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[Advanced closed-angle glaucoma with intercalary staphylomas].

The case of a 70-year-old woman displaying a quasiabsolute glaucoma with large scleral juxtalimbic ectasias at both eyes is reported. The gonioscopic examination shows a closed-angle glaucoma developing for about 10 years with subacute crises, neglected by the patient. Vision at the right eye 1/50 nc, intraocular pressure at the right eye = 34.4 mmHg vision at the left eye = 3/50 nc, intraocular pressure at the left eye = 41.4 mmHg. The ocular examination reveals a small anterior chamber, sectorial iridic atrophies, a mydriatic pupil, the camerular angle closed. The fundus of the eye shows the atrophy of the papilla and excavation with the C/D ratio 0.9 at the right eye and 0.8 at the left eye. It is pointed out that the closed-angle glaucoma may have a subacute course, leading finally to the quasiabsolute stage, with large scleral ectasias like in the open-angle glaucoma.

Acute Disease↗

[Retinitis pigmentosa associated with glaucoma].

Analysis of 1400 cases of retinitis pigmentosa revealed that (1) 32 cases (2.3%) were associated with glaucoma, of which (2) 30 cases were of the angle closure type; (3) the C/D ratio was normal in over one half of the cases, and in 5 cases the optic disk remained normal after 1/2-5 years of persistent IOP elevation; (4) in 31 cases (97%) the blood pressure was below the norm of equivalent age group; and (5) pathologic examination of the trabecular meshwork in 14 cases showed no excessive pigment deposition to obstruct the outflow channels.

Adolescent↗

Argon laser iridoplasty: a primary mode of therapy in primary angle closure glaucoma.

Argon laser iridoplasty was performed in 40 eyes of 33 patients of primary angle closure glaucoma. There were 12 male and 21 female patients. The mean ages of the male and female patients were 51 years and 48.4 years respectively. Forty eyes were divided into two groups. Group I consisted of ten eyes of subacute angle closure glaucoma and group II included thirty eyes of chronic angle closure glaucoma. Argon laser iridoplasty was performed with Coherent 9000 model using laser settings of spot size 200 micron, duration 0.2 second and power 0.7 watt. A total of 80 spots were applied over 360 degree circumference. The intraocular pressure control (below 22 mm Hg) was achieved after iridoplasty in all the eyes (100%) in group I, where as in group II the intraocular pressure was controlled in 70% eyes. The follow up period varied from 3 months to one year with a mean of eight months. The success rate with iridoplasty was directly related to the extent of peripheral anterior synechiae, optic disc cupping and presence of visual field changes.

Acute Disease↗

Angle closure glaucoma precipitated by aerosolized atropine.

Angle closure glaucoma is an infrequent form of glaucoma occurring when the filtration mechanism for the aqueous humor is obstructed by apposition of the peripheral iris to the trabecular meshwork. Anatomic features associated with acute-angle closure include congenitally small anterior segments, increased lens thickness, and shallow anterior chamber depth. We present two patients who developed signs and symptoms of angle closure glaucoma after receiving aerosolized atropine for treatment of chronic obstructive pulmonary disease. We recommend that before instituting therapy with an inhaled anticholinergic agent, the patient should be questioned concerning prior history of angle closure glaucoma symptoms and signs and the anterior chamber depth should be examined using iris illumination. Patients having shallow anterior chambers, or possible prior angle closure glaucoma attacks, should be examined by an ophthalmologist before inhalant anticholinergic therapy.

Administration, Inhalation↗

Infectious crystalline keratopathy occurring in an eye subsequent to glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil.

We present a case of infectious crystalline keratopathy occurring after 5-fluorouracil filtering surgery. The patient had discrete, branching, white crystalline lesions in the anterior corneal stroma. Cultures grew Streptococcus viridans, and gram-positive cocci were demonstrated in corneal tissue biopsy specimens. Toxic and immunosuppressive properties of 5-fluorouracil may have participated in the pathogenesis of the infectious crystalline keratitis.

Chronic Disease↗

[Surgical treatment of closed-angle glaucoma].

