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Frequent consumption of milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables and intakes of dietary folate and riboflavin but not vitamins B-12 and B-6 are inversely associated with serum total homocysteine concentrations in the US population.

BACKGROUND: Elevated circulating total homocysteine (tHcy) is an independent risk factor for vascular diseases. OBJECTIVE: We investigated the relation between dietary intakes and serum tHcy in the US population. DESIGN: Data from the third National Health and Nutrition Examination Survey (1988-1994) were used to investigate the associations between food consumption frequency and dietary B vitamin intakes and serum tHcy in 5996 persons. RESULTS: Multivariate-adjusted tHcy concentrations were approximately 15.2% higher in subjects who never consumed milk than in those who consumed milk >30 times/mo, approximately 6.4% higher in subjects who never consumed yogurt than in those who consumed yogurt >15 times/mo, approximately 7.4% higher in subjects who never consumed cold breakfast cereals than in those who consumed cold breakfast cereals >30 times/mo, approximately 6.3% higher in subjects who never consumed peppers (includes red, yellow, green, and hot chili peppers) than in those who consumed peppers >30 times/mo, and approximately 16.5% higher in subjects who never consumed cruciferous vegetables than in those who consumed cruciferous vegetables >30 times/mo. Consumption of citrus fruit and juices, cheese, meats, coffee, or tea had no significant association with tHcy. Folate (beta=-0.0017, P for trend=0.004) and riboflavin (beta=-0.2851, P for trend=0.027), but not vitamin B-6 (beta=0.0505, P for trend=0.70) and cobalamin (beta=-0.0035, P for trend=0.58), were inversely related to serum tHcy after adjustment for confounders. CONCLUSIONS: In this population-based study, milk, yogurt, cold breakfast cereals, peppers, and cruciferous vegetables were inversely related to serum tHcy. This association may be explained by increased intakes of folate and riboflavin.

Adult↗

A comparative study of intragastric acidity during post-breakfast and pre-dinner administration of low-dose proton pump inhibitors: a randomized three-way crossover study.

BACKGROUND: The absorption and bioavailability of proton pump inhibitors is influenced by food intake. Proton pump inhibitors bind to the parietal cell active proton pump, which is maximally stimulated after dinner: usually the largest meal of the day. However, it has not been fully clarified whether the efficacy of proton pump inhibitors differs between post-breakfast and pre-dinner dosing. AIM: To perform a pH-monitoring study to clarify this issue for two low-dose proton pump inhibitors. SUBJECTS AND METHODS: The subjects were 20 healthy male volunteers (seven Helicobacter pylori-positive and 13 H. pylori-negative), who were divided into two groups of 10 and administered 15 mg lansoprazole or 10 mg rabeprazole, respectively. All subjects underwent ambulatory intragastric 24-h pH- monitoring under three conditions allocated randomly: (i) without medication, (ii) seventh day of post-breakfast administration and (iii) eighth day of pre-dinner administration of each drug. RESULTS: There was no significant difference in the percentage time during which pH > or =4.0 in the 24-h period between post-breakfast and pre-dinner administration of both drugs (56.6% vs. 55.8%; P = 0.557), although intragastric acidity during administration of both drugs was significantly lower than that without medication. CONCLUSIONS: The timing of drug administration does not significantly influence the efficacy of low-dose proton pump inhibitors.

2-Pyridinylmethylsulfinylbenzimidazoles↗

Inter-brand differences in iron content of breakfast cereals and their impact on measurement of iron intake.

BACKGROUND/AIMS: Fortified breakfast cereals (FBCs) are an important source of iron in the UK diet. In order to quantify their contribution to iron nutrition, food composition data for these products must be accurate. The very large amount of products available, together with inter-brand differences in iron content mean that discrepancies between the iron content of many FBCs and values in standard food composition databases (FCD) exist. The variation in reported iron contents of FBCs was examined and the impact of this variation on measurement of iron intake using standard food composition tables was investigated. METHOD: Data on the reported iron content of 128 FBCs were collected. Completed food diaries from 291 participants of the UK Women's Cohort study were used in the analysis. Mean iron intake from a 4-day food diary was calculated using UK food tables' values for FBCs. This was repeated using values reported by the manufacturer for each brand of cereal. The two sets of results were then compared. RESULTS: There is wide variation in iron content of breakfast cereals available in the United Kingdom. Use of FCD values instead of brand-specific values under- or overestimates an individual's iron intake by as much as 28 or 22% respectively. These results suggest that use of FCD values for breakfast cereals is potentially a source of substantial error in measurement of individuals' iron intake. CONCLUSION: Dietitians need to be aware of inter-brand differences in iron content and formulate advice accordingly. Failure to collect brand-specific data for the iron content of FBCs could lead to measurement error in measuring iron intake in dietary studies.

