The minor role of hydrochloric acid in experimental production of peptic ulcer in dogs.
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Contents of Na+, K+, Ca2+, Mg2+, Zn2+ and Cl- in gastric mucosa of normal and retinol-deficient rats were determined by X-ray spectroscopic analysis. Diet free of retinol was established to increase content of cations Na+, K+, Ca2+, Mg2+, Zn2+ as well as of Cl- anion in rats' gastric mucosa. Accumulation of Ca2+ and K+ ions in gastric mucosa promotes secretion of HCl under the condition of retinol deficiency in the body. Raised content of Cl- anions in gastric mucosa may be a proof of activated hydrochloric acid secretion.
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A comparative study of the oxyntic cells of the stomach of Vertebrates is presented. A system of membranous tubules which is apparently inter-convertible with the luminal plasma membrane is described as an important structural feature in all classes. In all Vertebrates with the sole exception of Mammals, this system shares a common cell with the structures involved in the secretion of zymogen. In Mammals it becomes segregated into a specialized cell type, the parietal cell, characterized in addition by the presence of a long tortuous intracellular canaliculus, which serves as its secretory pole. The hypothesis is presented and discussed that the parietal cell is capable of achieving a higher efficiency in hydrochloric acid secretion by the existence of the intracellular canaliculus which makes the immediate surroundings of the secretory pole independent of the contents of the gastic lumen. In Birds (whose gastric glands do not possess parietal cells) a corresponding effect can be achieved only by complex structures such as the compound gastric glands. An explanation is hereby offered for the unique features of the Avian stomach.
The authors studied the effect of high-fat and high-protein diets on the activity of some enzymes of rat gastric mucosa parietal cells. It was found that the high-protein diet (40% of protein in terms of caloricity) causes an increase in the activity of both the mitochondrial enzymes of Mg2+-ATPase and HCO-3-ATPase and enzymes of the plasma membrane (K+-ATPase and cytoplasm (carboanhydrase). The high-fat diet (60%) of fat in terms of caloricity) produces different effects on the above-indicated enzymes: the activity of Mg2+-ATPase decreases, while that of HCO-3-ATPase rises; at the same time the activity of K+-ATPase and carboanhydrase diminishes. It was shown that the enzymatic systems responsible for hydrochloric acid secretion in the stomach show a delicate response to a qualitatively different nutrition.
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