PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Integrated functions”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 289 records · Page 16Linked to original sources
PubMed1987

Growth of mouse vaginal epithelial cells in culture: functional integrity of the estrogen receptor system and failure of estrogen to induce proliferation.

Normal mouse vaginal epithelial cells isolated from ovariectomized ca. 40-day-old BALB/cCrg1 mice were purified by Percoll density gradient centrifugation and grown in primary culture using a collagen gel matrix and a serum-free complete medium. During the 9-day culture period, a 6-fold increase in cell number was observed. Addition of estrogen to the medium did not enhance epithelial cell proliferation. In fact, all doses of estrogen (180 fM to 18 nM) were inhibitory, resulting in only a 3- to 4-fold increase in cell number by day 9 of culture. Continuous exposure to estradiol (1.8 nM) for 9 days in the serum-free complete medium resulted in a decrease in cytosolic estrogen receptors with associated nuclear accumulation of estrogen receptors. A corresponding increase of cytosolic progestin receptors was also observed, indicating that no qualitative modification of the estrogen receptor system had occurred. Thus, despite its effectiveness in specific product synthesis (progestin receptors), estrogen does not stimulate proliferation of vaginal cells in this culture system, but rather inhibits epithelial cell proliferation.

Animals↗
PubMed1994

Role of efferent and afferent vagal nerve activity during reproduction: integrating function of oxytocin on metabolism and behaviour.

The vagal nerves convey information between the brain and the gastrointestinal tract in both afferent and efferent direction. The efferent vagal nerves regulate gastrointestinal secretory and motor function and also the activity in the endocrine system of the gut. Gastrointestinal function and anabolic metabolism is optimized during gestation and lactation as a means of saving energy for this calorie-demanding process. This enhanced activity seems to involve central oxytocinergic transmission which increases efferent vagal nerve activity as reflected by altered levels of gastrointestinal hormones in plasma. In parallel a behaviour pattern characterized by sedation is induced. In addition, vagal afferents transfer information from the gut to the brain, e.g. as to the presence or absence of calories in the gastrointestinal tract. It is well known that satiety and sedation following a meal is in part caused by an activation of vagal afferents in response to food intake. Cholecystokinin released from the intestine is one of the factors that triggers the afferent vagal nerve activity. Also reproductive "interactive behaviours" such as milk ejection and maternal behaviour can be induced by CCK via afferent activation of vagal nerves. In contrast, when no food reaches the gut, milk production and ejection is blocked. Parts of these effects are vagally mediated, since they can be observed in vagotomized rats receiving full amounts of calories.

Afferent Pathways↗
PubMed2006

Effect of an integrated functional stability program on injury rates in an international netball squad.

The cost-effectiveness and efficacy of athlete profiling and injury prevention programs is influenced by procedural specificity, philosophy of athlete development within the sporting body and the dynamics within the multidisciplinary team (MDT). This article reports on the implementation of a multidisciplinary approach to injury reduction and performance development in an international netball squad. Problems with player compliance, training anxiety and injury rates sparked a decision to seek an alternative training approach. A reactive sports medicine system, poor player self-responsibility and inadequate player understanding of the anatomy and biomechanics of sound training, inadequate screening procedures and perceived conflict between sports science and sports medicine personnel were identified as causative factors. A new program was designed where common objectives were identified, and individual roles delineated. A functional profiling session was performed as a team activity and comprised player self-evaluation and netball specific movement analysis. Mechanisms of injury, training anxieties and modification of the overall program to ensure continued progression rather than a false plateau were illustrated through this process. From the above findings a strategy was outlined and comprised a foundation programme, a transitional phase, specific prophylactic programs, and sport specific sessions. A consistent approach was formulated across all disciplines in order to maximise transference of the new training program (TP). Training compliance was increased and interdisciplinary conflict prevented when dealing with different levels of training tolerance. Rate of injury in all vulnerable areas was markedly reduced. No training or overuse related injuries were sustained. Addressing fundamental functional problems and working openly and cooperatively towards a common goal, the members of the MDT were able to prevent injury, make significant gains in physiological performance and improve players' confidence and commitment to training over the defined period.

