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Real-time sonography of pleural opacities.

Fifty patients with radiographic pleural or pleural-based opacities were examined with high resolution real-time sonographic sector scanning. In 90% of cases selected for thoracentesis, fluid sufficient for diagnosis was obtained. Complex, septated pleural loculations contained an exudative effusion in 74% of the patients, while anechoic areas yielded exudative and transudative effusions with almost equal frequency. The use of real-time scanning is stressed because of greater flexibility and shorter examination time compared to compound scanning, and its utility for portable scanning on critically ill patients.

Bronchoscopy↗

Factors affecting the development of pneumothorax associated with thoracentesis.

This study is a retrospective survey of the variables that may influence the development of pneumothorax after thoracentesis. In a 30-month period, a computer search of hospital records identified 342 thoracenteses, of which 154 were done with conventional techniques by the clinical services, and 188 were done with sonographic guidance. Other factors surveyed included the patients' age, sex, underlying pulmonary disease, and overall clinical condition; the size of the effusion; the type of tap (diagnostic or therapeutic); the amount and type (exudate or transudate) of fluid acquired; and the size of the needles used. The technique used was the most significant single risk factor affecting the development of pneumothorax (18% for clinical vs 3% for sonography-guided thoracenteses). The incidence of pneumothorax decreased when a smaller amount of pleural fluid was aspirated (mean, 246 ml aspirated from patients who did not vs 472 ml from those who did develop pneumothorax) and when thin needles were used (4% pneumothorax with 20-gauge or smaller and 18% with larger than 20-gauge needles). The other factors surveyed did not influence the development of pneumothorax. Our results show that sonography-guided thoracentesis is complicated by pneumothorax significantly less often than is thoracentesis done with conventional techniques. Use of the smallest possible needle and aspiration of the smallest possible amount of fluid will also result in fewer cases of pneumothorax.

Adult↗

[Diagnostic importance of zinc in the etiologic determination of pleural effusions].

Concentration of zinc in blood serum and effusion was determined in 104 patients with the pleural effusion of different etiology. The importance of zinc concentration in serum and effusion was analyzed, as well as their relation regarding the differential diagnosis of pleural effusion. It was established that the isolated zinc concentrations in serum and pleural effusion could not be used separately either in differing transudates from exudates or in the diagnosis of the pleural diseases. The average value of zinc in the pleural effusion in relation to the serum value in patients with tuberculosis effusion was 1.37, higher than 1 in all patients and was significantly different from the average value of the ratio 0.74 in patients with nonspecific and malignant pleural effusions. The relation of zinc concentration in the effusion and serum higher than 1.0 reliably indicated the presence of tuberculous pleurisy.

Adult↗

Comparison of four methods for determination of total protein concentrations in pleural and peritoneal fluid from dogs.

OBJECTIVE: To compare 4 techniques for determination of total protein concentrations in peritoneal and pleural effusions from dogs. SAMPLE POPULATION: 23 peritoneal and 12 pleural fluid samples from 35 dogs with various abnormalities. PROCEDURE: Samples were collected into tubes containing EDTA, centrifuged, and stored at -20 C until total protein concentrations were assessed. Protein concentration in each sample was determined by use of urine test strips, refractometry, and Bradford and biuret techniques. Accuracy of each method was determined, using dilutions of human control sera. RESULTS: There was good correlation among results of all quantitative procedures. Results of the biuret technique were more accurate than results of the Bradford assay. Refractometry underestimated protein concentration in samples with < 20 g of protein/L. Results of urine test strips correctly classified effusion samples into 2 groups on the basis of total protein concentrations less than or greater than 20 g/L. CONCLUSIONS AND CLINICAL RELEVANCE: Results of any of these 4 techniques can be used to rapidly and efficiently differentiate peritoneal and pleural fluid from dogs into transudates and exudates on the basis of total protein concentration less than or greater than 20 g/L, respectively.

Animals↗

Nasal glands in nasal allergy.

