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An interleaved tracking procedure to monitor unstable psychometric functions.

In some experimental situations, the psychometric function underlying performance may not be stable, but instead may shift along the stimulus axis in response to changes in attention, learning, or task difficulty. When this occurs, the measured threshold may be influenced and the slope of the measured function will be inaccurately shallow. With commonly used experimental procedures, it is difficult to know whether a shallow psychometric function slope is a true reflection of the sensory process, or is a result of "averaging" a highly variable underlying function. Here, a new method is described of estimating psychometric function slope from the variability in two interleaved adaptive tracks, consulted on alternate trials, that is resistant to the effects of shifting performance levels. Further, a mechanism is described for assessing the likelihood that a threshold was, in fact, stable over the course of its measurement. Computer simulations are reported as well as verification of the method in measurements of human performance on a psychophysical task. Several conditions of externally imposed variability were simulated to establish the ability of these procedures to identify unstable functions and produce accurate slope estimates. The procedures worked well for thresholds shifting by as little as 4 dB if the variation did not occur too rapidly. The procedure and associated analyses are recommended as a relatively "free" means of calculating slope and quantifying threshold reliability with little extra experimental effort.

Attention

Attentional shift towards the rightmost stimuli in patients with left visual neglect.

In a search task where four letters were displayed to the right of a central fixation point, right brain-damaged patients with visual neglect showed the fastest response when the target was at the rightmost position and progressively slower responses as it moved towards the center of the display. This finding confirms Kinsbourne's claim that in visual neglect an important role is played by the magnetic attraction that the extreme end of the right structured space exerts on the patient's attention.

Adult

Shifting visual attention and selecting motor responses: distinct attentional mechanisms.

Does shifting visual attention require the same central mechanism as that required for selecting overt motor responses? In Experiment 1, Ss performed 2 tasks: a speeded manual response to a tone and an unspeeded report of a cued target letter in a brief masked array. Stimulus onset asynchrony (SOA) between tone and array was varied. If the attention shift to the target was delayed by the first task, then there should be more second-task errors at short SOAs and on trials with slow first-task responses. In fact, SOA effects and dependencies were minimal. Results were unchanged in further experiments in which the relation between cue and target was symbolic, spatially "unnatural," or based on the color of the target. Two additional experiments validated key assumptions of the method. The results confirm that although selection of motor responses constitutes a processing bottleneck, the control of visual attention operates independently of this bottleneck.

Adult

PET studies of parietal involvement in spatial attention: comparison of different task types.

Five experiments are described that concern the mechanisms that direct attention to spatial and non-spatial features of a stimulus and the effects that attention has on the visual system's analysis of that stimulus. Shifts of attention from one spatial location to another activated the superior parietal lobe and this activation was fairly independent of the task performed on the attended object, the response made to the attended object, and whether the shift of attention was controlled endogenously or exogenously. Maintaining attention tonically on a location or a particular visual feature such as shape, colour or motion did not produce a superior parietal response. Tonic attention to a feature (colour, shape, motion) or location, however, did produce enhancements in the response of various regions that are probably specialized for processing the attended visual feature. The activation of superior parietal cortex during shifts of spatial attention as well as the activation of parietal-occipital cortex when attention is tonically maintained on a location suggest that the parietal cortex plays an important role in spatial computations.

Animals

Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens in rats.

Reversible lidocaine-induced lesions of the nucleus accumbens (N.Acc.) impaired performance on the spatial win-shift, but not on the cued win-stay, radial arm maze task. Pretraining lesions on the former task did not affect foraging for 4 pellets during either the training or test phases. In contrast, lesions given prior to the test phase significantly disrupted retrieval of 4 pellets on the 8-arm maze. Comparable deficits also were observed in rats trained to forage for 4 pellets on an 8-arm maze without prior win-shift experience. State-dependent drug effects were ruled out by replicating the disruptive effects of lidocaine infusions into the N.Acc. on spatial win-shift performance in rats receiving this treatment prior to both training and test phases. These results suggest that the N.Acc. may interact with the hippocampus to guide foraging behavior requiring memory of previous spatial locations on a maze.

Animals

Shift in cognitive asymmetries between wakings from REM and NREM sleep.

Twelve subjects were awakened from REM and NREM sleep and tested on three tests designed to measure functions attributed to the left cerebral hemisphere and three tests designed to measure right hemisphere function. A significant shift in cognitive profile was found in the direction of tasks attributed to left hemisphere performance following waking from NREM sleep relative to waking from REM sleep. These results are consistent with the observed reciprocal oscillations between left and right functions during the waking period and imply that performance of these specialized functions may be controlled by some of the same mechanisms that govern biorhythms.

Adult

The relationship between alcohol intoxication and power in real-life non-alcoholic couples.

