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PubMedDate not supplied

[Pathogenesis of functional retardation of physical and sexual development in adolescents. Status of somatotropic and gonadotropic function].

A study of somatotropic and gonadotropic functions in male adolescents with functional retardation of physical and sexual development has shown an important role of the deficiency of gonadotropins, especially FSH, in the pathogenesis of this condition. LH secretion in retarded physical development (RPD) is lowered to a lesser degree and positively correlates with testosterone deficiency. The feedback in the hypothalamohypophyseogonadal function in RPD is less frequently affected and to a lesser degree than gonadotropic functions. Of the tested methods (tests with TRH, L-DOPA and bromocriptine) STH reserves are better revealed with L-DOPA and TRH tests, gonadotropic reserves, especially LH,--with TRH and bromocriptine tests. The stimulating TRH effect on the growth hormone is indicative of the versatility and nonspecificity of its action on the pituitary gland in functional developmental disorders.

Adolescent↗

PubMed1986

The graft-versus-host reaction and immune function. IV. B cell functional defect associated with a depletion of splenic colony-forming units in marrow of graft-versus-host-reactive mice.

Studies were conducted to determine whether a functional B cell defect occurred in the bone marrow of mice experiencing a GVH reaction (GVHBM). GVH reactions were induced in AxCBA F1 adult mice by an injection of A strain lymphoid cells. The GVH reaction was confirmed by immunosuppression and thymus histology. At various intervals after GVH induction, GVHBM was tested for its ability to restore B cell function in adult thymectomized irradiated mice reconstituted with normal thymocytes. GVHBM cells obtained seven days after GVH induction restored but slightly the plaque forming cell (PFC) response to sheep erythrocytes and the mitogen response to lipopolysaccharide (LPS). GVHBM cells obtained 10 days or later failed to reconstitute the PFC or LPS responses. GVHBM cells suppressed neither the T or B cell function of normal spleen cells nor the LPS mitogen response of normal bone marrow cells. In addition, the splenic colony-forming units (CFU-s) in GVHBM were slightly decreased by day 10 after GVH induction and markedly depressed by day 22 after GVH induction. These results suggest that the GVH reaction may affect two different events in B cell differentiation. The early decrease in functional B cells that occurs before there is any change in the CFU-s population suggests a direct effect on B cell production, whereas the later absence of functional B cells could be due to the marked decline in stem cell production (CFU-s).

Animals↗

PubMed1978

Obesity and thyroid function. 3. Relationship between some indicators of thyroid function and the energy metabolism of striated muscle in obese women.

1. In a group of 23 obese women the relations between some indicators of thyroid function (thyroxine-binding globuline--T4BG, triiodothyronine-binding globuline--T3BG, Achilles tendon reflex--ART) on the one hand and activities of enzymes of the energy metabolism (hexokinase--HK, triose phosphate dehydrogenase--TPDH, lactate dehydrogenase--LDH, glycerol-3-phosphate dehydrogenase--GPDH, citrate synthease--CS, malate dehydrogenase--MDH, hydroxyacyl--COA dehydrogenase) in the quadriceps femoris muscle on the other hand were investigated. 2. Correlations were found between T4BG and TPDH, LDH and GPDH activities, between T3BG and TPDH and GPDH activities and between the value of the Achilles tendon reflex and TPDH activity. Functionally these enzymes activities are associated with glycolysis and hydrogen transport from cytoplasmatic NADH2. No correlations were found between enzymes of the aerobic metabolism incl. enzymes of fatty acid oxidation and indicators of thyroid function. 3. The results indicate a relationship between thyroid function and enzymes involved in glycolysis and hydrogen transport from cytoplasmatic NADH2. They do not suggest, however, the unequivocal conclusion that in obese women with reduced thyroid function there is a generally reduced energy supplying metabolism in skeletal muscle.