The efficacy of sclerocyclodialysis surgical technique was analyzed in 65 patients (67 eyes) with closed-angle glaucoma with organic blocking of the anterior chamber corner. Ophthalmic tone normalization directly after surgery was achieved in all the cases; in late periods (1 to 3.5 years after the operation) the best hypotensive effect with improved or preserved visual functions was observed mainly in the patients with the initial or well-developed stages of the glaucomatous process.

Follow-Up Studies↗

Corneal decompensation after argon laser iridectomy--a delayed complication.

We report six eyes in six patients in which corneal decompensation developed 18 or more months after argon laser iridectomy (ALI). In addition to the level of laser energy used, other risk factors included performing ALI during an attack, diabetes, and a cornea damaged by glaucomatous attack. The interval between the ALI and corneal decompensation ranged from 18 months to 3 1/2 years.

Adult↗

Management of contact lens associated Acanthamoeba keratitis.

Four patients with contact lens associated Acanthamoeba keratitis were treated at Wills Eye Hospital between 1987 and 1989. Two patients had used daily wear soft contact lenses and two had worn hard contact lenses. All four patients were treated with topical antibiotics (propamidine and neomycin), oral ketoconazole, and varying amounts of topical steroids. Two of these patients received topical clotrimazole. All four patients eventually required surgery for either control of their infection (three cases) or control of secondary disease (glaucoma and cataract). Medical therapy for Acanthamoeba keratitis remains problematic, and therefore prevention of this disease by avoidance of risk factors remains paramount.

Acanthamoeba Keratitis↗

[The partner eye in unilateral malignant glaucoma].

The fellow eyes of 9 Patients suffering of unilateral classical malignant glaucoma have been throughly examined short after the onset of malignant glaucoma. In 3 cases they were apparently normal, in other 3 cases they exhibited an intermittent primary angle closure glaucoma and in the remaining 3 ones an absolute glaucoma. The therapeutic options of these fellow eyes are discussed.

Adult↗

Combined technique of argon-laser and neodymium-YAG laser photocoagulation for narrow-or closed-angle glaucoma.

A combined laser technique was applied in 76 eyes with narrow- or closed-angle glaucoma. In the first act circular Argon-laser iridoplasty was performed, to be followed by peripheral Nd-YAG laser iridotomy. Before the laser application, intraocular pressure was decreased using medicamentous antiglaucoma therapy to 30 mmHg or less. Argon-laser iridoplasty was performed in the peripheral third of the total iris circumference applying cca 20 laser spots. Eight days later, Nd-YAG laser iridotomy was performed at the site of the previous Argon-laser spot. Postoperative intraocular pressure was normal in 64 out of 76 eyes (84.2%) on the last check-up, and the additional antiglaucoma medications was significantly reduced. In a small number of cases i.e. 24 eyes (31.6%), the medical therapy was altogether cancelled. In 12 eyes (15.8%) the laser treatment has failed, and antiglaucoma surgery had to be performed subsequently. The observation period ranged from 4 to 25 months.

Adult↗

[Current concepts in malignant glaucoma].

The paper reports on the main pathogenic types of anatomical blocking of the aqueous humor circulation in malignant glaucoma: pupillary, secondary iridolenticular, ciliovitreolenticular, iridociliovitreous blocks and in suprachoroidal effusion. The paper also presents some of the entities correlated with malignant glaucoma: glaucoma with blocked angle following the administration of miotics, traumatisms, the operations of scleral obstruction for retina detachment, panretinal photocoagulation and thrombosis of the retina central vein.

Acute Disease↗

The management of glaucoma in nanophthalmos.

Patients with nanophthalmos are prone to develop a chronic painless type of glaucoma in middle age, probably due to the natural increase in the size of the lens which is already relatively too large for the small eye. Although the underlying mechanism is obscure, a slowly progressive "creeping" chronic angle-closure is postulated, but gonioscopic evaluation is difficult due to the shallow anterior chamber, with grade I and slit angles. Response to medical treatment is poor and miotics may even make the condition worse by producing relative pupillary block and by relaxing the lens zonule. Ordinary glaucoma surgery is to be avoided in nanophthalmos because of the fear of postoperative ciliary-block malignant glaucoma. Periopheral iridectomy performed in five eyes at an advanced stage of the chronic angle-closure did not facilitate glaucoma control in three eyes, and in two eyes in which the operation was combined with posterior sclerotomy, the eyes became blind from vitreous hemorrhage. Lenx extraction in five eyes controlled the glaucoma but was followed by choroidal effusion and nonrhegmatogenous retinal detachements in two eyes and blindness in another eye when combined with a posterior sclerotomy. No firm therapeutic recommendations can be made on the basis of the author's experience in the six reported cases. Conventional medical therapy seems ineffectual even when begun early in the glaucoma. Conventional glaucoma surgery must be performed early, before permanent damage to the outflow mechanism occurs but removal of the lens must be anticipated. The surgeon must also remain aware of the high incidence of serious posterior-segment complications which inexplicably follow glaucoma or lens surgery in nanophthalmos, as described by Brockhurst.

