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Opposite effects of gastrin on cell proliferation in the antrum and other parts of the upper-gastrointestinal tract in the rat.

The effect of gastrin on DNA synthesis and mitotic activity in the mucosa of the upper-gastrointestinal tract was explored in unanesthetized rats with a gastric fistula. Animals were killed at 4-hr intervals, after starting a 3-hr intravenous infusion with the lowest dose of gastrin provoking a maximal acid output. Tritiated thymidine was injected 1 hr before killing. Autoradiography was used, and labeling and mitotic indices were estimated in the fundic, antral, duodenal, and jejunal mucosa. The proliferative activity in the fundic, duodenal, and jejunal glands was significantly increased 16 hr after the administration of gastrin. In the antral glands, however, a significant decrease in both labeling and mitotic indices was observed. Rhythmic variations in proliferative activity were observed in the antral, duodenal, and jejunal mucosa in control animals. They were different from those in the gastrin-treated animals. Our data confirm the trophic action of gastrin in the fundic, duodenal, and jejunal mucosa. They also indicate an inhibitory effect of this hormone on cell proliferation in the antral mucosa.

Animals↗

Iatrogenic problems following gastric surgery.

It is difficult to truly define iatrogenic complications in the postsurgical state in that the surgery is a condition originated by physician intervention and thus any problems that occur may be technically considered as physician created. In this article we attempt to demonstrate problems that occur both due to technical errors and the choice of operative procedure. In addition, unusual postsurgical anatomy is illustrated with the hope of avoiding further iatrogenic problems from lack of recognition.

Afferent Loop Syndrome↗

Clonal identity of Candida albicans in the oral cavity and the gastrointestinal tract of pre-school children.

The clonal relationship between oral and fecal Candida albicans isolated from children of pre-school age was examined using RAPD analysis. Significantly higher levels of C. albicans were found in saliva, dental plaque, carious specimens and stools of 56 patients with severe caries as compared to 52 healthy control subjects. The highest prevalence was found in carious specimens and a strong correlation was observed between its presence in saliva, dental plaque, carious specimen and feces. RAPD analysis of isolates from 23 patients with simultaneous oral and fecal C. albicans revealed clonal counterparts present in both oral and stool samples in 15 cases; five patients harbored closely related strains; and three patients harbored unrelated strains. Our results demonstrate a strong correlation between oral and gastrointestinal C. albicans colonization. We assume that carious teeth may constitute an ecologic niche for C. albicans potentially responsible for recurrent oral and non-oral candidiasis.

Abscess↗

Closure of a controlled biliary fistula complicating partial cholecystectomy with endoscopic biliary stenting.

An elderly woman presented 2 months after partial cholecystectomy performed for gangrenous cholecystitis with choledocholithiasis and a controlled biliary fistula. Despite ductal clearance of stones via endoscopic retrograde sphincterotomy and stone extraction, bilious drainage via the fistulous tract persisted. Endoscopic insertion of a 10F Amsterdam endoprosthesis resulted in complete closure of the fistula within 6 wk. This case represents the first example of closure of a biliary fistula after partial cholecystectomy.

Aged↗

[Acute post-operative peritonitis in gastro-enterological surgery. Opinion of the intensive care unit (author's transl)].

Acute purulent post-operative peritonitis is highly severe and difficult to diagnose. Six symptoms have a real prognostic value: shock, acute renal insufficiency, respiratory failure, jaundice, acidosis and septicaemia. If more than three of these signs of severity coexist, the mortality rate reaches nearly 100%. A patient with evidence of acute diffuse post-operative peritonitis must be operated on after a short preoperative treatment to restore a situation altered by shock, renal failure and pulmonary edema. Antibiotic agent alone, though necessary, cannot bring recovery. The maintenance of high nutritional intake for excess caloric expenditure is essential. The effects of the early decision of a surgical reintervention are studied in 27 patients with only two recoveries.

Acute Disease↗

Management of a persistent pancreatic fistula secondary to a ruptured pseudocyst with endoscopic insertion of an expandable metal stent.

A case of pancreatic fistula successfully managed by the endoscopic insertion of an expanding-mesh metal stent into the pancreatic duct is reported. The patient had developed a fistula following rupture of a pancreatic pseudocyst, and attempted transpapillary drainage using plastic endoprostheses had failed due to prosthesis migration. Insertion of a Strecker metal stent was followed by rapid and sustained clinical improvement and cessation of fistula drainage.

Aged↗