Achilles Tendon↗

PubMed1984

Functional analysis of human T cell subsets defined by monoclonal antibodies. VI. Distinct and opposing immunoregulatory functions within the OKT8+ population.

In the present study, we investigated the immunoregulatory potential of OKT8+ cells after in vitro activation. Initial studies had demonstrated that the T cell marker OKT4 identifies T cell sets containing helper cells, whereas OKT8 reacts with the suppressor and cytotoxic T cell effectors. More detailed analysis of the OKT4+ subset, however, demonstrated that there is functional heterogeneity in the OKT4+ population. The evidence for this heterogeneity arose from studies on (1) the relative radiosensitivities of the distinct immunoregulatory functions of cells contained within this set, and, (2) the effects of the state of activation of this population on immune function. For example, OKT4+ cells included radiosensitive helper cells, radioresistant helper cells, and radiosensitive inducers of suppressor cells. Furthermore, after activation, the OKT4+ population also contained cells capable of suppressing B cell differentiation. Since activation of the OKT4+ population results in the emergence of cells with counterbalancing immunoregulatory properties, it was of interest to determine whether the state of activation of the OKT8+ population influences the immunoregulatory potential of this subset. In the experiments reported here E+ cells were cultured with pokeweed mitogen (PWM) for 60-70 h and then thoroughly depleted of OKT4+ cells, leaving OKT8+ cells. The ability of the PWM-activated OKT8+ cells (first culture) to exert suppressive activity was determined by adding graded numbers of these cells to fresh autologous OKT4+ cells and B cells. The cell mixtures were cultured in the presence of PWM for 5 days and then assayed for plaque-forming-cell (PFC) activity by the reverse hemolytic plaque assay. Our studies demonstrate that activation of OKT8+ cells results in the emergence of cells with apparently counterbalancing immunoregulatory properties. Activated nonirradiated OKT8+ cells consistently suppressed B cell immunoglobulin production. However, the immunoregulatory function mediated by irradiated activated OKT8+ cells is highly dependent on the magnitude of the helper activity obtained with fresh OKT4+ cells. Thus, irradiated activated OKT8+ cells suppressed the generation of PFC only when the level of helper activity was optimal. However, when the level of help was not optimal, no suppressor activity was observed; rather, under these conditions, irradiated activated OKT8+ cells amplify the PFC response. We would emphasize that the amplification function of irradiated OKT8+ cells depends strictly on the presence of fresh OKT4+ cells. Irradiated activated OKT8+ cells alone are not helper cells, since addition of these cells to B cells thoroughly dep

Antibodies, Monoclonal↗

PubMed1983

Terbutaline serum concentrations related to different lung function parameters and beta-receptor function.

In eight asthmatic and six normal subjects serum terbutaline concentrations were correlated with changes in FEV1, MEF50%, Gaw, sGaw, and plasma cAMP concentrations after administration of 0.5 mg terbutaline subcutaneously, 5 mg orally, and an oral placebo. In asthmatics and normals the changes in serum terbutaline levels and plasma cAMP levels were closely correlated and in the same range. No change in lung function parameters was registered in normals, whereas in asthmatics a significant improvement was shown. In asthmatics all lung function parameters closely parallelled the changes in serum terbutaline concentrations and cAMP plasma concentrations, the FEV1 being the least variable lung function parameter. The maximal effect in FEV1 occurred 30-60 min after the subcutaneous dose and 2-4 h after the oral dose. The FEV1 improvement showed a linear relationship with the serum terbutaline concentration between 1.6 and 6 ng/ml. In contrast with theophyllines and anticholinergics, serum terbutaline concentrations showed a very low interindividual variance. Nevertheless it appeared that prediction of a certain improvement in lung function was not possible on the basis of the serum concentration. Since changes in plasma cAMP values after terbutaline therapy were similar in normals and asthmatics, the lung function improvement in the asthmatics suggests that if a beta-adrenergic defect exists, this must be mainly situated in the lung tissue.