Adult↗

The importance of the time interval between insulin injection and breakfast in determining postprandial glycaemic control--a comparison between human and porcine insulin.

This study assessed the effect of the time interval between insulin injection and breakfast in determining subsequent postprandial glycaemic control and also whether this differed between highly purified porcine insulin and human insulin (crb) in six diabetic patients (age range 24-36 years, duration of diabetes greater than 10 years) usually treated with twice daily Actrapid MC and Monotard MC and with stable insulin requirements and diabetic control. On separate mornings each patient was given, after an overnight fast, their usual dose of either Actrapid MC and Monotard MC or Humulin S and Humulin Zn injected 5, 20, or 40 min before a standard breakfast. The postprandial glycaemic profile was not significantly different at any of the three time intervals with Actrapid MC and Monotard MC. However, with the human insulin the profile was significantly better at the 40 min interval than at the 5 min interval (p less than 0.05) and this was also better than any of the profiles with the porcine insulin, there being a significant difference between the two types of insulin (p less than 0.05). These findings suggest that the time interval between insulin injection and breakfast may be more important with human insulin than with porcine insulin.

Adult↗

Intermediate acting insulin given at bedtime: effect on blood glucose concentrations before and after breakfast.

Six C-peptide deficient diabetics receiving twice daily mixtures of short and intermediate acting insulins were selected for study because of persistently raised blood glucose concentrations before and after breakfast. They were investigated to assess the effect of moving their evening injection of intermediate acting insulin to bedtime. The patients' usual twice daily insulin treatment was optimised and compared with the bedtime regimen during inpatient metabolic studies and an outpatient crossover study. With the conventional injection regimen blood glucose concentration rose sharply from 0500 to reach a fasting mean value of 10 +/- SE 1 . 6 mmol/l (180 +/- 29 mg/100 ml) and 16 . 8 +/- 2 . 2 mmol/l (303 +/- 40 mg/100 ml) after breakfast. By contrast, when the evening dose of intermediate acting insulin was delayed until bedtime the nocturnal rise in blood glucose concentration started later and was significantly lower both fasting (7 . 5 +/- 1 . 1 mmol/l (135 +/- 20 mg/100 ml); p less than 0 . 02) and after breakfast (13 . 2 +/- 1 . 4 mmol/l(238 +/- 25 mg/100 ml); p less than 0 . 02). Fasting blood concentrations of ketone bodies (3-hydroxybutyrate) were also significantly decreased. Plasma free insulin concentrations showed the predicted changes in five of the six patients. Blood glucose profiles collected over four months during the outpatient study confirmed the beneficial effect of giving intermediate acting insulin at bedtime.

Adult↗

Influence of the intake of fortified breakfast cereals on dietary habits and nutritional status of Spanish schoolchildren.

A study was performed on the breakfast habits of 200 schoolchildren between 9 and 13 years of age. The subjects were classified into two groups: group C, children who consumed fortified breakfast cereals (65 boys and 35 girls), and group NC, children who did not (64 boys and 36 girls). The different dietary habits and the nutritional status of the two groups were analyzed. Haematological, biochemical, anthropometric, and dietary data were collected, the latter involving a 5-day food record. The children of the C group were found not only to have a more complete and nutritive breakfast, but also showed better dietary patterns for the rest of the day. Their lipid intake (% kJ) was lower and the carbohydrate intake (g/d and % kJ) higher than in the NC children. The intakes of thiamine, pyridoxine, folates, and beta-carotenes were also higher in group C. Better dietary habits were reflected in higher blood levels of some important compounds. Group C children had higher retinol, serum folate, and riboflavin levels than NC children. The percentage of children with hypercholesterolaemia (serum cholesterol > 4.5 mmol/l) was higher amongst those of the NC group: 37% as compared with 18% of the C children.

