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The perspective of the person with Alzheimer disease: which outcomes matter in early to middle stages of dementia?

As more persons with Alzheimer disease are diagnosed earlier in the disease progression, their perspectives, values, and preferences warrant closer attention from clinicians, service planners and providers, and the research community. Demographic changes suggest that more persons with early-stage Alzheimer disease will be living alone. Their treatment, housing, and service preferences, as well as values about desirable health, mental health, and cognitive and functional outcomes may differ from those of their concerned families. Clinicians and researchers must identify relevant domains of life quality from the perspective of the person with dementia and develop individually sensitive, reliable, and valid instruments to assess, monitor, and evaluate outcomes of care and services.

Aged↗

[Dementia: diagnosis and treatment].

Demographic changes are dramatically increasing the importance of dementia disorders, and among them Alzheimer's disease (AD), which accounts for over 50% of age-associated dementias. Early diagnosis is important in order to detect reversible disorders and, on the other hand, to exploit newly available treatment options as soon as possible. For detection of dementia and differential diagnosis a two-step approach is advocated. Screening is carried out by the primary care physician, who refers the patient for differential diagnosis and thorough workup to a specialist or specialized institution, such as a memory clinic. Patient management is, as usual in geriatric medicine, a multidisciplinary task. The new therapeutic options make early diagnosis mandatory to ensure optimum benefit for the patient in Alzheimer's disease, which today can be diagnosed with sufficient accuracy. Vascular dementia, which is second to AD in frequency of occurrence, can best be prevented and treated by vigorous management of cardiovascular risk factors. In addition to drug treatment, psychotherapeutic approaches (particularly milieu therapy) help to keep patients in their accustomed setting for much longer and to alleviate the caregivers' burden.

Aged↗

[Situation of genetics services in Chile].

Due to the demographic changes in Chile, where preventable causes of death are being controlled and congenital malformations arise as an important cause of morbidity and mortality during infancy, of pathological pregnancies and reproductive alterations, medical genetics is becoming increasingly important. Using data from an inquiry that was answered by thirteen medical genetics centers in the country, this article reviews the history of the discipline in Chile, the available resources, the existent services, the main problems found and their eventual solutions, genetics teaching and the research that is being conducted.

Chile↗

[Rehabilitation from the economic viewpoint--how is geriatric rehabilitation positioned in the German health care system?].

The paper summarizes the answers to given questions and the lecture held on the occasion of a hearing of the Enquete-Kommission "Demographic change" of the German Parliament. The subject was the problem of cost-effectiveness of rehabilitation measures. The position of geriatric rehabilitation in Germany as an established and efficient method is described. The indication for rehabilitation must be correctly and individually determined, and the treatment should be available to patients in all communities.

Activities of Daily Living↗

[Large dams, health and nutrition in Africa: beyond the controversy].