Thirty real life couples were randomly assigned to one of three groups, a control group, a men drink group (only men drinking alcohol), or a women drink group (only women drinking alcohol). The purpose was to test whether alcohol intoxication leads to shifts in power among men and women using an estimation task together with a measure of power fantasies. Men were more powerful in terms of outcome both in the control group and the women drink group, but women became more powerful when men drink. Responsibility aspects of the process follow this pattern and the process becomes more complex when women drink. Men over-estimate their influence especially as far as process is concerned. Power fantasies decrease for both men and women only when women drink. It is suggested that sex role stereotyping can explain the findings.

Adult

A continuous-flow model for phonatory reaction time.

The purpose of this study was to validate a proposed continuous-flow model of phonatory reaction time by investigating the temporal order of selected laryngeal and neurophysiological events involved in a phonatory reaction time task. Ten normal speakers participated in a phonatory reaction time task. Laryngeal positioning movements prior to vocal fold closure (laryngeal shift) and onset of vocal fold vibration (acoustic onset) were recorded with an electroglottograph. P300 brain potentials were collected simultaneously, and they served as an index of a central process underlying reaction time. The obtained temporal ordering of laryngeal shift, P300, and acoustic onset supported a continuous-flow model of phonatory reaction time. Use of this model might yield information that is more accurate in explaining physiological function and more precise in describing temporal patterning than the serial model.

Adult

Neuropsychological aspects of dementia of motor neuron disease: a report of two cases.

We describe the neuropsychological data from two cases of dementia of motor neuron disease. In both cases, a gradually progressive presenile dementia began prior to the development of motor neuron disease involving predominantly bulbar musculature. These data, along with the neuropathologic findings available in one case, suggest that dementia of motor neuron disease differs from that of Alzheimer's disease (AD). Both patients displayed major alterations of personality and comportment. Neuropsychological test results revealed marked attention deficits, particularly on tasks requiring sustained effort and on those requiring ability to shift from one line of thinking to another. Confrontation naming, verbal fluency, insight, and judgment also showed extensive impairment. By contrast, verbal and nonverbal memory remained intact after several years of illness. This pattern is quite different from that seen in AD, where memory deficits are salient.

Aged

HOROPLAN: computer-assisted nurse scheduling using constraint-based programming.

Nurse scheduling is a difficult and time consuming task. The schedule has to determine the day to day shift assignments of each nurse for a specified period of time in a way that satisfies the given requirements as much as possible, taking into account the wishes of nurses as closely as possible. This paper presents a constraint-based, artificial intelligence approach by describing a prototype implementation developed with the Charme language and the first results of its use in the Rouen University Hospital. Horoplan implements a non-cyclical constraint-based scheduling, using some heuristics. Four levels of constraints were defined to give a maximum of flexibility: French level (e.g. number of worked hours in a year), hospital level (e.g. specific day-off), department level (e.g. specific shift) and care unit level (e.g. specific pattern for week-ends). Some constraints must always be verified and can not be overruled and some constraints can be overruled at a certain cost. Rescheduling is possible at any time specially in case of an unscheduled absence.

France

Asymmetries in hand movement during block design construction.

Changes in patterns of hand use were examined as a function of task demand characteristics. Using blocks, right- and left-handed male and female subjects were asked to simultaneously construct two replicas of presented patterns, one with each hand. With the presentation of visual-spatial patterns, a shift toward use of the left hand from baseline was observed. This change was least evident among right-handed females. The observed shift in hand use toward the left on a visuo-constructive block design task might suggest differential involvement of the right hemisphere with changes in task demand characteristics.

Adult

Infants' pitch perception: inharmonic tonal complexes.

Two experiments assessed the effects of inharmonicity on 7- to 8-month-old infants' perception of the pitch of tonal complexes. A number of harmonic and inharmonic complexes were presented in a visually reinforced operant head turn procedure. In both experiments, infants demonstrated the ability to discriminate two harmonic complexes based on missing fundamental frequencies of 160 and 200 Hz. After learning this basic task, infants learned to discriminate inharmonic complexes, which were created by shifting the partials of the harmonic complexes upward by 30 Hz (experiment 1) or 20 Hz (experiment 2). Finally, three spectrally different inharmonic complexes represented each pitch, and infants attempted to categorize those complexes according to their pitches. In both experiments, infants successfully discriminated the pitches of the spectrally varying tonal complexes, but their performance deteriorated for the more strongly inharmonic complexes of experiment 1. These results suggest that, as for adults, the salience of pitch for inharmonic sounds decreases with increasing inharmonicity.

Female

Cortisol reactivity and cognitive performance in a continuous mental task paradigm.

The after-effects of fatigue or stress on the performance of cognitive tests have been particularly difficult to demonstrate. In this study we examined whether salivary cortisol, used as an index of stress evoked by the continuous performance of mental tasks, reflected individual differences in cognitive performance. In a within-subject experiment in which 24 subjects were exposed to 4 hours of continuous mental activity and to a control session, significantly higher cortisol levels were found during the continuous task session. Cognitive performance was assessed before and after each session. The relevant test parameters involved aspects of verbal memory, concept shifting and divided attention. When subjects were divided into two groups based on the magnitude of individual cortisol responses to the continuous tasks, it was found that the subgroup with higher cortisol responses decreased in attention compared with their attention after the control session. In contrast, the performance of the subgroup with no or lower cortisol responses did not differ between the two sessions. There was no evidence of similar effects on verbal memory or concept shifting.

