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At least 253 records · Page 14Linked to original sources
PubMed1982

The influence of antiviral serum on cells infected with herpes simplex virus type 1.

Homologous immune serum (IS) had an inhibitory effect on the accumulation of specific viral antigens in VERO cells infected with herpes simplex virus type 1. When infected cells were incubated in the presence of IS, lower amounts of viral, both intracellular and membrane, antigens were found by quantitative immunofluorescence and immune cytolysis as compared to same infected cell incubated in the absence of IS. The possible mechanisms of this effect are discussed.

Animals↗
PubMedDate not supplied

Cytomegalovirus-antibody-negative lymphocytes have increased permissiveness for human immunodeficiency virus.

Synergistic activity between cytomegalovirus (CMV) and human immunodeficiency virus (HIV) was observed. In vitro, lymphocytes which were CMV-antibody-negative showed greater cytopathic effects due to HIV than those which were antibody-positive. These cytopathic effects included increased cell death and greater virus production. In vitro stimulation of host lymphocytes with CMV was found to be analogous to that of interleukin-2 stimulation in terms of HIV production and cytopathic effects.

Antibodies, Viral↗
PubMed1989

Evaluation of a monoclonal antibody pool for rapid diagnosis of respiratory viral infections.

A pool of monoclonal antibodies (MAbP) was evaluated both as a method of cell culture confirmation and as a rapid diagnostic screen for viral infection in respiratory secretions. The MAbP was used in a two-step fluorescent staining procedure on cells harvested from cultures (phase 1) and on exfoliated nasopharyngeal or tracheal cells (phase 2). Antibodies in the MAbP were directed against respiratory syncytial virus, adenoviruses, parainfluenza virus types 1, 2, and 3, and influenza viruses A and B. Individual antiviral antibody stains were used to identify specific viruses from MAbP-positive specimens. In phase 1 (cell culture confirmation only), 241 respiratory specimens were tested. MAbP sensitivity and specificity were 91 and 94%, respectively. In phase 2, 376 respiratory specimens were evaluated by direct staining of exfoliated cells, and these results were compared with results of cell culture isolation. The sensitivity and specificity of the MAbP used in direct specimen testing were 69 and 97%, respectively. These results indicate that the MAbP is highly specific and fairly sensitive for detection of seven different respiratory viruses in one testing procedure. The MAbP is a rapid screening technique for respiratory secretions and is potentially a cost-effective approach to viral detection.

Adenoviruses, Human↗
PubMedDate not supplied

[Pathology and immune lysis of cells infected with measles virus isolated from subacute sclerosing panencephalitis].

The Si strain isolated from a patient with subacute sclerosing panencephalitis like reference measles virus strains was shown to induce in cell cultures formation of symplasts and spindle-shaped cells, cytoplasmic and intranuclear inclusions, pathology of mitosis, appearance of intracellular and surface virus-induced antigens. The presence of the latter caused cell cytolysis under the effect of measles immune sera and complement.

Antigens, Viral↗