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At least 289 records · Page 16Linked to original sources
PubMed2001

[Potential functional differentiation of genome in the course of evolution and approaches to its study. I. Neontological annals of evolution and its analysis].

It is shown that the division of phylogenetical branches descends anisotomically. One new branch becomes evolutionary not active. Another one continues actively to develop. It allows to consider a system of present-day organisms as neonatological annals of evolution. A question arises on distinctions in the constitution of genomes of organisms belonging to active and inactive phylogenetic branches.

Evolution, Molecular↗
PubMed2001

[Potential functional differentiation of genome in the course of evolution and approaches to its study. II. Elucidation of diversity of phylogenetic lines].

It has been shown elsewhere (Chupov, 2001) that the branching of phylogenetical trunks goes by anisotomical way. Thus, in one of newly formed branches a possibility remains of a further evolutionary transformation, while taxa belonging to another branch sink into a prolonged evolutionary stasis. In the author's opinion, such a phenomenon is to be accompanied by distinctions in constitution of genetical cell devices of the taxa belonging to the branches with evolutionary contrasting potencies. In the article, an attempt is done to consider some other approaches relevant to this problem.

Evolution, Molecular↗
PubMed2003

[Effect of low-intensity laser radiation on the functional potential of neutrophilic granulocytes in blood of tumor-bearing animals].

Peripheral blood was sampled for cytochemical assay of cationic proteins from three groups of animals--intact ones, those with tumor C45 and bearers of the same tumor treated with helium-laser radiation and chemotherapy. Radiotherapy involved such manifestations of enhanced nonspecific antitumor resistance and, in particular, mobilization of the cellular component, as increased number of neutrophils containing cationic protein granules and relatively high levels of such proteins in them. Cytochemical assay of cationic proteins in neutrophil granules may serve as a criterion of nonspecific antitumor resistance assessment.

Animals↗
PubMed1992

GAP-43 expression in macroglial cells: potential functional significance.

Although growth-associated protein-43 (GAP-43) was initially considered to be neuron-specific, it has more recently been found in astrocytes, oligodendrocytes, Schwann cells, glial cell equivalents in embryonic Drosophila and other non-neuronal cells. Here I summarize evidence for the presence of GAP-43 in macroglial cells (i.e., astrocytes and oligodendrocytes) cultured from neonatal rat cortex and describe its developmental expression in a lineage-specific and cell-type-specific manner. These and other data suggest that GAP-43 is a multifunctional protein involved in the synthesis of membranes associated with the growth of various types of cellular processes, including those of macroglial cells.

Animals↗
PubMed2004

[Detection and potential function of anti-FSH antibodies in patients with spermatogenesis dysfunction].

OBJECTIVE: To detect the anti-FSH antibody using ELISA, and further probe into the role of anti-FSH in infertile patients. METHODS: The anti-FSH antibody was detected using ELISA in the serum of patients with spermatogenesis dysfunction, of infertile patients with normal sperm density and motility, and of normal fertile males. RESULTS: The positive rate of anti-FSH antibody in the patients with oligospermia and/or asthenospermia [22.4% (22/98)] was significantly higher than that in the normal fertile [4% (2/50)] (P < 0.05) and that in the infertile patients with normal sperm density and motility [6.7% (2/30)] (P < 0.05). The positive rate of anti-FSH antibody in the patients with oligospermia and/or asthenospermia was lower than that in the patients with azoospermia [54.5% (12/22)] (P < 0.05). There was no significant difference in the positive rate between the normal control and the sterile males with normal sperm density and motility. CONCLUSION: The anti-FSH antibody may be an important factor to cause spermatogenesis dysfunction by combining FSH to form immune compound and depress the activation of FSH.

Antibodies↗
PubMed2006

[Range of potential functions of the Drosophila melanogaster hdc gene].

The Drosophila melanogaster hdc gene controls trachea branching, which starts during embryo development. Expression in imaginal disks and reproductive organs suggests additional functions for the hdc gene. The gene was demonstrated to have a maternal effect, which was denied previously. Analysis of cell proliferation in imaginal disks with hdc mutations showed that the gene does not possess tumor suppressor properties at the levels of mosaic cuticle clones of adults and transplanted imaginal disks. Transplanted imaginal disks homozygous, but not heterozygous, for an hdc mutation were found to affect oogenesis in the recipient females, implicating the hdc activity in exchanging signals between different organs. Amino acid sequence analysis of the Hdc protein revealed a region homologous to the human HRS proteins, which directly interact with the NF2 tumor suppressor on experimental evidence.

Amino Acid Sequence↗