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PubMed1994

[What should be the duration of a treatment with antidepressive agents?].

The main clinical factors involved in deciding the length of an antidepressant treatment are briefly reviewed in the framework of current classifications of affective disorders. History of previous episodes and the polarity of depressive illness have a major role in such a process. Current definitions of remission, relapse and recurrence are given. In the context of a single depressive episode, treatment must be continued for at least 4 months after the start of clinical improvement in order to prevent a relapse. In case of recurrent depressive episode, the indications of a long-term treatment must be discussed. Some issues unsettled as to the adequate dosage of such a treatment, as well as to the length of treatment in other types of depressive states.

Antidepressive Agents↗
PubMed1993

[Mianserin: pharmacology and clinical aspects of an effective antidepressive agents].

Among the non-tricyclic "newer" antidepressants, mianserin is one of the most thoroughly investigated agents. In the present review its chemical and pharmacological properties, as well as clinically relevant aspects of the use of this antidepressant are discussed. In the first instance, mianserin is indicated for the treatment of depressive illness associated with anxiety and agitation, even including severe forms of depression. Mianserin is characterised by a favourable side effect profile and low toxicity, and thus offers distinct advantages in the treatment of he elderly, as also in patients with a suicidal tendency.

Cerebral Cortex↗