Chromoblastomycosis in India. A review and report of two new cases.
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The authors are confirming the efficacy of the combination of Anfotericina B y 5-fluorocitosine in the treatment of Cromoblastomicosis. The used program was as follows: 50 mg. of Anfotericine-B by intravenous injection every two days during 13 weeks (39 dosis). Simultaneously tablets of 500 mg. of 5-fluorocitesina, every 6 hours, oral, also daily during 13 weeks (194 gramos dosis total) were given. The two treated patients were under monthly control during 10 months and observing no relapse of the disease, with other words there exists already a clinical and histological cure (healing). In one case it was observed a change in the ble blood chemistry which spontaneously normalized when suspending the combined treatment for one week and did not repeat when starting a new treatment.
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We present a case of brain abscess caused by Cladosporium trichoides which reappeared fifteen months later, in spite of a surgical procedure and antifungal chemotherapy. The importance of a complete neurosurgical resection of the lesion which determines the prognosis is emphasized. Based on amphotericine B, flucytosine, and itraconazole, the antifungal treatment is not fully standardized. Regular clinical and CT scan controls are necessary because of frequent recurrence.
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