The population in sub-Saharan Africa is growing faster than increases in food production, resulting in a net decrease in food production per capita. The Food and Agriculture Organization has stated that there is a "risk of widespread hunger" which could be prevented by "effective planning of water resources". However, the potential effects of such schemes on the human population are often inadequately assessed and the effect of large dams on human health is not clear. The potential risk to human health of water resources was emphasized a few years ago but no effective preventive programs were implemented, probably because of inadequate availability of information and lack of awareness. The effects on health of "large" water resource projects are not uniform within a population. Decision-makers have tended to focus on the positive effects, to obtain support for their plans. These include: 1) improvement in the well-being of the population (safe water more readily available, new infrastructure, better access to health care) and 2) increases in the food supply (more vegetables and fish available due to irrigation). Thus, there has been a logical expectation that more, better quality food will become available as a result of these schemes, whereas in fact, health and nutrition has often worsened, particularly in young children. Most of the diseases associated with water resource management are communicable, including diseases directly related to the presence of large quantities of water, such as: malaria, which increases in incidence immediately after the building of the dam, after which a new balance develops between the human population and the parasites, schistosomiasis, the disease which increases most in response to the building of dams, particularly in its most severe gastrointestinal form, diarrhea, as water is a major means of dissemination for many organisms, including those causing digestive tract infections and gastroenteritis (amebiasis, salmonellosis, cholera), due to poor sanitation, other parasitic infections, such as onchocerciasis and trypanosomiasis, which should be monitored as they may also threaten the population. Other communicable diseases may appear or increase in incidence with the influx of migrants to the irrigated area. Sexually-transmitted diseases and HIV infection are a particular problem. The large numbers of insects (mosquitoes, blackflies) may also have harmful effects on populations adapting to the new environment. These effects are related to each other and to the environmental changes. New types of food affect people's feeding habits and generate new sources of income. However, they may also lead to new and higher expenditure. There are also likely to be major socio-demographic changes associated with changes in reproductive behavior and women's activities. The location and nature of new homes and infrastructure (e.g. schools, health centers, roads) also contribute to the success or failure of the dam project. There are many constraints to be considered and a more comprehensive approach to the problem is required. Health and nutritional status may be used as simple indicators of the ability of the population to adapt to a new environment. This makes it possible to construct a causal model to identify the most effective and relevant areas of intervention. Health and nutrition issues are of vital importance and scientific findings should be used in decision-making processes for planning future large dam schemes.

Africa South of the Sahara↗

Changes in profiles of students admitted to Florida allopathic medical schools 1990-1996.

The demographic and academic profiles of first-year classes entering the three allopathic medical schools in Florida (UM, UF, and USF) between 1990 and 1996 have been summarized. In general, the high academic standards for admission (high GPAs and MCAT scores) have been maintained, and in some cases, increased. The percentages of women admitted to the first-year classes at UM and UF have increased in recent years, and the number of women enrolled in MD programs in Florida has increased by 26% since 1990. At the University of Miami, the student body has reached gender parity. There also has been a marked shift in the ethnicity of medical students in the state of Florida. Non-hispanic white students have decreased by 9% to 64.4% of the total population. Black students and hispanic students have made modest gains, and now constitute 7.4% and 11.5% of the population, respectively. Asian students have made the largest gain (6.4%), now making up 15.8% of all Florida medical students. In contrast, there has been no sustained increase in the overall number of underrepresented minority students admitted to first-year classes despite national programs and institutional commitments to do so. These changes have not occurred just at Florida medical schools. They parallel far broader national trends resulting from a dramatic increase in the number of medical school applicants and demographic changes in the applicant pool.

Black or African American↗

The frail elderly in the family.

Longer life expectancy, better health and higher levels of financial independence will characterise the elderly of the future. These will result in a greater variety of living and care arrangements including an increasing proportion of older people who will choose to live on their own. Caring for a frail elderly person in the family requires a change of family roles, a process often accompanied by emotional upheavals. The degree of difficulty experienced will be linked to the level of economic and physical dependence of the elderly person. Demographic changes will add new dimensions to the problems of care. In four generation families, which will be more common, the burden of care will shift to adult grand children. Fewer children and grand-children will be available to share care responsibilities. A range of commercial and welfare services will be required to meet the increasing range of needs. Careful evaluation is needed in monitoring both improvements and the risks to the frail elderly and the family in the changing scenario.

Aged↗

Pathogenesis, etiology and epidemiology of myelodysplastic syndromes.

