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Seborrheic dermatitis and HIV infection. Qualitative analysis of skin surface lipids in men seropositive and seronegative for HIV.

We measured skin surface lipids (cholesterol, free fatty acids, triglycerides, wax esters, and squalene) in patients seropositive for human immunodeficiency virus (HIV) and those seronegative for HIV with and without seborrheic dermatitis. Cholesterol and wax ester fractions were similar in all four groups but triglycerides and squalene were significantly increased and free fatty acids significantly decreased in HIV-positive patients, regardless of the presence of seborrheic dermatitis. In addition, a strong negative correlation was found between free fatty acid and triglyceride levels. We conclude that abnormalities of skin surface lipids are not associated with the development of seborrheic dermatitis in HIV-positive persons but are associated with HIV infection itself.

Acquired Immunodeficiency Syndrome↗

Ketoconazole 2% cream versus hydrocortisone 1% cream in the treatment of seborrheic dermatitis. A double-blind comparative study.

Seventy-two patients with seborrheic dermatitis were treated once daily with 2% ketoconazole cream (n = 36) or 1% hydrocortisone cream (n = 36) on a double-blind basis for 4 weeks. For the global evaluation, no significant difference could be seen between the two groups. The clinical response was 80.5% in the ketoconazole group and 94.4% in the hydrocortisone group. For the different symptoms combined (scaling, redness, itching, and papules), no significant difference was seen between the two groups when the total scores at week 2 and at week 4 were compared with the initial scores. The incidence of side effects in both groups was comparably low.

Administration, Cutaneous↗

[Is juvenile seborrheic dermatitis a candidiasis? Studies of a possible link with microbial infections].

Infantile seborrheic dermatitis (ISD), a disease occurring in the first months of life, is an erythematosquamous skin disease of unknown origin. This article presents results of microbial studies in 20 patients with ISD. Isolation of candida in a high percentage may indicate a primary role of this micro-organism in the etiology of this disease. It is striking that this disease often starts after disturbing the microbial colonization of the intestinal tract. Often ISD develops during the transition of breastfeeding to humanized cow milk.

Bottle Feeding↗

Seborrheic dermatitis: a newly reported side effect of neuroleptics.

Of 42 chronic patients with neuroleptic-induced parkinsonism, 25 were found to have seborrheic dermatitis; this side effect was seen in only 1 of 17 acute patients with neuroleptic-induced parkinsonism. Parkinsonian symptoms may precede the onset of seborrheic dermatitis in patients receiving chronic neuroleptic treatment.

Adult↗