The entire nasal mucosa from a patient with nasal allergy and hay fever was studied by the whole mount method, and the density of submucous glands was determined. Their density was essentially greater than in normal noses in all parts of the nose, especially on the conchae. This finding indicates that new-abnormal-glands form in the course of the disease, glands which also differ morphologically from the normally occurring glands. As this greatly increases the secretory capacity of the mucous membrane, there is a patho-anatomical basis for assuming that the nasal secretion in allergy is formed exclusively by the existing glands. Other sources of nasal secretion, such as exudation and transudation under normal conditions and in allergy, as well as the mode and causes of gland formation, are discussed.

Adolescent↗

Tumor-associated trypsin inhibitor (TATI) in pleural effusions.

The purpose of this study was to evaluate the usefulness of tumor-associated trypsin inhibitor (TATI) determination in serum and pleural fluid for differential diagnosis of relapsing pleural effusions. The concentrations of TATI were determined in samples of serum and pleural fluid from 51 patients with pleural effusions comprising 20 benign exudates, 5 transudates and 26 malignant effusions. TATI levels overlapped in benign and malignant fluids. This precludes the use of this marker for diagnosis of pleural effusions. For this purpose CEA seems to be the best tumor marker with a sensitivity frequently higher than that of cytology.

Biomarkers, Tumor↗

Pleural fluid lysozyme in human disease.

A prospective study was conducted to define the content, significance, and source of lysozyme present in the pleural fluid in human diseases. The pleural fluid lysozyme activity is similar in various malignant and nonmalignant transudates and exudates, and is of limited diagnostic value. The pleural fluid activity correlated well with that of paired serum samples but it had poor correlation with the disease state, the pleural fluid granulocyte counts, and total white blood cell counts. The data suggest that the pleural fluid lysozyme may be derived primarily from the blood and that it is not the product of inflammatory or neoplastic cells in the fluid itself.

Carcinoma↗

Aetiology and management of acute cardiac tamponade.

OBJECTIVE: To review current concepts in the aetiology and management of patients with cardiac tamponade. DATA SOURCES: A review of articles reported on acute cardiac tamponade. SUMMARY OF REVIEW: Cardiac tamponade is defined as a haemodynamically significant cardiac compression caused by pericardial fluid. The fluid may be blood, pus, effusion (transudate or exudate) or air and treatment involves correction of the cardiac diastolic restriction by removing pericardial fluid during either pericardiocentesis or thoracotomy. Pericardiocentesis is usually performed for urgent management of an acute tamponade. A thoracotomy is required when a tamponade exists following coronary artery bypass grafting, cardiac rupture, penetrating or closed cardiac trauma and aortic dissection or where a pericardial clot is likely. Removal of pericardial fluid by percutaneous catheterisation of the pericardial sac traditionally uses the subxiphoid 'blind' approach., However, pericardial aspiration is often currently performed under transthoracic echocardiographic guidance with the commonest site of needle entry being on the chest wall at or near the apex and the needle directed perpendicular to the skin. The pericardial fluid is drained using an indwelling 'pigtail' catheter, preferably with close monitoring of the pulmonary artery wedge pressure, as rapid removal of large volumes of pericardial fluid (> 500 mL) may result in a 'decompressive syndrome' causing pulmonary oedema. The fluid is sent for culture and Gram-stain and analysed for glucose, protein, lactate dehydrogenase, haemoglobin and white cell count. If appropriate the fluid is also analysed for amylase, and cholesterol and sent for cytology, serology and parasitic studies and viral, mycobacterial and fungal cultures. CONCLUSIONS: Cardiac tamponade may present as an acute or subacute syndrome of elevated central venous pressure and hypotension. Pericardiocentesis using echocardiographic guidance and right heart catheter control is often the method of choice for acute removal of fluid.

Journal Article↗

[Clinico-chemical study of body cavity effusions].

