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PubMed1989

Fast neutron teletherapy in advanced epidermoid head and neck cancer. A review.

An extensive review of clinical studies employing fast neutron teletherapy for advanced epidermoid carcinomas of the head and neck is presented. Head and neck tumors have represented an excellent study site because of their accessibility to physical examination for measurement of tumor response, and because early neutron beams have had poor depth dose characteristics, making the treatment of more deeply seated tumors technically difficult. A summary of the major trials comparing neutron and mixed-beam (combination neutron and photon) therapy with conventional therapy indicates no conclusive evidence of improvement in local control or survival rates for the experimental arms. Exceptions to this are the Hammersmith experience and the slightly higher lymph node control rates seen in two studies. An evaluation of toxicity indicates that with the new generation of cyclotrons, complication rates may approach parity with those of photon linear accelerators.

Carcinoma, Squamous Cell↗

PubMed2003

Implementation of HACCP and prerequisite programs in school foodservice.

OBJECTIVE: The objective of this study was to determine food safety procedures and practices related to the hazard analysis critical control point (HACCP) program and prerequisite program implementation in school foodservice. DESIGN: This descriptive study used a mailed questionnaire to determine procedures and practices related to HACCP and prerequisite programs implemented in schools. Demographic questions related to school foodservice directors and districts were included. Subjects/settings The questionnaire was mailed to a national random sample of 600 district school foodservice directors, all 536 district school foodservice directors in Iowa, and 33 directors of school districts known to have centralized foodservice systems. Statistical analyses Descriptive statistics were used to summarize data. Principal component factor analysis with varimax rotation identified underlying factors for HACCP procedures and practices items. Cronbach's alpha determined reliability for items within a factor. Multiple linear regression determined relationships among variables, and independent t tests were used to compare centralized and conventional foodservice systems. RESULTS: Of 1,169 questionnaires mailed, 414 school foodservice directors responded (35.4% response rate). HACCP programs were implemented in 22% of school districts. Two thirds of the directors had food safety certification. Centralized systems implemented more food safety procedures (21.4+/-5.6, 20.4+/-5.1, P=.04) and practices (26.1+/-3.5, 24.8+/-4.5, P=.002) than did conventional systems. Having one or more employees with primary responsibility for food safety resulted in a higher number of procedures and practices implemented (P=.031). APPLICATIONS/CONCLUSIONS: School districts need to implement prerequisite programs so that they are ready for HACCP implementation. There are opportunities for dietitians to provide consulting, training, and technical assistance to schools on HACCP implementation.

Adult↗

PubMed1993

Statistical analysis of neural organization.

1. The responses of 32 taste neurons in the solitary nucleus of the rat to 12 stimuli were analyzed with multidimensional scaling (MDS) and cluster analysis (CA) procedures. These analyses of empirical taste data were compared with similar analyses of two model data sets of known configuration to help clarify the implications of these methods commonly used in forming conclusions about the organization of the taste system. 2. To relate to possible conclusions about groupings in taste, both model data sets were chosen as the best possible examples of ungrouped data, the first being completely regular (in the form of a checkerboard) across the taste space, the second randomly arranged. The analysis of the present empirical data appear to be similar to the present ungrouped models, more so the random than the regular model, in the sense that all are amenable to grouping. 3. Because of the similarity of these model MDS and CA solutions to the present empirical solutions and to most published analyses of this sort, the idea is suggested that the appearance of the plots per se for empirical data does not support the conclusion of grouping. And, technically, MDS and CA do not have the statistical power to provide conclusions about issues of neural organization. 4. MDS and CA analyses have two very powerful roles relating to their ability to disclose the hidden organization of complex data sets; they may lend support for or refute theories about the data sets developed from other considerations, and may help generate theories for further consideration. The question of groupings is only one of many such issues. 5. Because data in the present and other reports are quite adequately accounted by MDS solutions of low dimensionality, it is suggested that their organization is characterized as continuous (i.e., rather than belonging to several disjoint spaces). 6. The use of correlations as distance measures in MDS and CA procedures distorts the spatial solutions, making analysis by visual inspection misleading. For example, using correlations, the true or natural spatial arrangements of data sets are probably less circular or spherical than shown in published MDS solutions. Also they are probably more evenly distributed across the space in the sense that the points are actually more concentrated toward the centers of the spaces; this may have strong influences on interpretations of the general form of the solutions. CA solutions can be influenced in analogous fashion. These problems of distortion of the solutions can be avoided with use of direct, linear estimates of distances. (ABSTRACT TRUNCATED AT 400 WORDS)

