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Results for “Scleroderma, Systemic”

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PubMed1988

[Disorders of regional blood circulation in systemic scleroderma: early diagnosis and possibility of its correction].

Clinical and instrumental manifestations of disorders of the regional blood circulation were studied in 47 patients with sclerodermia systematica. Hemodynamic changes of the lesser circulation were marked in patients under 44 with more active disease, longer disease duration, pulmonary pathology and cardiac decompensation. Sclerodermic vasculitis played the main role in lesser circulatory disorders. Additional factors were pulmonary and cardiac involvement and concomitant chronic nonspecific pulmonary diseases. Changes of intraorganic vessels and heart failure could result from hepatic circulatory disorders. The authors indicated a possibility of correction of pulmonary hypertension by combining the basic antirheumatic drugs with symptomatic therapy including spasmolytics and cardiac glycosides.

Adult↗
PubMed1988

[Sjögren's syndrome in systemic scleroderma].

Combined investigation of 43 patients with sclerodermia systematica (SSD) was conducted to detect Sjogren's syndrome (SS) and to study SSD association with SS. Four groups of patients were defined: with marked SS (10), primary SS (12), probable SS (13), and without SS manifestations (8). Comparative characterization has shown that SS is detected slightly more frequently in a chronic course of SSD, combines with manifestations of sclerodactyly, telangiectasia, calcinosis, however esophageal hypomobility, indurative skin changes and contractures which are typical of SSD, occur less frequently than in SSD patients without SS. SSD association with SS is characterized by polyarthralgia, arthritis, marked Raynaud's syndrome, the frequency and rather high RF titers, the detection of anti-Ro and anti-La, and a significant rise of the level of circulating immune complexes determined by SS influence. SS manifestations in SSD are retention pains in the parotid glands, signs of clearness on sialograms, periductal sclerosis in the form of rings in morphological investigation of the parotid glands.

Adult↗
PubMed1986

A cytogenetic analysis of twenty cases of systemic scleroderma.

Cytogenetic studies were performed on 20 patients with diffuse scleroderma who had not received recent or high doses of irradiation; 1,267 cells were examined. Neither the culture medium composition nor the disease had any significant effect on the frequency of structural chromatidic or chromosomal abnormalities.

Adult↗
PubMed1986

[Study of the circulating lymphocytes populations in systemic scleroderma, chronic discoid lupus erythematosus and dermatomyositis].

The authors studied the peripheral blood lymphocytes in any autoimmune diseases. In scleroderma the T-lymphocytes and ratio T4/T8 are decreased and B-lymphocytes are normal. In the LEDC the T-lymphocytes are decreased and B-lymphocytes are increased. In dermatomyositis the B-lymphocytes are increased and T-lymphocytes are decreased, the ratio T4/T8 is normal.

Chronic Disease↗
PubMed1987

[Vital capillary microscopy and with ophthalmoscope-detected findings in progressive systemic scleroderma].

Nineteen patients suffering from scleroderma (average age 56.6 years; 18 women, 1 man) were examined by in vivo capillary microscopy of the nail fold. The possibility of achieving results with the ophthalmoscope was examined. The correspondence between ophthalmoscopic and television microscopic results was evaluated. With the ophthalmoscope hemorrhages were found in 68% of the patients, reduction in the number of capillaries in 79%, avascular areas in 79%, and dilated capillaries in 84%. The correspondence between the findings of the two methods was 80% and more, so that examination of the nail fold capillaries with an ophthalmoscope can help to verify the diagnosis of scleroderma. This method should be employed whenever scleroderma is suspected and microscopical equipment is not available.

Adult↗