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Changing role of endoscopy in the new millennium. Bushell Lecture, Asia-Pacific Digestive Week 2001.

Endoscopy has confronted many challenges, including serology tests for Helicobacter pylori, virtual colonoscopy and magnetic resonance cholangiopancreatography. These new modalities might eventually replace endoscopy in diagnosing digestive tract diseases. New advancements such as capsule endoscopy, infrared spectroscopy, optical coherent tomography, and various therapeutic procedures have opened new horizons in the field. Endoscopists should keep their mind open and be prepared for the changing role of endoscopy in the new millennium.

Digestive System Diseases↗

A prospective randomized comparative study on the safety and tolerability of transnasal esophagogastroduodenoscopy.

BACKGROUND AND STUDY AIM: Transnasal esophagogastroduodenoscopy (EGD) with a small-caliber endoscope is well tolerated by patients. However, the effect of this procedure on cardiopulmonary function has not been fully investigated. The aim of this prospective, randomized study was to investigate the effect of transnasal EGD in comparison with transoral EGD on cardiopulmonary function. PATIENTS AND METHODS: The study involved 450 patients referred for diagnostic EGD. Patients were randomly assigned to one of three types of unsedated EGD (150 patients per group): transnasal EGD using a small-caliber endoscope (the "XP-N" group), transoral EGD using the same small-caliber endoscope ("XP-O" group), and transoral EGD using a conventional endoscope ("XQ" group). Systolic and diastolic blood pressure, pulse rate, and arterial oxygen saturation were monitored before, and 2, 4 and 6 minutes after intubation, and just after endoscope extubation. Gagging episodes were also counted, to determine tolerance. RESULTS: It was not possible to perform transnasal EGD in 12 patients (8.0%). A small amount of epistaxis was observed in eight (5.8%) of 138 patients who were examined successfully by transnasal EGD. Systolic and diastolic blood pressure, pulse rate, rate-pressure product (pulse rate x systolic blood pressure/100), and the drop in arterial oxygen saturation in the XQ group were significantly greater than in the XP-N and XP-O groups at each time point. In the XP-N group, these parameters were significantly lower than those in the XP-O group at 2 minutes after intubation. Of the tree groups the number of gagging episodes was significantly lower in the XP-N group. CONCLUSION: Transnasal EGD is safer than transoral EGD as it is associated with fewer adverse effects on cardiopulmonary function and is better tolerated by patients.

Adult↗

[Emergency surgical management of lesions from ingestion of caustics. Role of primary endoscopic classification].

Management of caustic ingestion in adults improved in the last decade due to the new diagnostic developments, the better predictability of injuries from signs and symptoms, the intensive care improvements and the more aggressive surgical approach for the most severe lesions. In fact, the early surgical treatment of severe lesions for ingestion of caustic and corrosive substances may reduce mortality, morbidity and hospitalization. The role of early endoscopic examination is today worldwide accepted: is herein proposed a new endoscopic classification of caustic lesions adjusted after a retrospective analysis of a twenty years experience in this field, and applied in twelve patients affected by severe esophageal and gastric injuries then submitted to emergency surgical treatment and survived. It showed a great usefulness in selection of patients to submit immediately to surgery and may play a fundamental role in indications and timing of surgical management of severe injuries by caustic ingestion.

Adult↗

Guideline for the management of ingested foreign bodies.

This is one of a series of statements discussing the utilization of gastrointestinal endoscopy in common clinical situations. The Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy prepared this text. In preparing this guideline, a MEDLINE literature search was performed, and additional references were obtained from the bibliographies of the identified articles and from recommendations of expert consultants. When little or no data exist from well-designed prospective trials, emphasis is given to results from large series and reports from recognized experts. Guidelines for appropriate utilization of endoscopy are based on a critical review of the available data and expert consensus. Further controlled clinical studies are needed to clarify aspects of this statement, and revision may be necessary as new data appear. Clinical consideration may justify a course of action at variance to these recommendations.

Digestive System↗

Plexosarcoma: endoscopic ultrasound and electron-microscopic characteristics of a stromal tumor.

Endoscopic ultrasound is useful for managing submucosal masses; however, some of these lesions can be difficult to classify except with full histological and electron microscopic evaluation. A 72-yr-old woman was seen with upper GI bleeding. Endoscopy showed a 1.7-cm sessile ulcerated submucosal mass in the duodenal bulb. Endoscopic ultrasound revealed an echolucent submucosal mass arising from the fourth echolayer, the muscularis propria of the duodenal wall. These findings suggested that the lesion was a leiomyoma. The patient eventually had the lesion resected because of recurrent bleeding. Histologically it was a spindle cell tumor that on electron microscopy showed neuronal elements consistent with a plexosarcoma, or gastrointestinal autonomic nerve tumor. These lesions account for some one third of all gastrointestinal stromal tumors. Despite their low grade malignant histologic appearance, local recurrence or hepatic metastases occur in about 70% of patients.

Aged↗

[Current developments in the field of endoscopy in the treatment of digestive system disorders].

A review is given of new developments of endoscopic treatment of diseases of the gastrointestinal tract. Endoscopic treatment is possible in patients with peptic stricture or inoperable tumors of the oesophagus, achalasia of the oesophagus, oesophageal varices, polyps and angiodysplasia of the large bowel, stomach and duodenum, choledocholithiasis and unresectable stenosing tumors of the bile ducts. In comparison with surgical therapy endoscopic treatment is relatively simple and has a much lower morbidity and mortality, especially in patients with an increased surgical risk.

Aged↗

Endoscopic imaging technology.

Upper gastrointestinal endoscopy has evolved from semiflexible instruments of large diameter to a generation of high-resolution electronic and fiberoptic instruments of narrow diameter with many diagnostic and therapeutic capabilities. Resolution and color fidelity are important considerations in endoscopy, and advances in technology have resulted in substantial improvements in both over the last decade. Enhancements in electronic imaging techniques and developments in networking will make image transfer and shared data easier in the coming years, and image processing may help refine diagnostic endoscopy.

Computer Systems↗