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PubMed2003

Factors influencing medical informatics examination grade--can biorhythm, astrological sign, seasonal aspect, or bad statistics predict outcome?

AIM: To investigate whether and to what extent various parameters, such as individual characteristics, computer habits, situational factors, and pseudoscientific variables, influence Medical Informatics examination grade, and how inadequate statistical analysis can lead to wrong conclusions. METHODS: The study included a total of 382 second-year undergraduate students at the Rijeka University School of Medicine in the period from 1996/97 to 2000/01 academic year. After passing the Medical Informatics exam, students filled out an anonymous questionnaire about their attitude toward learning medical informatics. They were asked to grade the course organization and curriculum content, and provide their date of birth; sex; study year; high school grades; Medical Informatics examination grade, type, and term; and describe their computer habits. From these data, we determined their zodiac signs and biorhythm. Data were compared by the use of t-test, one-way ANOVA with Tukey's honest significance difference test, and randomized complete block design ANOVA. RESULTS: Out of 21 variables analyzed, only 10 correlated with the average grade. Students taking Medical Informatics examination in the 1998/99 academic year earned lower average grade than any other generation. Significantly higher Medical Informatics exam grade was earned by students who finished a grammar high school; owned and regularly used a computer, Internet, and e-mail (p< or =0.002 for all items); passed an oral exam without taking a written test (p=0.004), or did not repeat the exam (p<0.001). Better high-school students and students with better grades from high-school informatics course also scored significantly better (p=0.032 and p<0.001, respectively). Grade in high-school mathematics, student's sex, and time of year when the examination was taken were not related to the grade, and neither were pseudoscientific parameters, such as student zodiac sign, zodiac sign quality, or biorhythm cycles, except when intentionally inadequate statistics was used for data analysis. CONCLUSION: Medical Informatics examination grades correlated with general learning capacity and computer habits of students, but showed no relation to other investigated parameters, such as examination term or pseudoscientific parameters. Inadequate statistical analysis can always confirm false conclusions.

Astrology↗

PubMed1977

Continuing education for general practice--a learning system.

A learning system for continuing education for general practitioners is described and illustrated by examples from educational programmes held in Doncaster. The work that needs to be done by organizers in planning, organizing, implementing, and evaluating educational programmes is outlined. I hope that this will help other organizers of continuing education.

Education, Medical, Continuing↗

PubMed2002

Using homework in therapy for depression.

There is a growing body of research evidence that demonstrates that completion of homework assignments is significantly correlated with outcome in cognitive therapy. The cognitive model of depression sees homework as an intrinsic aspect of the therapy process. Homework serves a number of purposes, including generalizing learning from the session into everyday life and fostering the independent practice of skills acquired during treatment. We review a number of commonly occurring problems that arise when seeking to engage the client in homework. The negotiation and implementation of homework assignments is a core clinical skill, and we present a range of strategies the clinician can use to optimize its effectiveness. It is vital that practitioners have an awareness of their own role and expectations in developing homework assignments.

Cognitive Behavioral Therapy↗

PubMed2001

Multicontextual occupational therapy intervention: A case study of traumatic brain injury.

Cognitive deficits after a traumatic brain injury can result in significant functional limitations in all areas of daily living. An individual's ability to generalize learning may be limited, thus making it harder to live independently in the community. Assessing a client's metacognitive skills and awareness level may help to establish a baseline understanding about the supervision required and the most suitable living arrangements. This study describes a multicontextual, community re-entry occupational therapy programme directed at awareness training and compensation for cognitive problems in a 34-year-old man with traumatic brain injury. Intervention consisted of metacognitive training, exploration and use of effective processing strategies, task gradations and practice of functional activities in multiple environmental contexts. Strategies such as self-prediction, self-monitoring, role reversal and the use of checklists were used. Results after six months of intervention show improvements in the client's awareness level, enhancement of his occupational function, increased satisfaction with performance and a decrease in the level of attendant care. Additional studies are recommended to validate the findings.

