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At least 271 records · Page 15Linked to original sources
PubMed1989

Evaluation of the functional integrity of endothelium in perfused lungs.

Prostacyclin (PGI2) formation and the saturable uptake of 5-hydroxytryptamine (5HT) were studied as indices of endothelial integrity in isolated lungs. 5HT uptake was characterized by its kinetic parameters Km and Vmax. These were calculated from multiple indicator dilution data on the basis of an organ model of 5HT uptake. Perfused dog lung lobes were exposed to plasma activated with yeast (YAP) or zymosan (ZAP). YAP induced a transient elevation of Km. This increase probably reflects endothelial injury. Vmax remained unchanged, suggesting that the perfused endothelial surface remained stable. PGI2 biosynthesis was negligible in the control period, but started immediately after exposure to ZAP or YAP. It was proportional to the transient elevation of Km and to the pulmonary oedema. The data suggest that PGI2 might be a marker of severe endothelial distress.

Animals↗
PubMed1984

Preservation of functional integrity during long term storage of a biological membrane.

Sarcoplasmic reticulum vesicles freeze-dried in the presence of trehalose retain most of their original biological activity for short periods. When the dry vesicles are stored for longer periods in air, Ca2+-transport becomes uncoupled from ATPase activity within a few days. However, when they are stored under vacuum, ATPase activity, Ca2+ transport, and coupling between Ca2+ transport and ATP utilization are maintained essentially intact for at least 110 days.

Adenosine Triphosphatases↗