PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Gaussian process”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15Linked to original sources

Self-organizing maps: stationary states, metastability and convergence rate.

We investigate the effect of various types of neighborhood function on the convergence rates and the presence or absence of metastable stationary states of Kohonen's self-organizing feature map algorithm in one dimension. We demonstrate that the time necessary to form a topographic representation of the unit interval [0, 1] may vary over several orders of magnitude depending on the range and also the shape of the neighborhood function, by which the weight changes of the neurons in the neighborhood of the winning neuron are scaled. We will prove that for neighborhood functions which are convex on an interval given by the length of the Kohonen chain there exist no metastable states. For all other neighborhood functions, metastable states are present and may trap the algorithm during the learning process. For the widely-used Gaussian function there exists a threshold for the width above which metastable states cannot exist. Due to the presence or absence of metastable states, convergence time is very sensitive to slight changes in the shape of the neighborhood function. Fastest convergence is achieved using neighborhood functions which are "convex" over a large range around the winner neuron and yet have large differences in value at neighboring neurons.

Algorithms↗

Hemispheric processing of spatial frequencies in two commissurotomy patients.

To test the hypothesis that in humans the left brain hemisphere is specialized for processing high spatial frequencies while the right hemisphere is specialized for processing low spatial frequencies, pairs of Gaussian windowed sinusoidal gratings were presented for 167 msec within the left and right visual fields of two commissurotomy patients. The gratings employed had spatial frequencies ranging from 1 to 8 cycles per degree, and horizontal or vertical orientations. The two gratings in each pair were identical in spatial frequency but could differ in orientation. Subjects reported if their orientations were the same or different. Twelve normal controls were also run. Accuracy data provides no indication of a relative advantage for high frequencies in the RVF or low frequencies in the LVF. One commissurotomy subject showed a trend in the reverse direction; the other was better with LVF presentations for all spatial frequencies. Control subjects failed to show a spatial frequency x visual field interaction. These outcomes suggest that at the processing stages required by the task, the hemispheres are not specialized for particular ranges of spatial frequencies.

Adult↗

Enhancing spot detection and reducing noise from digitized electrophoretic gel images using area processing filters.

Twenty area processing filters and filter combinations were evaluated in an effort to optimize presentation of two-dimensional electrophoretic profiles to the Laplacian spot finder for maximal spot detection sensitivity. Images of electrophoresis gels were obtained by digitizing polyacrylamide gels at 1024 x 1024 picture elements (pixels) resolution with 256 grey scale levels using the charge coupled device (CCD) camera of the Millipore Bio Image 110S computerized imaging system. The images were imported into an Apple Macintosh microcomputer and selectively enhanced by applying various area processing filters. Previously described least squares fit, low-pass, Gaussian and median filters were used to reduce noise in the digitized images. These filters differ in that during the summation process the least squares template weighs the immediately adjacent pixels more heavily than the Gaussian template. The low-pass filters weigh all neighboring pixels equally. Median filters replace the pixel of interest with the middle (median) value of the pixel neighborhood. An analysis of convolution filter sizes indicated that a 7 x 7 matrix was optimal for 22 cm x 22 cm gels. When using the median area processing procedure, however, the 3 x 3 filter was found to be superior to the 7 x 7 filter. The 7 x 7 least squares filter significantly improved detection of low abundance polypeptides while having only minimal effects on the high abundance polypeptides. The 7 x 7 Gaussian and 3 x 3 median filters also improved detection of low abundance polypeptides but reduced the integrated areas of the high abundance polypeptides and thus their integrated optical densities as well.(ABSTRACT TRUNCATED AT 250 WORDS)

Electrophoresis, Polyacrylamide Gel↗

Modeling neural activity using the generalized inverse Gaussian distribution.

Spike trains from neurons are often used to make inferences about the underlying processes that generate the spikes. Random walks or diffusions are commonly used to model these processes; in such models, a spike corresponds to the first passage of the diffusion to a boundary, or firing threshold. An important first step in such a study is to fit families of densities to the trains' interspike interval histograms; the estimated parameters, and the families' goodness of fit can then provide information about the process leading to the spikes. In this paper, we propose the generalized inverse Gaussian family because its members arise as first passage time distributions of certain diffusions to a constant boundary. We provide some theoretical support for the use of these diffusions in neural firing models. We compare this family with the lognormal family, using spike trains from retinal ganglion cells of goldfish, and simulations from an integrate-and-fire and a dynamical model for generating spikes. We show that the generalized inverse Gaussian family is closer to the true model in all these cases.

Action Potentials↗

Retrospective analysis of refractive errors in children with vision impairment.

