SEARCH · PubMed Health

Results for “Placenta, Retained”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 271 records · Page 15Linked to original sources

PubMed2001

The relationship between milk yield and the incidence of some diseases in dairy cows.

Logistic regression models were used to examine the relationship between milk yield and incidence of certain disorders. Lactations (n = 2197) of 1074 Holstein-Friesian cows from 10 dairies (25 to 146 cows per dairy) in Lower Saxony were studied. The 305-d yield from the previous and current lactations served as the standards for milk yield. Eight disorder complexes were considered: retained placenta, metritis, ovarian cysts, mastitis, claw diseases, milk fever, ketosis, and displaced abomasum. Each disorder complex was modeled separately. In addition to milk yield, the influences of the lactation number, the calving season and the other disorder complexes were examined with the "herd" factor taken into account. A correlation between retained placenta, mastitis, and milk fever to milk yield during the previous lactation was found to be probable and for ketosis and displaced abomasum such a correlation was found to be possible. A connection to the yield in the current lactation was shown for ovarian cysts, claw diseases, and milk fever. No relationship to milk yield existed for metritis. An influence of the lactation number was also demonstrated in various models. Single models allowed a demonstration of the influences of both milk yield and lactation number. Limitations of the model types are discussed.

Animals↗

PubMed2004

Effects of diseases on reproductive performance in Swedish Red and White dairy cattle.

The objectives of this study were to evaluate the effect of diseases on days open (DO), days to first breeding (DFB) and days from first breeding to conception (DFBC) using survival analysis models, and to assess the significance of the sire component and its possible confounding effect. The data consisted of a random sample of 20% of all herds enrolled in Swedish recording system and using 100% artificial insemination with at least 15 Swedish Red and White cows calving in 1991. The follow-up period was from 45 to 145 d after calving. After editing, the data sets had 23,927, 28,197, and 22,089 cows for days open, days to first breeding, and days from first breeding to conception, respectively. The Cox models included parity, calving season, cow milk production and age at first calving as fixed effects, and herd and sire as random effects. Ten disease groups were considered as possible risk factors for the reproductive traits. Disease groups were treated differently if they occurred before or after 45 d postpartum. Diseases occurring in the first 45 d after calving were treated as time-independent covariates and diseases occurring after day 45 were treated as time-dependent covariates for days open and days to first breeding. The percentages of censored cows were 35% for days open, 19% for days to first breeding, and 33% for days from first breeding to conception. Days open increased in cows with dystocia, stillbirth, retained placenta, metritis, or other diseases occurring in the first 45 d after calving, and in cows with metritis, mastitis, or other diseases occurring after 45 d. Days to first breeding increased in cows with stillbirth, retained placenta, milk fever, mastitis, foot and leg problems, or other diseases occurring before day 45, and in cows with metritis, mastitis, foot and leg problems, or other diseases occurring after 45 d. Days to first breeding decreased in cows treated for ovulatory dysfunctions either before or after 45 d. Days from first breeding to conception increased in cows with dystocia, stillbirth, retained placenta, metritis, or ovulatory dysfunctions occurring before first breeding, and in cows with mastitis occurring after first breeding. Although the additive genetic components were significant for all traits considered, the sires did not act as confounders because only a small amount of variability for the traits considered in this study was explained by the sires, with estimated heritabilities of 2% on the logarithmic scale and from 3 to 4% on the real scale.

Animals↗

PubMed1998

Effect of diseases on the culling of Holstein dairy cows in New York State.

The effect of seven diseases on culling was measured in 7523 Holstein cows in New York State. The cows were from 14 herds and had calved between January 1, 1994 and December 31, 1994; all cows were followed until September 30, 1995. Survival analysis was performed using the Cox proportional hazards model to incorporate time-dependent covariates for diseases. Different intervals representing stages of lactation were considered for effects of the diseases. Five models were fitted to test how milk yield and conception status modified the effect of diseases on culling. Covariates in the models included parity, calving season, and time-dependent covariates measuring diseases, milk yield of the current lactation, and conception status. Data were stratified by herd. The seven diseases and lactational risks under consideration were milk fever (0.9%), retained placenta (9.5%), displaced abomasum (5.3%), ketosis (5.0%), metritis (4.2%), ovarian cysts (10.6%), and mastitis (14.5%). Older cows were at a much higher risk of being culled. Calving season had no effect on culling. Higher milk yield was protective against culling. Once a cow had conceived again, her risk of culling dropped sharply. In all models, mastitis was an important risk factor throughout lactation. Milk fever, retained placenta, displaced abomasum, ketosis, and ovarian cysts also significantly affected culling at different stages of lactation. Metritis had no effect on culling. The magnitude of the effects of the diseases decreased, but remained important, when milk yield and conception status were included as covariates. These results indicated that diseases have an important impact on the actual decision to cull and the timing of culling. Parity, milk yield, and conception status are also important factors in culling decisions.