Journal Article↗

PubMed2003

Megavariate data analysis of mass spectrometric proteomics data using latent variable projection method.

There are many data mining techniques for processing and general learning of multivariate data. However, we believe the wavelet transformation and latent variable projection method are particularly useful for spectroscopic and chromatographic data. Projection based methods are designed to handle hugely multivariate nature of such data effectively. For the actual analysis of the data we have used latent variable projection methods such as principal component analysis (PCA) and partial least squares projection to latent structures based discriminant analysis (PLS-DA) to analyze the raw data presented to the participants of the First Duke Proteomics Data Mining Conference. PCA was used to solve problem #1 (clustering problem) and the PLS-DA was used to solve problem #2 (classification problem). The idea of internal and external cross-validation was used to validate the model obtained from the classification analysis. The simple two-component PLS-DA model obtained from the analysis performed well. The model has completely separated the two groups from all the data. The same model applied on two-thirds of the data showed good performance by external validation with independent test set of remaining 13 specimens obtained by setting aside the spectra of every third specimen (accuracy of 85%).

Artificial Intelligence↗

PubMed1999

Win-stay, lose-shift strategies for repeated games-memory length, aspiration levels and noise.

Win-stay, lose-shift, the principle to retain a successful action is a simple and general learning rule that can be applied to all types of repeated decision problems. In this paper I consider win-stay, lose-shift strategies with diverse memory sizes and strategies that adapt their aspiration levels, i.e. the payoff level considered as "success". I study their evolution for the Prisoner's Dilemma, as well as in a rapidly changing environment, where a randomly selected game is assigned to the players. For win-stay, lose-shift strategies with memory one the average payoffs are computed and their evolutionary stability is discussed. Using computer simulations I show that the win-stay, lose-shift strategies with longer memory are very successful both for the Prisoner's Dilemma, where cooperation dominates even for high noise levels, and the randomly assigned games, where the players achieve nearly the expected Pareto optimal payoffs. I discuss the impact of noise and show that the memory length of the players increases with the noise level. These results indicate that the win-stay, lose-shift principle is a very successful strategy in repeated games with noise.

Animals↗

PubMed1987

Stimulus properties of benzodiazepines: correlations with binding affinities, therapeutic potency, and structure activity relationships (SAR).

Using a two-lever operant choice task, rats were trained to discriminate diazepam (3.0 mg/kg) from saline under a fixed-ratio 10 (FR10) schedule of reinforcement. Once the discrimination was learned, generalization studies were conducted using various doses of 17 benzodiazepine derivatives. The diazepam stimulus generalized in a dose-related manner to each of these compounds. ED50 values were compared with available data on displacing affinities (Ki values) for tritiated diazepam brain binding in man, and with human therapeutic potency. A significant correlation (r = 0.88, n = 9) was found between benzodiazepine binding affinities and ED50 values derived from the diazepam stimulus generalization assay. A significant correlation (r = 0.92, n = 10) was also found between drug discrimination ED50 values and human therapeutic potencies. Finally, the benzodiazepine structure activity relationships generated from the drug discrimination studies closely paralleled the known structure activity relationships for these agents. The results provide further evidence that benzodiazepines exert their pharmacological effects through an interaction with benzodiazepine receptors.

Animals↗

PubMed1992

Nucleus basalis lesions in neonate rats induce a selective cortical cholinergic hypofunction and cognitive deficits during adulthood.

