer surgical techniques, MR interpretations should provide description of labral tears and assessment of cartilage defects, as well as, capsule/iliofemoral ligament injury, femoroacetabular impingement, and tears of the ligamentum teres to aid preoperative planning and help provide prognostic information.

Adult↗

Documentary analysis in CAM research: Part 2.

The analysis of documents can provide insights into important social and political issues related to complementary and alternative medicine (CAM). This paper identifies some important sources of documents and outlines some of the advantages and disadvantages of using documents in social research. A number of analytic strategies are illustrated with examples to demonstrate the potential for documentary analysis to answer particular CAM-related research questions. These strategies are described as quantitative content analysis, qualitative descriptive analysis, qualitative interpretive analysis and semiotic analysis. It is argued that documents are a convenient source of data and that their analysis can enrich our understanding of CAM. Part 1 covered quantitative and qualitative strategies. Part 2 focuses on semiotic analysis and the methodological strengths and weaknesses of the different strategies.

Biomedical Research↗

Documentary analysis in CAM research: Part 1.

The analysis of documents can provide insights into important social and political issues related to complementary and alternative medicine (CAM). This paper identifies some important sources of documents and outlines some of the advantages and disadvantages of using documents in social research. A number of analytic strategies are illustrated with examples to demonstrate the potential for documentary analysis to answer particular CAM-related research questions. These strategies are described as quantitative content analysis, qualitative descriptive analysis, qualitative interpretive analysis and semiotic analysis. It is argued that documents are a convenient source of data and that their analysis can enrich our understanding of CAM. Part 1 covers quantitative and qualitative strategies and Part 2 focuses on semiotic analysis.

Biomedical Research↗

Veganism as status passage: the process of becoming a vegan among youths in Sweden.

In a town in northern Sweden, 3.3% of the 15-year-old adolescents were vegans in 1996. This study describes the process of becoming a vegan among adolescents and interprets the informants' descriptions by constructing categories, which later on were related to relevant theories. Group interviews were conducted with three vegans and in-depth interviews were performed with three other vegan adolescents. The methodology was grounded theory and the adolescents' perceptions were analyzed in the framework of symbolic interactionism. Three types of vegans were identified: the Conformed Vegan, the Organized Vegan, and the Individualistic Vegan. The decision to become a vegan was reported to be influenced by perceived internal reasons such as ethics, health, distaste for meat, and preference for vegetarian food. In addition, friends, family, school, media, and music influenced the decision to become a vegan. The perceived consequences of becoming a vegan were positive as well as negative and differed between the three types of vegans. Veganism as a new type of status passage with specific characteristics was illustrated. No modifications or new properties were discovered that add to the theory of status passage which indicates that the general model is applicable also in a vegan context.

Adolescent↗

Individual differences in reasoning: implications for the rationality debate?

Much research in the last two decades has demonstrated that human responses deviate from the performance deemed normative according to various models of decision making and rational judgment (e.g., the basic axioms of utility theory). This gap between the normative and the descriptive can be interpreted as indicating systematic irrationalities in human cognition. However, four alternative interpretations preserve the assumption that human behavior and cognition is largely rational. These posit that the gap is due to (1) performance errors, (2) computational limitations, (3) the wrong norm being applied by the experimenter, and (4) a different construal of the task by the subject. In the debates about the viability of these alternative explanations, attention has been focused too narrowly on the model response. In a series of experiments involving most of the classic tasks in the heuristics and biases literature, we have examined the implications of individual differences in performance for each of the four explanations of the normative/descriptive gap. Performance errors are a minor factor in the gap; computational limitations underlie non-normative responding on several tasks, particularly those that involve some type of cognitive decontextualization. Unexpected patterns of covariance can suggest when the wrong norm is being applied to a task or when an alternative construal of the task should be considered appropriate.

Cognition↗

Children's communicative abilities revisited: verbal versus perceptual disambiguating strategies in referential communication.