Afferent Pathways↗

PubMedDate not supplied

Eye health of industrial workers in Southeastern Nigeria.

A cross-sectional ophthalmological survey to determine the ocular health in Nigerian industries was undertaken in four randomly selected industrial establishments in Enugu State of Nigeria. The industrial establishments studied were the cement factory, coal mine, saw mill and iron/steel works where motor spare parts are fabricated. Of the 646 workers, 184 (28.5%) had a history of industrial accidents, 81 (12.5%) of which affected the eye. Eye injury was most commonly caused by metal chips, cement dust, fragments of wood, pieces of coal stone and welders' arc rays all of which could be prevented by wearing appropriate protective eye coverings. Contusion injury was the most common type of injury reported. Eye accident rate varied from factory to factory as also did the wearing of protective eye devices. overall, the percentage of workers using protective eye cover was 16.7% but there was a significant difference between the factories in this respect, protective eye wear being more often used in factories with higher eye accident rates. A total of 646 technical workers had detailed ophthalmological examination. The types and frequencies ofvisual disorders seen as well as the nature and causes of eye injuries were determined. Five hundred and twenty-eight workers (81.7%) had eye disorders. Presbyopla was responsible for 203 (31.4%) of these disorders while 169 (26.2%) were refractive errors. Of the others, pterygium and pingueculum together numbered 179 (27.7%) while cataract was found in 79 (12.2%) subjects. The results showed a high frequency of eye injuries among industrial workers and a low level of use of protective eye cover while at work. It is recommended that legislation requiring the use of protective devices in high-risk industries should be vigorously enforced to improve the eye health of Nigerian industrial workers.

Accidents, Occupational↗

PubMed2005

Capella's gastroplasty: metabolites and acute phase proteins changes in midline and bilateral arciform approaches.

BACKGROUND: Obesity has adverse health effects. Dietary reeducation does not seem to offer sustained weight loss. For appropriately selected patients, surgery may be beneficial. AIM: To evaluate early postoperative metabolic response to surgery in patients submitted to Capella's gastroplasty using two different surgical approaches to the abdominal cavity. PATIENTS/METHOD: Twenty patients (9 males and 11 females, aged 21 to 53 years) were randomized prior to submission to either one of the surgical access incisions (bilateral arciform or supra-umbilical midline incisions). Blood samples were collected at the beginning and end of the operation, 12 (T-12 h) and 24 hours (T-24 h) postoperatively. Dieresis and synthesis time, blood loss, planimetry of operative field, operative time, hospital stay, hemoglobin, hematocrit, lymphocytes, potassium, albumin, erythrocyte sedimentation rate, C-reactive protein, glucose, pyruvate, lactate and ketone bodies were analyzed. RESULTS: Dieresis time was significantly decreased when median approach was used. Total operating time, hospital stay, hematocrit, hemoglobin, lymphocyte count, potassium and albumin concentrations were similar in both groups. C-reactive protein (T-12 h), glucose and pyruvate concentrations (T-24 h) increased significantly after completion of surgical procedure. Ketone bodies concentrations were significantly decreased 24 hour following completion of surgical procedure. CONCLUSION: Capella's gastroplasty induces metabolic and inflammatory changes in blood parameters. There is no evidence of technical superiority of arciform over midline incisions in this study.

