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[Value of computed tomography in acute adrenal failure].

Three patients with acute adrenal insufficiency of different causes are presented. In all three cases the adrenals were grossly enlarged and showed additional more specific changes that made a definite CT diagnosis possible in spite of the fact that clinical signs were rather non-specific in two of the three cases.

Acute Disease↗

[Behavior of plasma androgens in cases of adrenal pathology].

Following chromatographic separation, the RI method has been used to examine the behaviour of plasmatic androgens in a group of normal subjects, in two patients with Addison's disease and two patients with hypercorticoadrenalism, due respectively to corticoadrenal adenoma and bilateral adenomatous hyperplasia. A significant reduction in adrenal androgens was observed in patients suffering from Addison's disease. The most interesting information, however, was the paradoxical reduction in DHEA and delta 4-A in patients with corticoadrenal hyperfunction.

11-Hydroxycorticosteroids↗

Adrenocortical postirradiation fibrosis.

At autopsy, the adrenal zona reticularis showed linear hyaline fibrosis in 19 cases of cancer, after averages of six months and 5,000 roentgens of irradiation to the abdominal, lumbar, or pelvic regions. The associated roentgen dose was significantly greater than when postirradiation adrenal fibrosis was absent. Primary radiation damage to the reticular vascular plexus is suspected.

Adrenal Cortex↗