BACKGROUND AND OBJECTIVE: The myelodysplastic syndromes are common hematological malignancies affecting predominantly elderly people. Patients usually present with chronic cytopenias which gradually worsen due to progressive bone marrow failure or transformation into acute myeloid leukemia. Disease prevention is more cost-effective than therapeutic intervention and the establishment of the etiology and pathogenesis of MDS therefore assumes considerable importance. This review will outline current concepts of the pathobiology of MDS, putative etiological insults and the mechanisms of disease initiation as well as recent contributions to the descriptive epidemiology of these disorders. EVIDENCE AND INFORMATION SOURCES: The authors of the present review have a long-standing interest in the pathogenesis, etiology and epidemiology of MDS. Journal articles covered by the Science Citation Index and Medline have been reviewed and personal experience and discussion with international experts collated. STATE OF THE ART AND PERSPECTIVES: The initiation processes for the development of MDS remain unknown. A poorly defined transforming event affects a pluripotent or multipotent progenitor cell in the bone marrow, conferring a growth advantage upon it and eventually establishing clonal hematopoiesis. An important pathogenetic mechanism in MDS is premature intramedullary cell death via excessive apoptosis, explaining the apparent paradox of a cellular marrow in combination with peripheral cytopenias (ineffective hematopoiesis). Therapy-related MDS/AML following exposure to alkylating agents is the only clear etiological factor thus identified. Increasing evidence for exposure to benzene and radiation and the development of MDS is emerging. Benzene hematotoxicity is mediated via both genotoxic and non-genotoxic mechanisms, leading to aplasia, apoptosis and initiation (via genetic mutation) of clonal disorders such as MDS. Further studies of benzene hematotoxicity and therapy-related MDS should provide models for the elucidation of initiation events in MDS pathogenesis. The importance of such studies is emphasized by the rising frequency of MDS which largely reflects improved diagnostic criteria, increased physician awareness and extended use of diagnostic procedures in the elderly. Demographic changes will lead to a marked increase in MDS over the next few decades.

Animals↗

[Present and future of internal medicine].

To mention the crisis of Internal Medicine has become a commonplace, that is extremely wrong, because Internal Medicine is stronger than ever, with many recent and important contributions like randomised clinical trials, metaanalysis, evidence-based diagnosis, cost-benefits analysis, etc. We consider as Internists the General Internist, the sub-specialist and the primary care physician. Among them, it is the General Internist who needs to redefine his working areas, that are progressively moving from the hospital into ambulatory care. Internal Medicine is stretched by 3 strong vectorial forces: 1. Its own development and technological progress. 2. Economical factors trying to limit increasing costs. 3. Social forces demanding a better quality of care Internal Medicine shall need to equilibrate all these forces and be prepared to solve future challenges such as demographic changes, including an ageing population, the compression of morbidity, increasing demands of better care and quality of life, contemption of excessively high costs and now technical and ethical problems. The internist should be the best prepared specialist to cope with these challenges; but to better assume them, deep changes in pre and post graduate medical education are needed.

Forecasting↗

[Epidemiological transition in Latin America: a comparison of four countries].

BACKGROUND: In the last decade, Latin America has experienced important transformations in its health conditions, due to demographic changes and a rapid urbanization process. AIM: To analyze socioeconomic, demographic and epidemiological changes in Chile, Guatemala, Mexico and Uruguay and relate them to the different stages in the demographic and epidemiological transition of these countries. MATERIAL AND METHODS: Data was obtained from official information of local and international organizations such as Pan-American Health Organization, United Nations, Latin American Center for Demography (CELADE) and World Bank. RESULTS: Guatemala is in a pre-transition stage with a high proportion of communicable diseases as causes of death (61%) as compared with Mexico (22%), Chile (13%) and Uruguay (7%). Mexico is in a prolonged transition situation and Chile is close to Uruguay in a post-transitional stage. Despite decreasing rates of mortality, the proportion of deaths represented by chronic diseases and injuries has increased to over 30% in all countries, except Uruguay. Adjusted mortality rates for cardiovascular diseases are lower in Latin American countries, as compared to Canada. However, excepting Guatemala, there are differences in the pattern of cardiovascular disease, with a higher mortality due to cerebrovascular and a lower mortality due to coronary artery diseases. CONCLUSIONS: An increment in non communicable diseases is expected for the next decades in Latin America. Analysis of demographic and epidemiological transition is crucial to define health policies and to adequate health systems to the new situations.

