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At least 271 records · Page 15Linked to original sources

A voting-based computational framework for visual motion analysis and interpretation.

Most approaches for motion analysis and interpretation rely on restrictive parametric models and involve iterative methods which depend heavily on initial conditions and are subject to instability. Further difficulties are encountered in image regions where motion is not smooth-typically around motion boundaries. This work addresses the problem of visual motion analysis and interpretation by formulating it as an inference of motion layers from a noisy and possibly sparse point set in a 4D space. The core of the method is based on a layered 4D representation of data and a voting scheme for affinity propagation. The inherent problem caused by the ambiguity of 2D to 3D interpretation is usually handled by adding additional constraints, such as rigidity. However, enforcing such a global constraint has been problematic in the combined presence of noise and multiple independent motions. By decoupling the processes of matching, outlier rejection, segmentation, and interpretation, we extract accurate motion layers based on the smoothness of image motion, then locally enforce rigidity for each layer in order to infer its 3D structure and motion. The proposed framework is noniterative and consistently handles both smooth moving regions and motion discontinuities without using any prior knowledge of the motion model.

Algorithms↗

Fundus analysis and visual prognosis of macular hemorrhage in pathological myopia without choroidal neovasculopathy.

PURPOSE: To analysis and evaluate the fundus characteristics and visual prognosis of macular hemorrhage in pathological myopia without choroidal neovasculopathy. METHODS: Thirty-seven patients (38 eyes) of pathological myopia with macular hemorrhage and without choroidal neovascularization (CNV) underwent color photograph and fundus fluorescein angiography (FFA) examinations. Indocyanine green angiography (ICGA) was also performed on 11 patients (11 eyes). Follow-up ranged from 3 to 21 months. RESULTS: The macular hemorrhage in pathological myopia without CNV demonstrated oval, less than 1PD, without edema and exudation. Lacquer cracks appeared at the site of previous subretinal bleeding in 84.2% of the eyes. The visual acuities were improved in 81.6% of eyes during the follow-up period. ICGA revealed linear hypofluorescence in 7 of 11 eyes (63.6%), indicating a ruptured Bruch's membrance at the onset of subretinal bleeding. CONCLUSION: A rupture of choriocapillaris complex and Bruch's membrane causes macular hemorrhage of pathological myopia without CNV, leading to the formation of a new lacquer crack. Its prognosis is favorable.

Adolescent↗

[Automatic discriminatory analysis of visually evoked potentials waveforms in normals and amblyopes].

We presented a method of discriminatory analysis for the discrimination of P-VEP waveforms in frequency domain, and used this analysis in the discrimination of the P-VEP waveforms of normal eyes and amblyopic eyes. In this analysis, the amplitudes and the phases of the first to the sixth harmonics of P-VEP waveforms were calculated, thus 12 parameters of the P-VEP waveform were obtained for the discriminatory analysis. The P-VEP waveforms of thirty-one normal eyes and thirty-one amblyopic eyes were used to establish the discriminatory system. The result of clinical application showed that this method of Discriminatory Analysis was effective for the discrimination between normal and amblyopic P-VEP.

Amblyopia↗

Comparison of different methods of ST measurement for evaluation of myocardial ischaemia in Holter monitoring.

Long-term ambulatory electrocardiographic monitoring [AEM] of the ST segment is clinically the most practical test for the documentation and quantification of myocardial ischaemia. However, there is still some controversy about the validity of ST measurements in Holter monitoring. Therefore, in the present study, in a series of 26 patients with angiographically proven (greater than 70%) coronary heart disease and a positive exercise electrocardiogram, the number, duration and the severity of symptomatic and asymptomatic ischaemic episodes were measured by (1) the ST change at the J point, (2) the ST change 0.07-0.10 s after the J point (immediately before the T wave), (3) the change of the slope of the ST segment, and (4) the area under the ST segment, with a Reynolds Pathfinder III and compared with visual analysis. At the J point (1) there were a total of 264 episodes with a duration of 3947 min and a maximum of 0.35 mV, before the T wave (2) 276 episodes with a duration of 3440 min and a maximal change of 0.40 mV; looking at the slope of the ST segment (3) the figures were 118, 1041 min and regarding the area under the ST segment they were 198, 2385 min. In conclusion, ST deviations are safely detected by automated analysis of the ST segment. Compared with visual analysis (220 episodes), deviation of the ST1 (J point) and ST2 point (80 ms thereafter) overestimate the incidence of true ischaemic ST depression by about 20%.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Disease↗

Renal cortex visualization and analysis of dynamic CT curves of the kidney.

