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Knowing its gender without knowing its name: differential access to lexical information in a jargonaphasic patient.

According to recent models of word production, when we name a picture, we first retrieve the meaning of the object, and then we independently retrieve the written or sound form of the word corresponding to the picture. In languages like French, in which words have a gender, theoretical models disagree with respect to the moment at which this information is retrieved. The lemma model (Levelt et al., 1999) posits that we access this information before the sound or written form of the word is retrieved. In contrast, the"Independent network"(IN) model (Caramazza, 1997) model posits that we access gender after retrieval of either the sound or written form of the word. This paper reports a single-case study of an aphasic patient, BA, who showed deficits affecting spoken and written production in the presence of largely preserved comprehension abilities. Experimental testing indicated that she presented with a deficit functionally localized in the access to lexical representations. Results in picture naming and in gender identification also revealed that BA identified the gender above chance level, whether she produced a correct response, a phonemic error, or a neologism. In contrast, when she was unable to produce a spoken or written response, she could not identify the gender. This pattern of performance is consistent with the lemma model in which access to lexical syntax is required before access to phonological form can take place.

Acoustic Stimulation↗

The influence of age and gender on drug use in the United Kingdom--a review.

The aim of this study is to review UK epidemiological research in light of studies on the influence of age and gender on drug use in young people. Literature for this review came from English language publications using a structured search strategy. Within the UK, drug use is commoner in young males than other population groups. When integrated social development models are employed, drug use is seen to be determined by the complex interaction of factors such as age, parental monitoring, and peer group associations. Suggested research directions include combining structural equation modeling with large-scale, UK-based longitudinal social development model studies to develop prevention and intervention efforts that are sensitive to the role of individual, social, and cultural factors.

Adolescent↗

Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers.

The work of liver stem cell biologists, largely carried out in rodent models, has now started to manifest in human investigations and applications. We can now recognize complex regenerative processes in tissue specimens that had only been suspected for decades, but we also struggle to describe what we see in human tissues in a way that takes into account the findings from the animal investigations, using a language derived from species not, in fact, so much like our own. This international group of liver pathologists and hepatologists, most of whom are actively engaged in both clinical work and scientific research, seeks to arrive at a consensus on nomenclature for normal human livers and human reactive lesions that can facilitate more rapid advancement of our field.

Biliary Tract↗

Bio-medical entity extraction using support vector machines.

OBJECTIVE: Support vector machines (SVMs) have achieved state-of-the-art performance in several classification tasks. In this article we apply them to the identification and semantic annotation of scientific and technical terminology in the domain of molecular biology. This illustrates the extensibility of the traditional named entity task to special domains with large-scale terminologies such as those in medicine and related disciplines. METHODS AND MATERIALS: The foundation for the model is a sample of text annotated by a domain expert according to an ontology of concepts, properties and relations. The model then learns to annotate unseen terms in new texts and contexts. The results can be used for a variety of intelligent language processing applications. We illustrate SVMs capabilities using a sample of 100 journal abstracts texts taken from the {human, blood cell, transcription factor} domain of MEDLINE. RESULTS: Approximately 3400 terms are annotated and the model performs at about 74% F-score on cross-validation tests. A detailed analysis based on empirical evidence shows the contribution of various feature sets to performance. CONCLUSION: Our experiments indicate a relationship between feature window size and the amount of training data and that a combination of surface words, orthographic features and head noun features achieve the best performance among the feature sets tested.

Algorithms↗

Younger and older adults' use of mental models as representations for text materials.

Recent work suggests that formation and use of mental model (representations of situations described) is an integral part of discourse comprehension. In an experiment comparing younger and older adults on this aspect of text comprehension, subjects heard readings of a list of sentences and took a forced-choice recognition test. The test contained 2 types of distractors with an equal degree of verbatim similarity to the target sentences. One type described the same situation as the corresponding target sentence; the other did not. If mental models are an integral part of text representation formed at encoding, then a large number of confusions of the first, but not the second, type of distractor with the target sentence would be obtained. Younger and older adults showed this pattern to equal degrees. These data are consistent with those indicating that linguistic competence remains stable over the adult years (cf. Light, 1988).

