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At least 253 records · Page 14Linked to original sources
PubMed1989

Thyroid neoplasms containing mature fat: a report of two cases and review of the literature.

Thyrolipoma or adenolipoma of the thyroid, defined as a thyroid adenoma containing mature fat tissue, is rare and has been reported only seven times. Moreover, the presence of mature fat tissue has been described in only one case of thyroid carcinoma (papillary subtype). We describe one case of thyrolipoma and one case of fat containing follicular carcinoma of the thyroid, and we reviewed the literature on the presence of adipose tissue in the thyroid. It was found that aside from the above conditions, mature adipose tissue has been reported in diffuse lipomatosis of the thyroid, some amyloid goiters, a colloid goiter, and even some normal thyroids. Aside from the presence of mature fat tissue, the clinicopathologic features of fat containing thyroid tumors are not different from those of their usual counterparts.

Adenocarcinoma↗
PubMed2001

[Iodine deficiency and thyroid neoplasms in the Krakow region].

The aim of the study was to evaluate the correlation between incidence rate (IR) of thyroid cancer and severity of iodine deficiency. The influence of iodine prophylaxis on IR was also investigated. The suspension of iodine prophylaxis in 1980 resulted in goitre prevalence increase in schoolchildren (up to 60%) and elevated TSH levels in neonates observed in early 1990-ties. In 1990 rise in thyroid cancer IR was observed. IR of papillary and follicular carcinoma in 1995 were 1.6 and 1.5 respectively. Papillary to follicular ratio was about 1.0. Such a high prevalence of follicular cancer was specific for iodine deficient regions. In 1997, after introduction of mandatory model of iodine prophylaxis in Poland, increase in papillary thyroid cancer IR was observed, reaching in 1998 6.23 per 100,000 inhabitants. Papillary to follicular cancer ratio rose to 2.48. In 1999 no further increase in thyroid cancer IR was observed. Increase in papillary cancer incidence between 1990 and 1999 may be related to overlapping of iodine deficiency and other cancer risk factors i.e. radiation after Chernobyl accident.

Adenocarcinoma, Follicular↗
PubMed1997

[The role of imaging diagnosis in the study of thyroid neoplasms].

The aim of this paper was to evaluate the role of imaging techniques and methods in the diagnosis of thyroid tumours. The main aim was to analyse the various imaging methods and to search for an integrated diagnosis based on clinical and laboratory evaluations and techniques such as fine needle aspiration biopsy for which imaging is used as a guide. The authors stress the importance of analysing the sensitivity of the various methods in preoperative staging. The methods examined here include: scintigraphy, ultrasound, fine needle aspiration biopsy, Doppler ultrasound, color-Doppler scan, TC and magnetic resonance.

Biopsy, Needle↗
PubMed1981

[Thermography in the diagnosis of thyroid neoplasms].

Thermographic procedures were used in the examination of 70 patients suspected of bearing thyroid tumors in whom 131I scanning had revealed hypofunction of nodes ("cold" nodes) as well as 38 patients who had been operated for thyroid tumors at different periods. Thermographic diagnosis of primary thyroid tumor was confirmed histologically in 49 cases. Pseudonegative results were established in 5 cases. Pseudopositive results were recorded in 6 out of 21 cases of benign lesions of the thyroid. Recurrences were identified thermographically in 16 patients operated for thyroid tumors. No pseudonegative results were obtained.

Adenoma↗
PubMed2003

Prevalence and incidence of cytoplasmic yellow bodies in thyroid neoplasms.

CONTEXT: Cytoplasmic yellow bodies are a common and frequent histologic finding in hyalinizing trabecular adenoma of the thyroid gland, a morphologically distinctive neoplasm, and are visible in fine-needle aspiration biopsy of the tumor. OBJECTIVE: To determine the prevalence and frequency of cytoplasmic yellow bodies in common thyroid tumors. DESIGN: Microscopic slides of random cases of papillary carcinoma (61 cases), follicular adenoma (27 cases), and Hürthle cell adenoma (12 cases) were searched for cytoplasmic yellow bodies. SETTING AND PATIENTS: Slides were from patients who had undergone surgery at Mayo Clinic, Rochester, Minn, and were obtained from the Mayo Clinic Tissue Registry. MAIN OUTCOME MEASURE: Presence or absence of cytoplasmic yellow bodies. RESULTS: Cytoplasmic yellow bodies were found in papillary carcinoma (62%), follicular carcinoma (22%), and Hürthle cell adenoma (83%) but were very infrequent numerically in each tumor type. CONCLUSIONS: Cytoplasmic yellow bodies may be present in papillary carcinoma and in follicular and Hürthle cell adenomas, but because they are uncommon in these tumors, they are unlikely to be found in fine-needle aspiration biopsy smears. Therefore, cytoplasmic yellow bodies are a useful cytomorphologic indicator of hyalinizing trabecular adenoma of the thyroid gland.