Abomasum↗

PubMed1998

Ascending dose tolerance study of intramuscular carbetocin administered after normal vaginal birth.

OBJECTIVE: To determine the maximum tolerated dose (MTD) of carbetocin (a long-acting synthetic analogue of oxytocin), when administered immediately after vaginal delivery at term. MATERIALS AND METHODS: Carbetocin was given as an intramuscular injection immediately after the birth of the infant in 45 healthy women with normal singleton pregnancies who delivered vaginally at term. Dosage groups of 15, 30, 50, 75, 100, 125, 150, 175 or 200 microg carbetocin were assigned to blocks of three women according to the continual reassessment method (CRM). RESULTS: All dosage groups consisted of three women, except those with 100 microg (n=6) and 200 microg (n=18). Recorded were dose-limiting adverse events: hyper- or hypotension (three), severe abdominal pain (0), vomiting (0) and retained placenta (four). Serious adverse events occurred in seven women: six cases with blood loss > or = 1000 ml, four cases of manual placenta removal, five cases of additional oxytocics administration and five cases of blood transfusion. Maximum blood loss was greatest at the upper and lower dose levels, and lowest in the 70-125 microg dose range. Four out of six cases with blood loss > or = 1000 ml occurred in the 200 microg group. The majority of additional administration of oxytocics (4/5) and blood transfusion (3/5) occurred in the dose groups of 200 microg. All retained placentae were found in the group of 200 microg. CONCLUSION: The MTD was calculated to be at 200 microg carbetocin.

Abdominal Pain↗

PubMed1998

Recommendations for recording and calculating the incidence of selected clinical diseases of dairy cattle.

The report upon which the current discussion is based was prepared in response to the increasing interest of the dairy industry in the recording of clinical disease data. The major objective was to introduce guidelines and standards for the recording and presentation of the diseases of dairy cattle. Eight clinically identifiable diseases of economic importance to the dairy industry were considered: milk fever, retained placenta, metritis, ketosis, left displaced abomasum, cystic ovarian disease, lameness, and clinical mastitis. Standardized definitions for these diseases were established through consultation with industry partners. Two approaches to summarization and reporting were proposed. For retrospective analysis, which is used when historical data are summarized for genetic evaluation for example, lactational incidence risk (cumulative incidence) has been recommended. For current analysis, which is used for herd health monitoring, a true incidence rate has been recommended. Milk fever and retained placenta were exceptions to the latter because of their short periods of risk. For these two diseases, lactational incidence risks are reported.

Abomasum↗

PubMed2003

Intravenous nitro-glycerine versus general anaesthesia for placental extraction--a sequential comparison.

BACKGROUND: Postpartum haemorrhage due to retained placenta is one of the commonest life-threatening conditions during the third stage of labour. Uterine relaxation is usually required to facilitate placental removal. 'Full-stomach' obstetric patients (which includes those who delivered within 48 h), parturients with a history of antepartum or recurrent postpartum hemorrhage, grand multiparity, twin pregnancy, and those with cardiac abnormalities may benefit from an alternative to volatile-based general anaesthesia for uterine relaxation to avoid complications associated with the technique (e.g. aspiration pneumonitis and cardiovascular compromise). CASE REPORT: A 34-year-old gravida 4, para 3 parturient with rheumatic valvular heart disease presented with retained placenta and postpartum haemorrhage on two consecutive deliveries and had the placenta removed manually by the same surgeon under two different anaesthetic techniques. On the first occasion, general anaesthesia was administered whereas only i.v. fentanyl and nitro-glycerine were used on the second occasion. The postoperative course was uneventful on both occasions. CONCLUSIONS: The use of nitro-glycerine was found to be efficacious for manual removal of placenta with minimal haemodynamic perturbations, avoiding the use (and associated risks) of general anaesthesia for uterine relaxation. The ability of nitro-glycerine to reduce spontaneous uterine activity, induce uterine relaxation, coupled with its short duration of action and high efficacy, may render it a safe alternative to general anaesthesia for facilitating intrauterine manoeuvres. Nitro-glycerine may be useful especially in patients with associated co-morbid chronic cardiac conditions, e.g. rheumatic heart disease, which is characterised by impaired haemodynamics and cardiac reserves.

