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At least 271 records · Page 15Linked to original sources
PubMed1989

Evolution of motor activity tests into a screening reality.

Measures of activity have changed in ways that their utility in screening for neurotoxicity has vastly improved. New computer pattern recognition systems now provide rapid, objective tools for identifying animal behavior. Advances in data analysis procedures have replaced the percent change in overall activity level with measures of initiations, total time and temporal structure for multiple behaviors and sequences. These advances can distinguish hyperactivities induced by different mechanisms and rank their neurotoxic potential, a feat not possible with photocell devices generally used in laboratories today. With the recent technological improvements, it is possible that a measure of activity will become one of the best predictors of malfunction in the central nervous system.

Amphetamine↗
PubMed1993

Predicting neurobehavioral patterns following anterior communicating artery aneurysm.

This multiple case report presents two groups of survivors from aneurysms of the anterior communicating artery (ACoA); amnesic and non-amnesics, to examine the similarities and differences in neuropsychological profiles. All six patients were consecutive admissions to acute inpatient rehabilitation, and exhibited generally intact attention, concentration and intellectual ability. Confabulation and personality changes were observed only among the amnesic ACoA patients. However, difficulties in concept formation and perseverative responding was observed in all subjects. A neurobehavioral hypothesis addressing the underlying mechanism of the main features of the "ACoA syndrome" is presented.

Adult↗
PubMed1994

Qualitative research: what do we know about teaching good nutritional habits?

Drawing from a number of qualitative studies, a set of basic principles is presented for development of sound, effective nutrition education material. First, research is needed each and every time a new intervention or materials development project is initiated. This research should include formative, process, and outcome testing. Second, reality checks are needed. Programs and materials need to be tested in the settings and for the purpose for which they are intended. Third, messages need to be tailored to the audience. Certain concepts, such as the Dietary Guidelines, may be more or less universal, but the actual educational process and materials need to be tailored to specific target groups. Generic messages do not work. Sound scientific methodology is readily available as well as empirical principles to guide in the development and testing of nutrition education programs and materials, but each new intervention must be tested because there is always a creative element involved. Research will be ineffective, however, unless the right questions are asked and the right people (usually requiring a multidisciplinary team) are used to find the answer.

Adult↗
PubMed1990

Cognitive deficits and thought disorder: II. An 8-month followup study.

Schizophrenic (n = 21) and manic (n = 19) patients were followed up an average of 8 months after an index assessment during an acute admission. These patients were tested at both assessments with laboratory tasks measuring distractibility and reality monitoring and were examined with clinical ratings of positive and negative thought disorder. For manic patients, none of the measures predicted the patients' clinical state of followup, while negative thought disorder, although rare, was temporally stable. For the schizophrenic patients, both negative thought disorder and distractibility were temporally stable, and more severe negative thought disorder was found at index assessment in patients who were psychotic at followup. The differential utility of laboratory and clinical indices for the prediction of overall clinical state is related to these data.

Adult↗
PubMedDate not supplied

Incidence and correlates of depersonalization following head trauma.

Using the criteria of the Structured Clinical Interview for DSM-III-R Dissociative Disorders (SCID-D), we assessed the incidence of feelings of unreality among a sample of 70 persons who had sustained head injuries. Among those whose head trauma could be classified as mild, more than 60% complained of a depersonalization syndrome. Among those with a significant period of unconsciousness, only 11% had similar complaints. There was a high comorbidity with post-traumatic stress disorder and vertigo. Feelings of unreality were not associated with cognitive impairment or elevated personality test scores, nor were there significant relationships with gender or involvement in litigation. A conservative estimate of incidence of depersonalization among persons with minor head trauma is 13%, while, at the upper end, as many as 67% of persons who sustain mild head injury may experience feelings of unreality.

Adolescent↗
PubMed1994

Lack of insight in schizophrenia.