Ibotenic acid was infused into the nucleus basalis magnocellularis (nBM) of 2-day old rats to eliminate immature cholinergic neurons before they develop functional synaptic connections in the neocortex. For bilaterally lesioned neonates, cognitive testing was initiated 2 months after lesioning and animals were sacrificed at 8 or 12 months of age. Lesioned animals exhibited a marked deficit in the retention of passive avoidance behavior, as well as in the acquisition of 2-way active avoidance behavior. Lesioned animals also made significantly more alternation errors than control animals in the Lashley III spatial maze and showed severe impairments in general learning, reference memory and working memory during 17-arm radial maze testing. For all 4 tasks, neonatally lesioned animals did not show any recovery to the performance level of control animals. Histological analysis of the subcortex from lesioned animals during adulthood revealed: (1) a substantial reduction in acetylcholinesterase-positive cells (presumably cholinergic) within the nucleus basalis, (2) decreased acetylcholinesterase staining in neocortex and (3) a gliosis essentially restricted to the globus pallidus. Surrounding brain regions were apparently not damaged as a direct result of excitotoxin infusion. Neurochemically, neonate nBM lesioning produced a long term cholinergic hypofunction as evidenced by significant reductions of 25% and 18% in frontal cortex choline acetyltransferase (CAT) activity at 12 and 8 months of age, respectively. By contrast, prefrontal cortical concentrations of biogenic amines and their metabolites were unaffected, thus indicating a degree of neurochemical specificity for these neonatal nBM lesions. The persistent cortical cholinergic hypofunction in lesioned animals may be related to the long term deficits in learning/memory abilities that were also observed. It is suggested that neonatal nBM lesioning could provide a useful animal model for elucidating the plasticity of the developing brain after cortical anervation.

Acetylcholinesterase↗

PubMed1983

Using pictorial representations as communication means with low-functioning children.

Three low-functioning children were successfully taught pictorial representations as communication means. Initially, the subjects were trained to associate cards representing objects with the corresponding objects. Then, they were trained to respond to: (a) cards depicting body positions, (b) cards depicting body positions related to objects, and (c) cards representing simple activities as well as activities involving two children. Subsequently, they were trained to complete cards representing activities involving two children, independently, and to choose the roles for the execution of these activities. At last, they were taught to select from among cards on display, to complete such cards, and to choose the roles for the execution of the activities all by themselves. During the program high generalization learning was observed.

Autistic Disorder↗

PubMed1979

Perception of contingency and mental retardation.

It is argued that the general learning difficulties exhibited by mentally retarded persons are similar in many respects to the learning difficulties of nonretarded persons who are in a state of learned helplessness (Seligman, 1975) or who are external in locus of control orientation. It is suggested that studies of locus of control and learned helplessness as theoretical constructs both directly concern the perceiving of relationships between behavior and outcomes, and that a systematic investigation of perception of contingency might increase our understanding of some of the learning difficulties of mentally retarded persons. An overview is given of the results of the few studies that have addressed perception of contingency and mental retardation, and suggestions for future research are offered.

Humans↗

PubMed1976

[On the evolution of voice (author's transl)].

The paper gives a short survey of the phylogenetic development of the laryngeal and supralaryngeal apparatus from amphibians to man. The increasing differentiation of vocal behaviour, paralleling the differentiation of the vocal apparatus, is outlined and special reference is made to the non-verbal component in human language. It is stressed that animal vocal repertoires can be extremely rich, but in contrast to human verbal behaviour they are generated almost exclusively by laryngeal modulations and only to a minimal degree by supralaryngeal activity (i.e. articulation). A phylogenetic development can also be seen in the cerebral organization of vocal behaviour. In amphibians, reptiles and lower mammals, the dorsal midbrain-pons transitional zone seems to be the only area responsible for the production of vocal utterances. This area probably serves in integrating vocal fold movements, expiration, intra- and extra-oral muscle activity into species-specific vocal patterns; its destruction results in mutism. In higher mammals, including man, this area does not lose its original function but is brought under the control of the cortex around the anterior sulcus cinguli (supplementary motor area and anterior cingulate gyrus). The latter seems to play an essential role in the initiation of vocal utterances in situations which do not have a rigid stimulus-response characteristic, i.e. in voluntary vocal behaviour. The highest level of voice production, finally is represented by the cortical face area, the destruction of which is without consequence to the innate vocal behaviour of animals but produces dysarthria in man. This area (together with its associated structures, such as the cortex-pontine nuclei-cerebellum-thalamus-cortex circuit) seems to be essential for the production of verbal or, more generally, learned vocal behaviour.