Adolescent↗

The relationship between breakfast and whole diet energy profiles in a group of preschool children.

The energy profile of the diet of the Spanish population is imbalanced, showing excessive intake of fats and protein and insufficient intake of carbohydrates. The aim of the present study was to investigate whether this imbalance also existed in 110 preschool children between 2 and 6 years of age, and to examine the relationship between their breakfast and whole diet energy profiles. The results obtained show that subjects who consumed less carbohydrate (< 50% of energy intake) or more fat (> 35% of total intake) at breakfast showed poorer energy profiles and poorer fat quality over their whole diet. Significant and positive correlations were found between energy supplied at breakfast by protein, fats, carbohydrates, saturated, monounsaturated and polyunsaturated fatty acids, and the same parameters measured for the whole diet.

Analysis of Variance↗

Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction.

The effects of food on the pharmacokinetics of vardenafil were examined in 25 healthy adult males. Single-dose vardenafil 20 mg was administered in a randomized four-way crossover design after an overnight fast (at 8 a.m.), after consumption of a high-fat breakfast (at 8 a.m.), on an empty stomach (at 6 p.m.), and after a typical moderate-fat evening meal (at 6 p.m.). Serial blood samples were analyzed for vardenafil and metabolite (M1) levels. When administered after an overnight fast and after a high-fat breakfast, vardenafil geometric mean Cmax was 17.14 and 14.0 micrograms/L, respectively, and AUC was 66.78 and 67.09 micrograms./h/L, respectively; the median tmax was 1 hour under fasting conditions and 2 hours with consumption of high-fat breakfast. When administered in the evening on an empty stomach and after a moderate-fat meal, vardenafil geometric mean Cmax was 14.22 and 13.04 micrograms/L, respectively, and AUC was 51.97 and 59.12 micrograms.h/L, respectively. The median tmax was 1 hour after fasting or a moderate-fat meal in the evening. All treatments were well tolerated. Thus, while a high-fat meal may alter Cmax slightly and delay the absorption up to 1 hour, a moderate-fat meal has no clinically relevant effect on vardenafil pharmacokinetics. Dosage changes are not warranted based on the wide therapeutic index and the efficacy observed with vardenafil in Phase III studies that were not restricted with respect to food.

3',5'-Cyclic-GMP Phosphodiesterases↗

Noninvasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen.

The contributions of hepatic glycogenolysis to fasting glucose production and direct pathway to hepatic glycogen synthesis were quantified in eight type 1 diabetic patients and nine healthy control subjects by ingestion of (2)H(2)O and acetaminophen before breakfast followed by analysis of urinary water and acetaminophen glucuronide. After overnight fasting, enrichment of glucuronide position 5 relative to body water (G5/body water) was significantly higher in type 1 diabetic patients compared with control subjects, indicating a reduced contribution of glycogenolysis to glucose production (38 +/- 3 vs. 46 +/- 2%). Following breakfast, G5/body water was significantly higher in type 1 diabetic patients, indicating a smaller direct pathway contribution to glycogen synthesis (47 +/- 2 vs. 59 +/- 2%). Glucuronide hydrogen 2 enrichment (G2) was equivalent to body water during fasting (G2/body water 0.94 +/- 0.03 and 1.02 +/- 0.06 for control and type 1 diabetic subjects, respectively) but was significantly lower after breakfast (G2/body water 0.78 +/- 0.03 and 0.82 +/- 0.05 for control and type 1 diabetic subjects, respectively). The reduced postprandial G2 levels reflect incomplete glucose-6-phosphate-fructose-6-phosphate exchange or glycogen synthesis from dietary galactose. Unlike current measurements of human hepatic glycogen metabolism, the (2)H(2)O/acetaminophen assay does not require specialized on-site clinical equipment or personnel.

Acetaminophen↗

Determination of deoxynivalenol in wheat-based breakfast cereals marketed in Portugal.