Adult

Superior parietal cortex activation during spatial attention shifts and visual feature conjunction.

Positron emission tomography was used to measure changes in the regional cerebral blood flow of normal people while they searched visual displays for targets defined by color, by motion, or by a conjunction of color and motion. A region in the superior parietal cortex was activated only during the conjunction task, at a location that had previously been shown to be engaged by successive shifts of spatial attention. Correspondingly, the time needed to detect a conjunction target increased with the number of items in the display, which is consistent with the use of a mechanism that successively analyzes each item in the visual field.

Attention

Patterns of cerebral activation while mental images are rotated and changed in size.

Event-related brain potentials were recorded while subjects performed either a rotation or a size scaling transformation of a mental image. Images had to be rotated 0 degrees, 60 degrees, or 120 degrees or their size had to be enlarged by factors of 1:1, 1:3, or 1:5. Both tasks were accompanied by pronounced negative slow potentials, which extended over several seconds. The relative maximum of these shifts emerged at central to occipital leads. Over the occipital cortex, the negative potential had a similar amplitude level in all conditions and both tasks. However, at parietal and central areas, the negative slow wave changed in relation to the difficulty of the task. The amplitude increased with increasing rotation demands and if the scaling operation required an exact computation of the coordinates of the image. None of these effects could be attributed to an inverse change of P300.

Adult

Cortical DC-potentials as electrophysiological correlates of hemispheric dominance of higher cognitive functions.

Cortical activation during cognitive processing was assessed with a new, noninvasive electrophysiological method: Cortical DC-potentials were recorded from frontal, central, temporal and parietal electrode positions on the scalps of 150 normal adult subjects while they performed cognitive tasks involving language, calculation, music and spatial vision. During the 10-s registration period, shifts in DC-potentials were analyzed with reference to a baseline 3-s preperiod. 15-30 trials were averaged. A lateralized preponderance of negativity by more than 3 microV was used as the criterion of hemispheric dominance. Language tasks caused left-sided lateralization in 76% of the right-handers (n = 80), bilaterally equal surface negativity in 15% and right-sided lateralization in 9%. During the same tasks, 22% of the left-handers (n = 45) had right-sided lateralization. Calculation tasks produced left-sided lateralization in 65% of the right-handers and left-handers. Music tasks caused more right-sided (53%) than left-sided (39%) lateralization dependent on musical training. Visuospatial processing yielded a right temporoparietal lateralization in 77%.

Adolescent

Event-related potential correlates of non-motor anticipation.

A slow negative shift called "stimulus-preceding negativity" (SPN) has been observed preceding feedback. The aim of the present study is to investigate whether the SPN is related to perceptual or conceptual anticipation. Event-related potentials (ERPs) were recorded in an S1-S2-S3 sequence with intervals of 3 s. S1 was an auditory warning signal; the task stimulus presented at S2 consisted of two digits on which subjects (n = 8) performed an arithmetic task. They had to match their solution with a probe stimulus presented at S3. Perceptual anticipation was manipulated by varying the discriminability of S2 (intact vs. degraded). Conceptual anticipation was manipulated by varying the amount of information processing required at S2 (easy vs. difficult arithmetic). Motor preparation was varied by requiring a speeded versus a delayed response. No negativity was found before the task stimulus (S2), whereas the probe stimulus (S3) was always preceded by a negative shift. The amplitude of this negative shift was larger under the speed than under the delayed instruction. Its amplitude showed a left-hemisphere preponderance and was larger for the difficult than for the easy condition. ERPs preceding task stimuli seem to reflect functionally different processes from ERPs preceding probe and feedback stimuli. The difference is explained in terms of motivational factors that come into play with feedback and probably play a role in the anticipation of the probe stimulus.

Acoustic Stimulation

Physical load on the cardiovascular system in different work tasks.

This review of the cardiovascular load at work is based on the concept of stress and strain in dynamic work. The relationship between oxygen consumption (VO2) and heart rate (HR) and work load and the effects of intervening variables are described. The relationship between relative aerobic strain (RAS) and HR is shown to be dependent on the type and combination of muscular work. Significant differences in cumulative HR curves over 8-h shifts have been detected between the profile groups "producing muscle forces" or "coordinating motor functions" and others; the HR remained above the level of 110 beats X min-1 for about 50, 30, and 5% of the shift time, respectively. VO2, HR, and RAS are described in more detail during tasks in milk delivery, mail delivery, and logging, during tasks in the construction and steel industries, and during tasks in the municipal sector. Special attention is paid to work tasks in which the load on the cardiovascular system is above the "acceptable" level. Peak loads which increase strain to the maximal RAS level are described. The change in RAS with ageing is shown to increase in work tasks which include the production of muscle forces and the coordination of motor functions.

Adult