The way seven- and nine-year-old French children and adults interpret ambiguous object descriptions was studied in four experiments. All four experiments followed the same basic procedure and consisted of two phases. During the training phase, plastic blocks varying in shape, colour and size were associated with fruit names. Some objects were always given just one label, the generic term, whereas others could be given either the generic or the specific label. For example, large circles were referred to as 'pommes' ('apples'), and large blue circles as 'reinettes' (a kind of apple). Still others were given no name at all. During the test phase of the experiment, subjects were presented with referentially ambiguous messages and asked to point to a given object (Experiments 1, 2 and 3) or to draw an object (Experiment 4). The messages consisted of either a generic term preceded by an article (e.g. '(la pomme'-'the apple') or a verbal description based on a colour adjective (e.g. 'le bleu'-'the blue one'). When presented with the generic term, older children and adults persistently chose the object for which no specific term had been given during the training phase. When presented with an adjective description, they chose the referent for which no fruit name had been given during the training phase. Younger children's choices depended on whether the article preceding the description was definite or indefinite. These results are consistent with the Gricean approach to referential communication proposed by Jackson & Jacobs (1982) and with an extended version of the principle of contrast proposed by Clark (1987, 1988).

Child↗

Whose quality of life? A commentary exploring discrepancies between health state evaluations of patients and the general public.

There is often a discrepancy between quality of life estimates from patients and the general public. These discrepancies are of concern to the disability community, who worry that the public does not understand how valuable life can be for people with disabilities; policy planners, who must decide whose quality of life estimates to use in economic analysis; and practitioners and patients facing difficult medical decisions, who may have to worry that people have difficulty imagining unfamiliar health states. We outline several factors that may contribute to these discrepancies. Discrepancies might occur because patients and the public interpret health state descriptions differently--for example, making different assumptions about the recency of onset of the health state, or about the presence of comorbidities. Discrepancies might also arise if patients adapt to illness and the public does not predict this adaptation; because of response shift in how people use quality of life scales; because of a focusing illusion whereby people forget to consider obvious aspects of unfamiliar health states; because of contrast effects, whereby negative life events make people less bothered by less severe negative life events; and because of different vantage points, with patients viewing their illness in terms of the benefits that would result from regaining health, while the public views the illness in terms of the costs associated with losing good health. Decisions about whose values to measure for the purposes of economic analyses, and how to measure discrepancies, should take these potential contributing factors into account.

Adaptation, Psychological↗

Self-regulation of affect in attention deficit-hyperactivity disorder (ADHD) and non-ADHD boys: differences in empathic responding.

This study examined differences in empathy and other emotions between boys with and without attention deficit-hyperactivity disorder (ADHD). Empathy was measured by an empathy response task (ERT) and through self- and parent reports of emotion. On the ERT, children responded verbally to 8 fictitious stories. Results from the ERT revealed that boys with ADHD were less empathic than boys without ADHD. Boys with ADHD less frequently matched the emotion they identified in the character with the one identified in themselves and gave fewer character-centered interpretations in their descriptions of the character's emotion. Parent-report data revealed that boys with ADHD exhibited more behavioral manifestations of sadness, anger, and guilt than did boys without ADHD. No differences were found, however, on measures of emotional intensity or emotional reactions to external contingencies. The results are discussed with respect to current theories of ADHD.

Affect↗

The Wilfred Fish memorial lecture. The Hunterian tradition in dentistry.

The influence of William and John Hunter upon the development of Medicine and Dentistry in Britain has endured for more than two centuries. John Hunter's first book set out the morphological details of the teeth and their associated structures. From this basis he sought to attain an understanding of physiological and pathological processes by studies of the entire animal kingdom and by experimentation. His foundations of scientific dentistry were built upon by John Tomes and Wilfred Fish in subsequent centuries, both invoking the use of microscopy to enhance Hunter's naked eye descriptions and to interpret the results of experiments. Both, too, are inseparably linked with the history of the Royal College of Surgeons of England by the parts they played in establishing and preserving the place of their profession in that great repository of Hunter's teachings.

History of Dentistry↗