PURPOSE: Emmetropization is the reduction in neonatal refractive errors that occurs after birth. Ocular disease may affect this process. We aimed to determine the relative frequency of ocular conditions causing vision impairment in the pediatric population and characterize the refractive anomalies present. We also compared the causes of vision impairment in children today to those between 1974 and 1981. METHODS: Causes of vision impairment and refractive data of 872 children attending a pediatric low-vision clinic from 1985 to 2002 were retrospectively collated. As a result of associated impairments, refractive data were not available for 59 children. An analysis was made of the causes of vision impairment, the distribution of refractive errors in children with vision impairment, and the average type of refractive error for the most commonly seen conditions. RESULTS: We found that cortical or cerebral vision impairment (CVI) was the most common condition causing vision impairment, accounting for 27.6% of cases. This was followed by albinism (10.6%), retinopathy of prematurity (ROP; 7.0%), optic atrophy (6.2%), and optic nerve hypoplasia (5.3%). Vision impairment was associated with ametropia; fewer than 25% of the children had refractive errors < or = +/-1 D. The refractive error frequency plots (for 0 to 2-, 6 to 8-, and 12 to 14-year age bands) had a Gaussian distribution indicating that the emmetropization process was abnormal. The mean spherical equivalent refractive error of the children (n = 813) was +0.78 +/- 6.00 D with 0.94 +/- 1.24 D of astigmatism and 0.92 +/- 2.15 D of anisometropia. Most conditions causing vision impairment such as albinism were associated with low amounts of hyperopia. Moderate myopia was observed in children with ROP. CONCLUSIONS: The relative frequency of ocular conditions causing vision impairment in children has changed since the 1970s. Children with vision impairment often have an associated ametropia suggesting that the emmetropization system is also impaired.

Adolescent↗

The inverse Gaussian distribution as a model of hospital stay.

Properties of the inverse gaussian distribution are presented with comments on fitting the distribution to lentgh-of-stay data. A conceptual framework for the hospitalization process is described; it suggests that the inverse gaussian distribution has considerable potential as both a descriptive and prescriptive model of length of stay, especially in the setting of psychiatric hospitals.

Humans↗

Min-max hyperellipsoidal clustering for anomaly detection in network security.

A novel hyperellipsoidal clustering technique is presented for an intrusion-detection system in network security. Hyperellipsoidal clusters toward maximum intracluster similarity and minimum intercluster similarity are generated from training data sets. The novelty of the technique lies in the fact that the parameters needed to construct higher order data models in general multivariate Gaussian functions are incrementally derived from the data sets using accretive processes. The technique is implemented in a feedforward neural network that uses a Gaussian radial basis function as the model generator. An evaluation based on the inclusiveness and exclusiveness of samples with respect to specific criteria is applied to accretively learn the output clusters of the neural network. One significant advantage of this is its ability to detect individual anomaly types that are hard to detect with other anomaly-detection schemes. Applying this technique, several feature subsets of the tcptrace network-connection records that give above 95% detection at false-positive rates below 5% were identified.

Algorithms↗

Radial Hilbert transform with Laguerre-Gaussian spatial filters.

We analyze the point spread function (PSF) of the image processing system for radial Hilbert transform and propose a novel spiral phase filter, called the Laguerre-Gaussian spatial filter (LGSF). Theoretical analysis and real experiments show that the LGSF possesses some advantages in comparison with the conventional spiral phase plate (SPP). For example, the PSF of the imaging system with a LGSF presents smaller suboscillations than that with the conventional SPP, which allows us to realize a radial Hilbert transform for achieving a high contrast edge enhancement with high resolution.

Journal Article↗

Detection and modeling of non-Gaussian apparent diffusion coefficient profiles in human brain data.

This work details the observation of non-Gaussian apparent diffusion coefficient (ADC) profiles in multi-direction, diffusion-weighted MR data acquired with easily achievable imaging parameters (b approximately 1000 s/mm(2)). A technique is described for modeling the profile of the ADC over the sphere, which can capture non-Gaussian effects that can occur at, for example, intersections of different tissue types or white matter fiber tracts. When these effects are significant, the common diffusion tensor model is inappropriate, since it is based on the assumption of a simple underlying diffusion process, which can be described by a Gaussian probability density function. A sequence of models of increasing complexity is obtained by truncating the spherical harmonic (SH) expansion of the ADC measurements at several orders. Further, a method is described for selection of the most appropriate of these models, in order to describe the data adequately but without overfitting. The combined procedure is used to classify the profile at each voxel as isotropic, anisotropic Gaussian, or non-Gaussian, each with reference to the underlying probability density function of displacement of water molecules. We use it to show that non-Gaussian profiles arise consistently in various regions of the human brain where complex tissue structure is known to exist, and can be observed in data typical of clinical scanners. The performance of the procedure developed is characterized using synthetic data in order to demonstrate that the observed effects are genuine. This characterization validates the use of our method as an indicator of pathology that affects tissue structure, which will tend to reduce the complexity of the selected model.

