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PubMed1964

[TUMORS IN OLD AGE].

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Gastrointestinal Neoplasms↗
PubMed2004

[Clinical features and prognostic factors in primary adenocarcinoma of the appendix].

BACKGROUND/AIMS: Primary appendiceal adenocarcinoma is a rare neoplasm that constitutes less than 0.5% of all gastrointestinal neoplasm. The aim of this study was to figure out its clinicopathologic characteristics that are not well understood. METHODS: We reviewed the medical records of nineteen patients (9 males and 10 females) with histologically proven appendiceal adenocarcinoma. They had been treated at Asan Medical Center between June 1989 and December 2002. Their median follow-up duration was 72.5 months. RESULTS: Their median age was 56.5 (range, 33-80) years. Thirteen patients had mucinous variants and the other five had adenocarcinoma. Seven patients (36.8%) were diagnosed as acute appendicitis. In fact, none of the patients was diagnosed correctly before surgery. The operative procedure, included right hemicolectomy in 9 patients, appendectomy alone in 2 patients, and debulking of their tumors or a biopsy in 8 patients. The 5-year survival rate was 20.5%. The patients with mucinous type had better prognosis than those with the non-mucinous type (p<0.01). In the patients with mucinous type, the survival rate after debulking operation was similar to that after right hemicolectomy. CONCLUSIONS: The most important prognostic factor of primary appendiceal adenocarcinoma was histology. The outcome of debulking operation is being watched compared with that of right hemicolectomy in mucinous variant.

Adenocarcinoma↗
PubMed2005

[Epidemiologic and radiobiologic features of neoplasms in respiratory and gastrointestinal tracts among patients who had occupational contact with uranium].

Morbidity structure among workers engaged into main production of nuclear industry had prevailing lung cancer (1.93 per 1,000), gastric carcinoma (1.09) and colon cancer (0.72). The lung cancer patients demonstrated the highest concentrations of uranium in lung tissue (0.8313 g/g) and liver tissue (0.3548 g/g); those with gastric carcinoma and of reference group--in lung radix nodes (0.1855 and 0.3685 g/g respectively).

Gastric Mucosa↗
PubMed1984

Endoscopic diagnosis of a bleeding ileal carcinoid tumour.

Carcinoid tumour accounts for one per cent of all gastrointestinal neoplasms and has been reported in 0.5% of appendicectomy specimens. Local gastrointestinal complications occur infrequently and we report a case of repeated and massive gastrointestinal haemorrhage from a non-metabolically active carcinoid tumour of the distal ileum diagnosed by colonoscopy.

Carcinoid Tumor↗
PubMed1991

Gastrointestinal malignancy in patients with AIDS.

To clarify the prevalence and characteristics of gastrointestinal malignancy in patients with AIDS, we reviewed the demographics and clinical features of patients with AIDS and gastrointestinal neoplasms seen at North Central Bronx Hospital and Montefiore Medical Center during the past 8 yr. Malignant neoplasia complicated AIDS in 108/869 (12%) of the cases in our study. Most common was Kaposi's sarcoma (KS) (60%), followed by lymphoma (35%) and miscellaneous tumors (6.5%). The gastrointestinal tract was involved in 35/108 (32%) of patients with AIDS and neoplasia. Gastrointestinal tract involvement with KS usually was silent, although present, in every patient with KS who underwent autopsy. Lymphoma was most commonly non-Hodgkin's, and often produced symptoms. Uncommonly, the gastrointestinal tract was the primary site of neoplasms other than KS or lymphoma.

Acquired Immunodeficiency Syndrome↗
PubMed2006

A learning curve for endoscopic submucosal dissection of gastric epithelial neoplasms.

BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) has become a widely accepted method for treating gastrointestinal neoplasms. The objective of our study was to assess the learning curve for ESD of gastric epithelial neoplasms. PATIENTS AND METHODS: Clinicopathological data were retrospectively collected from 383 ESD procedures for gastric epithelial neoplasms that were performed over a 5-year period. Thirteen endoscopists were involved as operators during this period. In study 1, the performance of the two principal operators was assessed every 25 patients. In study 2, the performance of all 13 operators was assessed according to their experience. RESULTS: In study 1, the caseloads of the two principal operators were 188 and 118 ESD procedures. There were no significant differences found between successive groups of 25 patients with regard to en-bloc resection rate and bleeding and perforation complication rates. The size of the lesions and the resected specimen diameter increased significantly as the number of treated cases increased, whereas the average procedure time decreased significantly. In study 2, the operators' caseloads ranged from 1 to 188 cases, with 11/13 operators having experience of fewer than 30 cases. There was no significant difference in treatment efficacy and complication rates between the operators throughout the study period. The lesions were mainly located in the lower part of the stomach in the procedures performed by the 11 less experienced endoscopists. The procedure times shortened as experience in the method increased. CONCLUSIONS: Constant rates of both treatment efficacy and complications were achieved over a 5-year period of experience with ESD. A decrease in procedure time was found to be a marker of proficiency in this technique.

Clinical Competence↗