Acute-Phase Proteins↗

PubMed2003

Effects of high dose oral creatine supplementation on anaerobic capacity of elite wrestlers.

AIM: The purpose of this study was to investigate the effect of high dose oral creatine supplementation on anaerobic capacity of elite wrestlers. METHODS EXPERIMENTAL DESIGN: comparative randomized design. SETTING: Wingate anaerobic tests of the participants were taken at the Human Performance Laboratory of the Department of Physical Education and Sports in The Middle East Technical University, Ankara, Turkey. PARTICIPANT: 20 active international level wrestlers participated (22 to 27 years old). INTERVENTIONS: the daily dosage of creatine or placebo was divided into 4 equal amounts (5 gx4 = 20 g). Every 5 g of supplement was dissolved in 250 ml water and it was given to participants 1 hour before breakfast, lunch, dinner, and workout session. MEASURES: subjects underwent a 30-s Wingate Anaerobic tests until exhaustion in pre- and post-tests. After the pretest measurements were completed, participants were classified as creatine (Cr., n=10) and placebo (Pl., n=10) groups with regard to their average anaerobic power scores obtained during the test. RESULTS: Results of paired "t"-test revealed that there was no significant change in placebo group between pre- and post-test in average and peak anaerobic power. However, average and peak power mean scores obtained from post-test (8.123+/-0.448 W/kg and 10.523 +/-1.004 W/kg) were significantly (p<0.01) higher than pretest (7.233+/-0.483 W/kg and 8.992+/- 0.665 W/kg) for creatine group. Results of the independent "t"-test also indicated that the mean gained scores of creatine group in average and peak power were significantly higher than placebo group (p<0.01). CONCLUSION: This study demonstrates that short-term high dose oral creatine supplementation has an ergogenic effect on anaerobic capacity of elite wrestlers.

Adult↗

PubMed2003

Integrating service development with evaluation in telehealthcare: an ethnographic study.

OBJECTIVES: To identify issues that facilitate the successful integration of evaluation and development of telehealthcare services. DESIGN: Ethnographic study using various qualitative research techniques to obtain data from several sources, including in-depth semistructured interviews, project steering group meetings, and public telehealthcare meetings. SETTING: Seven telehealthcare evaluation projects (four randomised controlled trials and three pragmatic service evaluations) in the United Kingdom, studied over two years. Projects spanned a range of specialties-dermatology, psychiatry, respiratory medicine, cardiology, and oncology. PARTICIPANTS: Clinicians, managers, technical experts, and researchers involved in the projects. RESULTS AND DISCUSSION: Key problems in successfully integrating evaluation and service development in telehealthcare are, firstly, defining existing clinical practices (and anticipating changes) in ways that permit measurement; secondly, managing additional workload and conflicting responsibilities brought about by combining clinical and research responsibilities (including managing risk); and, thirdly, understanding various perspectives on effectiveness and the limitations of evaluation results beyond the context of the research study. CONCLUSIONS: Combined implementation and evaluation of telehealthcare systems is complex, and is often underestimated. The distinction between quantitative outcomes and the workability of the system is important for producing evaluative knowledge that is of practical value. More pragmatic approaches to evaluation, that permit both quantitative and qualitative methods, are required to improve the quality of such research and its relevance for service provision in the NHS.

Delivery of Health Care↗

PubMed1995

Hyperthermia--its actual role in radiation oncology. Part III: Clinical rationale and results in deep seated tumors.

