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PubMed1975

The occurrence of Mycoplasma arthritidis in the throat and middle ear of rats with chronic respiratory disease.

Twenty-three rats with chronic respiratory disease were examined for the presence of Mycoplasma arthritidis in the throat and middle ear. Samples were taken at necropsy and swabbed onto an agar medium. Morphologically typical colonies were subcultured and identified serologically. All of the rats showed evidence histopathologically of chronic respiratory disease, and typical M pulmonis colonies were isolated from 21 of 23. M arthritidis was isolated from 7 (30=) of the middle ears and 3 (13%) of the throats, confirming a previous observation of the occurrence of this organism in the middle ear of rats and also indicating it can be present in the throat.

Animals↗
PubMed2002

The natural history and clinical characteristics of aspirin-exacerbated respiratory disease.

BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome characterized by chronic rhinitis, nasal polyps, asthma, and precipitation of asthma and rhinitis attacks after ingestion of aspirin (ASA) and most nonsteroidal anti-inflammatory drugs (NSAIDs). Most information about the disease in the United States has come from small samples of patients. OBJECTIVE: The purpose of this study was to examine the natural history and clinical characteristics of 300 AERD patients, referred to our institution for aspirin desensitization. METHODS: All potential AERD patients were evaluated using a standard questionnaire that included information about clinical characteristics and natural progression of their disease, previous history of reactions to ASA and other NSAIDs, current use of medications, and ethnic backgrounds. All patients underwent oral ASA challenges to prove they had AERD. RESULTS: From patients' history we found that the average age at onset of AERD was 34 years, and that 57% were female. Counting ASA as an NSAID, 33% had previously reacted on two occasions to NSAIDs and 36% on more than three occasions to NSAIDs, whereas only 27% had reacted to one NSAID before they came to us for evaluation. Our patients had averaged 5.5 episodes of sinusitis per year. There were no significant differences in the clinical characteristics or use of medications between genders. Ethnicity was heterogeneous in most participants. CONCLUSIONS: AERD begins in the third decade of life and in both sexes. The disease progressed over the 13 years between historical onset and current evaluation, with more sinusitis and need for controller medications over time. There was no ethnic or familial distribution of AERD.

Acute Disease↗
PubMed1989

Respiratory disease mortality patterns among South African iron moulders.

To assess the influence of foundry exposure on malignant and non-malignant respiratory disease, the proportional mortality ratio (PMR) was used to compare the cause of death distributions of the 578 dead members of the Iron Moulders Society of South Africa, recipients of the union's death benefit fund between 1961 and 1983. Comparisons were made with the age and period specific white male deaths. For the 419 members where job information was available, the influence of occupation (journeyman, production moulder) was assessed using different techniques--the relative proportional mortality ratio (RPMR), the mortality odds ratio (MOR), and the proportional cancer mortality ratio (PCMR) for comparison. Excess PMRs were found for cancer of the trachea, bronchus, and lung (1.71, p = 0.03; Poisson one sided test) for those over 65 and for non-malignant respiratory disease (1.58, p = 0.01) and for injuries and poisonings (2.61, p less than 0.0001) in those under 65. Reduced PMRs were found for all cancers (0.75, p = 0.03) and all circulatory disease (0.91, p = 0.12) in those under 65. When comparing job types, raised risks were obtained for journeymen using all methods (RPMR, MOR, PCMR) but the small cell sizes rendered the results non-significant. The raised PMRs due to respiratory disease are unlikely to be due to smoking because of a poor association with other causes of death related to smoking. A more likely explanation is that these excess rates for malignant and non-malignant respiratory disease are due to exposure to the foundry environment. Of additional concern are the high PMRs due to injuries and poisonings, which could be related to the high accident rates in the iron and steel industry.

Cohort Studies↗
PubMed1989

The frequency, distribution and effects of antibodies, to seven putative respiratory pathogens, on respiratory disease and weight gain in feedlot calves in Ontario.

