The chronic effect of nomifensine on rat stereotyped behavior.
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Transient compression of the umbilical cord has been implicated as a potential cause of unexplained brain damage and/or fetal death. We induced acute fetal hypoxia by compressing the umbilical cord of the fetal rat with a microvascular clamp. Direct observation of fetal behavior immediately after cord compression identified a three-phase behavioral response to acute hypoxia, consisting of an initial suppression in motor activity, a brief period of hyperactivity, and a secondary suppression of movement. All three phases occurred in less than 2 minutes from the onset of hypoxia. The stereotypic hypoxic response of rat fetuses may be adaptive as a means of removing mechanical sources of umbilical cord compression. Among fetuses exposed to alcohol in utero, the response to hypoxia was diminished in intensity and duration. Because of their altered hypoxic response, alcohol-exposed fetuses may therefore be at greater risk from transient cord compression in utero.
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Three experiments were conducted to evaluate response allocation of stereotypy during free-operant and restricted-operant conditions. Five children with autism or related developmental disabilities participated in at least one and up to three of the experiments. In Experiment 1, the stereotypic response that emerged as most probable during a free-operant phase was restricted, and response allocation was again evaluated. The results for 3 participants showed that restricting the high-probability response was correlated with covarying reductions in a nontargeted stereotypy. In Experiment 2, the effect of environmental enrichment on response allocation was evaluated. One participant reallocated behavior to appropriate object manipulation, 1 participant showed no change in behavior, and a 3rd participant reallocated behavior to object manipulation only when the putative stimulus products of the object manipulation matched those of stereotypy. In Experiment 3, additional interventions were implemented to promote response reallocation. Results showed that both response restriction and reinforcement for object manipulation decreased stereotypy and increased object manipulation. Collectively, the results of these experiments point to a need for complex evaluations of interventions for stereotypy.
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