A neuropsychological etiology has been suggested for lack of insight in schizophrenia patients, mainly based on frontal, right parietal, right hemisphere, or diffuse cerebral dysfunctions. The aim of this study ws to investigate the neuropsychological pathogeny of lack of insight in schizophrenia patients. We examined a sample of 40 DSM-III-R schizophrenia inpatients admitted because of a recrudescence of symptoms. Schizophrenic symptoms were evaluated through the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms. Neurologic explorations included an assessment of frontal neurologic signs, abnormal involuntary movements, and soft neurologic signs. Lack of insight was assessed through three items from the Manual for the Assessment and Documentation of Psychopathology (AMDP). A global index from these three items (lack of feeling ill, lack of insight, and uncooperativeness) was obtained. A neuropsychological battery composed of tests involving many functional areas of the brain was used. No correlation between bad performance and lack of insight was found on any test. On the contrary, lack of insight was associated with better performance on immediate verbal, immediate visual, and delayed visual memory tasks. Moreover, the three components of lack of insight were extracted as an independent factor when they were included together with the positive and negative symptoms, neurologic abnormalities (frontal and soft neurologic signs, and abnormal movements), and a global measure of cognitive performance. The results of the study do not support the neuropsychological hypothesis of lack of insight.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1991

Concordance between two measures of dream bizarreness.

To assess the level of concordance between two published measures of dream bizarreness, 100 randomly selected dreams from 93 college students were scored for primary process using the Auld, Goldenberg, and Weiss scale and for dream distortion using Zepelin's scale. This analysis yielded a strong relationship between these measures, indicating adequate concurrent validity for the content analysis of the construct of dream bizarreness.

Adult↗
PubMed1988

[Diagnosis of "cataphasia" based on a drawing].

Drawings done by a patient before examination led to the suspicion of cataphasia, in view of previous experience of similar pictures drawn by verbigerate patients, and this proved to be so. We assume that the verbigerate affection of the thinking process is pictorially reflected in spontaneous casual drawing. In a less spontaneous situation, on other hand, the patient will not be so completely disorganised, and thus the author of an utterly confused drawing can still retain some measure of mental control in the course of tests.

Adult↗
PubMed1995

Pathogenesis of delusions.

This overview of attempts to shed light on the pathogenesis of delusions provides a sense of promise, because we are grappling with the right problems, and reasons for both optimism and skepticism. Optimism is justified because some of the approaches have yielded empirical support and can be tested profitably in research. Skepticism is warranted because we remain unclear about precisely what delusions are; and we have as yet no means of identifying them with a laboratory test. Hence, we must rely on the problematic nature of clinical observation of the inner experiences of patients to make progress. The different mechanisms proposed still require considerable testing, but scrutiny of current results suggests that anomalous experience as a stimulus for delusion formation has been better documented than proposals invoking disordered reasoning or motivational deviances. Nevertheless, no view is as yet established, and each may have some relevance to solving the delusion puzzle.

Delusions↗
PubMed2000

The study of locomotor pointing in virtual reality: the validation of a test set-up.

The goal of this experiment was to validate an experimental set-up for studying locomotor pointing. The specific and also original element of this set-up was the interactive nature of virtual reality and movement production. This interaction was achieved through the coupling of a treadmill and a Silicon Graphics system. This latter system generated on a screen (3 x 2.3 m) an environmental array that moved according to the action produced by subjects on a treadmill. The task was to place either foot on a spatial target that appeared on the floor in front of the subject's displacement trajectory. We analyzed the step length patterns of subjects approaching these targets, along with the current target-subject relationship. The results are in agreement with a perception-action coupling type of control mechanism that operates continuously as the subject approaches the desired target. Apparently, these findings mirror observations of real-life locomotion, indicating that the present set-up provides a valid and useful tool for examining human locomotion.

Adult↗
PubMed1998

Self-monitoring dysfunction and the schizophrenic symptoms of alien control.