Renal cortex visualization and dynamic renal computed tomography (CT) were carried out by bolus injection of contrast medium. In vivo renal cortex visualization showed that renal cortex volume and cortex thickness are both inversely correlated with age. The percentage volumes of cortex and columns of Bertin are correlated inversely in non renal-failure subjects. Percentage volumes of cortex tend toward low values in renal failure and status after renal transplantation. In analyzing dynamic renal CT curves, the corticomedullary junction time is a good index of mild impairment of renal function.

Acute Kidney Injury↗

Synaptic mechanisms of a tonic EPSP in crustacean visual interneurons: analysis and simulation.

Light-evoked synaptic responses of identified visual interneurons, sustaining fibers (SFs), were quantitatively analyzed, and a neuronal cable model was used to calculate voltage attenuations and predict synaptic responses. The cable model is based on morphological measurements of SFs filled with Lucifer yellow and passive membrane properties assessed by current injection in the proximal portion of the dendritic arbor. The morphological and electrophysiological measurements were made in different preparations on homologues of the same identified interneurons. The excitatory postsynaptic potential (EPSP) elicited with high-intensity light consists of a transient phase (mean amplitude 33.1 mV) and a second phase (the plateau) that decays slowly relative to the membrane time constant (mean amplitude 24.4 mV). The mean extrapolated reversal potentials are -19.1 mV for the transient and -22.3 mV during the plateau. The change in input conductance associated with the plateau phase of the response showed a peak of 121% above the resting input conductance and decayed to approximately 50% above resting conductance over several seconds. Compartmental cable models (18, 19) were used to calculate voltage attenuations and local synaptic conductances within the SF dendritic tree. The dendrites are electrotonically compact, and voltage attenuations average 6% for current flowing distally from the recording site (injected) and 45% for current flowing proximally to the recording site. The steady-state EPSP is associated with a calculated 80% decrease in the net dendritic membrane resistivity. The synaptic response, calculated for an EPSP distributed throughout the dentritic tree (using this conductance change and the measured steady-state reversal potential) was 27.0 mV, compared with an observed mean value of 24.4 mV. The calculated relationship between steady-state EPSP amplitude and dendritic membrane resistivity (Rs) is a sigmoidal function that resembles the intensity/response function of the SF. We can therefore correctly predict the transformation from light intensity to compound EPSP amplitude by calculating the intervening synaptic membrane resistivity and voltage values. These functions are affected in a predictable manner by the passive membrane resistivity (Rm) and the EPSP reversal potentials. Tetrodotoxin (TTX) application abolished all SF spiking but left the EPSP essentially unchanged, suggesting that the neuronal pathway from photoreceptors to SFs is mainly or entirely comprised of nonspiking (i.e., TTX-insensitive) elements.

Animals↗

GenePro: a Cytoscape plug-in for advanced visualization and analysis of interaction networks.

MOTIVATION: Analyzing the networks of interactions between genes and proteins has become a central theme in systems biology. Versatile software tools for interactively displaying and analyzing these networks are therefore very much in demand. The public-domain open software environment Cytoscape has been developed with the goal of facilitating the design and development of such software tools by the scientific community. RESULTS: We present GenePro, a plugin to Cytoscape featuring a set of versatile tools that greatly facilitates the visualization and analysis of protein networks derived from high-throughput interactions data and the validation of various methods for parsing these networks into meaningful functional modules. AVAILABILITY: The GenePro plugin is available at the website http://genepro.ccb.sickkids.ca.

Algorithms↗

[Application of positron emission tomography in diagnosis and treatment of lung cancer].

