PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “FLUORIDE POISONING”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15Linked to original sources
PubMed2001

Fluorides in the new millennium.

Water fluoridation is known to be the most successful public health measure of the 20th century. More than half a century later, we are still reaping the benefits of fluoridation. We now know that the most important mechanism of fluoride action occurs through daily low-dose exposures. The battle between demineralization and remineralization occurs constantly, and fluoride shifts the balance to the latter. This dynamic, daily process far supersedes the pre-eruptive fluoride incorporation in importance. Fluoride, however, is now available in a variety of very different forms, useful in waging the war on caries. Nevertheless, opponents of this therapeutic agent maintain that its widespread use should be curtailed. Although the benefits of fluoride can no longer be disputed, fluoride supplementation must be supported and approached with consideration of total fluoride exposure.

Cariostatic Agents↗
PubMed1999

[Effect of calcium and cristata L extracts on bone mineral density and urinary mineral of rats].

In order to study the effect of cristata L for preventing fluoride toxicity, forty male SD rats were randomly divided into five groups. The control group(NC) was fed with staple feed stuff and tap water, the other four groups were fed with staple feed-stuff and high fluorine water. Except the high fluorine group(F), the other groups were fed with cristata L(FC), high calcium(FCa) and cristata L with high calcium(FCCa) respectively. The results showed that the serum calcium, urinary sodium, calcium, hydroxyproline(HOP) and fluorine contents of high fluorine groups were higher than that of control group; and the urinary calcium content of high calcium group was higher than that of control group. The body weight, BMC and BMD of high fluorine groups was lower than that of control group. The weight of groups FC, FCa and FCCa were significantly higher than that of group F. The BMC and BMD of group FCCa were significantly higher than that of group F. This implies that the food high in fluorine can affect the bone mineral density and urinary minerals of rats, the food supplemented with calcium can reduce the effect of high fluorine, and the food supplemented with both calcium and cristata L is better.

Animals↗
PubMedDate not supplied

Reversal of fluoride induced cell injury through elimination of fluoride and consumption of diet rich in essential nutrients and antioxidants.

The objective of the present communication is to address the issues concerning reversal of fluoride induced cell injury and disease (i.e. fluorosis) through the elimination of fluoride and consumption of a diet containing essential nutrients and antioxidants. Humans afflicted with fluorosis, as a result of consuming fluoride contaminated water or food, have been investigated. Hospital based diagnostic procedure for early detection of fluorosis, through retrieval of history, clinical complaints, testing of blood, urine and drinking water for fluoride using ion selective electrode technology, along with X-ray of the forearm have been carried out. Confirmed cases of fluorosis were introduced to an intervention protocol consisting of (1) provision of safe drinking water with fluoride levels less than 1 mg/L and (2) counselling on nutritional supplementation with focus on adequate intake of calcium, vitamins C, E and antioxidants. The patients were monitored at frequent intervals up to one year and the results are reported. With a standardized early diagnosis, elimination of fluoride intake and supplementation of a diet rich in essential nutrients and antioxidants, we have shown that the fluorosis can be reversed.

Adolescent↗
PubMed1976

Prevention of bony fluorosis in aluminum smelter workers. A 15-year retrospective study of fluoride excretion and bony radiopacity among aluminum smelter workers -- Pt. 4.

1. Fifty six aluminum smelter workers with 10 to 43 years' occupational exposure, and who had been previously studied medically, were re-x-rayed. Average urinary fluoride concentrations since 1960 were estimated to range from 2.78 mg/liter preshift and 7.71 mg/liter postshift. 2. Roentgenographic studies in 1960-66 and 1974 failed to reveal any evidence of fluoride associated bony change. 3. Although these workers represent a self-selected group, their magnitude and duration of exposure far outweighs any other group working at present or in the past at this plant. The implication that they have uniformly self-selected as fluoride resistant individuals is improbable. 4. These data indicate that group post-shift ur a long period is not associated with enhanced risk of bony fluorosis. If preshift urinary fluoride concentrations are less than 4 mg/l, the same results appears to apply.

Adult↗
PubMed1976

Prevention of bony fluorosis in aluminum smelter workers. Absorption and excretion of fluoride immediately after exposure -- Pt. 1.

1. A program for the prevention of excessive fluoride absorption among aluminum smelter workers is described. This surveillance is based upon knowledge of the portals of entry, distribution, bone deposition and excretory patterns of this element. 2. The control program is based on the thesis that the concentration of fluoride in the urine two to three days after cessation of work-related exposure reflects the bony burden of this element among this occupational group. Further, this program assumes that the concentration of urinary fluoride after three to five days of shift work reflects the extent of work exposure, adequacy of hygienic and engineering controls and work practices. The limitations of such program as it applies to individual samplings of workers is emphasized. 3. A balance between inhaled fluoride and urinary excretion over a 24-hour period (beginning with work exposure) is attempted. An approximate model for aluminum smelter workers in a near equilibrium F balance is constructed. The role of particle size distribution as a determinant of body loading is emphasized. Because of considerable variation in uptake possible with differing particle size distributions, the actual body F loading potential is inadequately determined on the basis of F concentrations in air. These data also suggest that gaseous fluoride is probably adsorbed upon particulates and absorbed at the alveolar level in the same fashion as respirable particulate fluoride. 4. The regression of ambient fluoride on urinary excretion suggests that the present threshold limit value for fluoride might be more appropriately set at 2 mg/M33 for an eight-hour day.

Air Pollutants, Occupational↗
PubMed2002

[Study on metabolism of preventive anti-fluorine agent on rats].

In order to study the metabolism of preventive anti-fluorine agent, 30 rats are randomly divided into high-dose, low-dose and a control groups. The high dose (400 mg/kg.d) and low dose (16 mg/kg.d) are orally administrated respectively, and the content of boron and/or zinc in urine, dung, serum, bone, liver, muscles, brain tissues is determined. The results showed that during the administration of this agent, the content of boron in urine and the content of zinc in dung increases obviously in both high-dose and low-dose groups and their discharge rate is consistent with the dose given. The content of boron and zinc in bone, liver, and zinc in serum, muscles, brain tissues increases evidently compared to that in control group but decreases rapidly after administration of the agent. The findings revealed that there is a rapid metabolism of boron and zinc in the body of rats. The highest content of the agent is observed in bones. The content ranks second in liver and muscles but no accumulative effects are observed.

Animals↗