Adenocarcinoma, Follicular↗
PubMed1990

Intraoperative pathologic diagnosis of thyroid neoplasms. Report on experience with 504 specimens.

Intraoperative pathologic examination with frozen section (FS) was performed on 504 specimens of thyroid tissue obtained from 457 patients over a period of 9 years. After examination of permanent sections (PS) a malignant neoplasm was diagnosed in 57 specimens (11.3%); 50 (87%) of these were primary thyroid carcinoma, four (8%) metastatic carcinoma, and three (5%) malignant lymphoma. The FS diagnosis was "benign" in 448 (88.9%), "malignant" in (30) 5.9%, and "deferred" in 26 (5.2%). The sensitivity of FS diagnosis of malignancy was 53% and the specificity and positive predictive value 100%. The negative predictive value was 97.8% and overall accuracy 97.9%. The PS disclosed a malignant neoplasm in 62% of specimens in which FS diagnosis was "deferred." Sixty-eight percent of papillary carcinomas, 87% of undifferentiated carcinomas, and a single case of medullary carcinoma were diagnosed with FS examination. A FS diagnosis of malignancy was not made in any of the ten specimens containing follicular carcinoma; in all ten the neoplasms were well-differentiated and eight were encapsulated and minimally invasive. The inability to diagnose follicular carcinoma intraoperatively with FS is the most significant factor accounting for the relatively low sensitivity of FS diagnosis of malignant thyroid neoplasms.

Carcinoma↗
PubMed1988

[Fine-needle biopsy in the early diagnosis of thyroid neoplasms].

Among the patients directed to the Department of Endocrinology of the Institute of Internal Medicine for diagnostic examinations of the thyroid, 726 (647 women and 79 men, of age between 16 and 79 years) were qualified to surgery after scintigraphic detection of cold nodules. From this group, 474 patients had thin-needle biopsy specimens taken for cytologic examination. The results of the latter examinations have been compared with those of histologic examination performed on the tissue removed during surgery. The occurrence of a malignant tumor (in 99.1%--thyroid cancer) was found in 108 patients (22.8%) from the group having thin-needle biopsy performed. Comparison of the results of cytologic examination with those of postoperative histologic examination demonstrated low sensitivity of biopsy examination (50.0%), as opposed to high specificity (96.2%) and high accuracy (85, 3%). Analysis of the false-negative results (54/108) revealed that the main causes of errors are difficulties in differentiation of adenoma from follicular carcinoma. Widening of the indications to surgery by a group of patients with adenoma will increase sensitivity to 84.8% and will require including into the operated group of about 50% of patients with scintigraphically diagnosed cold nodules: The introduction of the new term: "urgent strumectomy", has been proposed; also a diagnostic algorithm, useful for early diagnosis of malignant tumors of the thyroid, has been discussed.

Adolescent↗
PubMed1987

Fine-needle biopsy cytology and DNA analysis. Their place in the evaluation and treatment of patients with thyroid neoplasms.

Fine-needle aspiration allows sampling of tissues without surgical biopsy. This technique provides accuracy, speed, patient acceptance, and individual cells for the study of neoplasia. When this procedure is combined with DNA analysis, it is possible to obtain preoperatively additional diagnostic and prognostic information superior to that obtained by clinical and morphologic methods alone. This information is of utmost importance when planning appropriate treatment.

Biopsy, Needle↗
PubMedDate not supplied

Loss of heterogeneous ribonucleoprotein A(2)/B(1) expression in thyroid neoplasms.

OBJECTIVE: To determine whether a difference exists in the immunohistochemical expression of heterogeneous ribonucleoprotein (hnRNP) A(2)/B(1) between benign and malignant thyroid lesions and to assess whether a gradient of expression could be found in normal thyroid, adenomas, and thyroid malignant tumors. METHODS: Formalin-fixed, paraffin-embedded archival tissues from 32 cases (8 nodular goiters, 8 follicular adenomas, 8 follicular carcinomas, and 8 papillary carcinomas) were immunostained with monoclonal antibody 703D4, directed against hnRNP A(2)/B(1), applied at a concentration of 10 microg/mL. The streptavidin-biotin peroxidase method was used to label bound monoclonal antibody. Positivity was independently scored by two pathologists, who used a three-tiered scale. RESULTS: The benign thyroid tissues, including the hyperplastic and adenomatous lesions, demonstrated 3+ granular cytoplasmic staining for hnRNP A(2)/B(1), except in two cases (one nodular goiter and one follicular adenoma) in which 2+ staining intensity was noted. In contrast, the papillary and follicular carcinomas failed to stain with the antibody, except in two cases that showed weak (1+) staining. CONCLUSION: hnRNP A(2)/B(1) immunostaining appears to distinguish benign from malignant thyroid lesions. Loss of hnRNP A(2)/B(1) expression seems to be a characteristic feature of thyroid malignant lesions.

Adenocarcinoma, Follicular↗