Adult↗

PubMed1995

[Functional and anatomical results after surgical treatment of ruptures of the rotator cuff. 2: postoperative functional and anatomical evaluation of ruptures of the rotator cuff].

PURPOSE OF THE STUDY: The authors examined the anatomic condition and the function of the rotator cuff obtained after an average period of four years following surgical repair in a series of 100 full thickness rotator cuff tears. The aim was to assess the validity of Constant's scoring method and to analyse risk factors and the frequency of recurrent tears. MATERIAL AND METHODS: The series comprised 98 patients, 62 men and 36 women whose average age was 56 years. It included 69 tears of less than 2 cm in size (39 cases) or between 2 to 4 cm (3 cases) of the supra-spinatus, 22 tears of the supra- and infraspinatus measuring between 2 to 4 cm, and 9 massive tears. The tendon of the long head of the biceps was pathological in 1/3 of cases. All 98 patients were operated on by the same surgeon using the same repair technique, and all followed ambulatory rehabilitation along the same principles of self-rehabilitation applied pre operatively. In each patient function was assessed using Constant's scoring method, and the condition of the repaired cuff was determined by ultrasonography at the time of clinical follow-up. The average follow-up period was 4 years (2 to 6 years). RESULTS: Ultrasonography revealed intact cuffs in 65 per cent, thinned cuffs in 11 per cent and recurrent full thickness tears in 24 per cent of cases. The risk of recurrent tear increased with the extent of the tear to be repaired (57 per cent), in older patient (25 per cent) and with a higher level of post-surgical occupational use (18 per cent). A drop in the post-operative Constant score had a predictive value for a full thickness recurrent defect. DISCUSSION: Constant's scoring method appears to be a reliable, reproducible method for analysing functional results following surgical repair of full thickness cuff tears and to reflect the anatomic condition of the repaired cuff. At clinical follow-up, the anatomic condition of the cuff is more determinant of final functional results than initial tear size. CONCLUSIONS: Assessment of functional results must be complemented by anatomic examination using ultrasonography in order to specify the size of any possible recurrent defect and to detect thinning of the cuff which cannot be identified by Constant's score. Analysis of the risk factors for recurrent tear led the authors to question the necessity of repairing massive tears in older patients and pointed to the valuable advantages of reinforcing fragile cuffs during initial repair especially in very active patients.

Adult↗

PubMed1995

Congenital deficiency of histidine-rich glycoprotein: failure to identify abnormalities in routine laboratory assays of hemostatic function, immunologic function, and trace elements.

Histidine-rich glycoprotein (HRGP) has many biologic activities, but its physiologic function is still unclear. To show the physiologic function of HRGP, we studied five patients with congenital HRGP deficiency. Hemostatic screening tests, activities of natural anticoagulants and fibrinolytic proteins, markers of thrombin and plasmin generation, plasma levels of platelet-specific proteins, thrombin times with various concentrations of bovine thrombin, prolongation of thrombin time after addition of heparin or demartan sulfate, and contact activation of blood coagulation were normal or nearly normal in these patients. Serum concentrations of immunoglobulin, functional activity of the classical and the alternative pathway of complement, lymphocyte subsets, and serum concentrations of soluble interleukin-2 receptor were approximately normal in all patients, and serum concentrations of copper and zinc were completely normal. These results suggest that the physiologic functions of HRGP are limited when compared with its biologic activities. However, because the patients examined had plasma HRGP levels of 20% to 35% of normal, it is possible that 20% of normal HRGP level is sufficient for its physiologic functions.

Antigens, CD↗

PubMed1994

Functional and physical characterization of the cell cycle ubiquitin-conjugating enzyme CDC34 (UBC3). Identification of a functional determinant within the tail that facilitates CDC34 self-association.