Deoxynivalenol (DON), also known as vomitoxin, is one of a group of closely related secondary fungal metabolites--the trichothecenes--and is produced predominantly by several species of the genus Fusarium, especially Fusarium graminearum. The present study was carried out to evaluate the natural occurrence of DON in different kinds of wheat-based breakfast cereals widely consumed by the population. A total of 88 commercially available samples of wheat-based breakfast cereals were randomly collected from different supermarkets in Lisbon, Portugal. The samples were analyzed using immunoaffinity column, and DON was quantified by liquid chromatography. Detection limit was 100 microg/kg. Average recovery of DON was 80%. Of 88 analyzed samples, 72.8% contained levels of DON between 103 and 6,040 microg/kg, with mean level of 754 microg/kg, and 24 samples (27.2%) were not contaminated (< 100 microg/kg). These results indicate an incidence of this mycotoxin in these products, and the authors suggest a monitoring for the prevention of molds and mycotoxins. This is the first report in Portugal on natural contamination with DON in wheat-based breakfast cereals.

Chromatography, Liquid↗

[Analysis of factors affecting breakfast skipping by male students undergoing hard training for sports].

PURPOSE: The purpose of this survey was to find factors affecting breakfast skip rates for male students participating in sports, and to determine how to improve their nutrition. METHODS: The survey was conducted on 86 male students (58 who played sports and 28 who did not). A questionnaire was supplied to all, containing questions concerning daily food eating behavior. The student's answers were evaluated according to the guidelines of the Ministry of Health and Welfare. In addition, blood pressure, body mass index, and serum levels of uric acid, triglycerides and ferritin were measured in all subjects. RESULTS: The breakfast skip rate was 36% for the sports club affiliation group, and 46.4% for the non-affiliation group. Students who were not supplied with meals from their mothers or dormitory food service had more irregular meal times, skipped breakfast more, and drank less milk and miso soup often than the students supplied with meals. Students playing sports, but not supplied with meals, had a lower evaluation regarding eating habits and higher serum levels of serum uric acid and ferritin, compared to the students supplied with meals. CONCLUSIONS: The eating habits of male students are affected by whether they receive meals or not. It is considered that the higher levels of serum uric acid and ferritin in the students not supplied with meals is due to their irregular eating habits and heavy exercise. It is suggested that nutritional guidance is needed for such students.

Feeding Behavior↗

Effect of breakfast on selected serum and cardiovascular variables.

We compared high-density lipoprotein cholesterol (HDL-C) and other blood and cardiovascular variables of subjects when they had been fasting overnight to those values when they had eaten breakfast. The subjects were 47 men (24 to 70 years) and 34 women (23 to 63 years) who visited our laboratory on two occasions, once fasting and once after breakfast, at the same time of the morning, exactly 1 week apart. Systolic (SBP) and diastolic (DBP) pressures and heart rates (HR) were recorded, and 24-ml blood samples were obtained from an antecubital vein and analyzed for hemoglobin (Hgb), hematocrit (Hct), HDL-C, total cholesterol (T Chol), triglycerides (Trig), total calcium (T Ca), ionized calcium (Ca++), and phosphorus (P). When subjects were fasting, their SBP, HR, Trig, T Ca, and Ca++ were lower than when they had eaten breakfast. SBP, DBP, Hgb, and Trig of the women were lower than those of the men; and HDL-C and phosphorus of the women were higher. Several correlations between variables were significant only when subjects were fasting. These were SBP with age, Hct with T Ca, and T Chol with Trig. Several correlations were significant only for one sex. For the women only, SBP, DBP, and HR were correlated with T Chol, and Trig and HDL-C were correlated with T Ca. For the men only, Hgb was correlated with HDL-C, Trig, T Ca, and P; and HDL-C was correlated with Trig.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

The influence of different types of breakfast on the absorption of paracetamol among members of an ethnic group.

It is well known that food influences the absorption and therapeutic efficacy of many drugs. In this study, the influence of three different types of breakfast, on the absorption of paracetamol was studied in a South African ethnic population group (Tswanas). The results indicated that breakfasts with a high fat content delayed the absorption of paracetamol to the largest extent while breakfasts with a high carbohydrate content delayed the absorption of paracetamol to a lesser extent.

Acetaminophen↗

[The estimation of the frequency of the consumption of breakfasts among rural children].