Adult↗

The prediction of glaucoma from ocular biometric data. Part 1. An application of multiple regression analysis.

Two sets of multiple regression equations (prediction systems) were derived from the analysis of ocular biometric data obtained from glaucoma patients (16 open angle; 16 angle-closure) and 75 normal subjects. Discriminant scores were established for both sets of equations which minimised the number of false negatives. One set, the 'Glaucoma Equations' was applied to the data to segregate the glaucoma from the normal subjects. The other prediction system, the 'Classification Equations,' was then applied to the group defined as glaucomatous to discriminate between patients in the angle-closure and open angle categories. The performance of these equations, obtained by comparing the predicted and actual classifications for this sample, was such that between 9 and 12% of false positives and 0 and 3% false negatives were found on the 'Glaucoma Equations' and between 6 and 12% of false positives with no false negatives on the 'Classification Equations.'

Age Factors↗

Survey of the first-degree relatives of glaucoma patients.

Family histories were taken from 124 index patients, who had presented with either angle-closure or open angle glaucoma to the University Department of Ophthalmology, Manchester, between 1967 and 1972. Their first-degree relatives numbered 886, i.e. siblings, offspring and parents. Relatives were contacted by post and asked to attend for eye examination. Out of a total of 886 relatives, only 187 relatives were actually examined. The reasons for this low attendance rate are discussed; e.g. 423 relatives had already died.

Age Factors↗

Trabeculectomy: long-term follow-up.

The postoperative course of 309 eyes subjected to trabeculectomy has been studied over a 7-year period. The results have been compiled with regard to effectiveness to maintain a normal range of intraocular pressure with and without postoperative medication. The figures have been assessed in toto and for 3 groups of glaucoma, namely, open angle, chronic angle-closure, and acute angle-closure. Results support those of other reports to show that trabeculectomy gives satisfactory control over the years in a reasonably high proportion of eyes and with relatively few postoperative complications. There is also a small group of combined trabeculectomy with cataract extraction.

Cataract Extraction↗

Combined cyclodialysis and cataract extraction.

Combined cyclodialysis and cataract extraction was performed on 78 eyes in a consecutive series of 26 years duration. This operation was performed on eyes with severe glaucoma, inadequately controlled on maximum medical therapy, and with a cataract needing extraction. Glaucoma types included open-angle, angle-closure with peripheral anterior synechias, combined open-angle and angle-closure, and secondary to uveitis. Seventy of the 78 eyes had follow-up of six months or more and the results in these 70 eyes were analyzed. In thirteen percent of the eyes in this study the postoperative intraocular pressure was the same or higher than the preoperative level, or reductions of intraocular pressure were not clinically significant. Eighty-seven percent (61 eyes) had a clinically significant lowering of intraocular pressure following the combined procedure. Thirty-nine percent (27 eyes) of the 70 eyes in this study had a tension of 0-14 mm Hg, and 44% (31 eyes) had a tension of 15-20 mm Hg. Intraocular pressure was improved significantly more often in patients over 60 years of age. Resulting intraocular pressures of 14 mm Hg or less were more likely when the cyclodialysis was performed in the lower quadrant. The results of the combined procedure were not significantly influenced by the type of glaucoma involved or by a history of previous glaucoma surgery. Bleeding was a frequent complication, but was not related to resulting intraocular pressure. Other complications were rare. We conclude that combining cyclodialysis with cataract extraction is safe and effective, and is a suitable procedure when there is need for surgery to relieve severe glaucoma, along with a need for cataract extraction.

Adolescent↗