Like several other ubiquitin-conjugating enzymes, the yeast cell cycle enzyme CDC34 (UBC3) has a carboxyl-terminal extension or tail. These tails appear to carry out unique functions that can vary from one ubiquitin-conjugating enzyme to the next. Using biophysical techniques we have determined that the tail of CDC34 constitutes a highly structured and extended domain. Although the tail of CDC34 is the largest tail identified to date (125 residues), we have found that only 39 residues lying adjacent to the catalytic domain are necessary and sufficient for full cell cycle function and that this region fulfills a novel function that may be common to the tails of other ubiquitin-conjugating enzymes. Cross-linking studies demonstrate that this region facilitates a physical interaction between CDC34 monomers in vitro. Furthermore, phenotypic analysis of various CDC34 derivatives expressed in different cdc34 mutant strains indicates that this region facilitates the same interaction in vivo. Based on these findings, it appears that the cell cycle function of CDC34 is dependent upon the ability of CDC34 monomers to interact with one another and that this interaction is mediated by a small region of the CDC34 tail. The similarity of this region with sequences contained within the tails of the UBC1 and UBC6 enzymes suggests that these tails may function in a similar manner.

Anaphase-Promoting Complex-Cyclosome↗

PubMed1978

Adherent cell function in murine T lymphocyte antigen recognition. II. Definition of genetically restricted and nonrestricted macrophage functions in T cell proliferation.

The mechanisms by which adherent cells, presumably of mononuclear phagocytic lineage, influence in vitro antigen-specific activation of murine T lymphocytes was examined. Two distinct functions for macrophages could be discerned. One macrophage function is dependent on a soluble factor produced by cultured adherent cells and is most easily studied with complex multideterminant antigens. This factor is neither antigen-specific nor MHC-restricted in its action in that PEC, regardless of haplotype, produce factor in the absence of antigen. A second function, antigen-specific T cell activation, is seen when antigens of more restricted heterogeneity are used, such as those under the control of Ir genes. This latter activity demands identity or partial identity between the antigen-presenting cell and the primed T cell, thus suggesting an additional specific, genetically restricted function for macrophages in in vitro antigen recognition. Whether these adherent cell functions are mediated by all or distinct subsets of cells was not established.

Animals↗

PubMed1993

Functional imaging in computed tomography. The use of contrast-enhanced computed tomography for the study of renal function and physiology.

RATIONALE AND OBJECTIVES: Computed tomography (CT) numbers may provide the raw material for calculations of important physiologic parameters, such as organ regional perfusion and glomerular filtration rate. Because, except in cases of severe renal dysfunction, iodinated intravascular contrast agents are excreted primarily by passive glomerular filtration, the decline in their concentration in blood or tissues will reflect renal function. The time evolution of contrast agent distribution within the kidney, from blood to tubules, can also be seen as a measure of renal function. The authors illustrate how CT numbers may be employed to obtain useful data regarding renal function. METHODS: Two CT methods were used to yield information on renal function. Delayed CT: 2 hours after administration of 200 mL of a contrast agent (iohexol) for a routine CT, a patient with normal renal function was brought back to the scanner, and a single fixed section through the abdomen, including the psoas muscles, was imaged; the scan was repeated at 2, 3, and 4 hours. Large regions of interest were selected in soft tissue, and six measurements of CT numbers were taken and averaged for each time; after taking logs, these were plotted against time. Dynamic CT: A rapid bolus of 40 mL nonionic contrast agent was injected into an antecubital vein at 5 mL/sec. At a fixed level, images were taken through the center of the kidneys at 5-second intervals for 2 minutes after injection. The patient was allowed to breathe gently throughout the examination. Regions of interest were selected over the kidney and the aorta, and curves of CT numbers against time were generated; a Patlak plot was performed using the parameters measured. Using the renal CT numbers collected during the first 2 minutes after injection, it was possible to analyze the handling of the contrast agent and to obtain a measure of the glomerular filtration rate. RESULTS: Delayed CT: Data yielded good values for glomerular filtration rate; the typical patient illustrated had a glomerular filtration rate per unit extracellular fluid volume of 0.005 min-1. Dynamic CT: The correlation coefficient for the line fit was 0.97, a value typically found in these studies, indicating the efficacy and ruggedness of this method in spite of the patient's shallow breathing throughout the examination. CONCLUSIONS: Computed tomography offers the potential for quantitative and physiologic measurement that has not been widely explored. The problem with the delayed CT technique is that since measurements are made at 2 hours and onward, it is applicable only to patients who have received larger doses of contrast. Otherwise, the CT numbers are low and the measurement error, large. Also, bringing the patient back to the scanner 2 hours later may be inconvenient to both patient and radiologist, and may disrupt case scheduling. This method is, however, less inconvenient than the established blood-level measurement. The dynamic CT method yields a new measure of renal clearance, namely, clearance per unit volume of kidney. The disadvantages of this method are the radiation burden involved in repeated rapid CT scans and the fact that, if renal disease is uneven, a nonrepresentative slice could be chosen. Its advantages are its simplicity and that it can be completed within the first 2 minutes of a CT examination. It may be expected to have an interesting application to situations in which there is known renal disease. Although difficulties are associated with both of these techniques that could prevent their general adoption as clinical routines, they nevertheless should find application in selected patients and should prove useful research tools in the study of renal disease.

