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Regional distribution of Na-K-ATPase specific activity in the large intestine of the rat and man.

Segmental heterogeneity of colonic electrolyte transport has been demonstrated in rat and man. We determined whether this is reflected by regional differences in Na-K-ATPase activity. In rats, Na-K-ATPase specific activity was significantly lower in the caecum than in the proximal colon, distal colon, and rectum. In man, biopsy specimens of macroscopically intact mucosa in 26 subjects showed no difference in Na-K-ATPase specific activity along the colon axis. We conclude that Na-K-ATPase distribution may contribute to electrolyte transport differences between rat caecum and colon but not between colonic segments in either rat or man. In an additional series of 11 patients with proximal intestinal resections colonic Na-K-ATPase specific activity was slightly but significantly higher than in controls, possibly representing an adaptive process.

Adult↗

The difference in the clearance of interstitial albumin by the lymphatics from the stomach and the small and large intestine.

The capacity of the lymphatics to clear interstitial albumin was compared between the stomach, small intestine, and colon. The lymphatic and vascular transport in the stomach and colon was similar, clearing approximately 9 per cent of interstitially injected radioiodinated serum albumin by the thoracic duct lymph and 2 to 3 per cent by the blood in a five hour period. More than a third of the injected material remained at the site of injection. The small intestine was cleared of 37 per cent of the albumin by the lymph and more than 6 per cent by the blood, leaving less than 9 per cent at the injection site in the same period of time. Evidence that the small intestine was more effective and rapid in clearing interstitial albumin than either the stomach or colon was statistically significant.

Albumins↗

[Hydrolases in the large intestine in rats with various experimental pathologies].

In the colon mucous membrane, activity of a wide range of membrane and mainly intracellular enzymes was studied in the organism at different conditions. The data obtained suggest participation of digestive hydrolases in the colon not only on postdigestive processes but, in certain states of the organism, in digestive processes too.

Animals↗

[Motor activity of the small and large intestines of patients with the generalized form of myasthenia (an x-ray study)].

The author studied the intestinocolonic function by X-ray methods in 84 patients with generalized myasthenia prior to and following surgical treatment (thymectomia). It was established that in myasthenia the intestinal motor function in the majority of the patients is decreased. These motor disorders have a functional character and are connected with the main disease. They disappear after operations as the function of the cross-sectional striped and smooth muscles are restituted.

Adolescent↗