Brain↗

Variety identification of wheat using mass spectrometry with neural networks and the influence of mass spectra processing prior to neural network analysis.

The performance of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry with neural networks in wheat variety classification is further evaluated.1 Two principal issues were studied: (a) the number of varieties that could be classified correctly; and (b) various means of pre-processing mass spectrometric data. The number of wheat varieties tested was increased from 10 to 30. The main pre-processing method investigated was based on Gaussian smoothing of the spectra, but other methods based on normalisation procedures and multiplicative scatter correction of data were also used. With the final method, it was possible to classify 30 wheat varieties with 87% correctly classified mass spectra and a correlation coefficient of 0.90.

Journal Article↗

Comparison of the performance of three maximum Doppler frequency estimators coupled with different spectral estimation methods.

The performance of three spectral techniques (FFT, AR Burg and ARMA) for maximum frequency estimation of the Doppler spectra is described. Different definitions of fmax were used: frequency at which spectral power decreases down to 0.1 of its maximum value, modified threshold crossing method (MTCM) and novel geometrical method. "Goodness" and efficiency of estimators were determined by calculating the bias and the standard deviation of the estimated maximum frequency of the simulated Doppler spectra with known statistics. The power of analysed signals was assumed to have the exponential distribution function. The SNR ratios were changed over the range from 0 to 20 dB. Different spectrum envelopes were generated. A Gaussian envelope approximated narrow band spectral processes (P. W. Doppler) and rectangular spectra were used to simulate a parabolic flow insonified with C. W. Doppler. The simulated signals were generated out of 3072-point records with sampling frequency of 20 kHz. The AR and ARMA models order selections were done independently according to Akaike Information Criterion (AIC) and Singular Value Decomposition (SVD). It was found that the ARMA model, computed according to SVD criterion, had the best overall performance and produced results with the smallest bias and standard deviation. In general AR(SVD) was better than AR(AIC). The geometrical method of fmax estimation was found to be more accurate than other tested methods, especially for narrow band signals.

Doppler Effect↗

Sensitivity of empirical metrics of rate of absorption in bioequivalence studies.

PURPOSE: The sensitivity and effectiveness of indirect metrics proposed for the assessment of comparative absorption rates in bioequivalence studies [Cmax, Tmax, partial AUC (AUCp), feathered slope (SLf), intercept metric (I)] were originally tested by assuming first-order absorption. The present study re-evaluates their sensitivity performances using the more realistic inverse Gaussian (IG) model characterizing the input process for oral drug administration. METHODS: Simulations were performed for both the first-order or exponential model (EX) which is determined by only one parameter, the mean absorption time (MAT = 1/k(a)), and the IG model, which additionally contains a shape parameter, the relative dispersion of absorption time distribution (CV2A). Kinetic sensitivities (KS) of the indirect metrics were evaluated from bioequivalence trials (error free data) generated with various ratios of the true parameters (MAT and CV2A) of the two formulations. RESULTS: The behavior of the metrics was similar with respect to changes in MAT ratios with both models: KS was low with Cmax, moderate with SLf and AUCp, and high with I and Tmax following correction for apparent lag time (Tlag). Changes of the shape parameter CV2A, however, were not detectable by Cmax, Tmax, SLf, and AUCp. Changes in both MAT and CV2A were well reflected by I with CV2A - ratio > 1. I exhibited approximately full KS also with CV2A - ratio < 1 when a correction was first applied for the apparent lag time. CONCLUSIONS: The time profile of absorption rates is insufficiently characterized by only one parameter (MAT). Indirect metrics which are sensitive enough to detect changes in the scale and shape of the input profile could be useful for bioequivalence testing. Among the tested measures, I is particularly promising when a correction is applied for Tlag.

Antipsychotic Agents↗

Fraser cords and reversal of the café wall illusion.

Morgan and Moulden have shown that the café wall illusion can be explained by the effects of processing with a difference-of-Gaussians filter which reveals Fraser twisted cords in the figure. It is deduced that their account leads to the novel prediction of the reverse tilt illusion if the width of the mortar lines is suitably increased. This prediction is confirmed by demonstration.

Female↗

Multivariate determination of glucose concentrations from optimally filtered frequency-warped NIR spectra of human blood serum.