Contrast Media↗

PubMed1993

Premorbid functioning, cognitive functioning, symptoms and outcome in schizophrenia.

In this study we examined the relationship between premorbid functioning, outcome, cognitive functioning and positive and negative symptoms of schizophrenia. Cognitive functioning and symptoms were examined longitudinally in a sample of 39 subjects with schizophrenia (according to the DSM-III criteria). Subjects were assessed at admission to hospital and six months later during a period of relative remission. Premorbid functioning was significantly associated with negative symptoms but not with positive symptoms at both the acute phase and the remitted phase of the illness. Outcome was also associated with negative symptoms at admission and with both positive and negative symptoms at follow-up. Deficits on cognitive tests of verbal reasoning and concept formation were significantly associated with poor premorbid functioning and outcome.

Adolescent↗

PubMed1995

Functional MR imaging in the evaluation of the patient with epilepsy. Functional localization.

Functional magnetic resonance imaging is able to define noninvasively the location of eloquent cortex responsible for speech, motor, and visual function, and it holds promise for localizing other important functional tissues in the future. Such localization is extremely important to the epileptologist and surgeon planning surgical resection of an epileptic focus. Early work identifies the actual seizure focus using similar techniques. Magnetic resonance, with functional magnetic resonance added to high-resolution magnetic resonance imaging and magnetic resonance spectroscopy, has the potential of providing, in a cost-effective manner with one noninvasive modality, the functional, anatomic, and chemical parameters pertinent to the management of the seizure patient.

Brain↗

PubMed1996

[Super selective amytal test for functional evaluation of the brain--a less invasive functional test].

In the neurosurgical field, it is very important to evaluate localized function of the affected region preoperatively. In order to investigate lateralized and localized brain function, we have developed an alternative to the original Wada test, and refer to it as the super selective amytal test (SSAT). We performed super selective catheterization of the target artery after conventional carotid angiography, injected Amytal (amobarbital, 30-100 mg) through a micro-catheter, and identified potential local function. In ten cases, including AVM, aneurysm, and brain tumor, we investigated localized function of the affected site preoperatively by SSAT, and chose our treatment based on the results of this test. There was a good correlation between the results of the SSAT and the results of surgery in every case. There were no prolonged neurological complications of this test. Evaluation of the results of the SSAT should be interpreted under precise DSA control, since blood flow in the brain differ among individuals. This test may contribute to our knowledge of localized function in the cerebral cortex and deep brain areas in neurosurgical patients.