Anesthesia, General↗

PubMed1997

The association of serum nonesterified fatty acids and cholesterol, management and feeding practices with peripartum disease in dairy cows.

A prospective study was conducted to determine the relationship of serum nonesterified fatty acids (NEFA) and cholesterol concentrations and herd management practices to the occurrence of metritis, mastitis and retained placenta in Holstein cows in Michigan. Serum samples were collected once prepartum and once postpartum from 257 cows. Animals were under observation for disease occurrence from the date of calving until 3 months postpartum. Metabolic variables used were (1) prepartum only; (2) postpartum only; (3) the NEFA/cholesterol ratio for both pre- and postpartum samples. Management variables included maternity management, feed management, and factors such as season and parity. Multivariable logistic models with random-effect terms to account for the herd effect were used for data analysis. Results showed that: (1) metabolic events associated with energy insufficiency-increased fat mobilization and serum lipoprotein metabolism-were related to increased risk of metritis and retained placenta; (2) higher energy consumption during the last weeks of the dry period might reduce disease risk at parturition; (3) serum NEFA and cholesterol concentrations have potential as indicators of disease risk in dairy cows.

Animal Feed↗

PubMed2000

Effect of disease on reproduction in the dairy cow: a meta-analysis.

Effects on reproduction of dystocia, stillbirth, abortion, milk fever, retained placenta, metritis, cystic ovaries, anestrus, ketosis, displaced abomasum, locomotor disorders, and mastitis were reviewed. Papers were considered if they provided quantitative estimates of diseases on days to first estrus, days to first service, conception rate at first service, days from first service to conception, days to conception or days open, calving interval, conception rates at various days post partum (dpp), and number of services per conception or per cow. Only papers in English in peer-reviewed journals were selected for analysis of post 1960 data from intensive dairy regions. Seventy papers fulfilled the selection criteria. Summary estimates of disease effects were calculated according to meta-analysis methods, and study designs were described in detail to identify possible heterogeneity of the results. Stillbirth, milk fever, displaced abomasum and mastitis had no effect on reproduction. Clinical ketosis, dystocia and retained placenta were associated with 2 to 3 more days to first service and with a 4 to 10% lower conception rate at first service, resulting in 6 to 12 more days to conception. Locomotor disorders were associated with an average increase of 12 d to conception, with wide variation depending on lesions and stage of occurrence. Metritis was associated with 7 more days to first service, 20% lower conception rate at first service, resulting in 19 more days to conception. Cystic ovaries were associated with 6 to 11 more days to first service and with 20 to 30 more days to conception. Anestrus was associated with 26 more days to first service and with an 18% lower conception rate at first service, resulting in 41 more days to conception. Abortion was associated with 70 to 80 more days to conception.

Abomasum↗

PubMedDate not supplied

A randomized controlled trial of oxytocin administered at the end of the second stage of labor versus oxytocin administered at the end of the third stage of labor in the prevention of postpartum hemorrhage.