PURPOSE: Combined hyperthermia and radiation therapy has been reported to yield higher complete and durable responses than radiotherapy alone in superficial tumors. In deep seated tumors the effect of the combined treatment is still under research. METHODS: The literature and own clinical data are reviewed with regard to biological and physical fundamentals and clinical results. RESULTS: Clinical phase I to II studies have applied regional hyperthermia in the abdomen, the pelvic region and the extremities. Usually primary advanced, persistent or local recurrent and metastatic tumors were selected for treatment either due to poor response to conventional therapy or for effective palliation. The clinical data are presented concerning the following topics: invasive thermometry, temperature parameter in tumor and normal tissue, toxicity, tumor response, treatment planning, clinical trials and prognostic factors. Clinical results of thermoradiotherapy for advanced or recurrent rectal cancer, cervical cancer and soft tissue sarcomas are reviewed in detail. In addition, the prognostic relevance of temperature parameters and physiological conditions such as global tumor perfusion are discussed. CONCLUSION: Clinical issues of optimization of regional thermoradiotherapy are: improvement of hyperthermia technique, analysis of biological effects and mechanisms involved in temperature elevation, selection of appropriate study concepts for specific tumor sites. Part I has covered biological and technical fundamentals of clinical hyperthermia and has been published in Strahlenther. Onkol. 168 (1992), 183-190. Part II has covered clinical fundamentals and results in superficial tumors of clinical hyperthermia and has been published in Strahlenther.

Algorithms↗

PubMed2000

Age at first intercourse in an Australian national sample of technical college students.

OBJECTIVE: This study aims to broaden the current body of knowledge regarding the sexual behaviour of young Australians by examining the age and correlates of age of first intercourse in a national sample of Technical and Further Education apprentices. METHOD: In 1995, students at randomly selected technical colleges in Australia were surveyed on HIV-related issues. Questionnaires were administered to a stratified cluster sample of automotive, hairdressing and commercial cookery apprentices. Respondents were asked the age at which they first had heterosexual vaginal or anal intercourse. RESULTS: Of 4,055 respondents aged 15-24 years, 3,848 answered the question; 3,195 (83%) had had intercourse. Males and females did not differ significantly. Median age at first intercourse was 16 (range 12-23). In multivariate analysis, older age at first intercourse was associated with: greater age at interview; higher school education; church attendance; and State of residence. The model, however, accounted for only 14% of the variance in age at first intercourse. CONCLUSIONS AND IMPLICATIONS: In this sample, those apprentices who completed secondary school became sexually active later on average than those who left before the end of Year 10. For sex education to occur before sexual initiation, it needs to be offered in primary schools and the first year of high school (aged 11-13 years). Further, as technical college students are likely to initiate sex earlier than their age mates still at school, colleges may be in a position to take responsibility for the continuing sexual education of this group, especially for those students entering college at 15 or 16 years of age.

Adolescent↗

PubMed1999

Effects on parameters of glucose homeostasis in healthy humans from ingestion of leguminous versus maize starches.

BACKGROUND: Due to their lower glycaemic index, leguminous seeds affect human carbohydrate metabolism lesser than do cereals. Problems, however, could arise from side effects, e.g., increasing flatulence. AIM OF THE STUDY AND METHODS: In 26 healthy subjects, metabolic and symptomatic responses following acute ingestion of equivalent amounts of pure pea starch (NASTAR (Cosucra BV, Rosendaal/The Netherlands), crude yellow pea flour (CPC Deutschland, Germany), and modified and unmodified cornstarches (SNOWFLAKE and SIRONA, Cerestar/Germany) were assessed, i.e., plasma glucose, serum insulin, C-peptide, hydrogen exhalation, and flatulence. RESULTS: Pure pea starch elicited less hyperglycaemia (minus 47 %), hyperinsulinaemia (minus 54 %), and C-peptide secretion (minus 37 %) as compared to cornstarch (p<0.05), while the responses to modified versus unmodified corn starch were similar (8 subjects, n.s.). Pure pea and corn starches were equally well tolerated, while flatulence and breath hydrogen concentration were increased only after the intake of crude pea flour. Maldigestion of pea flour was calculated to be around 10 % (reference lactulose). CONCLUSIONS: The well-known metabolic advantages of pea starch over cornstarch were confirmed. Tolerability of pure pea starch was excellent, but not of crude pea flour. Provided it has the same technical characteristics, pure pea starch as a "prebiotic" could replace cornstarch in industrial food production.