Adult↗

PubMed1997

[Functional MRI of higher brain function with gradient echo on clinical MR unit].

MR imaging of brain function has been successfully performed at 1.5 T clinical MR unit. In the early studies, functional MRI were performed with simple stimulation such as visual and motor. Recently, many investigators have attempted to demonstrate the specific brain localization of higher brain functions such as memory, imagination, language and so on. In this study, we attempted the functional MRI for motor and word imagination with gradient echo sequences on clinical MR unit. In our experiences, motor cortex was activated on motor imagination task and Broca area was activated on word imagination task, respectively. We demonstrated the higher brain functions were able to be demonstrated on clinical MR unit with gradient echo sequences.

Frontal Lobe↗

PubMed1997

Functional magnetic resonance imaging of visual function in postpapilledema optic atrophy.

We studied a girl with intraventricular brain tumor who developed postpapilledema optic atrophy and severe concentric visual field constriction in both eyes. The patient had mild symptoms despite severe visual field loss. We performed functional magnetic resonance imaging using two kinds of visual stimulation to assess her residual visual function. The functional magnetic resonance imaging demonstrated that the activity in her association visual cortex was largely intact bilaterally, although the activation of the calcarine cortex was decreased in the left calcarine cortex. Her activity in the visual cortex seemed to correspond well to her visual symptom. Functional magnetic resonance imaging may be useful in objectively documenting residual visual function in patients with severe visual loss.

Adolescent↗

PubMed1997

[Relationship between systolic and diastolic function of the left ventricle in patients with impaired relaxation of the left ventricle without symptoms of heart failure. Attempt at quantitative estimation of diastolic function in the impaired relaxation stage].

UNLABELLED: Diastolic dysfunction of left ventricle appears very often in patients with coronary artery disease (CAD) and hypertension (HT) and is a main cause of heart failure in 30-40% of all cases. Relation between systolic and diastolic function of left ventricle (LV) is commonly known but not documented well enough. Moreover, no quantitative classification of diastolic dysfunction is still available. AIM OF THE STUDY: To find out the relations between the parameters of systolic and diastolic function of LV in patients with CAD or HT with impaired relaxation of LV without symptoms of heart failure and to make up the quantitative classification of diastolic dysfunction in the stage of impaired relaxation of LV. METHODS: Investigations were carried out in 57 patients (mean age 55.5 +/- 11.5) with angiographically proven CAD and in 91 patients (mean age 56.3 +/- 10.6) with HT and angiographically excluded CAD, all without regional myocardial contractility abnormalities and valvular heart diseases. Control group consisted of 54 healthy subjects (mean age 55.4 +/- 11.4). During 2D echocardiography examination left ventricular end-diastolic (LVEDD) and end-systolic diameters (LVESD) and left atrial dimension (LA) were obtained. Using Doppler method transmitral inflow indices: E velocity (E), A velocity (A), E velocity integral (E-VTI), A velocity integral (A-VTI), total velocity integral (T-VTI), E deceleration time (DT), isovolumic relaxation time (IVRT) and aortic flow velocity integral (Ao-VTI) were measured. Only patients with E/A < or = 1 and--to exclude pseudonormalization of mitral inflow--with DT > or = 140 ms were qualified to the study. We proposed diastolic dysfunction ratio (DDR) calculated from formula: DDR = E/A x E-VTI/T-VTI. Using AFVI, LV outflow diameter, heart rate (HR) and body surface area cardiac index (CI) was calculated. RESULTS: In studied group there were significantly higher values of LA, A, IVRT, DT and lower values of E, E/A, E-VTI and DDR compared to controls. There were no significant differences between these groups in HR, LVEDD, LVESD, T-VTI and CI. No significant differences in any of studied parameters were found between subgroups with CAD and HT. Among healthy subjects in subgroup with abnormal mitral inflow pattern (E/A < or = 1) there were significantly higher values of LA, IVRT, DT and lower values of DDR than in sugroup with normal one. Both subgroups did not differ in LVEDD, LVESD, CI. In the studied group there was positive correlation between DDR and CI (r = 0.69, p < 0.001), DDR and IVRT (r = 0.71, p < 0.001), DDR and DT (r = 0.61, p < 0.001), CI and E (r = 0.34, p < 0.01), CI and IVRT (r = 0.52, p < 0.001), CI and DT (r = 0.42, p < 0.001), CI and E/A (r = 0.54, p < 0.001), CI and E-VTI (r = 0.43, p < 0.001). In the control group significant correlation was found only between DDR and IVRT (r = 0.64, p < 0.02) and between DDR and DT (r = 0.52, p < 0.02) but not between DDR and CI. Using DDR DD was divided into 3 classes: class I with DDR > 0.47, class II with 0.47 > or = 0.30, and class III with DDR < 0.30. Applying of such intervals of values of DDR determined the groups which significantly differed between themselves in CI, IVRT and DT. CONCLUSIONS: (1) In patients with CAD or HT with impaired relaxation of LV without symptoms of heart failure there is relation between parameters of systolic and diastolic function of LV: the more advanced diastolic dysfunction, the more impaired systolic function. (2) In healthy subjects there is no relation between parameters of systolic and diastolic function of LV. (3) DDR is a good indicator of quantitative estimation of diastolic dysfunction in the stage of impaired relaxation of LV.

