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PubMed2004

[A cephalometric study of the craniofacial morphology in adult patients with unoperated cleft palate.].

PURPOSE: To evaluate the effects of cleft palate on the craniofacial morphology in adult patients with unoperated cleft palate by cephalometric analysis. METHODS: X-ray cephalometry was used for the study of craniofacial morphology carried out in 7 male and 8 female patients with unoperated cleft palate. Pointing measurements were done with the methods of Downs and Steiner. The data of the cephalometric measurements were compared with that of Guangxi native normal adults by t test. RESULTS: The unoperated cleft palate patient,s SNA,ANS-Ptm(FH) and L1-MP were smaller or shorter than those of normal group while Po-NB was longer. There was significant difference between the two groups (P<0.05 or 0.01). CONCLUSIONS: The deformities of adult patients with unoperated cleft palate were mainly considered to be that the anterior and posterior length of maxilla show hypoplastic while the vertical height of the maxilla the length of anterior cranial fossa and mandible was normal. But the retrusion of alveolar mandible led to chin protrusion.

Adult↗

PubMed1992

Minuscule submucous cleft palate. Cadaver study.

Otitis media is almost universal in cleft palate patients, at least during infancy. A lesser cleft manifestation, the occult submucous cleft palate, is identifiable in living patients by surgical dissection or flexible fiberoptic nasopharyngoscopy. We addressed the hypothesis that an even more subtle form of submucous cleft palate, involving both an abnormal musculus levator veli palatini and an abnormal musculus uvulae, is associated with otitis media. We studied 35 adult human cadaver specimens for histologic and infrared photographic transillumination evidence of what we have identified as the minuscule submucous cleft palate. None of the specimens had evidence of clinical otitis media, or clinical abnormality of the palate. Approximately one fifth of the specimens had evidence of minuscule submucous cleft palate: minimal bulk of the musculus uvulae and haphazard organization of the fibers of the musculus levator veli palatini. These data support the nasopharyngoscopic inference that in occult submucous cleft palate, there is both hypoplasia of the musculus uvulae and abnormal orientation of the fibers of the musculus levator veli palatini. Although not significant statistically, a trend was suggested for minuscule submucous cleft palate to be associated with indicators of prior otitis media.

Adult↗

PubMed2005

Septopalatal protraction for correction of nasal septal deformity in cleft palate infants.

OBJECTIVE: It is proposed to test the practicality of septopalatal protraction in the unilateral cleft palate infant for purposes of straightening the nasal septum and thus relieving nasal airflow obstruction and its detrimental sequelae. METHODS: Alternate infants affected with complete unilateral palatal clefts had septopalatal protraction for a period of 6 to 8 weeks (protraction group; n = 4). Septal deviation was measured by a standardized technique that used computed tomography scans. The remaining infants had no protraction and served as controls (nonprotraction group; n = 5). Septal deviation was measured in the nonprotraction group from palatoseptal dental molds. RESULTS: A total of 9 patients were studied. All patients in the nonprotraction group had worsening of nasal septal deviation over a period of 8 weeks compared with the protraction group, which had complete nasal septal straightening. Differences in septal angle deviation between the protraction group and nonprotraction group at the end of the study were statistically significant (P < or = 0.01) as measured by the paired Student t test. CONCLUSIONS: Septopalatal protraction in the newborn appears to provide a means for correcting nasal septal deviation in complete unilateral cleft palate infants. Septopalatal protraction in the newborn is relatively easy and safe.

Cleft Palate↗

PubMed1982

A three generation family study of cleft lip with or without cleft palate.