BACKGROUND: Frith & Done (1988) have proposed that the experience of alien control symptoms in schizophrenia is related to a failure by such individuals to monitor effectively their own willed intentions, actions and thoughts. METHOD: To examine this hypothesis, a heterogeneous group of 35 patients, all carrying a DSM-III-R diagnosis of schizophrenia (or schizophreniform psychosis) and 24 non-patient controls, completed a battery of neuropsychological and cognitive tests, which inter alia, included four putative measures of self-monitoring. Patients took part in a detailed clinical interview to assess current levels of symptomatology. RESULTS: Patients generally performed at a lower level on most components of the test battery, including the four self-monitoring tests. Moreover, patients currently experiencing symptoms of alien control tended to experience greater difficulty with each of the self-monitoring tests; an effect that was relatively independent of neuropsychological or general cognitive function. CONCLUSIONS: The relationship between poor self-monitoring and the presence of alien control symptoms provides support for Frith & Done's account of the origins of these symptoms in schizophrenia.

Adult↗
PubMed1994

Exploring the maze of adverse reactions to foods.

Nowhere in medicine is a test or battery of tests more needed than in the diagnosis of adverse reactions to foods. Such tests are not at present a reality. Research produces tests that individually appear to show validity, but when challenged with the entire range of possible adverse reactions and their results, the tests fall short. Considering the range of mechanisms involved in adverse reactions to foods, this is to be expected. There is a tendency to discount positive test results when they fail to cover all of the parameters desired. The inherent weakness in any test is that all available formats explore a single or limited reaction route. The reality is the presence of multiple routes, multiple target organs, and multiple external variables not subject to programming into a single test. Considering the range of possibilities, it is amazing that any existing tests show any clinical validity at all. We as scientists should not denigrate any study that shows a significant degree of reliability, even within a limited range. This simply halts progress. An encouraging study should be used as a stepping stone to a more comprehensive format for evaluating the overall range of adverse reactions and providing us with at least some inroads in coping with this most difficult problem. To quote Sir Peter Medawer on receiving the Nobel Prize in Science: "Nothing must be said or written that diminishes the likelihood that someone else will get at the truth."

Allergens↗
PubMed1981

Does helplessness cause depression, or do only depressed people become helpless? Comment on Alloy and Abramson.

Alloy and Abramson reported that depressed people are accurate at assessing response-outcome contingencies, whereas normal people display various distortions. It is argued that such a finding causes problems for a learned helplessness theory of depression, because it suggests that people can only detect some of the conditions necessary for producing helplessness after they are already depressed. The presumed causal relation between helplessness and depression may be strengthened if one assumes that helplessness prevents the development of active hypothesis-testing strategies that would otherwise produced biased assessments of contingency.

Cognition↗
PubMed1994

Pseudomemory in hypnotized and simulating subjects.

High hypnotizable (n = 23) and low hypnotizable simulating (n = 13) subjects received pseudomemory suggestions. High hypnotizable and low hypnotizable simulating subjects were equally likely to pass the target noise suggestion during hypnosis and were also equally likely (high hypnotizables, 47.83%; low hypnotizable simulators, 64.29%) to report pseudomemories when tested for pseudomemory after instructions to awaken. As in previous research with task-motivated subjects, pseudomemory rate (high hypnotizables, 47.48%; low hypnotizable simulators, 46.15%) was not reduced by informing subjects that they could distinguish fantasy and reality in a nonhypnotic state of deep concentration. At final inquiry, after deep concentration, high hypnotizable and low hypnotizable simulating subjects' pseudomemories remained comparable (43.48% and 38.46%, respectively). Unlike previous research, high hypnotizable subjects did not report more unsuggested noises and more pseudomemories of novel sounds than did awake low hypnotizable simulating subjects. Pseudomemory reports were generally consistent with subjects' ratings of whether the hypnotist expected them to believe the sounds were real or imagined.

Adult↗