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PubMed2000

Co-localization of PKCepsilon with various GABA(A) receptor subunits in the mouse limbic system.

The distribution of PKCepsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCepsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, and lowest in the prelimbic cortex and basolateral amygdala. Co-localization of PKCepsilon immunoreactivity with the GABA(A) receptor alpha1, beta 2/3, and gamma2 subunits varied by subunit and brain region examined, with the majority of co-localization occuring in the dentate gyrus, nucleus accumbens and basolateral amygdala. These results demonstrate that PKCepsilon may interact with GABA(A) receptors in a subunit- and region-specific manner, and provide a potential anatomical basis for recent behavioral and biochemical evidence that PKCepsilon modulates GABA(A) receptor function.

Animals↗
PubMedDate not supplied

[Glutamate dehydrogenase activity in the structures of the rabbit brain limbic system].

The activity of glutamate dehydrogenase (EC 1.41.1.3) is studied in homogenates and subcellular fractions of five limbic structures: regio superior, regio inferior of hippocampus, fascia dentata, septum and corpora mamillaria. The lowest activity of the enzyme is found in regio superior of hippocampus. 80% of the total enzyme activity of primary fractions is found in "crude" mitochondria. After centrifugation of the latter within the linear sucrose density gradient the distribution of the enzume activity is similar for different structures and the highest activity is found in the region of sucrose molarity from 1.44 up to 1.50 M which corresponds to the mitochondria distribution region. 50% of the total found activity is in the fraction enriched by mitochondria, 30% is in the fraction enriched by nerve endings with the high activity of glutamate decarboxylase. It was found for different fractions that 1 mM of ADF with 0.2 mM NAD-H+ produces about 10-fold increase in the enzyme activity. Pyridoxal-5'-phosphate inhibits the enzyme from inactivation. The results are discussed in connection with the possible role of pyridoxal-5'-phosphate in regulation of the glutamate dehydrogenase activity in vivo.

Acetylcholine↗
PubMed1975

[Functional interrelationships of the structures of the limbic system during initiation of seizure activity].

A functional epileptogenic focus was created by repeated electrical stimulation of the limbic structures activated by the conditioned sensory stimulus. Seizure activity in response to the conditioned stimulus was observed only in the hippocampus though other limbic structures were also stimulated. After bilateral electrolytic lesion of the septum no highly synchronized seizure activity was observed in response to the conditioned signal. In this case spontaneous high amplitude activity was found. These observations permit suggesting that the hippocampus plays the role of an initiator of the seizure activity, whereas the functional connection between the septum and hippocampus promotes its final synchronization.

Amygdala↗