A family study of cleft lip, with or without cleft palate, was based on those treated by operation at The Hospital for Sick Children, London, between 1920 and 1939 in order to give information on the proportion affected of children and grandchildren. The probands were those who had survived, were successfully traced, and found to have had at least one child. Care was taken to exclude patients who were traced through a child, whether normal or affected, and not through the usual tracing procedure. Patients with recognised syndromes were also excluded. Because the series was based on patients who had survived and reproduced it was biased in favour of those with milder degrees of the malformation, and against those with any severe associated malformation. The proportion affected of children of probands was 3.15% (+/- 0.56), of sibs 2.79% (+/- 0.52), and of parents 1.18% (+/- 0.37), respectively. The lower proportion of parents affected is attributed to reduced reproductive fitness of patients born two generations ago. The proportion affected of nephews and nieces, aunts and uncles, and grandchildren was 0.47% (+/- 0.18), 0.59% (+/- 0.13), and 0.8% (+/- 0.6) respectively. The proportion affected of first cousins was 0.27% (+/- 0.08). The birth frequency of cleft lip (+/- cleft palate) is estimated to be about 0.1% in England. There were two first cousin and one second cousin marriages among the marriages of the parents. There was no increase of cleft palate among the relatives of the probands. The proportion of sibs affected increased with increasing severity of the malformation in the proband, where the proband was female, and where the proband had an affected parent or already had one affected sib. It was not, however, increased where a more remote relative was affected. The proportion of children affected was not increased when the proband had an affected parent or sib, but few families provided information. The most economical hypothesis to explain the findings is the multifactorial threshold model. The birth frequency of the malformation and the family patterns found make it improbable that one single mutant gene makes a major contribution to the liability to develop the condition.

Adult↗

PubMed1997

Musculature of the soft palate: clinico-anatomic correlations and therapeutic implications in the treatment of cleft palates.

OBJECTIVE: Hypoplasia of the maxilla, often described as a classic sequela to surgical repair of the cleft palate, has been rare in our experience. We believe that our surgical technique, which includes dividing the nasal mucosa and the abnormal muscular insertions at the posterior border of the hard palate, is an important factor in preventing this sequela. METHOD: We compared the anatomy of 12 normal palates in cadavers to the anatomy of cleft palates seen at operation and to the anatomy of one cleft palate in a fetus aged 34 weeks. RESULTS: In cleft palates, the muscular fibres have an abnormal sagittal orientation, inserting on the posterior border of the hard palate. CONCLUSION: The division of both the nasal mucosa and these abnormal muscular insertions at the posterior border of the hard palate enables the surgeon to eliminate the abnormal posterior pull of these fibers on the maxilla.

Cleft Palate↗

PubMed2006

Epignathus combined with cleft palate, lobulated tongue, and lingual hamartoma: report of a case.

A case of epignathus combined with cleft palate, lobulated tongue, and lingual hamartoma is reported. A newborn female presented with a large skin-covered mass arising from the palate, cleft palate, and lobulated tongue with a soybean-sized lingual lesion. The palatal and lingual masses were removed on the 9th day after birth. A cystic lesion was also found on the nasal septum after removal of the palatal mass; this lesion was resected at its base. Glossoplasty was performed after excision of the lingual lesion. Histologically, the palatal mass was diagnosed as epignathus. The cystic lesion was suspected to be meningothelial tissues on the basis of hematoxylin-eosin (HE) and immunohistochemical staining: Vimentin and epithelial membrane antigen were positive, and factor VIII was negative. The mass of the tongue dorsum was diagnosed as hamartoma. No recurrence of epignathus or evidence of meningocele have been observed after 5 years of follow up.

Abnormalities, Multiple↗

PubMed1994

"Mask lifting" in orthomorphic facial correction of bilateral cleft palate.

In bilateral cleft palate patients, abnormal obliquity and narrowness of orbits are noted on radiographs, computed tomographic scans, and magnetic resonance imaging investigations. Deformity of bony structures (increase in transverse length) is sometimes associated with malposition of eyelids, which results in a typical antimongoloid facies. Five patients were treated, and we report our series to illustrate the problem and its correction using the "mask-lift" procedure, initially described by Tessier and Krastinova.

Cleft Lip↗

PubMed1993

Dermatoglyphics in cleft lip and cleft palate anomalies.

Dermatoglyphic characteristics of sixty nine cases of cleft lip with or without cleft palate and twenty eight isolated cleft palate cases were evaluated for digital patterns, interdigital patterns, palmar simian crease and sydney line, and model types of C- and D-line terminations. Increased frequency of ulnar and radial loops than the arches and whorls was observed in cleft lip with or without cleft palate patients compared to controls. Interdigital patterns were less frequent in cleft lip and cleft palate patients. Simian crease and Sydney line were more common in patients than in controls. Model types of C- and D-line terminations showed variations in patients and controls. Wider 'atd' angle (more than 30 degrees) and dermatoglyphic asymmetry were noted in the patient groups. The findings suggest the dichotomy or heterogeneity of cleft lip and cleft palate anomalies. The role and utility of dermatoglyphics in genetical etiology of congenital defects were emphasized.

