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A structure-based expert model of the ICD-10 mental disorders.

BACKGROUND: Many authors have highlighted that a classificatory system such as the ICD-10 or the DSM-IV should attempt to integrate categorical as well as dimensional aspects rather than relying only on a categorical distinction. METHODS: In the current study, a method is presented that allows both perspectives to be considered. Based on their clinical experience, 20 therapists were asked to rate a selection of ICD-10 mental disorders in terms of their similarity. The resulting data were processed by nonmetric multidimensional scaling on individual basis as well as mean basis and a cluster analysis. RESULTS: From a categorical point of view, the resulting mean cognitive map and the cluster analytic groups showed a good concordance with the ICD-10 F groups. Additionally, analogies to the critical observations with regard to the classification systems could be observed. From the dimensional point of view, there were two dimensions found (cognition and psychosis) which showed high correlations in the mean map. CONCLUSIONS: The method presented in this study offers an opportunity to account for dimensional as well as categorical aspects of classification by exploring the structure of the ICD-10 mental disorders directly from the point of view of therapists and thus creating the basis for an expert model.

Algorithms↗

Category-specific representations of social and nonsocial knowledge in the human prefrontal cortex.

Complex social behavior and the relatively large size of the prefrontal cortex are arguably two of the characteristics that distinguish humans from other animals. Grafman presented a framework concerning how the prefrontal cortex (PFC) controls complex behavior using stored structured event complexes (SECs). We report behavioral and imaging data from a modified go/no-go paradigm in which subjects had to classify words (semantic) and phrases (SEC) according to category. In experimental trials, subjects classified items according to social or nonsocial activity; in control trials, they classified items according to font. Subjects were faster to classify social than nonsocial semantic items, with the reverse pattern evident for the social and nonsocial SEC items. In addition, the conditions were associated with different patterns of PFC activation. These results suggest that there are different psychological and neural substrates for social and nonsocial semantic and SEC representations.

Activities of Daily Living↗

Age of recognition of pervasive developmental disorder.

In DSM-III, pervasive developmental disorder is divided into two major categories: infantile autism and childhood onset pervasive developmental disorder. The criteria differ, primarily, in the age of onset. The authors studied 129 patients who had received diagnoses of pervasive developmental disorder or a related disorder and found only five cases of apparent childhood onset pervasive developmental disorder. These five patients were behaviorally indistinguishable from those with other diagnoses. Practically, age of onset may be more appropriately termed "age of recognition," and its use as a major diagnostic criterion for such disorders may not be justified.

Adolescent↗

Psychiatric diagnosis across cultural boundaries.

Diagnosis across cultural boundaries has become a practical rather than an esoteric matter as migration, the number of effective psychiatric therapies, and access to psychiatric care have increased. Cross-cultural diagnosis involves such theoretical considerations as diagnostic categories, pathoplasticity of psychiatric disorder, so-called culture-bound syndromes, "emic" (intracultural) versus "etic" (cross-cultural) conceptual frameworks, and different reporting of symptoms and expression of signs from one cultural group to another. Important clinical issues include distinguishing cultural belief systems from delusions and understanding the special problems of minority, migrant, and refugee patients.

Cross-Cultural Comparison↗

Full-fat cream.

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Famous Persons↗