The general objective was to determine the incidence of postpartum hemorrhage when oxytocin was administered at the end of the second stage of labor compared to when oxytocin was administered at the end of the third stage. The specific objectives were to determine the mean amount of blood loss, duration of the third stage of labor, need for additional uterotonics and blood transfusion, incidence of hypotension and retained placenta, and mean difference in hemoglobin levels. A randomized controlled trial was conducted in a tertiary care training hospital. 130 women with term, singleton, live pregnancies in cephalic presentation who delivered vaginally were included. Patients were randomly allocated to receive oxytocin after the second stage or after the third stage of labor. Oxytocin was administered as a continuous intravenous infusion. The placenta was delivered by controlled cord traction after placental separation. Blood loss was measured by weight, and the corresponding volume was computed. Relative risk was calculated. Incidence of postpartum hemorrhage, volume of blood loss, duration of the third stage of labor, need for additional uterotonics and blood transfusion, incidence of hypotension and retained placenta, and difference in hemoglobin levels were the main outcome measures. There was a decreased incidence of postpartum hemorrhage (39.66% vs. 48.61%, relative risk [RR] = 0.82, 95% confidence interval [CI] = 0.55-1.21) and less amount of blood loss (557.93 ml vs. 636.84 ml, p = 0.352) when oxytocin was administered at the end of the second stage of labor. There was less need for additional uterotonics (12.07% vs. 13.89%, RR = 0.87, 95% CI = 0.35-2.14), and blood transfusion (5.17% vs. 5.56%, RR = 0.87, 95% CI = 0.22-3.99). There was a smaller mean difference in hemoglobin (16.20 g/dl vs. 20.29 g/dl, p = 0.145). Mean duration of the third stage of labor were comparable (7.93 minutes vs. 7.96 minutes, p = 0.863). However, more patients developed hypotension (3.45% vs. 1.39%, RR = 2.48, 95% CI = 0.23-26.70). All results were not statistically significant. There was no incidence of retained placenta. There is a trend towards a reduction of the risk of postpartum hemorrhage when oxytocin is administered at the end of the second stage of labor. This is not accompanied by an increased risk for any morbidity.

Asia↗

PubMed1983

Synchronization of parturition in beef cattle using delay as well as induction.

Two methods for synchronization of parturition in beef cattle were examined. In the first experiment, four groups of cows and heifers were used: untreated (C, n=9), 10 mg flumethasone on day 281 of gestation (F, n=9), 100 mg progesterone daily from days 276 through 283 and 50 mg progesterone on day 284 (P, n=6), and (P+F on day 284, n=7). Variances in gestation lengths (C, 26.01; F, 0.77; P, 11.97; P+F, 1.93) and proportions of cows and heifers with retained placentas (C, 0/9; F, 4/9; P, 1/6; P+E, 0/7) differed significantly among groups. Differences among groups in calving difficulty scores and proportions of dead calves were not significant. Four of the thirteen cows and heifers treated with progesterone required assistance in calving and all four delivered dead calves. Pulling of these calves was not accompanied by uterine contractions. Conversely, the difficult calvings in the control- and flumethasone-treated cows and heifers were accompanied by uterine contractions. In the second experiment, two groups of cows were used: 1) a single injection of 20 mg dexamethasone on either day 276, 277 or 278 followed by injections of saline every 12 h for 2.5 additional days (n=6), and 2) repeated injections of 20 mg dexamethasone every 12 h for 3 days beginning on day 276, 277 or 278 (n=8). The interval from time of first treatment to calving was not different between groups (43.6 and 43.0 h, respectively). Differences between calving difficulty scores, proportions of dead calves and incidence of retained placentas were not significant. Induction very close to the expected calving date could reduce the problems of retained placenta; however, methods must be identified to safely delay parturition.

Journal Article↗

PubMed2006

Influence of macro and micro minerals in the peri-parturient period on fertility in dairy cattle.

Infertility in dairy cattle is a complex, multi-factorial problem that cannot be evaluated in isolation of other diseases and disorders. Clearly there is a role for the prevention of problems in the peri-parturient period, in particular hypocalcaemia, mastitis, lameness and retained placenta (RP), that all have a negative impact on the subsequent fertility of the cow. Minerals, trace elements and vitamins play a vital role in the prevention of these disorders at this time. Macro minerals are involved in the acid base status of the dairy cow and influence calcium metabolism. The use of anionic salts in combination with adequate calcium and magnesium supplementation may help to improve dry matter intakes and reduce negative energy balance in the post-calving period as well as prevent hypocalcaemia. Vitamin E and zinc are effective in prevention of mastitis that occurs predominantly in the first weeks of lactation, through enhanced antioxidant function and keratinisation of the teat canal. Lameness in dairy cattle also occurs mainly in lactation though most of the original insults to the hoof can occur prior to calving. Zinc and biotin are implicated in improving keratinisation of the hoof and prevention of this disease. Organic forms of zinc are retained better than inorganic sources and may provide greater benefit in disease prevention. Retained placenta can be reduced by prevention of hypocalcaemia and also adequate selenium status of the dairy cow. Selenium yeast is known to have higher retention in tissues and may play an important role in ensuring sufficient selenium is available to the cow for reduction of disease.