Adolescent↗

PubMed2006

The lack of isolated palatal clefts in Czech Gypsies.

Orofacial clefts are usually divided into three basic types: isolated cleft lip (CL), cleft lip and palate (CLP) and isolated cleft palate (CP). The incidence of specific cleft types in a population and their relative numbers show specific differences between ethnic groups and races. However, there are no available data about the incidence and relative numbers of orofacial cleft types (CL, CLP, CP) in the gypsy ethnic group. The aim of this study was to compare relative numbers of specific types of orofacial clefts between the Czech gypsy and non-gypsy populations. We conducted a retrospective epidemiological study using a set of all living patients with orofacial clefts born in the Czech Republic from 1964 until 2002. The cleft patients were subdivided into three groups: 5304 non-gypsy children, both parents of whom were non-gypsies (NN), 98 gypsy children, both parents of whom were gypsies (GG) and 18 children with one parent non-gypsy and one parent gypsy (NG). The relative number of isolated CP was 37.1% in NN children. However, the relative number of CP was significantly reduced to 5.1% (P < 0.01) in the GG group. Conversely, the relative number of CLP was higher (P < 0.01) in the GG group (62.2%) in comparison to the NN group (39.2%). The tendency to decrease in the relative number of CP and increase in the relative number of CLP was also apparent in the NG group, but not so well expressed. We hypothesize that the decrease in CP and increase in CLP and CL in gypsies might be caused by their genetic predis-position to CL. Since the CP originates later than CL during embryonic development, some CP arise in embryos with already existing CL giving rise to CLP. Consequently, the missing isolated CP might be hidden in the group of CLP patients postnatally.

Cleft Palate↗

PubMed1996

Submucous cleft palate: diagnostic methods and outcomes of surgical treatment.

The following statements summarize our interpretation of the literature regarding submucous cleft palate: Incidence and Diagnosis of Submucous Cleft Palate 1. In surveys of classic stigmata of submucous cleft palate among the general population, the incidence has been reported to be 0.02 to 0.08 percent. In the larger of these series, the incidence of velopharyngeal inadequacy among patients identified to have submucous cleft palate was 1 to 9. The incidence of occult submucous cleft palate is not known, since these patients will only be detected during the evaluation of patients who present with velopharyngeal inadequacy. 2. The diagnosis of submucous cleft palate is made by identification of the classic stigmata on physical examination. The diagnosis of occult submucous cleft palate is only pursued if the patient has velopharyngeal inadequacy. 3. For consistency in evaluating and reporting data, patients with an overt cleft of the secondary palate that extends beyond the uvula should be reported as having a cleft palate, and not a submucous cleft palate, even if a submucous cleft exists in a portion of the palate anterior to the overt cleft. 4. The true incidence of otitis media with effusion in the presence of submucous cleft palate has yet to be determined using a prospective study. Surgical Treatment of Velopharyngeal Inadequacy in Patients with Submucous Cleft Palate 1. The technique that has most consistently been documented to result in a significant correction of velopharyngeal inadequacy is the pharyngeal flap. There is recent evidence from one large center supporting the efficacy of the Furlow Z-plasty in selected patients with submucous cleft palate. Both these procedures appear to be most effective in patients with good lateral pharyngeal wall motion. 2. If a pharyngeal flap is performed as the primary procedure to act as an obturator against which the lateral pharyngeal walls appose for closure, we do not see the need for adjunctive palatal procedures. The dynamic component of velopharyngeal competence following such a pharyngeal flap consists of lateral wall motion, which is not enhanced by further surgical manipulation of the palate. However, a pharyngeal flap may be performed as an adjunctive procedure to a palatal pushback in order to provide lining for the resultant defect in the nasal mucosa. 3. The present literature does not support "prophylactic" operations on patients who present with the physical stigmata of submucous cleft palate prior to reaching an age at which it can be demonstrated by perceptual speech assessment that velopharyngeal inadequacy remained refractory to speech therapy. A significant number of patients will never develop velopharyngeal inadequacy; therefore, surgery would be unnecessary. In addition, objective data regarding the outcomes of different surgical techniques cannot be gathered if patients with submucous cleft palate are operated on without having had velopharyngeal inadequacy documented prior to those operations. 4. In order to objectively compare the outcomes of different surgical techniques, any future studies should be prospective and utilize uniform means of assessment. As minimum criteria, these would include preoperative and postoperative perceptual speech assessments performed by a trained speech pathologist and preoperative nasopharyngoscopy and multiview videofluoroscopy. The latter two studies should be repeated postoperatively only in those patients who have persistent velopharyngeal inadequacy.

