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Results for “MENINGOCOCCAL INFECTIONS”

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At least 271 records · Page 15Linked to original sources
PubMed1993

MRI evaluation and follow-up of bone necrosis after meningococcal infection and disseminated intravascular coagulation.

Disseminated intravascular coagulation (DIC) is a serious complication of meningococcal septicaemia. It often results in infarction of various tissues namely the skin, adrenal glands, kidneys, brain and, much less commonly, bones. We describe a patient who presented bone lesions after meningococcal septicaemia. In addition to plain radiography and scintigraphy the lesions were evaluated with MRI and have proved to be extensive and still progressive, approximately 18 months after the onset of the disease.

Bacteremia↗
PubMed1979

An epidemic of meningococcal infection at Zaria, Northern Nigeria. 2. The changing clinical pattern.

1,003 patients with meningococcal disease admitted to a single hospital during the course of a three-month epidemic were studied. A progressive decline in mortality, especially among patients with acute meningococcaemia, and a falling incidence of systemic and severe neurological complications among patients with meningitis were observed. It is suggested that the virulence of the causative group A meningococcus declined as the epidemic progressed.

Acute Disease↗
PubMed1981

[Clinical and experimental rifampicin passage through the hemato-encephalic barrier and its effectiveness in treating meningococcal infections].

Satisfactory permeability of rifampicin through the hematoencephalic barrier was shown in experimental rabbit meningococcal meningitis and in treatment of patients with meningococcal meningitis. The antibiotic level and retention time in the liquor depended on the drug dose and acidity of gastric juice. The dose of 10 mg/kg bw administered at 8--10-hour intervals was the most optimal. The high therapeutic efficacy of rifampicin in treatment of patients with the generalized forms of meningococcal meningitis enables its recommendation for the use as a reserve drug. Rifampicin may be used alone when penicillin is intolerable or ineffective. It also may be used for additional treatment of the patients after penicillin therapy. Rifampicin in combination with penicillin may be used in treatment of purulent meningitis and meningoencephalitis of a dubious etiology.

Animals↗
PubMed1994

Meningococcal infections in England and Wales: 1993.

One thousand two hundred and ninety-seven meningococcal isolates of clinical significance were submitted for examination to the PHLS Meningococcal Reference Unit in 1993; almost the same total as in 1992. Changes in the number of isolates from individual regions ranged from falls of 25% to increases of 42%. The incidence of meningococcal disease rose late in 1993, apparently affected by the epidemic of influenza. The number of statutory notifications reported to the Office of Population Censuses and Surveys was--for the first time--markedly higher than the number of laboratory diagnosed cases. Serodiagnosis was used to confirm an increased number of clinically suspected cases in 1993.

Adolescent↗
PubMed1999

[Clinical features of meningococcal infection in subjects with deficient terminal components of complement].

AIM: To evaluate clinical characteristics of meningococcal disease (MD) in individuals with terminal complement component deficiency (TCCD) who are thousands times more susceptible to MD than complement-sufficient persons. MATERIALS AND METHODS: 61 cases of MD in TCCD patients and 200 randomly selected cases of MD in complement-sufficient patients were analyzed. RESULTS: Meningitis without meningococcemia accounted for 17% of the MD episodes in the control group of complement-sufficient patients but none in individuals with TCCD who had meningococcemia (10%) or meningococcemia with meningitis (90%). Moderate disease predominated in patients with TCCD (70%) and no episodes of fatal disease were noted, whereas severe disease was more common in the control group which had an 8% case fatality rate and frequent complications such as endotoxic shock (15% of episodes) and brain edema (26%). The severity of the disease in TCCD patients did not differ between the first and subsequent episodes, between males and females, between episodes caused by serogroup A and B meningococci, etc. CONCLUSION: In comparison to complement-sufficient persons, the course of the disease in patients with TCCD is statistically less severe.

Adolescent↗
PubMed1971

Meningococcal infections. 3. Studies of group A polysaccharide vaccines.

Studies with 4 lots of group A meningococcal polysaccharides in 458 adult human volunteers showed that such vaccines are nontoxic and highly immunogenic. Comparisons of jet injection and subcutaneous (needle) methods of administration showed that both were equally immunogenic.

Antibody Formation↗