The purpose of the study was the estimation of the frequency and regularity of the consumption of breakfasts among rural children, and the examining of relations between the economic and social situation of families of the investigated children and the frequency of the consumption of breakfasts. The investigation included 2,584 girls and boys aged 7-15 years. The first breakfast was not eaten on the day of the investigation by over 1/5 of the schoolchildren, while light lunch was not eaten by over 1/8 school children. Children who come from well-off families consumed meals more regularly than children from poorer families.

Adolescent↗

[Study of qualitative and quantitative of dietary fibre composition in dry breakfasts and food supplements, contains wheaten brain].

Qualitative and quanitative composition of 15 samples of dry breakfasts and 19 variants food supplements, containing wheaten brain, was studied with a help of enzyme method, based on hydrolysis of protein and starch by enzymes, analogous with enzymes of digestive tract homo. It is shown, that the common contents of dietary fibres in samples of dry breakfasts is in limits from 11 up to 39%. Greatest contents IDF is observed in samples of breakfasts with addition of a thistle from 21 up to 35%, and greatest contents SDF with addition (see text for symbol) and beet - 9% and 7% accordingly. The common contents of dietary fibres in samples biologically active additives is in limits from 26 up to 73% that is caused by qualitative and quantitative structure of initial raw material. Group IDF in biologically active additive has made from 23 up to 69%, and contents SDF changes from 1% up to 19%.

Dietary Fiber↗

[Biological significance of the endogenous secretion of insulin in response to breakfast in diabetic children].

In 20 insulin dependent diabetics and in eight age-matched healthy children, we have measured basally HbA1 and the plasma lipid profile; and both basally and after a standard breakfast of 400 cal, blood glucose, C-peptide (CPR), immunoreactive glucagon (IRG), growth hormone and nonesterified fatty acids (NEFA). No difference was found in the lipid profile of diabetic and non diabetic children. In diabetics basal blood glucose was significantly correlated to both basal C-peptide (r = 0.5332, p less than 0.05) and to the ratio C-peptide/glucagon (r = 0.8563, p less than 0.01). The C-peptide response to the breakfast was accompanied of a significant increase in IRG and NEFA in diabetics, while in non-diabetics there was no change in IRG and a significant decrease in NEFA levels. Diabetic children with basal C-peptide levels higher than 0.6 ng/ml had lower blood glucose levels (187 +/- 43 vs 315 +/- 20 mg/dl, p less than 0.02), but no difference in blood glucose or any other parameter was observed as a function of the increase in CPR after breakfast. From these results we conclude that the evaluation of residual B-cell function in diabetic children by measuring the C-peptide response to a provocative stimulus is not more informative than the single basal measurement of C-peptide and does not have an additional biological significance, at least in hyperglycaemic insulin dependent diabetic children.

Blood Glucose↗

[Continuous recording of plasma glucose level after glucose tolerance and 3 different breakfast. Search for a normal post-prandial plasma glucose (author's transl)].

We have studied glucose tolerance test (GTT) and glucose after 3 different breakfast (50, 100, 150 g CHO), in order to define a postprandial glucose level for the detection and control of diabetes mellitus. If the breakfast is sufficient enough (100 or 150 g CHO) the response after breakfast is similar to GTT. The post meal glucose is < 1,5 g/L mean + 2 SD) at 35 mn and < 0,97 g/L at 108 mn. Glucose level over these limits set to search a diabetes. Nevertheless this study is restricted by two points: the subjects are young and the load must be sufficient enough (over 100 g CHO).

Adult↗

Methylphenidate hydrochloride given with or before breakfast: I. Behavioral, cognitive, and electrophysiologic effects.

Methylphenidate HCl (Ritalin) is usually given for the treatment of hyperactivity or attention deficit disorder (ADD) at 30 minutes to one hour before meals. This schedule is based on the assumption that, when taken with meals, its absorption or metabolism is altered. However, no behavioral or pharmacologic data exist to support this recommendation. Eleven patients with attention deficit disorder were tested to evaluate this hypothesis using a double-blind crossover design (methylphenidate with or before breakfast) with a placebo control condition. Parents' ratings, performance on a paired-associate learning test, and cortical auditory-evoked potentials were measured. All of these measurements showed clear differences between the placebo condition and conditions when medication was given. However, none of the measurements showed a significant difference between the conditions when methylphenidate was given with breakfast and the condition when methylphenidate was given 30 minutes before breakfast.

Analysis of Variance↗