Adult↗

PubMed1998

[A modified method of cardiac functional analysis for ECG gated SPECT: study of functional G-maps].

To evaluate the cardiac function accurately using ECG gated SPECT images, we performed a modified method of cardiac functional analysis (Functional G-maps). One hour after the intravenous injection of 1,110 MBq of 99mTc-tetrofosmin, gated SPECT data was acquired dividing a cardiac cycle into 12 frames. Every short-axis images were usually reconstructed using first 11 of 12 frames. The reconstruction of these images was repeated performing slice thickness correction. Because the apex-to-base length is different at any frame during a cardiac cycle, 10 slices of short-axis images were obtained with the same thickness for each frame. Subsequently each short-axis image was divided by 40 radii, and the time activity curve was generated from the total counts included in each segment plus both neighboring segments. Afterwards the curve fitting was performed using the second reverse Fourier function. From fitted curves and their differentials, we estimated a variety of parameters including Max (End-systolic count), Min (End-diastolic count), %CI (Percent count increase), Uptake, PCR (Peak contraction rate), PDR (Peak distention rate) and CT (Contraction time). In 5 normal subjects, %Max was greater in the anterior and septal regions, whereas %Min was greater in the apex and lateral regions. %CI and %PCR were similarly greater in the septal, anterior and inferior regions. On the other hand, %PDR in the lateral or inferior region was lower than the values in the other regions. In conclusion, this modified method is expected to be useful for accurate assessment of regional cardiac function and myocardial perfusion.

Adult↗

PubMed1996

Enhanced effects of bleomycin on pulmonary function disturbances in patients with decreased renal function due to cisplatin.

We examined whether cisplatin-induced nephrotoxicity augmented bleomycin-induced pulmonary toxicity in patients with testicular cancer treated with etoposide and cisplatin with (BEP) or without bleomycin (EP). Before and at 3-week intervals during chemotherapy, creatinine clearance and lung functions were measured. In patients receiving BEP, deterioration of renal function correlated with a decrease in transfer factor of the lungs for carbon monoxide (TLCO) and vital capacity (VC), parameters known to reflect bleomycin-induced pulmonary effects. Other lung functions did not correlate with renal function. In the EP group, no relationships were observed at all. These observations suggest enhanced pulmonary effects of bleomycin when combined with cisplatin. Therefore, attention should be paid to the potential development of bleomycin-induced pulmonary toxicity in patients treated with BEP.

Adolescent↗