OBJECTIVE: To determine the usefulness of positron emission tomography(PET) with fluoro-2-deoxyglucose (FDG-PET) in lung cancer. METHODS: Patients who presented between September 1999 and March 2000 with lung cancer or indeterminate lung lesions on chest CT scan were enrolled and underwent FDG-PET scanning. RESULTS: Of the 88 patients, 68 (77.3%) patients had malignancy and 20(22.7%) patients had a benign lesion. Of the 125 lung lesions, 80(64.0%) malignant lesions had a median standard uptake ratio (SUR) of 2.8(range 0-12.0), while 45(36.0%) benign lesions had a median SUR of 0(range 0-3.7). There was significant difference between the two groups. The diagnostic sensitivity and specificity of PET imaging for lung lesions were associated with the size of lesions but not with radiation or chemotherapy given before. The diagnostic specificity and accuracy of PET for lung lesions were significantly higher than those of CT scan. The sensitivity, specificity and accuracy of SUR method were 65.0%, 91.1% and 74.4% respectively and those of PET visual analysis were 95.0%, 95.6% and 95.2% respectively. The accuracy for lung lesions > or = 1.5 cm with SUR method was higher than that of lesions < 1.5 cm, being 93.8% and 62.3% respectively. The diagnostic sensitivity and accuracy of PET visual analysis for lymph node metastasis were significantly higher than those of CT scan. SUR was not correlated with the degree of cell differentiation, but it decreased significantly in small cell lung cancer after radiation or chemotherapy. CONCLUSIONS: PET is of advantage to the evaluation of lung lesions and diagnosis of lymph node metastasis in lung cancer. PET visual analysis is recommended in lung lesions after radiation or chemotherapy or with size < 1.5 cm in diameter.

Adult↗

Comparison of visual grading analysis and determination of detective quantum efficiency for evaluating system performance in digital chest radiography.

A study was conducted to compare physical and clinical system performance in digital chest radiography. Four digital X-ray modalities, two storage-phosphor based systems and two generations of a CCD-based system, were evaluated in terms of both their imaging properties (determination of presampling MTF and DQE) and clinical image quality (grading of the reproduction of anatomical details of 23 healthy volunteers using both absolute and relative visual grading analysis). One of the two storage-phosphor systems performed best in both evaluations and the first generation of the CCD-based system was rated worst; however, the other two systems were ranked differently with the two methods. The newest CCD-based system yielded a higher clinical image quality than the second storage-phosphor system, although the latter presented a DQE substantially higher than the former. The results show that clinical performance cannot be predicted from determinations of DQE alone, and that a system with lower DQE, under the quantum-saturated conditions in chest radiography, can outperform a system with higher DQE if the image processing used on the former is more effective in presenting the information in the image to the radiologist.

Equipment Design↗

Glaucoma visual field analysis by computed profile of nerve fiber function in optic disc sectors.

Automated perimetry has decreased the subjective aspects of data collection, but analysis has remained largely subjective. A microcomputer permits more objective analysis by regrouping and averaging data points in the threshold static visual field according to their retinotopic projection onto the optic disc rather than according to their eccentricity from the point of fixation. The applications of the technique include (1) following glaucomatous visual field loss, (2) differentiating glaucomatous from other forms of visual loss, and (3) studying the effects of aging on the visual field. Six formulas for data analysis are described, and their relative usefulness discussed. Percent loss or gain seemed to convey the most diagnostic information to the clinician. Percent of expected sensitivity was less than the decimal visual acuity when the diagnosis was glaucoma but greater when the diagnosis was cataract. In some cases this analytic method should provide information that could favorably affect patient management.

Adolescent↗

SeqExpress: desktop analysis and visualization tool for gene expression experiments.

SUMMARY: SeqExpress is a stand-alone desktop application for the identification of relevant genes within collections of microarray or SAGE experiments. A number of analysis, filtering and visualization tools are provided to aid in the selection of groups of genes. If R is installed then the application can use this to provide further analysis. AVAILABILITY: SeqExpress is available at: http://www.seqexpress.com

Algorithms↗

VisANT: an online visualization and analysis tool for biological interaction data.