Adult↗
PubMed2005

Multisensory spatial interactions: a window onto functional integration in the human brain.

Incoming signals from different sensory modalities are initially processed in separate brain regions. But because these different signals can arise from common events or objects in the external world, integration between them can be useful. Such integration is subject to spatial and temporal constraints, presumably because a common source is more likely for information arising from around the same place and time. This review focuses on recent neuroimaging data concerning spatial aspects of multisensory integration in the human brain. These findings indicate not only that multisensory integration involves anatomical convergence from sensory-specific ('unimodal') cortices into multisensory ('heteromodal') brain areas, but also that multisensory spatial interactions can affect even so-called 'unimodal' brain regions. Such findings call for a revision of traditional assumptions about multisensory processing in the brain.

Brain↗
PubMed1997

Effects of amisulpride, an atypical antipsychotic which blocks preferentially presynaptic dopamine autoreceptors, on integrated functional cerebral activity in the rat.

Amisulpride, a benzamide derivative with an atypical neuroleptic profile relieves the negative symptoms of schizophrenia when administered at low doses (50-150 mg). In an attempt to define the anatomical substrates involved in this action we have studied the effects of amisulpride on regional cerebral glucose utilisation (RCGU) in the awake lightly restrained rat, by quantitative autoradiography using [14C]2-deoxyglucose ([14C]2-DG). Amisulpride was administered 1 h before [14C]2DG i.v. injection, at a dose of 5 mg/kg which resulted in a striatal D2 receptor occupancy of 10% similar to that induced by doses of this compound used for the treatment of negative symptoms of schizophrenia. Amisulpride induced significant RCGU increases in cortical areas, in visual relays, in auditory structures and in several limbic structures. The pattern of changes in RCGU seen with amisulpride clearly differs from that of haloperidol, given at a dose resulting in a similar occupancy of striatal D2 receptors (0.01 mg/kg), which was mostly ineffective. The amisulpride-induced activation of RCGU in specific brain areas involved in the control of cognitive functions and motivational and emotional behavior, may at least in part, explain the efficacy of this compound in the treatment of negative symptoms of schizophrenia.

Amisulpride↗
PubMed1998

Functional integration among 5-hydroxytryptamine receptor families in the control of female rat sexual behavior.

Serotonin (5-HT) receptor interaction in the control of female rat lordosis behavior was examined. Ovariectomized rats, with bilateral implants in the ventromedial nucleus of the hypothalamus (VMN), were hormonally primed with 25 micrograms estradiol benzoate and 500 micrograms progesterone. Rats were infused with the 5-HT3 receptor antagonist, 3-tropanyl-indole-3 carbonylate (tropisetron; 500 ng), or were coinfused with the 5-HT3 receptor antagonist and the 5-HT2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI; 500, 1500, or 2000 ng). Additional ovariectomized, hormone-primed rats received bilateral VMN infusions with the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT; 200 ng), or were coinfused with the 5-HT1A receptor agonist and the 5-HT3 receptor agonist, m-chlorophenyl-biguanide (mCPBG; 250, 500, or 1000 ng). Lordosis behavior was observed prior to VMN infusion, during the infusion and for 30 consecutive minutes thereafter. Tropisetron reduced the lordosis to mount (L/M) ratio in every animal investigated but the decline was attenuated by coinfusion with DOI. Similarly, the L/M ratio declined following infusion with 8-OH-DPAT and the decline was dose-dependently reduced by coinfusion with mCPBG. Only the 5-HT3 receptor agonist altered the quality of the lordosis reflex. These studies provide evidence that the effects of 5-HT on female rat lordosis behavior involve the integrated activity of at least 3 different 5-HT receptor families.

8-Hydroxy-2-(di-n-propylamino)tetralin↗