Age Factors↗

PubMedDate not supplied

Tongue-palate contact during selected vowels in children with cleft palate.

This study reports tongue-palate contact recorded using electropalatography (EPG) during five vowels /i/, /theta/, /I/, /o/ and /backwards c/ spoken by school-aged children with cleft palate and a group of normal speakers. All the children had articulation disorders affecting consonants but none had obvious vowel errors. Two measures were taken from the EPG data at the temporal midpoint of the vowels. The first identified the percentage of vowels produced with complete coronal constriction and the second calculated amount of contact. The results showed that children with cleft palate frequently produced the high vowel /i/ with complete constriction, with 40% of /i/ targets articulated in this way. There were lower percentages for /theta/ and /I/ and no complete constrictions during the lower vowels /o/ and /backwards c/. None of the normal speakers produced any vowels with complete constriction. In terms of amount of contact, the vowels ranked /i/>/theta/>/I/>/o/>/backwards c/, with /i/ having the most and /backwards c/ the least contact. Although this ranking held for both groups, the cleft group had more contact than normal speakers, especially during high vowels. Complete constriction is viewed as a clinically relevant phenomenon that blocks oral airflow and as a result increases nasal airflow during vowels.

Adolescent↗

PubMed1984

[Stimulation in the treatment of hard palate cleft].

It is rare to observe a cleft of the hard palate after operation for secondary cleft palate. Four such cases were treated using a plate developed by the author and corrector-stimulatory apparatuses. Total recovery was obtained in one case, and marked pre-operative reduction in the palatal cleft in two patients. Treatment was ineffective in the fourth case, a patient who had previously undergone five operations. Treatment by stimulation was given for periods between 14 months to 4 years.

Adolescent↗

PubMed2001

Prenatal diagnosis of cleft palate by three-dimensional ultrasound.

Prenatal diagnosis of cleft palate is very important to prenatal consultation and management after birth. To examine if three-dimensional (3-D) ultrasound (US) is an accurate diagnostic method for clinical use, we analyzed our experience in detecting cleft palate by 3-D US. From June 1996 to January 2000, 21 fetuses with facial clefts were scanned by 2-D US, as well as by 3-D US. The coronal and oblique planes were reconstructed by 3-D US to detect the cleft palate. In addition, level II US was performed to find any possibly associated anomalies. All the scans were recorded on optic disks for final analysis. In our study, the gestational age when prenatal diagnosis was made by US initially was between 20 and 34 weeks. The accuracy for prenatal diagnosis of cleft lip with or without cleft palate by 3-D US was 100%, which was superior to that by 2-D US (p < 0.05). In addition, we proposed a novel method to evaluate the cleft palate systemically by 3-D US. In conclusion, from our study, fetuses with cleft lip combined with or without cleft palate can be easily differentiated by 3-D US. The reconstruction of coronal and oblique planes by 3-D US is a powerful tool for detecting cleft palate.

Cleft Lip↗

PubMed1992

Incidence and management of middle ear effusion in cleft palate patients.

For a complete overall rehabilitation of cleft palate patients a multi-disciplinary approach should be adopted. Plastic and Head and Neck Surgeons in whom most of the treatment are entrusted should be concerned not only at achieving palatal function and cosmetic acceptability but also the various other problems associated with cleft palate especially hearing loss. In this study, 66 patients with repaired and unrepaired cleft palates were examined for the presence of hearing loss due to middle ear effusion. The incidence of middle ear effusion was high (57.6%). It was also found that only eight of these patients (12.1%) ever complained of hearing loss or any associated symptoms and repair of the cleft palate did not influence the incidence of middle ear effusion. As such, screening should be done in all cleft palates and otolaryngologists should therefore play an important role in the multi-disciplinary team which should comprise the paediatrician, plastic surgeon, speech therapist, orthodontist and dental specialist.