Adult↗

PubMed1996

Effect of dose on the nasal absorption of epinephrine during cardiopulmonary resuscitation.

Delay in epinephrine administration during cardiopulmonary resuscitation (CPR) due to technical difficulties in obtaining an access site may be detrimental. To avoid this potential delay, we have previously shown that intranasal administration of phentolamine and epinephrine is a rapidly obtainable and feasible route of administration during CPR. A randomized blinded dose ranging study was performed in a controlled laboratory environment. Thirty mongrel dogs were randomized to one of the following dosage regimens: phentolamine, 0.25 or 2.5 mg/kg/nostril; epinephrine, 0.075, 0.75, or 7.5 mg/kg/nostril. Phentolamine was administered intranasally 1 minute before the intranasal administration of epinephrine to improve absorption. Each dog underwent 3 minutes of ventricular fibrillation followed by 7 minutes of closed chest CPR. Epinephrine was administered was administered at 3 minutes of CPR. Data from 26 dogs were included for analysis. Treatment B (0.25 and 7.5 mg/kg/nostril of phentolamine and epinephrine, respectively) produced the greatest elevation in coronary perfusion pressure (17 +/- 11 vs. 4 +/- 3 mm Hg for the next highest group, P < .003) and in epinephrine plasma concentrations (1,403 +/- 1,400 vs 290 +/- 182 ng/mL for the next highest group, P > .05). In addition, treatment B had the highest resuscitation rate, 100% (5/5) versus 0% to 50% for the other groups (P < .05). These data show that there is a dose response effect, with 0.25 and 7.5 mg/kg/nostril of phentolamine and epinephrine being the optimal dose studied. In addition, when administered in appropriate doses, intranasal epinephrine reaches the systemic circulation and increases coronary perfusion pressure and successful resuscitation during CPR in this canine model.

Absorption↗

PubMed2001

Locally advanced cervix cancer: chemotherapy prior to definitive surgery or radiotherapy. A single institutional experience.

Primary or neoadjuvant chemotherapy prior to definitive local therapy has potential advantages for locally advanced cervix cancer. It can downstage a cancer and allow definitive local therapy to be technically possible (surgery), or potentially more effective (radiotherapy). It can also eradicate subclinical systemic metastases. This report reviews a single institution's experience of neoadjuvant chemotherapy prior to definitive local therapy for cervix cancer over a 13-year period. One hundred and six patients were treated with this intent. The patients were analysed for their response to chemotherapy, treatment received, survival, relapse and toxicity. The chemotherapy was feasible and the majority of patients had a complete or partial response (58.5%). Eight patients did not proceed to local treatment. Forty-six patients had definitive surgery and 52 had definitive radiotherapy. The 5-year overall survival was 27% and the majority of patients died with disease. The first site of relapse was usually in the pelvis (46.2%). Late complications that required ongoing medical therapy (n=6) or surgical intervention (n=2) were recorded in eight patients (7.5%). On univariate analysis stage (P=0.04), tumour size (P=0.01), lymph node status (P=0.003), response to chemotherapy (P=0.045) and treatment (P=0.003) were all significant predictors of survival. On multivariate analysis, tumour size (P < 0.0001) and nodal status (P=0.02) were significant predictors of survival. Despite the impressive responses to chemotherapy of advanced cervix cancer, there is evidence from randomized trials that it does not improve or compromise survival prior to radiotherapy. As its role prior to surgery remains unclear, it should not be used in this setting outside a prospective randomized trial.

Adult↗

PubMed1998

A subgroup analysis of the Scripps Coronary Radiation to Inhibit Proliferation Poststenting Trial.