BACKGROUND: New techniques for determining relationships between biomolecules of all types--genes, proteins, noncoding DNA, metabolites and small molecules--are now making a substantial contribution to the widely discussed explosion of facts about the cell. The data generated by these techniques promote a picture of the cell as an interconnected information network, with molecular components linked with one another in topologies that can encode and represent many features of cellular function. This networked view of biology brings the potential for systematic understanding of living molecular systems. RESULTS: We present VisANT, an application for integrating biomolecular interaction data into a cohesive, graphical interface. This software features a multi-tiered architecture for data flexibility, separating back-end modules for data retrieval from a front-end visualization and analysis package. VisANT is a freely available, open-source tool for researchers, and offers an online interface for a large range of published data sets on biomolecular interactions, including those entered by users. This system is integrated with standard databases for organized annotation, including GenBank, KEGG and SwissProt. VisANT is a Java-based, platform-independent tool suitable for a wide range of biological applications, including studies of pathways, gene regulation and systems biology. CONCLUSION: VisANT has been developed to provide interactive visual mining of biological interaction data sets. The new software provides a general tool for mining and visualizing such data in the context of sequence, pathway, structure, and associated annotations. Interaction and predicted association data can be combined, overlaid, manipulated and analyzed using a variety of built-in functions. VisANT is available at http://visant.bu.edu.

Animals↗

Comparison of defect size between thallium-201 and technetium-99m tetrofosmin myocardial single-photon emission computed tomography in patients with single-vessel coronary artery disease.

Defect size on exercise-rest technetium (Tc)-99m tetrofosmin myocardial perfusion imaging was compared with that on exercise-reinjection thallium-201 imaging with 20 patients with 1-vessel coronary artery disease. In each patient, exercise-reinjection thallium-201 single-photon emission computed tomography (SPECT) and exercise-rest Tc-99m tetrofosmin SPECT imaging were performed. For visual analysis of the obtained SPECT images, the left ventricular myocardium was divided into 20 segments based on 3 short-axis slices from the apical, middle, and basal ventricular levels. For quantitative analysis, a square region of interest was placed on the center of each segment which was used for visual analysis, and relative regional activity to the normal reference region was calculated for each segment. By visual interpretation of the images, exercise Tc-99m tetrofosmin imaging showed a smaller defect size than exercise thallium-201 imaging (6.9 +/- 3.9 vs 8.8 +/- 3.0 segments, p <0.01). In contrast, rest Tc-99m tetrofosmin imaging showed a defect size similar to that on reinjection thallium-201 imaging (5.9 +/- 3.6 vs 5.6 +/- 3.9 segments, p = NS). Similarly, the mean defect sizes during exercise determined by quantitative analysis were smaller on Tc-99m tetrofosmin SPECT than those on thallium-201 SPECT at all tested threshold cutoff points ranging from 50% to 70%, whereas there were no significant differences in defect sizes between rest Tc-99m tetrofosmin and reinjection thallium-201 imaging. These data indicate that exercise Tc-99m tetrofosmin SPECT defect size determined either by visual analysis or by quantitative analysis may be smaller than on exercise thallium-201 SPECT.

Aged↗

Effect of the menstrual cycle on standard achromatic and blue-on-yellow visual field analysis of women with migraine.

BACKGROUND: It has been postulated that migraine and glaucoma may have common vascular causative factors. Significant sex-based differences in the incidence of many important ocular conditions raise the possibility that estrogens may have direct effects on the eye. We performed a study to determine the effect of the menstrual cycle on standard achromatic automated perimetry (SAP) and short-wavelength automated perimetry (SWAP) (blue-on-yellow perimetry) of women with migraine. METHODS: Both eyes of 73 normally menstruating women (31 subjects with migraine and 42 healthy control subjects) were included in the study. Subjects underwent a complete ocular examination including SAP and SWAP in both the follicular phase (12th to 13th day of the cycle) and the luteal phase (1 to 2 days before the onset of bleeding) of two consecutive menstrual cycles.We performed visual field analysis using the Humphrey Field Analyzer II with the full-threshold central 30-2 program. Mean sensitivity was calculated for the superior temporal, inferior temporal, superior nasal and inferior nasal regions separately. RESULTS: Thirteen subjects were lost to follow-up (5 in the migraine group and 8 in the control group), leaving 26 subjects and 34 subjects respectively. There was no significant difference in mean age between the two groups (33.9 years [standard deviation (SD) 3.4 years] vs. 35.1 years [SD 3.3 years]). The mean duration of migraine was 7.6 (SD 3.1) years (range 3-14 years). In both groups, serum estradiol levels were significantly lower (p = 0.001) and serum progesterone levels were significantly higher (p < 0.001) in the luteal phase than in the follicular phase. In the control group, the mean sensitivity values with SWAP were significantly lower in the luteal phase than in the follicular phase (p = 0.04). A similar decrease was observed for the subjects with migraine with both SAP and SWAP (p = 0.01). There was no difference in regional mean sensitivity between the two phases with either perimetric test in the control group. For the subjects with migraine, there was no difference in regional mean sensitivity between the two phases with SAP. However, with SWAP, the mean sensitivity for the nasal visual field locations was significantly lower in the luteal phase than in the follicular phase (p = 0.01). INTERPRETATION: Our study provides further evidence of an effect of sex hormones on the visual field of women with migraine. In addition to assessment of intraocular pressure, menstrual cycle phases should be considered in women with migraine at risk for glaucomatous optic neuropathy.