Animal Nutritional Physiological Phenomena↗

PubMed1994

Association between neutrophil functions and periparturient disorders in cows.

Neutrophil functions were examined in healthy periparturient dairy cows (n = 46) and in cows with retained placenta and metritis complex (n = 20); metritis (n = 18); or mastitis (n = 13). Blood samples (50 ml) were collected from each cow via jugular vein twice weekly from 1.5 weeks before to 4 weeks after parturition. Neutrophil function was evaluated, using 6 tests: random migration, chemotaxis, ingestion, myeloperoxidase activity (iodination), superoxide production (cytochrome C reduction), and antibody-dependent cell-mediated cytotoxicity. Ability to ingest bacteria and random migration activity of neutrophils from clinically normal cows were high around parturition and increased immediately after parturition, whereas myeloperoxidase activity and antibody-dependent cell-mediated cytotoxicity ability of neutrophils from these cows decreased after parturition. Measurement of neutrophil function in 4 ovariectomized cows revealed significant (P < 0.0005) seasonal changes in results of all 6 functional assays. We observed various defects of neutrophil function in all cows with abnormal conditions after parturition. Before parturition, superoxide production activity by neutrophils from cows with metritis and chemotaxis by neutrophils from cows with mastitis were significantly (P < 0.001 and P < 0.05, respectively) lower, indicating that a defect of neutrophil function may be a predisposing factor in the development of these disorders. In conclusion, the host defense role of neutrophils in periparturient cows was impaired, principally because of a defect in killing capacity, which may increase susceptibility to infections. We also investigated the in vitro effects of arachidonic acid metabolites and recombinant human colony-stimulating factors (rhCSF) on functions of neutrophils from clinically normal and postparturient cows with abnormalities, including retained placenta, metritis, or mastitis (n = 5/group). Each abnormal cow was matched for postpartum period with a clinically normal cow. Neutrophils from individual cows were preincubated with arachidonic acid metabolites (prostaglandin F2 alpha, 10(-7) M; prostaglandin E2, 10(-6) M; leukotriene B4, 10(-8) M; and lipoxin B, 10(-8) M) and rhCSF (rh-granulocyte-CSF, 1,000 or 6,000 U/ml; rh-granulocyte-macrophage-CSF, 5 or 15 ng/ml) in a 37 C water bath for 30 minutes before submitting them to function assays. There was no response by neutrophils from either clinically normal or abnormal postparturient cows to treatment with either arachidonic acid metabolites or rhCSF in any of the 6 functional assays. However, preincubation of neutrophils alone in a 37 C water bath for 30 minutes resulted in some alteration of neutrophil function.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

PubMed2005

Is endomyometrial injury during termination of pregnancy or curettage following miscarriage the precursor to placenta accreta?

AIMS: To determine the frequency with which myometrium is removed during vacuum terminations of pregnancy or dilatation and curettage after miscarriage, and to relate these findings to subsequent placenta accreta or its proxies. METHODS: Archival tissues from vacuum termination of pregnancy or dilatation and blunt curettage after miscarriage were examined for the presence of myometrium. The subsequent obstetric histories were scrutinised for manual removal of placenta, postpartum haemorrhage, or retained placenta. A retrospective study comparing the frequency of miscarriage and termination in women who had or did not have a manual removal was also performed. RESULTS: Myometrium was seen in the products of conception in 44% and 35% of termination and miscarriage tissues, respectively. One of nine women with myometrium at miscarriage had a postpartum haemorrhage in a subsequent pregnancy whereas, of the 21 women without myometrium at miscarriage, three required manual removal and seven had a postpartum haemorrhage afterwards. A past history of termination and/or miscarriage was more frequent in multigravid women who had a manual removal than those who did not. CONCLUSIONS: Endomyometrial injury is frequent at termination or dilatation and curettage after miscarriage, but the relation to subsequent placenta accreta remains unclear. Women requiring a manual removal of the placenta were likely to have had a past history of termination and/or miscarriage.

