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PubMed1989

Pyoderma gangrenosum and related disorders.

Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition with distinctive clinical characteristics and a frequent association with systemic diseases. Most frequently among the associated disease list are: inflammatory bowel disease, arthritis, and a variety of hematologic disorders. There is no specific treatment of PG; however, the effective treatment of an accompanying systemic disease, local therapy, and/or the use of topical or systemic agents known to be useful in neutrophil disorders, have been beneficial in most patients.

Humans↗
PubMed1978

Atypical pyoderma gangrenosum with leukemia.

Pyoderma gangrenosum (PG) has been increasingly reported in association with myeloproliferative disorders. Monoclonal gammaopathy, myeloma, myeloid metaplasia, and polycythemia have all been found in association with PG. Recently, seven cases of PG in association with leukemia have been described: three cases with acute myeloblastic leukemia, two cases with chronic myelogenous leukemia, one case with acute lymphoblastic leukemia, and one case with acute leukemia of either plasma cell or myeloblast origin. To these we add two cases of PG with acute myeloblastic leukemia. These patients often have an atypical clinical presentation for PG, with bullae and relatively superficial involvement obscuring the correct diagnosis.

Acute Disease↗
PubMed1989

[Cellular immunity in patients with ulcerous forms of chronic pyoderma undergoing treatment].

Clinical and immunologic examinations of 55 patients suffering from ulcerous forms of chronic pyoderma have revealed increased counts of the peripheral blood theophylline-sensitive T-lymphocytes before therapy. A decrease of the level of this subpopulation, mainly responsible for the suppressor-cytotoxic function of T-cells, during combined therapy including prospidin is suggestive of an immunocorrecting effect of this drug.

Adult↗
PubMed1989

Pyoderma gangrenosum with pulmonary involvement.

A 60-year-old woman had a typical pyoderma gangrenosum with monoclonal IgA gammopathy and atrophic gastritis. Two years after the onset of her skin disease, she had evidence of pulmonary abscesslike involvement. Corticosteroid therapy led to healing of skin and lung diseases. This case stresses the multisystemic manifestations of neutrophilic dermatoses with special attention to pulmonary involvement.

Drug Administration Schedule↗
PubMed1989

[Postoperative pyoderma gangrenosum and cancer of the breast. Apropos of a case].

Pyoderma gangrenosum (PG) is a extending necrotic ulceration with bluish and purplish red margins. This disease is often associated with ulcerative colitis, systemic, hematologic or rheumatic affections. However post-surgical idiopathic PG can occur. One post-mammectomy case is reported. PG can first be suspected on clinical aspect, lack of a specific etiology. PG is a diagnosis of exclusion that is made only after others possibilities are ruled out. The treatment is surgical excision and general corticotherapy.

Adult↗
PubMed1989

[Chancriform pyoderma].

A patient with chancriform pyoderma is described. He has been repeatedly examined with the use of routine serologic tests, Treponema pallidum immobilization and immunofluorescence tests and other laboratory analyses; this has permitted a correct clinical diagnosis. A 6-month follow-up, including clinical examinations and laboratory analyses, has confirmed the diagnosis.

Adult↗
PubMed1979

Pyoderma gangrenosum and myeloproliferative disorders. Report of a case and review of the literature.

The exact mechanism involved in the pathogenesis of pyoderma gangrenosum (PG) still remains unclear, yet there is an increasing number of reports associating PG with immunologic abnormalities. A correlation between PG and myeloproliferative disorders has also been described. We describe a patient with chronic myelocytic leukemia in whom PG developed during the course of illness. We present an immunologic analysis of this case, speculation on the pathogenesis of PG, and a review of the literature. We report the futility of current therapeutic modalities in the treatment of PG.

Adult↗
PubMed1989

[Ulcerative angiosarcoma of the cranial vault masquerading as a pyoderma].

This is a report on a patient suffering from a progressive ulcerative tumour of the vault of the cranium with accompanying osteolytic destruction. The disease pattern was interpreted first after a biopsy from the marginal wall of the inflammation as a case of pyoderma. It was only on postmortem examination that an angiosarcoma of the ulcerative type was correctly diagnosed. The ulcerative type of angiosarcoma is sometimes difficult to differentiate from inflammatory skin diseases.

Aged↗
PubMed1986

Pyoderma gangrenosum and erosive peripheral arthritis.

We describe two patients with biopsy-proven pyoderma gangrenosum who developed a peripheral erosive arthritis resembling that seen in psoriatic arthritis. This association is discussed with particular reference to reactive arthritis.