INTRODUCTION: In the Scripps Coronary Radiation to Inhibit Proliferation Poststenting (SCRIPPS) Trial, 192Ir significantly reduced angiographic, ultrasonographic, and clinical endpoints of restenosis. The objective of this analysis was to quantitate the impact of patient, lesion and technical characteristics on late angiographic outcome. METHODS: Patients with restenotic, stented coronary lesions were randomized to receive either 192Ir or placebo sources. Late luminal loss and loss index were calculated for several patient subgroups, including patients with diabetes, in-stent restenosis, multiple previous percutaneous transluminal coronary angioplasty (PTCA) procedures, longer lesion lengths, saphenous vein grafts, small vessel diameters, and minimum dose exposures < 8.00 Gy. Two-factor analysis of variance was used to test for an interaction between patient characteristics and treatment effect. RESULTS: In the treated group, late loss was particularly low in patients with diabetes (0.19 mm), in-stent restenosis (0.17 mm), reference vessel diameters < 3.0 mm (0.07 mm), and patients who received a minimum radiation dose to the entire adventitial border of at least 8.00 Gy. The loss index in each of these subgroups was similarly low at -0.02, 0.03, -0.02, and 0.03, respectively. By 2-factor analysis of variance, a significant interaction between subgroup characteristic and treatment effect (late loss) was found in patients with in-stent restenosis (p = 0.035), and patients receiving a minimum dose of 8.00 Gy to the adventitial border (p = 0.009). CONCLUSION: In this pilot study, patient characteristics associated with a more aggressive proliferative response to injury appeared to confer an enhanced response to radiotherapy. Furthermore, a dose threshold response to 192Ir was found with an enhanced response occurring when the entire circumference of the adventitial border was exposed to at least 8.00 Gy.

Analysis of Variance↗

PubMedDate not supplied

The health of Ontario First Nations people: results from the Ontario First Nations Regional Health Survey.

OBJECTIVE: To describe the health of First Nations adults residing on Ontario reserves using data from the Ontario First Nations Regional Health Survey (OFNRHS). METHOD: Communities were randomly selected; individuals were systematically selected based on gender and age. Health questions were parallel to those used in the National Population Health Survey (NPHS) and included general health, chronic conditions, substance use, and health service utilization. RESULTS: Response rate was 86% (N=1094) in participating communities; 23 of 30 selected communities participated. Most OFNRHS respondents reported that their health was good or better. Comparisons of OFNRHS participants with NPHS Ontario respondents showed: some chronic health conditions (including diabetes, high blood pressure) were more common; a greater proportion reported smoking; and a substantially lower proportion indicated that they consumed alcohol in the past year. CONCLUSIONS: The OFNRHS provides important province-wide data to inform decisions by the First Nations people about how to intervene effectively to improve their health status.

Adolescent↗

PubMed2000

Prevalence and pattern of occupational exposure to whole body vibration in Great Britain: findings from a national survey.

OBJECTIVES: To estimate the number of workers in Great Britain with significant occupational exposure to whole body vibration (WBV) and to identify the common sources of exposure and the occupations and industries where such exposures arise. METHODS: A postal questionnaire was posted to a random community sample of 22,194 men and women of working age. Among other things, the questionnaire asked about exposure to WBV in the past week, including occupational and common non-occupational sources. Responses were assessed by occupation and industry, and national prevalence estimates were derived from census information. Estimates were also made of the average estimated daily personal dose of vibration (eVDV). RESULTS: From the 12,907 responses it was estimated that 7.2 million men and 1.8 million women in Great Britain are exposed to WBV at work in a 1 week period if the occupational use of cars, vans, buses, trains, and motor cycles is included within the definition of exposure. The eVDV of >374,000 men and 9000 women was estimated to exceed a proposed British Standard action level of 15 ms(-1.75). Occupations in which the estimated exposures most often exceeded 15 ms(-1.75) included forklift truck and mechanical truck drivers, farm owners and managers, farm workers, and drivers of road goods vehicles. These occupations also contributed the largest estimated numbers of workers in Great Britain with such levels of exposure. The highest estimated median occupational eVDVs were found in forklift truck drivers, drivers of road goods vehicles, bus and coach drivers, and technical and wholesale sales representatives, among whom a greater contribution to total dose was received from occupational exposures than from non-occupational ones; but in many other occupations the reverse applied. The most common sources of occupational exposure to WBV are cars, vans, forklift trucks, lorries, tractors, buses, and loaders. CONCLUSIONS: Exposure to whole body vibration is common, but only a small proportion of exposures exceed the action level proposed in British standards, and in many occupations, non-occupational sources are more important than those at work. The commonest occupational sources of WBV and occupations with particularly high exposures have been identified, providing a basis for targeting future control activities.

