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PubMed2006

Pair formation and global ordering of strongly interacting ferrocolloid mixtures: an integral equation study.

Using the reference hypernetted chain (RHNC) integral equation theory and an accompanying stability analysis we investigate the structural and phase behaviors of model bidisperse ferrocolloids based on correlations of the homogeneous isotropic high-temperature phase. Our model consists of two species of dipolar hard spheres (DHSs) which dipole moments are proportional to the particle volume. At small packing fractions our results indicate the onset of chain formation, where the (more strongly coupled) A species behaves essentially as a one-component DHS fluid in a background of B particles. At high packing fractions, on the other hand, the RHNC theory indicates the appearance of isotropic-to-ferromagnetic transitions (volume ratios close to one) and demixing transitions (smaller volume ratios). However, contrary with the related case of monodisperse DHS mixtures previously studied by us [Phys. Rev. E 70, 031201 (2004)], none of the present bidisperse systems exhibit demixing within the isotropic phase, rather we observe coupled ferromagnetic/demixing phase transitions.

Journal Article↗
PubMed2000

Integration of nurse executives into executive level administration in Utah hospitals.

Nurse executives (NEs) in Utah acute care hospitals perceive that they are integrated into executive level administration. This perception is shared by NEs' career supporters and hinderers. To integrate NEs, influential colleagues used active methods, especially involvement. NEs add value to the administrative team by combining clinical and managerial expertise. NE integration is manifest in decision making, participation and interaction. Continued integration depends upon commitment from the chief executive officer (CEO), leadership in organizational change, addressing "glass ceiling" issues, and NEs' continuous demonstration of competence.

Career Mobility↗
PubMed1999

Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets.

The effect of cell-to-cell contact on Ca2+ influx and secretory responses in the beta-cell line MIN6 was studied using MIN6 pseudoislets, which are three-dimensional islet-like cell aggregates that develop when MIN6 cells are cultured for 6-8 days on gelatin. The formation of pseudoislets is dependent on the Ca2+-dependent adhesion molecule E-cadherin (E-CAD), since the process can be inhibited by incubation in the absence of Ca2+ or in the presence of an anti-E-CAD antibody. Glucose and alpha-ketoisocaproic acid (KIC) evoked a Ca2+ influx in only a small fraction of the MIN6 monolayer cells, whereas >80% of cell groups within the pseudoislets responded to both nutrients. In contrast, changes in the intracellular free Ca2+ concentration ([Ca2+]i) were observed in all or most monolayer cells or pseudoislet cell groups in response to physical or pharmacological depolarizing stimuli. No significant increase in insulin release was observed from MIN6 monolayer cells in response to nutrient or nonnutrient insulin secretagogues. Conversely, pseudoislets were found to respond significantly to both nutrients and nonnutrients. These results suggest that close cell-to-cell contact improves the functional responsiveness of MIN6 cells and that pseudoislets may therefore serve as a useful research model in the study of beta-cell function.

Calcium↗
PubMed1991

[Familiarity, favorability, and cognitive complexity: integration of frequency of interaction hypothesis and vigilance hypothesis].

Previous studies using Bieri's 'cognitive complexity' score had supported 'vigilance hypothesis' which assumed that impressions of unfavorable persons were more complex than favorable persons. Thus, Bieri's measure seemed to be invalid because the findings were completely contrary to 'frequency of interaction hypothesis', presented in the theoretical framework of 'cognitive complexity', which assumed that impressions of familiar persons were more complex than unfamiliar persons, since people could be supposed to have more intimate acquaintance with favorable persons. The purpose of present study was to indicate the invalidity was caused by the research design where familiarity was dependent on favorability and to show that even Bieri's score could support 'interaction hypothesis', if one variables could be statistically orthogonized to the other. In each of two surveys reported, about two hundred female undergraduates completed a Rep test where they rated favorable and unfavorable persons on the basis of some dimensions which included favorability and familiarity. The results obtained through various regression analyses supported the above predictions. Moreover, it was revealed that, with favorability controlled, Bieri's score showed almost linear increases as familiarity increased, though the score of extremely unfamiliar persons was rather higher than the score the linear function could predict.

Adult↗
PubMed2006

Integrative haptic and visual interaction for simulation of PMMA injection during vertebroplasty.