During 1983-85, 279 calves requiring treatment for bovine respiratory disease and 290 comparison (control) animals from 15 different groups of feedlot calves were bled on arrival and again at 28 days postarrival. Their sera were then analyzed for antibodies to seven putative respiratory pathogens. On arrival, the prevalences of indirect agglutination titers to Pasteurella haemolytica, P. haemolytica cytotoxin, Mycoplasma bovis and M. dispar were greater than 50%, the prevalence of titers to bovine virus diarrhea virus (BVDV) was approximately 40%, and the prevalences of titers to infectious bovine rhinotracheitis virus (IBRV), bovine respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) were all below 25%. Seroconversion during the first month after arrival occurred in more than half the calves to P. haemolytica cytotoxin, PIV3 and RSV. Seroconversion of agglutination titers to P. haemolytica, Mycoplasma and BVDV occurred in about 40% of calves, and seroconversion to IBRV was infrequent (less than 5%). Initial titers were negatively correlated to subsequent titer changes within organism. Initial titers, and titer changes between organisms were essentially independent. Light calves had an increased risk of being selected for treatment for respiratory disease. Seroconversion to P. haemolytica cytotoxin, RSV and BVDV were predictive of respiratory disease cases, explaining approximately 69% of all respiratory disease cases in the feedlots. It was not possible to accurately predict weight gain or relapse from the serological data.

Animals↗
PubMed1986

The exceedingly high burden of acute and chronic respiratory diseases--global situation and prospects.

Mortality data are presented for acute and chronic respiratory diseases, on a world-wide basis for the period 1970-1982, encompassing 76-88 countries, with a population of 1.1-1.3 billion. Despite the declining trend of respiratory conditions, mortality from acute respiratory infections is still rampant at the two extremes of the lifespan and pneumonia attains unacceptably high mortality rates in developing countries. Chronic respiratory diseases claim a significant proportion of lives in the old age groups in both developed and developing countries. It is now sufficient evidence that respiratory diseases are preventable and the reduction of mortality is possible through appropriate intervention programmes.

Adolescent↗
PubMed2000

[Gastroesophageal reflux and respiratory diseases].

There is a relationship between gastroesophageal reflux and respiratory diseases. Reflux may trigger and aggravate respiratory diseases especially bronchial asthma. Both clinical and experimental observations suggest that the pathogenic mechanisms may be a vagal reflex and/or microaspiration of gastric acid into the trachea. General measures to avoid reflux and proton pomp inhibitor together with inhaled corticosteroid are the choice for treatment of asthma associated with gastroesophageal reflux. Xanthine derivatives and beta 2 adrenergic agonist might be withheld in these patients. A laparoscopic surgical treatment may be an option for patients with persistent symptoms.

Asthma↗
PubMed1979

[Dispensary care of persons suffering from non-tuberculous respiratory diseases in czechoslovakia (author's transl)].

In Czechoslovakia phtisiology was enlarged into the specialization of tuberculosis and respiratory diseases by a decree of the Ministry of Health in 1966. The dispensary care of pneumophtisiological institutions aims--besides tuberculosis control--especially at the following groups of patients suffering from non-tuberculous respiratory diseases: 1. cases having tendency to deterioration or with a complicated course, 2. cases with functional disorders of the respiratory system, 3. cases in conditions which may influence unfavourably the respiratory disease. When patients with non-tuberculous respiratory diseases are in the care of other physicians, the pneumophtisiologists render necessary consultations and decide which patients will be taken over into the dispensary care of pneumophtisiological department.

Ambulatory Care↗
PubMed1996

Respiratory disease in thoroughbred horses in training: the relationships between disease and viruses, bacteria and environment.

A longitudinal study of respiratory disease in racehorses was carried out to assess its relative associations with different infectious agents and to examine any role that the environmental conditions might play. The relationships between coughing, nasal discharge, pyrexia and lower respiratory tract disease were also examined to provide information for improving clinical diagnosis, particularly of disease of the lower respiratory tract. Lower airway disease was closely associated with infection with Streptococcus zooepidemicus. It was also found that equine herpesvirus seroconversions and S pneumoniae infections were independently associated with the development of nasal discharge. Coughing was a specific, but insensitive measure of lower respiratory tract disease (specificity 84 per cent, sensitivity 38 per cent). However, horses that coughed were very likely to have had lower airway disease for more than one month. Horses housed on straw in loose boxes were twice as likely to suffer from lower airway disease as those kept on shredded paper in American barns. The study was not large enough to assess the significance of rarer infections but it did improve the definition of the problem of respiratory disease in racehorses and revealed some of the trends in the associations between viruses, bacteria and the environment in respiratory disease.

Adenoviridae↗
PubMed1992

Economic evaluation of treatments for respiratory disease.