Child↗

PubMed2002

The impact of early palatal obturation on consonant development in babies with unrepaired cleft palate.

OBJECTIVE: The purpose of this investigation was to determine whether palatal obturators enhance consonant development during babbling for babies with unrepaired cleft palate. PARTICIPANTS: Fourteen babies with cleft palate who had worn anterior palatal obturators prior to palatal surgery were matched to 14 unobturated babies according to cleft type, sex, and age at time of presurgical evaluation. MAIN OUTCOME MEASURES: Spontaneous vocalizations of the obturated and unobturated groups were compared to determine whether differences were evident in size of consonant inventory as well as place and manner of consonant production. RESULTS: Paired t tests revealed no significant differences between the groups in size of consonant inventory or place and manner of consonant production. There was a trend for babies in the obturated group to produce more glottal consonants. CONCLUSIONS: In general, the findings of this study suggested that palatal obturators do not appear to facilitate production of anterior palatal consonants during babbling.

Acoustic Impedance Tests↗

PubMed1996

Characteristics of cleft palate speech.

In recent years, interest in the nature of cleft palate speech and the influences on speech quality has increased. This overview of contemporary research reveals new perspectives on cleft palate speech development and the phonological consequences of early articulatory constraints. Cleft palate speech is perceived as the result of the synthesis between physical, physiological, cognitive and linguistic development. Developmental influences on cleft palate speech are considered in the context of early vocalisations of cleft and non-cleft children, followed by an examination of the literature on the development of babble, the emergence of early words and consonant development in children born with cleft palate. Speech development is then discussed from a phonological perspective interpreting reported characteristics as 'cleft-type developmental processes', for example, lack of target stabilisation; compensatory articulations; active/passive strategies; and systematic sound preference. Given these influences on speech development the extent to which cleft palate speech should be regarded as an 'articulatory disorder' has been reconsidered. Descriptions and interpretations of nasal resonance, nasal emission, and nasal turbulence are followed by discussion of articulatory errors in place and manner and patterns of change in cleft palate speech. Finally, some of the available evidence on speech in relation to structural imperfections, such as unrepaired clefts, velopharyngeal insufficiency, oro-nasal fistulae, dental and occlusal deviations, and open-mouth posture is summarised briefly. These new perspectives aim to facilitate more effective clinical management and to provide indications for future research.

Child, Preschool↗

PubMed1976

Hearing loss in prosthetically treated adults with cleft palate.

The effect of obturator treatment of cleft palate on middle ear disease and hearing loss has not been established. This study serves as an otologic and audiologic review of a previously reported adult population with cleft palate. A substantial improvement in hearing levels subsequent to obturation was demonstrated; however, it was believed to be based on stabilization of pathologic features of the ear with age. A statistically significant correlation of hearing level with length of use of prosthesis or with type of lesion could not be demonstrated. Results are compared with those reported on the only other adult population with cleft palate. Prosthetic management of cleft palates is not shown to be detrimental, as has been generally thought.

Adolescent↗

PubMed1990

Submucous cleft palate in the differential diagnosis of feeding difficulties.

Submucous cleft palate is a missed or forgotten diagnosis. We reviewed 81 patients with submucous cleft palate seen over a 15 year period; 26 of these patients were interviewed. The patients were divided into three main groups according to the referral pattern. Children under 2.5 years were referred by a paediatrician for feeding problems; children aged 2.5-10 were referred mainly by speech therapists; and those over 10 had a varied pattern of referral. Thirty nine of the 81 had problems with feeding, but of the 26 interviewed, 22 had feeding problems. Not all patients with a submucous cleft palate are symptomatic and require active treatment, but children with this condition have the same high incidence of middle ear disease as those with overt cleft palate. We suggest that the diagnosis of submucous cleft palate be included in the differential diagnosis of feeding difficulties, with early referral to a specialist cleft palate team.

Adolescent↗