In vertebroplasty, physician relies on both sight and feel to properly place the bone needle through various tissue types and densities, and to help monitor the injection of PMMA or cement into the vertebra. Incorrect injecting and reflux of the PMMA into areas where it should not go can result in detrimental clinical complication. This paper focuses on the human-computer interaction for simulating PMMA injection in our virtual spine workstation. Fluoroscopic images are generated from the CT patient volume data and simulated volumetric flow using a time varying 4D volume rendering algorithm. The user's finger movement is captured by a data glove. Immersion CyberGrasp is used to provide the variable resistance felt during injection by constraining the user's thumb. Based on our preliminary experiments with our interfacing system comprising simulated fluoroscopic imaging and haptic interaction, we found that the former has a larger impact on the user's control during injection.

Computer Simulation↗
PubMed1990

The integration of knowledge through interactive Computer-Enhanced Learning in medicine.

Rapid advances in Information Technology in recent years have provided powerful computers and software that can be innovatively applied to create powerful pedagogical courseware that go beyond what precursors like the PLATO project could do on the mainframes of yesteryear. This article focusses on the research and development that we have carried out which is applicable to the whole area of education (including medical education). It introduces the elements of hypertext, hypermedia and the pedagogical user interface. It illustrates the principles necessary for the communication of conceptual, functional and structural knowledge. It emphasises the key aspect of mastery of Information Technology necessary for a new dimension in Computer-Enhanced Learning that will be of relevance to the Information Society of the 21st century.

Computer-Assisted Instruction↗
PubMed1988

Brain state and plasticity: an integration of the reciprocal interaction model of sleep cycle oscillation with attentional models of hippocampal function.

The present paper relates the reciprocal interaction model for sleep cycle oscillation (McCarley and Hobson, ref. 29) to an attentional model of hippocampal function (Schmajuk and Moore, ref. 44). We consider mechanisms by which the interaction between gigantocellular tegmental field (FTG) cells and locus coeruleus (LC) activity proposed by the sleep cycle model may differentially modulate the information processing carried out in the hippocampus as described by the attentional model. Our fundamental assumption is that learning about the relevancy of different stimuli is proportional to the level of LC activation. If the environment becomes unpredictable during waking, the FTG and LC are activated and the LC facilitates hippocampal learning about stimulus relevancy. In a predictable situation during waking, FTG cells discharge rarely because no novelty is detected, and LC neurons are moderately active. If the predictable situation lasts, LC cells also decrease their activity, and a sleep period might start. At sleep onset, LC inhibition decreases and FTG activity is low leading to slow sleep. As FTG activity increases and LC activity reaches its low point, REM sleep starts. Because LC activity is low during REM sleep, values of stimulus relevancy remain unchanged. Since during sleep the threshold for external stimuli is high, only internally generated novel stimuli (subjectively perceived as dream mentation) may activate the LC. LC renewed inhibitory influence on the FTG ends REM sleep.

Animals↗
PubMed1994

[Effects of the training in integrity-promoting care on the interactions in a long-term ward].

A training programme in integrity-promoting care was given the staff of a long-term ward and practised during a three months intervention period. The effects were analysed in different parameters and compared with a control ward. This report describes analysis of video-recorded interactions (12 hs) during social activities between demented patients and caregivers and changes induced by the programme. The video-recorded episodes, containing mainly music and coffee sessions were interpreted from a model on interaction with demented patients suggested by Athlin and Norberg. The results indicate that the training programme and the guidance during the intervention resulted in increased understanding of demented patients' situation among the staff. They became more sensitive, adapted their cues and made the environment easier to interpret for the patients. This in turn led to the fact that the patients appeared more sensitive and clear in their cues. A positive circle developed.

Empathy↗
PubMed1997

Communication in integrated practice networks: using interactive video technology to build the medical office without walls.

As groups of physicians join networks to maximize their effectiveness with managed care systems, frequent communication and joint development of standardized clinical protocols become important. For physicians who are accustomed to being independent, frequent meetings are necessary to make these networks succeed. In larger networks, travel time becomes a significant drain on clinical effectiveness. Interactive video technology (IVT) providing full-motion two-way video communication is one potential solution to this problem of geography and time. The experience of our academic department with IVT is summarized and practical advice is provided for those considering the use of this new technology.

Communication↗
PubMed2003

Effects of quasiactive membrane on multiply periodic traveling waves in integrate-and-fire systems.

We consider the dynamics of a one-dimensional continuum of synaptically interacting integrate-and-fire neurons with realistic forms of axodendritic interaction. The speed and stability of traveling waves are investigated as a function of discrete communication delays, distributed synaptic delays, and axodendritic delays arising from the spatially extended nature of the model neuron. In particular, dispersion curves for periodic traveling waves are constructed. Nonlinear ionic channels in the dendrite responsible for a so-called quasiactive bandpass response are shown to significantly influence the shape of dispersion curves. Moreover, a kinematic theory of spike train propagation suggests that period-doubling bifurcations of a singly periodic wave can occur in dendritic systems with a quasiactive membrane. The explicit construction of period-doubled solutions is used to confirm this prediction.