Considerable quantities of health service resources are being devoted to tackling the problems posed by respiratory diseases and this can be expected to continue as the prevalence of such diseases increases. This paper provides an assessment of the most efficient use of these healthcare resources by reviewing the literature on economic evaluation relating to interventions in the field of respiratory medicine. Currently, this literature largely comprises cost-minimisation studies of both management and educational interventions. Asthma educational interventions, whether targeted at adults or children, appear to be effective in improving patient self-management and adherence to medications, and appear to be associated with a lower overall use of healthcare resources. In terms of management interventions the overall picture is rather less clear although there is some support for the greater efficiency of patient administration of beta-adrenergic agonists by metered dose inhalers over therapist-administered up-draft nebulisation. Two features of respiratory disease make evaluation in this field somewhat unusual: there are alternative methods of delivering therapy to patients, which makes patient compliance an important issue, and since most respiratory diseases are chronic conditions the long-term effectiveness of interventions must be assessed. The scarcity of cost-effectiveness and cost-utility studies in this field may, in part, reflect the difficulties of measuring outcomes in respiratory disease.

Costs and Cost Analysis↗
PubMed1980

The possible role of respiratory syncytial virus and Pasteurella spp in calf respiratory disease.

In a natural outbreak of respiratory disease during 1976, 31 of 43 calves showed moderately severe clinical signs which included pyrexia (maximum 42 degrees C) and tachypnoea. During the outbreak infection by respiratory syncytial virus (RSV) was demonstrated by isolation from nasopharyngeal swabs or by serology. Pasteurella haemolytica or P multocida were isolated from the blood of four and five calves respectively. In the month before disease 65 per cent of the calves showed significant antibody responses to P haemolytica. However a similar serological response to P haemolytica was demonstrated during 1975 in a comparable group of calves in which no disease and no infection with RSV was detected. No serological response to P multocida was demonstrated in either year. The temporal correlation of RSV infection with respiratory disease in the group of 43 calves was striking but the evidence neither reinforced nor discounted the possibility of interaction between RSV and P haemolytica infection in the pathogenesis of disease.

Animals↗
PubMed1992

[Significance of exposure of workers in the tanning industry and the prevalence of upper respiratory tract diseases].

Respiratory diseases are in prevalence under the other diseases in industry of leather. The exposition to the chemical irritances like bensen and toluene is very important, because a short exposition gives early symptoms. We found in 54% of examined population pathologic ORL cases in a sense of hypertrophic and atrophic forms rhinitis and pharyngitis. Bacterial flora is pathologic in 20% of examined workers and comparing positive bacteriologic form between nose and pharynges we found infections of mucose of nose more frequent than the throat. The occupational atmosphere and its microclime is very important in pathology of upper respiratory diseases. It is etiological factor in morphological changes of the respiratory mucosas. At the end, we can say that the ordinary monitoring which contains monitoring of working place, and biologic monitoring which means ORL, bacteriological, biochemical and toxicologic examinations must be regulated.

Humans↗
PubMed2003

Occupational respiratory diseases in the Czech Republic.

This paper presents the profile of occupational respiratory diseases in the Czech Republic. In a retrospective study the author analyzes structure, causes, occurrence, and trends of occupational diseases. Between 1996 and 2000, a total of 2,127 new cases were recorded, of which 62.0% were pneumoconioses caused by dust containing free silica, 21.0% were occupational asthma or allergic rhinitis and the rest were divided between lung cancer (10.0%), asbestos-related disorders (4.4%) and variety of other respiratory diseases (2.7%). During the period of the investigations, the decreasing trend of occupational respiratory diseases, which began in 1992, has continued.

Adult↗
PubMed1997

Ancillary therapy of bovine respiratory disease.

Ancillary therapy for bovine respiratory disease is covered with an emphasis on anti-inflammatories. Theoretic rationale and any available clinical data are reviewed for glucocorticosteroids as well as nonsteroidal anti-inflammatory drugs such as phenylbutazone, flunixin meglumine, and aspirin. Antihistamines, immunomodulators, diuretics, and bronchodilators are also discussed.

Adjuvants, Immunologic↗
PubMed1983

The effect of death certification and coding practices on observed differences in respiratory disease mortality in 8 E.E.C. countries.

