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PubMedDate not supplied

The central action of drugs affecting beta-adrenergic receptor. IV. The influence of intraventricularly administered drugs affecting beta-adrenergic receptor on blood pressure in rats.

Isoprenaline, propranolol, alprenol and sotalol administered intraventricularly (ivc) to anaesthetized rats induce hypotension. Propanolol and alprenolol given ivc to rats pretreated with isoprenaline increase blood pressure up to the values equal to those, previous to isoprenaline administration; another isoprenaline dose acts slightly hypotensively.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Changes in alcohol choice by chronically alcoholized cats as affected by tryptopham, its metabolites and preparations affecting its metabolism].

In cats unrestrictedly selecting alcohol and water during 5 months - 4.5 years under normal feeding, intraperitoneal injection of 1-tryptophan (5.5 and 65 mg/kg) lowered alcohol intake. Depending on the effect on water intake, a decrease (after a lower dose) or an increase (after a higher dose) in alcohol preference was observed. Tryptophan metabolites (mg/kg): dl-5-hydroxytryptophan (5-HTP, 6 and 12), tryptamine (2.5 and 5), 1-4 and dl-(2 and 6)kynurenine, as well as drugs modifying tryptophan metabolism, such as Ro-4-4602(2), an inhibitor of peripheral decarboxylase of aromatic amino acids, and allopurinol (2), an inhibitor of tryptophan pyrrolase (10 and 17), enhanced alcohol intake. Preference of alcohol was increased after tryptamine and 1-kynurenine and decreased after 5-HTP administration. Control injections of saline and distilled water resulted in a significant increase in alcohol and water intake. Saline increased preference of alcohol.

Absorption↗