Chile↗

Preventive strategies for the older dental patient.

The purpose of this article is to review preventive strategies with regards to caries, periodontal disease, xerostomia, and oral cancer which may be helpful in treating the older patient. Dramatic demographic changes projected for the older population will have a direct impact on the type and quantity of dental services delivered in the future. It will be advantageous for tomorrow's oral health professional to recognize these changes and to adapt preventive and treatment regimens accordingly.

Aged↗

The occurrence of breech presentation in Norway 1967-1994.

BACKGROUND: To study the occurrence of breech presentation and its association with demographic and geographic variables. METHOD: Population based cohort study from the Medical Birth Registry of Norway comprising all singleton deliveries 1967-1994, a total of 1,592,064 deliveries. Of these, 45,921 in breech presentation. RESULTS: From 1967 through 1994, the breech presentation proportion increased from 2.2% (95% CI 2.1-2.3) to 3.4% (95% CI 3.2-3.5). Breech presentation was associated with high maternal age and low birth order, as well as low gestational age and birthweight. The secular trend was mainly due to demographic changes in terms of increasing proportions of births with low birth order and high maternal age. Breech presentation was most frequent in urban areas. CONCLUSIONS: Strong associations were observed between breech presentation and low birth order as well as high maternal age. The findings are compatible with both intrinsic as well as environmental mechanisms. A full understanding of the birth order effect necessitates further studies based on sibship data. Prevention of premature delivery would be an effective measure for reducing the breech presentation proportion.

Adult↗

Can gerontological nursing survive?

By the year 2041, 11 million individuals 65 and over will reside in Canada. This drastic demographic change, coupled with the increasing acuity and complexity of the health care needs of seniors, creates an immense demand for nurses specialized in gerontology. But can gerontological nursing survive as a specialty and respond to this demand?

Aged↗

Audit of populations in general practice: the creation of a national resource for the study of morbidity in Scottish general practice.

STUDY OBJECTIVE: To create a national data resource for studying morbidity in Scottish general practice, complementary to existing information systems and available for management and research purposes at national and local levels. DESIGN: The Department of General Practice, University of Aberdeen has worked since 1988 to collect and analyse computerised information at practice, regional, and national levels by distribution of a floppy disk-based software program, which extracts a predetermined dataset from each general practice computer system. SETTING: Almost 100% of patients in Scotland are registered with a general practitioner. Scotland has a national computer system, General Practice Administration System for Scotland (GPASS), used by over 75% of all Scottish practices. Escalating costs of health care and demographic changes in the national population emphasise the monetary value of the gatekeeper role of general medical practice. General practitioners' increasing involvement in the provision and purchasing of care has raised the importance of the management of populations as well as the care of individual patients. PATIENTS: Collection of major morbidity and prescribing data from up to 2.4 million patients, approximately half the population of Scotland, takes place biannually. A subset of practices (population 282,700 patients; 52 practices) are continuously collecting doctor/patient contact information (symptoms or diagnoses). MAIN RESULTS: The data collected provide information at the level of the individual patient. Morbidity, prescribing, screening, and administrative data can be linked by patient, date or postcode. The sample population studied is representative by age, sex, deprivation, and sparsity (using the postcode) of the national population. Large sub-populations of patients satisfying a selected criteria can be extracted for further study of needs assessment or of epidemiological research. CONCLUSIONS: The gatekeeping role of Scottish general practice and the predominance of GPASS favours standardisation of methods of data capture and the construction of large regional, national, and Continuous Morbidity databases. Analysis by geographical, demographic, and temporal distributions allows the changing patterns of illness and provision of health care to be studied in substantial detail to the benefit of patients, doctors, and the national health service.

Adolescent↗

[Health, environment and sustainable development in Mexico].

