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At least 253 records · Page 14Linked to original sources
PubMed1990

Cutaneous metastases of a giant cell tumor of bone: case report.

A 47-year-old patient with the previous history of a giant cell tumor of the left femur presented with 3 cutaneous nodules located on the face. Histologic examination revealed skin metastases of a giant cell tumor of bone, with dermal and subcutaneous nodules characterized by multinucleate giant cells and mononuclear cells. The patient died 10 months later from widespread metastases to the lung and brain. A panel of enzymo- and immunohistochemical markers reactive and osteoclastic, fibroblastic and histiocytic determinants was tested on the cutaneous lesions. The results indicated osteoclastic lineage of the multinucleate giant cells whereas the mononuclear cells showed features of fibroblastic differentiation. Cutaneous metastasis from a giant cell tumor of bone is an extraordinary event and so far has only been reported once.

Bone Neoplasms↗
PubMed2004

Small margin excision of periocular basal cell carcinoma: 5 year results.

BACKGROUND: The traditional surgical management of nodular adnexal basal cell carcinomas (BCC) involves excision with 3-4 mm margins and primary repair. This may remove a significant area of healthy tissue, often necessitating a complicated reconstruction, without the confirmation that tumour excision is complete. METHODS: Nodular adnexal BCCs were excised with 2 mm margins, and the repair delayed for 2 days, providing time for histological confirmation of complete excision with formal paraffin sections. Any incompletely excised tumours underwent further resection, which was facilitated by the undisturbed wound edges. Repair was again delayed until further histological examination had confirmed complete excision. RESULTS: 5 year follow up data were available for 55 patients who had undergone small margin BCC excision with delayed repair. 10 patients required more than one excision to achieve clear margins. There were no recurrences. CONCLUSION: Small margin excision of nodular adnexal BCCs with delayed repair is a safe and efficient method. Delayed repair allows histological confirmation of complete excision and assists further resection if required. Preservation of healthy tissue is maximised allowing less radical reconstructive surgery without resorting to Mohs' labour intensive technique.

Adult↗
PubMed1991

Application of PCR amplification of DNA from paraffin embedded tissue sections to linkage analysis in familial retinoblastoma.

A family segregating for the retinoblastoma predisposition gene has been analysed using the polymerase chain reaction to exclude their son as being an affected gene carrier. The unusual feature of this family is that the affected child, who would ordinarily have been used to establish phase in a linkage study, died as a result of developing a second tumour some years ago. The only tissue available from this child was a paraffin embedded, formalin fixed histopathological specimen from the second tumour. It was possible to isolate DNA from this tissue and amplify the DNA flanking two polymorphic restriction enzyme sites to establish alleles which cosegregated with tumour predisposition. Archival material can now be used to offer families such as this prenatal screening to provide informed genetic counselling.

Base Sequence↗
PubMed1984

A patient with six primary carcinomata.

We report a patient who developed six different primary carcinomata over a period of 3 years. These were of sigmoid colon, left breast, left kidney, right breast and two basal cell carcinomata of her face. These were all excised and she remains well with no apparent metastases 5 years after her initial presentation. Although patients with multiple tumours are uncommon, recognition of such an occurrence is important to avoid attributing symptoms to metastases from a previously diagnosed tumour. Sequential primary tumours may be amenable to treatment.

Adenocarcinoma↗
PubMed1992

Malignant melanoma in a Hispanic male with nevus of Ota.

Nevus of Ota is uncommon in the non-Oriental population. We report a case of malignant melanoma with metastasis to the genitourinary tract in a Hispanic male with nevus of Ota. Thirty-six prior cases of nevus of Ota with malignant melanoma reported in the English language are reviewed. Sixty-eight percent were women; 76% were Caucasians. Metastatic disease was reported in 16%. Three patients had liver metastases. Our case was the first involving the genitourinary tract. All but one patient with metastatic disease died within 1 month of presentation. Despite the increased frequency of nevus of Ota in the Japanese, only 4 cases of malignant melanoma have been reported. Nevus of Ota would appear to be a risk factor for developing malignant melanoma in the Caucasian population.

Brain Neoplasms↗
PubMed1991

A new classification of Ota's nevus based on histopathological features.

According to the distribution of the dermal melanocytes, Ota's nevus was classified into 5 types: superficial (type S), superficial dominant (type SD), diffuse (type Di), deep dominant (type DD), and deep (type De). The histological types were, as expected, relatively well-correlated with the color of the nevus: the most brownish lesions represented type S or type SD, while the most bluish lesions showed types Di, DD or De. Furthermore these types were strongly correlated with the location of the nevus: types S and SD were more frequent on cheeks, whereas types Di, DD and De more frequently occurred on eyelid, temple and forehead. When combining both colorations and locations of the nevus, our classification appeared much more significant. Our new histological classification of Ota's nevus may be very useful in making a therapeutic prognosis of the disease.

Adolescent↗
PubMed1976

Phlebographic appearance and pathogenesis of venous malformations in the orbit.

A retrospective clinical and radiographic analysis of 20 patients with orbital venous malformations was performed. The malformations were fed by other veins rather than arteries. They may nearly always be demonstrated by orbital or jugular phlebography, though occasionally they will fill only following direct puncture. There appeared to be varied etiologies. A few were related to trauma or to other causes of increased intraorbital pressure. There is an association with periorbital hemangiomas suggesting developmental or congenital origin.

Adolescent↗
PubMed1982

Granular basal cell tumors in the skin of three dogs: a distinct histopathologic entity.

Granular cell variants of cutaneous basal cell tumors from three dogs are described. These tumors resemble a granular cell variant of basal cell tumor (carcinoma) in man. The tumors are characterized by classical basal cells as well as granular cells with numerous cytoplasmic granules. These granules are cytoplasmic vacuoles 0.3 micrometer to 1.5 micrometer that seem to be secondary lysosomes; they usually contain many small (42 nm), membrane-bound vesicles. No natural, non-neoplastic counterpart of these granular cells is known to exist in the skin, and the significance of the production and accumulation of the small vesicles is not known. The cytoplasmic granules, and their contents, resemble the granules of granular cell "myoblastoma" although granular basal cells are of epithelial origin.

Animals↗
PubMed1987

Encephalocraniocutaneous lipomatosis.

Encephalocraniocutaneous lipomatosis is a distinct clinical syndrome characterized by unilateral cerebral malformations and ipsilateral scalp, face, and eye lesions. The cutaneous lesions are confined to the head. The central nervous system lesions consist in part of cerebral hemiatrophy, porencephaly, and defective opercularization of the insula. The intracranial lesions and clinical symptomatology are progressive, and appear, in part, to have a vascular pathogenesis. This suggests that a primary defect in the formation of tissues derived from embryonic mesenchyme may be responsible for the syndrome and that tissues derived from ectoderm may be secondarily affected.

Adolescent↗
PubMed1994

Nevus of Ota.

Explore the source record for details and available documents.

Adult↗