Action Potentials↗
PubMed1996

Endosome dynamics regulated by a Rho protein.

Vesicular transport is a dynamic process that requires coordinated interactions between membrane and cytoskeleton. The mechanisms and molecules integrating these interactions are unclear. A Rho protein, RhoD, might provide a molecular link between membrane traffic and the cytoskeleton. Activated RhoD causes rearrangements of the actin cytoskeleton and cell surface, and governs early endosome motility and distribution.

Actins↗
PubMed2006

A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila.

BACKGROUND: Biological processes are mediated by networks of interacting genes and proteins. Efforts to map and understand these networks are resulting in the proliferation of interaction data derived from both experimental and computational techniques for a number of organisms. The volume of this data combined with the variety of specific forms it can take has created a need for comprehensive databases that include all of the available data sets, and for exploration tools to facilitate data integration and analysis. One powerful paradigm for the navigation and analysis of interaction data is an interaction graph or map that represents proteins or genes as nodes linked by interactions. Several programs have been developed for graphical representation and analysis of interaction data, yet there remains a need for alternative programs that can provide casual users with rapid easy access to many existing and emerging data sets. DESCRIPTION: Here we describe a comprehensive database of Drosophila gene and protein interactions collected from a variety of sources, including low and high throughput screens, genetic interactions, and computational predictions. We also present a program for exploring multiple interaction data sets and for combining data from different sources. The program, referred to as the Interaction Map (IM) Browser, is a web-based application for searching and visualizing interaction data stored in a relational database system. Use of the application requires no downloads and minimal user configuration or training, thereby enabling rapid initial access to interaction data. IM Browser was designed to readily accommodate and integrate new types of interaction data as it becomes available. Moreover, all information associated with interaction measurements or predictions and the genes or proteins involved are accessible to the user. This allows combined searches and analyses based on either common or technique-specific attributes. The data can be visualized as an editable graph and all or part of the data can be downloaded for further analysis with other tools for specific applications. The database is available at http://proteome.wayne.edu/PIMdb.html CONCLUSION: The Drosophila Interactions Database described here places a variety of disparate data into one easily accessible location. The database has a simple structure that maintains all relevant information about how each interaction was determined. The IM Browser provides easy, complete access to this database and could readily be used to publish other sets of interaction data. By providing access to all of the available information from a variety of data types, the program will also facilitate advanced computational analyses.

Database Management Systems↗
PubMed1993

A hierarchical model for evaluation and treatment of visual perceptual dysfunction in adult acquired brain injury, Part 1.

A developmental framework for evaluation and treatment of visual perceptual deficits in adults with acquired brain injury is presented. The framework is based on a review of research conducted on post-cerebrovascular accident subjects and subjects with traumatic brain injuries. Visual perceptual skill is conceptualized as a hierarchy of skill levels that interact and subserve each other. Higher level skills evolve from integration of lower level skills and are subsequently affected by disruption of lower level skills. Oculomotor control, visual field, and acuity form the foundation skills, followed by visual attention, scanning, pattern recognition, memory, and visual cognition. Brain injury can affect the integrity and interaction of each skill level and affect daily living function. Application of this framework dictates a bottom-up approach to evaluation and treatment, emphasizing identification and remediation of deficits in lower level skills to allow normal integration of higher level skill.

Adult↗
PubMed2006

A quantum Newton's cradle.

It is a fundamental assumption of statistical mechanics that a closed system with many degrees of freedom ergodically samples all equal energy points in phase space. To understand the limits of this assumption, it is important to find and study systems that are not ergodic, and thus do not reach thermal equilibrium. A few complex systems have been proposed that are expected not to thermalize because their dynamics are integrable. Some nearly integrable systems of many particles have been studied numerically, and shown not to ergodically sample phase space. However, there has been no experimental demonstration of such a system with many degrees of freedom that does not approach thermal equilibrium. Here we report the preparation of out-of-equilibrium arrays of trapped one-dimensional (1D) Bose gases, each containing from 40 to 250 (87)Rb atoms, which do not noticeably equilibrate even after thousands of collisions. Our results are probably explainable by the well-known fact that a homogeneous 1D Bose gas with point-like collisional interactions is integrable. Until now, however, the time evolution of out-of-equilibrium 1D Bose gases has been a theoretically unsettled issue, as practical factors such as harmonic trapping and imperfectly point-like interactions may compromise integrability. The absence of damping in 1D Bose gases may lead to potential applications in force sensing and atom interferometry.

Journal Article↗