Adult↗

scSNViz: visualization and analysis of cell-specific expressed SNVs.

MOTIVATION: Accurately characterizing expressed genetic variation at the single-cell level is essential for understanding transcriptional heterogeneity, allelic regulation, and mutational dynamics within complex tissues. However, few tools enable comprehensive visualization and quantitative analysis of expressed variants across individual cells. RESULTS: scSNViz is an R package for the exploration, quantification, and visualization of expressed single-nucleotide variants (SNVs) from cell-barcoded single-cell RNA sequencing (scRNA-seq) data. The software supports estimation of variant allele fractions, clustering of SNV expression profiles, and 2D and 3D visualization of individual SNVs or user-defined SNV groups. Beyond visualization, scSNViz facilitates investigation of cell-, cluster-, or lineage-specific variant expression patterns, as well as allelic dynamics including imprinting, random allele inactivation, and transcriptional bursting. It interoperates seamlessly with established single-cell frameworks-Seurat for clustering, Slingshot for trajectory inference, scType for cell-type annotation, and CopyKat for copy-number profiling-enabling integrative multi-omic analyses of expressed variation. AVAILABILITY AND IMPLEMENTATION: scSNViz is implemented in R and freely available at https://github.com/HorvathLab/scSNViz (DOI: 10.5281/zenodo.17307516). The package includes comprehensive documentation and example workflows designed for users with limited bioinformatics experience.

Software↗

Human intelligence and power spectral analysis of visual evoked potentials.

The relationship between intelligence and power spectra of visual evoked potential was investigated using 8 normal and 8 mentally retarded children as subjects. The results showed the power spectrum of mentally retarded has a peak at 4 to 6 Hz, whereas that of normal has two apparent peaks at 4 and 12 Hz. It appears the peak at 12 Hz reflects the difference of intelligence.

Adolescent↗

[Quantified EEG in the diagnosis of Alzheimer's type dementia].

79 subjects (mean age 70.2 ans, 31 males, 48 females) selected as probable dementia of the Alzheimer type, at the early stage of the disease and 17 normal aged people (mean age: 72.2, 5 males, 12 females) were recorded with a 16 channel computerized-EEG (C-EEG) with topographical analysis of the observed changes and with classical visual analysis of the EEG. Quite simple C-EEG parameters as mean dominant frequency (MF) and alpha to theta ratio are able to discriminate patients from normal with a greater accuracy than visual analysis. The values of 8.6 for the MF and 1.3 for the alpha/theta ratio are proposed as cut off values between normal and DAT patients. The topographical analysis appear to be of no additional usefulness in the discrimination of the two groups.

Aged↗

Time-resolved analysis and visualization of dynamic processes in living cells.

Recent development of in vivo microscopy techniques, including green fluorescent proteins, has allowed the visualization of a wide range of dynamic processes in living cells. For quantitative and visual interpretation of such processes, new concepts for time-resolved image analysis and continuous time-space visualization are required. Here, we describe a versatile and fully automated approach consisting of four techniques, namely highly sensitive object detection, fuzzy logic-based dynamic object tracking, computer graphical visualization, and measurement in time-space. Systematic model simulations were performed to evaluate the reliability of the automated object detection and tracking method. To demonstrate potential applications, the method was applied to the analysis of secretory membrane traffic and the functional dynamics of nuclear compartments enriched in pre-mRNA splicing factors.

Animals↗