National differences in respiratory disease mortality have been observed in eight member countries of the European Economic Community (E.E.C.). To investigate the extent to which death certification and coding practices explain such differences, a representative sample of certifying doctors in each country was asked to complete specimen death certificates for a bank of ten written case histories. The certificates from each country were coded firstly by their own offices and subsequently by the W.H.O. Reference Centre in the U.K. Large within- and between-country differences in the coded causes of death were found. Some of these differences were due to variations in the ways doctors certify deaths, others to the way certificates are coded in each country. These discrepancies explain part of the between-country differences in mortality in some disease categories. Comparisons of mortality statistics for respiratory diseases between different countries should therefore be viewed with caution. There is a need for further standardisation of death certification and coding practices in the E.E.C.

Death Certificates↗
PubMed1999

A space-time cluster investigation of an outbreak of acute respiratory disease in Norwegian cattle herds.

Outbreaks of acute respiratory disease occurred in several cattle herds in the south-east regions of Norway during the winter and spring of 1995. The present study was conducted to investigate the temporal and spatial dynamics of the occurrence of acute respiratory disease between January and April 1995 in the affected cattle herds, in two neighbouring counties in Norway. This was done to assess the possible role of an infectious agent in these outbreaks, as well as to investigate the possibility of transmission between neighbouring herds. During the study period, a total of 190 (19.8%) outbreaks occurred in 955 cattle herds located in the defined study area. Descriptive maps of the spatial and spatio-temporal patterns of the outbreak were generated, and two different statistical tests of space-time interaction (the Knox test and k-nearest neighbour test) and a cluster-detection test (the space-time scan statistic) were used. The results of all the space-time interaction tests strongly suggested that the case herds were clustered in time as well as in space. In addition, the space-time scan statistic defined the most-likely cluster to be located within the second veterinary district (Toten where the disease occurred) during 9-15 weeks in 1995. The relative risk of a herd being infected inside the most-likely cluster compared with the surrounding study area was estimated to be 3.59 (p=0.001). The transmission rate between neighbouring farms therefore appeared to have been higher within this cluster than in the surrounding study area. This study supports the hypothesis that one common source of infection was involved in the outbreaks during the study period.

Acute Disease↗
PubMed2005

Chronic hyperplastic eosinophilic sinusitis as a predictor of aspirin-exacerbated respiratory disease.

BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is a disease of intense eosinophilic inflammation that can produce fibrosis, hyperplasia, and remodeling. OBJECTIVE: To investigate the usefulness of quantifying severity of chronic hyperplastic eosinophilic sinusitis in predicting the presence of AERD. METHODS: Data were compared between asthmatic patients who reported exacerbations after aspirin ingestion and those who did not. The primary outcome measure was severity of sinusitis using a validated computed tomography (CT) scan-based scoring system. Indices of lower airway remodeling and other markers of inflammation were also evaluated. RESULTS: Twenty-one patients with AERD were compared with 19 patients with aspirin-tolerant asthma (ATA). Patients were well matched for asthma severity as shown by their similar lung function as measured by postbronchodilator forced expiratory volume in 1 second. Patients with AERD were distinguished by their sinus CT scores (AERD patients: 16.9; 95% confidence interval [CI], 13.4-21.3; ATA patients: 6.2; 95% CI, 4.2-9.1; P < .001), and they were considerably more likely to have nasal polyps (AERD patients: 90%; ATA patients: 26%; P < .001). In addition, AERD patients demonstrated increased total lung capacity (AERD patients: 107.9%; 95% CI, 99.9%-117.6%; ATA patients: 98.0%; 95% CI, 93.7%-102.5%; P = .05), reflecting a trend toward increased air trapping. No significant differences occurred in diffusing capacity, exhaled nitric oxide, eosinophilia, or exhaled breath condensate pH. CONCLUSIONS: AERD can be distinguished from ATA by the extent of hyperplasia on CT scan and the presence of nasal polyps. We hypothesize that AERD represents a remodeling process that affects both the upper and lower airways.

Adult↗
PubMedDate not supplied

[Anthropogenic environmental factors and their role in the occurrence of acute respiratory diseases].

The incidence of acute respiratory diseases (ARD) in two districts of the Orenburg Region which have different levels of environmental pollution was comparatively analyzed. The higher incidence of ARD in the more polluted district (Kuvandyksky) than in the control one (Belyaevsky). The incidence rate (41.8%) of ARD correlated with the level of the ambient air pollution by dust, CO, NO2, NF and fluoride aerosols in the Kuvandyksky district.

Acute Disease↗