Glucose concentrations over the 39-160 mg dl-1 range have been determined from 357 NIR (near-infrared) spectra of human blood serum in the spectral region from 6766 cm-1 to 4003 cm-1. A frequency-warping procedure was applied to the NIR data to compress 511 spectral components into 102 in the 6766-4003 cm-1 spectral region. Before the data compression process was carried out, the NIR spectrum of deionized water was subtracted from each of the blood serum spectra to remove the intrinsic high background absorption due to the water. PLS (partial least-squares) regression was coupled with time-domain digital Butterworth bandpass filtering in an optimization procedure. The optimization procedure was carried out over a range of centre frequencies and bandwidths for first- (two-pole), second- (four-pole) and third- (six-pole) order bandpass filters, and over a range of PLS factors. The optimal PLS model and filter parameters were determined from a sequence of three-dimensional performance response maps for different numbers of PLS factors and filter orders. As a basis for comparison, the same optimization process was carried out for a Gaussian filter design approach (i.e., Fourier filtering). Using the optimally filtered frequency-warped NIR spectral data, an SEP (standard error of prediction) of 13.2 mg dl-1 was achieved fro the test (monitoring) data using 14 PLS factors and a simple first-order (two-pole) digital Butterworth bandpass filter.

Blood Glucose↗

Levy scaling in random walks with fluctuating variance

Truncated Levy flights with correlated fluctuations of the variance (heteroskedasticity) are considered. A stylized model is introduced, in which the variance fluctuates between two possible values following a Markov chain process. Analogously to conventional truncated Levy flights with fixed variance, the central part of the probability distribution function of the increments at short time scales is found to be close to a Levy distribution. What makes these processes interesting is the fact that the crossover to the Gaussian regime may occur for times considerably larger than for uncorrelated (or no) variance fluctuations. Processes of this type may find direct application in the modeling of some economic time series, in which Levy scaling and heteroskedasticity are known to coexist.

Journal Article↗

Limits on the accuracy of 3-D thickness measurement in magnetic resonance images--effects of voxel anisotropy.

Measuring the thickness of sheet-like thin anatomical structures, such as articular cartilage and brain cortex, in three-dimensional (3-D) magnetic resonance (MR) images is an important diagnostic procedure. This paper investigates the fundamental limits on the accuracy of thickness determination in MR images. We defined thickness here as the distance between the two sides of boundaries measured at the subvoxel resolution, which are the zero-crossings of the second directional derivatives combined with Gaussian blurring along the normal directions of the sheet surface. Based on MR imaging and computer postprocessing parameters, characteristics for the accuracy of thickness determination were derived by a theoretical simulation. We especially focused on the effects of voxel anisotropy in MR imaging with variable orientation of sheet-like structure. Improved and stable accuracy features were observed when the standard deviation of Gaussian blurring combined with thickness determination processes was around square root of 2/2 times as large as the pixel size. The relation between voxel anisotropy in MR imaging and the range of sheet normal orientation within which acceptable accuracy is attainable was also clarified, based on the dependences of voxel anisotropy and the sheet normal orientation obtained by numerical simulations. Finally, in vitro experiments were conducted using an acrylic plate phantom and a resected femoral head to validate the results of theoretical simulation. The simulated thickness was demonstrated to be well-correlated with the actual in vitro thickness.

Anatomy, Cross-Sectional↗

The K-function for nearly regular point processes.

We propose modeling a nearly regular point pattern by a generalized Neyman-Scott process in which the offspring are Gaussian perturbations from a regular mean configuration. The mean configuration of interest is an equilateral grid, but our results can be used for any stationary regular grid. The case of uniformly distributed points is first studied as a benchmark. By considering the square of the interpoint distances, we can evaluate the first two moments of the K-function. These results can be used for parameter estimation, and simulations are used to both verify the theory and to assess the accuracy of the estimators. The methodology is applied to an investigation of regularity in plumes observed from swimming microorganisms.

Animals↗

Evaluation of the impact of finite-resolution effects on scintillation compensation using two deformable mirrors.

The impact of finite-resolution deformable mirrors and wave-front sensors is evaluated as it applies to fullwave conjugation using two deformable mirrors. The first deformable mirror is fixed conjugate to the pupil, while the second deformable mirror is at a finite range. The control algorithm to determine the mirror commands for the two deformable mirrors is based on a modification of the sequential generalized projection algorithm. The modification of the algorithm allows the incorporation of Gaussian spatial filters into the optimization process to limit the spatial-frequency content applied to the two deformable mirrors. Simulation results are presented for imaging and energy projection scenarios that establish that the optimal spatial filter waist to be applied is equal to the subaperture side length in strong turbulence. The effect of varying the subaperture side length is examined, and it is found that to effect a significant degree of scintillation compensation, the subapertures, and corresponding spacing between actuators, must be much smaller than the coherence length of the input field.

Journal Article↗