Abortion, Induced↗

PubMed1999

Effects of twinning on postpartum reproductive performance in cattle selected for twin births.

The effects of twinning, dystocia, retained placenta, and body weight on postpartum reproduction were evaluated for 3,370 single and 1,014 twin births. Females were bred by AI for 40 d followed by 20 or 30 d of natural service with equal numbers bred and calved in spring and fall. Percentage of dams cyclic by the end of the AI period was lower (P<.05) for dams birthing and nursing a single calf (92.4%) than for dams birthing twins and nursing zero (98.7%) or two (94.7%) calves. Whereas the interval from parturition to first estrus was shorter (P<.01) for dams birthing and nursing a single (56.9 d) than for dams birthing twins and nursing one (68.5 d) or two (69.6 d) calves, length of the interval was further reduced by dystocia in nonlactating dams of either twins or singles (type of birth x dystocia, P<.05). Ensuing pregnancy rates were also affected by type of birth and dystocia. Without dystocia, dams birthing and nursing a single calf had a higher pregnancy rate (79.2%) than dams birthing twins and nursing one (61.7%) or two (66.3%) calves, whereas the lower ensuing pregnancy rates associated with dystocia in dams of singles (71.9%) resulted in similar rates among dams of singles and twins with dystocia (type of birth x dystocia; P<.01). Having a retained placenta resulted in a lower incidence of (93.5 vs. 96.4%, with vs. without; P<.05) and a longer interval to (64.7 vs. 59.2 d; P<.01) estrus while reducing subsequent pregnancy rates (X = 9.6%) in 3 of the 7 yr evaluated (retained placenta x year, P<.01). Because all parous females were bred during the same calendrical period, the shorter gestation length for twin calves (275.6 vs. 281.3 d) resulted in a longer interval from parturition to conception for twin births, whereas means for conception date differed by only 2 d between dams of twins and singles. Furthermore, a reduction (P<.01) in the interval to conception occurred with dystocia in dams of singles (89.3 vs. 85.0 d, without vs. with dystocia) and of twins nursed by zero (116.9 vs. 83.5 d), one (100.2 vs. 92.8 d), or two (96.1 vs. 97.2 d) calves. Another detriment to fertility was the higher incidence of fetal mortality or abortions associated with twin vs. single pregnancies (12.4 vs. 3.5%; P<.01). However, despite the lower conception rates for dams of twins, the increased prolificacy provides an opportunity to increase total beef production with a twinning technology.

Animals↗

PubMed1999

Abortifacient effects of a unique class of vasoactive lipids from Pinus ponderosa needles.

Pinus ponderosa needle (PN) ingestion by late pregnant cows results in decreased uterine blood flow, premature parturition, and retained placentae. Further, plasma from PN-fed cows increases caruncular arterial tone (i.e., induces prolonged contraction) in an isolated perfused bovine placentome. A novel class of vasoactive lipids was isolated and identified using a bovine placentome assay-guided fractionation of CH2Cl2 extracts of PN. Placentome perfusion tests indicated that 1-12-dodecanedioyl-dimyristate (14-12-14) was the most potent of the PN lipids for increasing caruncular arterial tone. Late pregnant guinea pigs (GP) were used to evaluate the abortifacient activity of these vasoactive lipids. In Study 1, on d 50 of gestation, part of the control diet was replaced with chopped PN (Diet A) or chopped PN subjected to sequential extraction with diethyl ether (Et2O; Diet B); Et2O and CH2Cl2 (Diet C); and Et2O, CH2Cl2, and methanol (Diet D). The GP on Diets A and B exhibited shorter (P<.01) gestation lengths and reduced (P<.01) pig birth weights than GP on the control diet or Diets C and D. Further, only GP on Diets A and B exhibited retained placentae. In Study 2, on d 50 of gestation, part of the control diet was replaced with chopped PN that had been subjected to exhaustive CH2Cl2 extraction and then infiltrated with either CH2Cl2 alone (Diet E), CH2Cl2 containing 14-12-14 (Diet F), or CH2Cl2 containing isocupressic acid (Diet G); then solvents were evaporated. The GP consuming Diet F had shorter (P<.05) gestation lengths and reduced (P<.05) pig birth weights than did GP consuming Diets E or G. The GP consuming Diet F also exhibited a high incidence of retained placentae. These data provide evidence that a unique class of vasoactive lipids in PN exhibit abortifacient activity in guinea pigs.