Amphibians↗

PubMed1999

Occupational physicians' education and training across European Union countries.

The framework directive on improvements in the safety and health of workers is being implemented into the national legislation of European Union countries, and occupational physicians are requested to play a key role in undertaking preventive measures. Since there is no common specific requirement for the training and education of these health professionals, this report aims to provide a comparative picture of the educational process across European Union training bodies. Each curriculum provides theoretical knowledge and practical experience, but deep differences exist among different countries. Core knowledge is mainly based on the traditional disciplines (such as occupational hygiene, occupational toxicology, ergonomics, epidemiology and biostatistics, relevant legislation, and preventive medicine). General learning objectives should include assessment of the workplace environment, communication and education, legislation, occupational diseases, and relationships between health and work. Core experience, often based on task-based learning, emphasizes the need for assessment of a range of working environments; for surveillance, including the biological monitoring, of workers at risk; for assessment of disability, impairment, and fitness for work; for the clinical ability to recognize occupational diseases; for the formulation of differential diagnosis; and for management of workers developing disease in the course of their employment. New curricular elements (such as management, economics, quality assurance, and marketing) are being introduced in some institutions with the aim of stressing the renewed role of the occupational physician in meeting society and employers' needs. The need to educate and train a professional figure whose competence should allow the delivery of high-quality occupational health services across European Union countries compels the harmonization of the formative process of occupational physicians.

Curriculum↗

PubMed2006

The significance of sigma neurofeedback training on sleep spindles and aspects of declarative memory.

The functional significance of sleep spindles for overnight memory consolidation and general learning aptitude as well as the effect of four 10-minute sessions of spindle frequency (11.6-16 Hz, sigma) neurofeedback-training on subsequent sleep spindle activity and overnight performance change was investigated. Before sleep, subjects were trained on a paired-associate word list task after having received either neurofeedback training (NFT) or pseudofeedback training (PFT). Although NFT had no significant impact on subsequent spindle activity and behavioral outcomes, there was a trend for enhanced sigma band-power during NREM (stage 2 to 4) sleep after NFT as compared to PFT. Furthermore, a significant positive correlation between spindle activity during slow wave sleep (in the first night half) and overall memory performance was revealed. The results support the view that the considerable inter-individual variance in sleep spindle activity can at least be partly explained by differences in the ability to acquire new declarative information. We conclude that the short NFT before sleep was not sufficient to efficiently enhance phasic spindle activity and/or to influence memory processing. NFT was, however, successful in increasing sigma power, presumably because sigma NFT effects become more easily evident in actually trained frequency bands than in associated phasic spindle activity.

Adolescent↗

PubMed1990

Automaticity: a new framework for dyslexia research?

The performance of a group of 23 13-year-old dyslexic children was compared with that of same-age controls on a battery of tests of motor balance. A dual-task paradigm was used--subjects performed each test twice, once as a single task, and once as a dual task concurrently with a secondary task. Two alternative secondary tasks were used, the classic counting-backwards task and an auditory choice reaction task. Both secondary tasks were calibrated for each subject to ensure that their performance on the secondary task alone fell between pre-specified performance criteria. In all single-task conditions there was no difference between the performance of the two groups. By contrast, in 19 out of the 20 tests performed under dual-task conditions, the dyslexic group were significantly impaired, whereas the controls showed no impairment, thus resulting in significantly better performance by the control group than the dyslexic group. The sole exception was that the dyslexic children were not impaired on the easiest balance condition with the choice reaction task. Under the dual-task conditions the dyslexic children also performed worse than the controls on the secondary task. It is very hard to accommodate the findings within the traditional framework of a deficit specific to lexical skills. One plausible explanation of the results is that, unlike the controls, the dyslexic children need to invest significant conscious resources for monitoring balance, and thus their performance is adversely affected by any secondary task which serves to distract attention from the primary task. This need for "conscious compensation" suggests that for dyslexic children the skill of motor balance is poorly automatized. It is possible, therefore, that many of the reading deficits of dyslexic children are merely symptoms of a more general learning deficit--the failure to fully automatize skills.