This article is based on "Salud, ambiente y desarrollo humano sostenible: el caso de México," a document prepared in June 1997 by the Comité Técnico Nacional para el Desarrollo Sostenible. It opens with information regarding the epidemiologic and demographic changes that have taken place in Mexico, such as the decrease in communicable diseases, the rise in noncommunicable diseases, and the less conspicuous increase in lesions resulting from accidents or acts of violence. This is followed by a discussion of priority problems and problems of lesser magnitude in environmental health, specifically those relating to water and air quality, as well as disposal of household and dangerous wastes. Finally, it proposes three areas of intervention in light of the structural problems detected: the absence of an integrated information system covering the area of health, environment, and development; the absence of channels of communication within and between institutions and sectors, and the lack of coordination in planning and implementing programs and actions in this field.

Environmental Health↗

[Obesity, an unresolved challenge in Chile].

Socioeconomic and demographic changes in Chile, have modified its epidemiological profile. At the present time, the most important public health problems are non communicable chronic diseases, specially cardiovascular ailments. The prevalence of cardiovascular risk factors has also increased and obesity stands out. This review analyzes the present situation of obesity and other cardiovascular risk factors of nutritional origin, in Chile, and proposes intervention alternatives. At the present time 7% preschool children, 12% of school children, 24% of pregnant women, 10% of male adults and 24% of female adults are obese. This higher prevalence is even more pronounced in women of low socioeconomic level. Risk factors associated to obesity are an inadequate diet, with a higher consumption of fats and refined foods, sedentariness and hyperlipidemia. Primary and secondary care strategies must be devised to face this growing problem.

Adolescent↗

Three strikes and you're out: demographic analysis of mandatory prison sentencing.

Much of the debate about the costs and benefits of "three-strikes" laws for repeat felony offenders is implicitly demographic, relying on unexamined assumptions about prison population dynamics. However, even state-of-the-art analysis has omitted important demographic details. We construct a multistate life-table model of population flows to and from prisons, incorporating age-specific transition rates estimated from administrative data from Florida. We use the multistate life-table model to investigate patterns of prison population growth and aging under many variants of three-strikes laws. Our analysis allows us to quantify these demographic changes and suggests that the aging of prison populations under three-strikes policies will significantly undermine their long-run effectiveness.

Adolescent↗

[A marked increase in the rate of diagnosed prostate cancer in the Netherlands during 1990-1996].

OBJECTIVE: To study the variation of the number of histologically detected adenocarcinomas of the prostate in the Netherlands during the period 1990-1996. DESIGN: Retrospective. SETTING: National study. METHOD: Use was made of data from the National Automated Morbid-Anatomical Record Department (PALGA), Utrecht. The following data were established for each year of the study period: the total number of histological examinations of the prostate, the number of men involved (often several histological examinations of the prostate of the same man in the same year), how often adenocarcinoma was diagnosed by these examinations and how many men were involved, as well as the age of all carcinoma patients. These data were compared with those concerning variation and incidence of cancer of the prostate obtained from the Netherlands. Cancer Registration and the Central Statistics Office. RESULTS: In 7 years a total of 205,525 histological examinations of the prostate were performed in 179,298 men; the diagnosis 'adenocarcinoma of the prostate' was made 52,964 times in 44,182 men. The number of tissue examinations with the diagnosis 'carcinoma of the prostate' increased by 63% (from 5,596 to 9,146), the number of men in whom this diagnosis was made increased by 62% (from 4,710 to 7,614). The relative frequency of prostate carcinoma in relation to all examinations of the prostate increased in 6 years (1991-1996) from 22% to 28%. In that period, the (uncorrected) incidence increased by 50%, while mortality corrected for age remained the same. CONCLUSION: Of the marked increase of the number of detected cases of carcinoma of the prostate in the study period, only a small part could be attributed to demographic changes. Since autopsies have shown that there exists a large 'stock' of subclinical carcinomas, most of the growth can probably be explained by the more intensive diagnostics with prostate-specific antigen and transrectal ultrasonography.

Adenocarcinoma↗