Arthritis↗
PubMed1987

[Pyoderma gangrenosum and vasculitis. Pathogenic discussion apropos of 3 cases].

Three cases and a pathogenic discussion. We report three cases of clinically typical pyoderma gangrenosum (PG) remarkable for the presence, at histology, of inflammatory vascular lesions of varying intensity. Case No. 1. A 15-year old boy without previous pathology was admitted for necrotic cutaneous lesions typical of PG on both legs. Biopsy in the peri-ulcerous rim showed cellular infiltration of the dermis, principally by granulocytes, associated with granulocytic vasculitis with fibrinoid necrosis (fig. 1 and 2). Laboratory examinations only showed a decrease of CH 50, and attempts at making an aetiological diagnosis of this case of PG met with failure. PG regressed under treatment with disulone combined with topical corticosteroid therapy. Case No. 2. A 62-year old woman with no previous severe disease was admitted for PG of her right leg at the ulcero-necrotic stage (fig. 3). Biopsy in the PG rim showed infiltration of the dermis, predominantly by granulocytes, associated with granulocytic vasculitis and fibrinoid necrosis of the walls of small vessels (fig. 4). Investigations in search of a cause revealed benign thyroid gland hyperplasia. PG was cured after a 5-week oral treatment with minocycline. Case No. 3. This 63-year old woman with arterial hypertension was admitted for PG of both legs. Some lesions at a very early stage were bullous (fig. 5). Biopsy in the peripheral swelling showed polymorphous cellular infiltration of the dermis with a predominance of granulocytes. These cells infiltrated the vessels the walls of which were turgid but without fibrinoid necrosis (fig. 6).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

[Pyoderma gangraenosum with special reference to immunologic and hematologic parameters].

Clinically, the diagnosis "pyoderma gangraenosum" can easily be made on the basis of typical skin features. It has been agreed, so far, that numerous immune deficiencies may play a key role in the pathogenesis of this disease. On reviewing the recent case reports, we observe a change regarding the associated diseases in more than 50%: Whereas earlier reports refer to ulcerative colitis as the most frequent concomitant disease, we now find increasing evidence of hematologic problems in association with pyoderm gangraenosum.

Gangrene↗
PubMed1988

Pyoderma pathophysiology and management.

Cutaneous infections with Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa are major complications of epidermolysis bullosa. Application of impermeable occlusive dressings over denuded skin colonized with these bacteria results in rapid multiplication and the hazard of severe pyoderma. Approaches to the prophylactic treatment of these infections during the long-term management of epidermolysis bullosa are considered.

Administration, Cutaneous↗
PubMed1987

[Pyoderma gangrenosum and hemopathies. Apropos of 2 cases].

Pyoderma gangrenosum (PG) is an uncommon ulcerative disease of the skin. The cause is unknown but the condition is often associated with other diseases such as rheumatoid arthritis, ulcerative colitis, Crohn's disease or monoclonal gammopathy. The association between PG and haematological malignancies (acute leukaemia, Myeloproliferative disorders) is infrequent. Two cases of PG associated with haemopathy are described; one had primary thrombocythaemia and the other, acute myeloblastic leukaemia following for myeloma. The significance of this association is discussed in the light of other observations previously reported in the literature.

Adrenal Cortex Hormones↗
PubMed1987

[Fistulous pyoderma caused by Serratia liquefaciens].

Human infections with Serratia liquefaciens are rare. We therefore present a patient with fistulous pyoderma due to this pathogen. The success of the therapy of Serratia infections depends on determination of the resistance and sensitivity to antibiotics. Following the tentative diagnosis of dermal tuberculosis, histological, microbiological and X-ray examinations were performed. Serratia liquefaciens was identified by culture as the only cause of the skin lesions. After therapy with sulfamethoxazole trimethoprim, the lesions disappeared.

Adult↗
PubMed1987

Pyoderma gangrenosum of the head and neck.

Pyoderma gangrenosum is an ulcerative skin disorder usually associated with an underlying systemic disease. Head and neck involvement is rare, but possibly more common than once thought. The etiology of this disease is unclear, but may be related to an abnormal immunologic response. There are no pathognomonic histologic or laboratory findings; the diagnosis is made by the clinical appearance of the lesions and disease course. Treatment consists of immunosuppression and local wound care in addition to a search for and treatment of an underlying primary systemic disorder. A case report and review of the literature is presented with discussion of common head and neck manifestations, the differential diagnosis, and treatment alternatives.

Adult↗