Adolescent↗

PubMed1989

Computer-based visual communication in aphasia.

The authors describe their recently developed Computer-aided VIsual Communication (C-VIC) system, and report results of single-subject experimental designs probing its use with five chronic, severely impaired aphasic individuals. Studies replicate earlier results obtained with a non-computerized system, demonstrate patient competence with the computer implementation, extend the system's utility, and identify promising areas of application. Results of the single-subject experimental designs clarify patients' learning, generalization, and retention patterns, and highlight areas of performance difficulties. Future directions for the project are indicated.

Aphasia↗

PubMed2004

Participation of the thalamofugal visual pathway in a coarse pattern discrimination task in an open arena.

The purpose of this study was to examine the role of the thalamofugal pathway in far-field visual processing. Experiment 1 examined the role of the visual wulst and the ectostriatum in a far-field pattern discrimination task in a large open arena. Control pigeons, pigeons with ectostriatum lesions, and pigeons with wulst lesions were trained to discriminate between four patterns within the arena. Ectostriatum-lesioned pigeons were unimpaired and behaved similar to controls. By contrast, wulst-lesioned pigeons were severely impaired in the pattern discrimination task in the open arena and performed poorer than control pigeons and pigeons with ectostriatum lesions. Statistical analyses of regional contributions to the observed impairment identified the left visual wulst and bilateral hyperstriatum ventrale, which lies outside the wulst, as interesting areas. To ensure that the impairment was not due to a general learning deficit, experiment 2 involved training the pigeons in a pattern discrimination task carried out in an operant chamber, which presumably required use of near-field visual information. Wulst-lesioned pigeons were able to learn the task and performed at a level no different from control pigeons. The results of these experiments support the proposal that the wulst may be important for processing far-field information.

Animals↗

PubMed2002

Teaching veterinary parasitology: the North American perspective.

The American Association of Veterinary Parasitologists (AAVP) initiated a study of parasitology curricula in veterinary schools in the US and Canada in November 1989. An ad hoc committee (Task Force) and then the Education Committee developed a position paper on teaching parasitology in veterinary colleges. In addition to confirming the importance of parasitology as a discipline they recommended a set of general learning objectives and proposed topic-specific titles rather than parasite-/group-specific titles. Another problem observed in teaching parasitology was a significant reduction in time available to teach parasitology. One way to compensate for the lost classroom time is to utilize some of the technological advances in presenting the material to students.

Animals↗

PubMed1997

Phosphorus-31 magnetic resonance brain spectroscopy of children at risk for a substance use disorder: preliminary results.

The purpose of this exploratory investigation was to evaluate the heuristic potential of 31P magnetic resonance spectroscopy (MRS) in elucidating a neurobiologic component of the liability for a substance use disorder (SUD). We investigated 31P MRS spectra employing chemical shift imaging (CSI) derived from four distinct anatomic brain locations (i.e. frontal, occipital, right parietal, left parietal) in three groups of peripubertal children who are hypothesized to be at increasing levels of familial SUD risk. Specifically, we studied children with a positive paternal family history of SUD and a disruptive behavior disorder (DBD) diagnosis (SUD+/DBD+; n = 10), in contrast, to those with a positive paternal SUD history in the absence of other psychopathology (SUD+/DBD-; n = 13) and matched control children from normal families (SUD-/DBD-; n = 13). In addition, we examined neurocognitive tests of our subjects to determine any associations between cognitive capacities with regional 31P MRS spectra. The highest-risk sample (SUD+/DBD+) demonstrated a diminished proportion of phosphodiesters confined to the right parietal voxel. This right parietal phosphodiester proportion correlated only with the Information Scale score on a standard intelligence test for children. This suggested a relationship between general learning ability and motivation for academic achievement and right parietal physiology in the highest-risk sample. Variations in synaptic pruning could account for this observation.

Adolescent↗