Abortifacient Agents↗

PubMed2003

Percutaneous treatment of placenta percreta using coil embolization.

PURPOSE: To report the use of embolotherapy to avoid hysterectomy in rare placenta percreta. CASE REPORT: A pregnant 34-year-old woman (gravida 3, para 2) was admitted with premature rupture of membranes and vaginal bleeding in the 32nd week. Prenatal B-mode and Doppler ultrasound revealed marked hypervascularity of the placenta with disruption of the uterine-bladder interface consistent with placenta percreta. Since the patient insisted on uterine preservation, uterus and placenta were left in situ after caesarean section, which was followed by coaxial microcoil embolization of 6 pelvic arteries and postoperative methotrexate administration. Three months later, the patient had severe bleeding from the retained placenta, possibly under the influence of anticoagulation administered for pulmonary embolism. Emergent hysterectomy was performed. CONCLUSIONS: Coil embolization may avoid immediate hysterectomy and reduce peri-delivery blood loss in placenta percreta. However, retained placenta poses a serious risk, even after months, and secondary hysterectomy should be performed as an elective procedure after embolization.

Adult↗

PubMed1988

Relationship of uterine infections and folliculogenesis in dairy cows during early puerperium.

Postpartum uterine infections have been associated with reduced fertility in dairy cows; however, the mechanism by which uterine infections limit reproductive function has not been clearly determined. The purpose of this study was to elucidate the relationship between uterine infections in the early puerperium and the onset of folliculogenesis in dairy cows. The pattern and intensity of uterine infections and follicular dynamics were studied in cows that shed fetal membranes (n = 18), and in those that retained fetal membranes after parturition (n = 18). Endometrial swabs collected aseptically from each animal on Days 4, 8 and 12 after parturition were cultured. Ultrasound scanning of the ovaries was carried out on Days 4, B and 12 using a B mode, real-time, linear array ultrasound scanner. The total number of follicles was recorded, and the follicles were classified according to size as small (2 to 4 mm) or medium (5 to 7 mm). The severity of infection was higher (P<0.05) in retained placenta cows on Days 4, 8 and 12 compared to nonretained placenta cows. The total number of follicles was larger (P<0.05) in nonretained placenta cows on Days 4, 8 and 12 than in retained placenta cows. The distribution of different sizes of follicles on all days of observations was similar in both groups of cows (P>0.05). These data support the hypothesis that uterine infection may delay the initiation of folliculogenesis and suppress the rate of follicular growth in dairy cows in the immediate postpartum period.

Journal Article↗

PubMed1995

The outcome of placenta accreta in Kuwait (1981-1993).

OBJECTIVES: To study the demographic characteristics of patients with placenta accreta and to identify the clinical features, maternal and neonatal complications of this condition. METHODS: Sixteen cases of placenta accreta were identified in the Maternity Hospital of Kuwait during the period January 1981 to July 1993. Medical records were reviewed regarding past obstetric history, type of placenta, clinical presentation, maternal and fetal outcome. RESULTS: The rate of placenta accreta was found to be 98 per 1,000,000 deliveries. Emergency hysterectomy was needed in 87.5% of cases. There was one maternal death (6.25%) and three perinatal deaths (18.75%). Hemorrhage was the major presenting symptom either externally and antenatally in previa accreta or postpartum in accreta of the upper segment or internally in the same cases. The major postoperative complications were coagulopathy, urinary injury, pelvic hematoma and abscess, in addition to cardiac arrest. These complications, when considered separately, were not affected by a previous history of uterine scarring. CONCLUSIONS: Placenta accreta is a major cause of obstetric hemorrhage and has an adverse effect on maternal and neonatal outcome. It ought to be considered a possibility in patients with previous uterine scarring, placenta previa or retained placenta. It will remain a growing problem in the developing countries due to the rising incidence of previous multiple cesarean sections. Unfortunately the latter do not deter women in this part of the world from insisting upon having big families and refusing tubal ligation.

Adult↗