Adolescent↗

PubMed2003

Effects of physician gender on patient satisfaction.

OBJECTIVES: To measure the impact of physician gender on patient satisfaction, controlling for confounding patient variables, and to examine the extent to which differences in satisfaction with male and female physicians can be explained by physician practice styles. METHOD: New adult patients (n=509) were randomized to see male and female primary care physicians at a university medical center outpatient facility. Patient sociodemographics and self-reported health status (using the Medical Outcomes Study Short Form-36) were measured before the initial visit, and satisfaction with the physician was measured immediately following the visit. The entire medical encounter was videotaped and physician practice style was later analyzed using the Davis Observation Code. RESULTS: Female physicians spent a significantly greater proportion of the visit on preventive services and counseling than male physicians did, and male physicians devoted more time to technical practice behaviors and discussions of substance abuse. Visit length was not significantly different for male and female physicians. Patients of female physicians were more satisfied than were those of male physicians, even after adjusting for patient characteristics, visit length, and physician practice style behaviors. CONCLUSION: Patient satisfaction with primary care physicians appears to be influenced not only by patient characteristics and physician behaviors, but also by the gender of the provider. Possible explanations for this may be that psychosocial aspects of the physician-patient interaction are different for male and female physicians. Patients may also bring expectations about female physicians to the encounter, presuming them to be more empathetic, nurturing, and responsive.

Adult↗

PubMed2006

Effect of HCH contamination of diet on the growth performance and immune and antioxidant ability in growing/finishing pigs.

The effects of hexachlorocyclohexane (HCH) on growth performance and immune and oxidative stress in growing/finishing pigs were studied. Seventy-two pigs, with equal numbers of barrows and gilts, of the same genotype (Duroc x Landrace x Large White), were randomly assigned to three groups receiving the same basal diet, exposed to 0, 0.4 and 0.8 mg/kg technical HCH, respectively, for 90 days. Six pigs from each group were randomly picked out and slaughtered on a finishing feeding trial. The result showed that addition of HCH did not affect the growth performance significantly but increased the weight of kidney and thymus significantly. Total serum IgG and IgM were elevated significantly, but there were no significant differences in serum IgA, C3 and C4 among the groups. Addition of HCH to feedstuff reduced superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) activities in liver, reduced serum catalase (CAT) activity, and increased serum malondialehyde (MDA). Moreover, the activities of serum alanine aminotransferase and alkaline phosphatase were increased significantly. Addition of 0.4 mg/kg or 0.8 mg/kg HCH did not affect the growth performance but affected the immune and antioxidant potential.

Alanine Transaminase↗

PubMedDate not supplied

The role of nurses in installing telehealth technology in the home.

Home telehealth involves the use of video conferencing or remote monitoring equipment in patients' homes. The installation of hardware and training of patients has historically been performed by nurses, typically RNs. This article examines the experience of RNs as telehealth installers in the Informatics for Diabetes Education and Telemedicine (IDEATel) project, where RNs were responsible for the installation of the Home Telemedicine Units (HTUs) and for training patients in the use of the HTUs, blood pressure cuffs, and fingerstick glucose meters. Average installation and training time was 166 minutes (SD 51 min). Structured interviews with RN installers revealed that patient education and training accounted for roughly two thirds of the in-home time. Technology-related problems, especially those related to telecommunications, were the primary cause of installation difficulties. Thematic analysis of installer interviews identified eight major themes and confirmed the importance of both clinical and technical knowledge during the telehealth installation process.

Aged↗