The differential diagnosis of ascites is discussed. 107 dogs with ascites were examined. The mean age of the dogs was relatively high. Therefore many dogs were multimorbid. The classification of ascites into transudate and exudate was of limited value. The activity of the lactate dehydrogenase (LDH) in the ascitic fluid was a potent parameter in differentiating cardiac, neoplastic and infectious ascites. For the diagnosis of a neoplastic cause of the ascites, a LDH activity range from 200-1600 U/l was useful. The predictive value of the positive result was 87%, and the predictive value of the negative result was 88%.

Animals↗

[A case of essential thrombocythemia with pulmonary hypertension and bilateral pleural effusions].

A 79-year-old woman was admitted with general fatigue. Chest roentgenogram showed diffuse reticular shadows and bilateral pleural effusion. Peripheral blood studies revealed an elevation of platelet count (203.3 X 104/mm3). The case was diagnosed as essential thrombocythemia and treated with ACNU. The platelet count decreased. Bilateral pleural effusions increased gradually and their characteristics changed from bloody exudate to transudate. Biopsy of her pleura and thoracoscopy were carried out without significant results. Later, systemic edema, which suggested right heart failure, developed. The diagnosis of pulmonary hypertension and right heart failure was made by echocardiogram and right cardiac catheterization. Because perfusion scan of the lung revealed some perfusion defects, complication of pulmonary embolism was suspected. Bilateral pleural effusion and pulmonary artery pressure decreased with treatment by nifedipine, furosemide and isosorbide dinitrate. This is the first case report of essential thrombocythemia, pulmonary hypertension, right heart failure and bilateral pleural effusion.

Aged↗

Differential diagnosis of ascitic fluid: evaluation and comparison of various biochemical criteria with a special reference to serum ascites albumin concentration gradient and its relation to portal pressure.

Among various biochemical indices measured in 93 patients with ascites, ascitic LDH estimation was proved to be indiscreminatory, while ascites/serum LDH ratio has shown a diagnostic accuracy of 85 per cent. Ascitic total protein levels and ascites/serum total protein ratio (accuracy rates of 72 and 77% respectively) were limited, especially in differentiating the ascites due to heart failure. Serum ascites albumin gradient, showed a strong correlation to portal pressure (r, + 0.83 + 0.88), and was found to be the best diagnostic index (with an overall accuracy of 97 per cent) in distinguishing the 'transudative' from 'exudative' ascites. However, no index could discreminate the 'mixed' cases and provide the etiological diagnosis of the ascites.

Adult↗

Use of drains in foot surgery.

The purpose of this article is to describe how drains can be effective for foot surgeons. Emphasis is placed upon the closed-wound drainage system which was designed for outpatient surgery. Removing transudative or exudative fluids will promote the healing time of a wound that would otherwise delay tissue granulation. These drains eliminate dead space by exerting a negative pressure by means of a perforated catheter, tube, and reservoir. Edema is decreased, and layers of tissue are allowed to adhere faster. The portable closed wound drainage system removes drainage against gravity to allow faster rehabilitation.

Drainage↗

[Differential diagnosis of pleural diseases].

Diffuse and circular focal processes are radiologically recognized as possibly pleurally conditioned by the position near to the chest wall. A clarification is possible by means of the diagnostic pneumothorax, the pleuroscopy and the exploratory excision under vision. Callous processes may be of inflammatory and malignant genesis. Transthoracic punctures, punch biopsies and surgical exploration may become necessary for the clarification. The effusion is the most frequent symptom of pleural diseases. The differentiation of transudate and exudate is diagnostically as essential as a functional interpretation of the cell sediments of above all inflammatory effusions. Not all malignant processes are cyto-morphologically to be recognized as such. By means of the determination of the protein coagulation after Weltmann, simultaneously performed in the blood serum and in the effusion into the pleura, we, therefore, try to find additional informations. The colorimetric measuring of the contents of hyaluronic acid of pleura exudates serves the identification of diffuse mesotheliomas.

Biopsy↗