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Results for “Peripheral Nervous System Neoplasms”

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At least 253 records · Page 14Linked to original sources
PubMed1978

[Topographical diagnosis of orbital lesions with contact B-scan ultrasonography (author's transl)].

With contact B-scan ultrasongraphy it is possible, to determine the topographical relations of space occupieing lesions to the main orbital structures. This enables the examiner to answer three important questions: (1) In which part of the orbit the lesion is located? (2) Is the proptosis produced by a lesion separate from the muscles and the optic nerve or (3) are these structures themselves affected? Our results are compared with those made by A-scan ultrasonography. The existing range of echographical patterns known of orbital tumors is thus widened by the topographical diagnosis elicited by contact B-scan ultrasonography.

Abscess↗
PubMed1995

Novel fluorescence in situ hybridization approaches in solid tumors. Characterization of frozen specimens, touch preparations, and cytological preparations.

Fluorescence in situ hybridization has emerged as an extremely important tool for detection and characterization of nonrandom chromosome aberrations in cancer. Fluorescence in situ hybridization assays have been very reliable in cytogenetic tumor preparations, but have been more unpredictable in archival, paraffin-embedded specimens. We describe novel approaches for detection of chromosome aberrations in frozen tumor specimens, touch preparations, and cytological preparations. These approaches are both simple and reproducible, with minimal case-to-case variation in hybridization efficiency or hybridization signal quality. We demonstrate potential applications of these novel approaches by evaluating: 1) significance of normal karyotypes in malignant peripheral nerve sheath tumors; 2) p15/p16 copy number in prostate cancer; and 3) clonal chromosome 3p deletion in cytological preparations of pleural fluid from patients with mesothelioma.

Centromere↗
PubMed1994

Neurogenic tumors of the orbit.

Fifty-three patients with neurogenic orbital tumors were diagnosed and treated at our university hospital during the past three decades. There were 16 patients with juvenile pilocytic astrocytomas, 21 patients with meningiomas and 16 with peripheral nerve tumors. Of the 16 peripheral nerve tumor patients, 8 had schwannoma, 4 had neurofibroma, 2 had malignant schwannoma, one had paraganglioma and one had amputation neuroma. Optic nerve tumors were treated via a transfrontal craniotomy if there was no chiasmal involvement. Cases with chiasmal involvement, incomplete resections and recurrences were treated with radiotherapy (5000 cGy). Far advanced cases with progressive proptosis and ocular damage underwent exenteration. Peripheral nerve tumors were treated by local resection. Exenteration was applied when there was an advanced or malignant lesion. Four of the 16 glioma patients and 5 of the 21 meningioma patients died during follow-up. The prognosis for peripheral nerve tumors was generally good, except for malignant schwannomas. Two patients with this malignant tumor died within 2 years after surgery.

Adolescent↗
PubMed1994

Tumour of a peripheral nerve sheath with invasion of the lumbar spine.

Tumours of peripheral nerve sheaths are rarely malignant, and even when malignant they are only infrequently associated with extensive destruction of bone. The authors report the computed tomography and magnetic resonance imaging findings for an unusually large sheath tumour that presented with extensive destruction in the lumbar spine.

Aged↗
PubMedDate not supplied

[Cauda equina syndrome disclosing adenocarcinoma of the ethmoid].

Cauda equina metastases have been exceptionally described in sinusal neoplasms. MRI with gadolinium injection show up the primitive lesion and its neurologic extension. We report a case of cauda equina syndrome in which, only MRI, had show up intradural metastases and localised the ethmoïd sinus carcinoma.

Adenocarcinoma↗
PubMed1996

Cauda equina metastasis from ovarian malignancy.

SUMMARY: A case of cauda equina metastasis from ovarian serous papillary adenocarcinoma in a 51-year-old patient is reported. The clinical significance and different hypotheses on the metastatic route to the spine are discussed.

Cauda Equina↗
PubMed1997

[Perineurioma].

Perineurioma (storiform perineurial fibroma) is a rarely diagnosed benign tumour of perineurial cells. Presented tumour occurred subcutaneously in the right thigh of a 53-year-old man. It was well limited and consisted of whirl like and concentric laminar bundles of spindle and oval cells in variable local density. A storiform pattern was not present. Cells with richer cytoplasm, bland nuclei and solitary intranuclear pseudoinclusions formed focal meningioma like structures. Differential diagnosis had to distinguish benign neuronal tumours, myxoid variant of dermatofibrosarcoma protuberans and especially a "low grade" fibromyxoid sarcoma. A relevant immunohistochemical marker of perineurioma (for differential diagnosis) was the expression of epithelial membrane antigen (EMA) with negativity of S-100 protein.

Diagnosis, Differential↗
PubMed1997

Malignant peripheral nerve sheath tumor with extensive miliary metastases: a case report.

We report the course of a 19-year-old female who presented with a 13-year history of an occipital dermal tumor. Only five weeks after excision, the patient succumbed to cerebral dysregulation due to extensive miliary cerebral, hepatic, and pulmonary metastasis. The histologic features of the surgical specimen and the autopsy material differed suspiciously: a peculiar malignant progression of the tumor seemed to have occurred within five weeks.

Adult↗
PubMed1997

[Perineural invasion and surgical treatment of the pancreas head cancer].

It is thought that perineural invasion by pancreatic cancer takes place either by means of direct tumor invasion of the perineural space or by means of tumor invasion through the vessels perforating the perineurium. The manner of tumor progression may be divided into four types: (1) direct progression of cancer cells into the perineural space, (2) branching at the bifurcation of the nerve fascicle, (3) perineural invasion by a probing cancer tip, and (4) invasion beyond the perineurium through defects in it. Because pancreatic cancer is often followed by severe tumor invasion of surrounding organs, major blood vessels and extrapancreatic plexus, the survival rate after the conventional pancreatoduodenectomy has been unsatisfactory. Since 1977, the author has used extended pancreatectomy with a trans-lateral retroperitoneal approach, involving resection of the portal vein, extensive excision of the retroperitoneal lymph nodes and complete resection of the pancreatic head plexus. After this surgery, 11 patients survived for more than 3 years. The five-year survival rate was 25% in case where this operation was rated as being a macroscopic curative resection.

Humans↗
PubMed1997

Neuro-ophthalmologic manifestations of adenoid cystic carcinoma.

Intracranial adenoid cystic carcinoma is uncommon. We report two unusual cases of intracranial adenoid cystic carcinoma. The first patient presented with a steroid-responsive optic neuropathy from an orbital mass that simulated orbital pseudotumor, and subsequently developed intracranial involvement, presumably by contiguous perineural spread. The second patient presented with proptosis of the left eye, right facial weakness and numbness, and an intracranial mass, presumably from hematogenous metastatic spread.

Adult↗