Adolescent↗

An overview about biopharmaceutics in Europe.

In Europe, the concept of biopharmaceutics was first introduced at the end of the 70s by various highly informed young Europeans who took into full account the publications and studies carried out by the first generation of explorers in this area in the United States such as John Wagner, Gerhard Levy, and W.A. Ritschel, amongst others. Their primary aim was to develop bioavailability studies for the registration of generics or new dosage forms. They then worked on setting up a new system for drug dissolution in vitro, including in vitro and in vivo correlations to better define the formulations. All this research led to the publication of numerous reports on different congresses, the most important of these being the European Congress of Biopharmaceutics and Pharmacokinetics, which is held once every two years in a European country and includes a large number of participants with an attendance ranging from 300 to 500 persons. During this same period, books were published in French and other European languages such as English, German and Spanish, with the result that updated information was efficiently circulated throughout all European countries. In the near future, the introduction of the biopharmaceutical classification as well as new in vitro models will certainly make a positive contribution to the further development of research in this area.

Biological Availability↗

Server-based approach to web visualization of integrated three-dimensional brain imaging data.

The authors describe a client-server approach to three-dimensional (3-D) visualization of neuroimaging data, which enables researchers to visualize, manipulate, and analyze large brain imaging datasets over the Internet. All computationally intensive tasks are done by a graphics server that loads and processes image volumes and 3-D models, renders 3-D scenes, and sends the renderings back to the client. The authors discuss the system architecture and implementation and give several examples of client applications that allow visualization and analysis of integrated language map data from single and multiple patients.

Anatomy, Cross-Sectional↗

Graph theoretic modeling of large-scale semantic networks.

During the past several years, social network analysis methods have been used to model many complex real-world phenomena, including social networks, transportation networks, and the Internet. Graph theoretic methods, based on an elegant representation of entities and relationships, have been used in computational biology to study biological networks; however they have not yet been adopted widely by the greater informatics community. The graphs produced are generally large, sparse, and complex, and share common global topological properties. In this review of research (1998-2005) on large-scale semantic networks, we used a tailored search strategy to identify articles involving both a graph theoretic perspective and semantic information. Thirty-one relevant articles were retrieved. The majority (28, 90.3%) involved an investigation of a real-world network. These included corpora, thesauri, dictionaries, large computer programs, biological neuronal networks, word association networks, and files on the Internet. Twenty-two of the 28 (78.6%) involved a graph comprised of words or phrases. Fifteen of the 28 (53.6%) mentioned evidence of small-world characteristics in the network investigated. Eleven (39.3%) reported a scale-free topology, which tends to have a similar appearance when examined at varying scales. The results of this review indicate that networks generated from natural language have topological properties common to other natural phenomena. It has not yet been determined whether artificial human-curated terminology systems in biomedicine share these properties. Large network analysis methods have potential application in a variety of areas of informatics, such as in development of controlled vocabularies and for characterizing a given domain.

Algorithms↗

Developing interactive computer-based simulations: an object-oriented development methodology enhances computer-assisted instruction.

The purpose of this research was to investigate the application of object-oriented technology and AI techniques to enhance development of computer-based training simulations. Towards that end, a comprehensive computer-assisted instructional unit was developed to teach the skills and concepts of window-based applications, the OS/2 desktop, and the use of a patient care information system. By taking advantage of sophisticated computer graphics for the visual representation of objects and the behavioral modeling capabilities of the object-oriented language, domain knowledge modeling and human-computer interactions were implemented without complex natural language processing techniques. The results of this research indicate that nurses and physicians are able to learn the basic skills and concepts of computer systems and how to query for patient information. The new methodology described for building these computer-assisted instructional simulations significantly eased the training and teaching of large numbers of nurses and physicians and simplified their transition to a complex, computer-based hospital information system environment.

Computer Graphics↗

Cost-effectiveness of intraoperative imaging in carotid endarterectomy.

OBJECTIVE: There has never been a large, randomized controlled trial to assess the impact of intraoperative imaging on the success of carotid endarterectomy (CEA). This comparison involves cost-effectiveness analysis. METHODS: We constructed a decision-analytic model to compare effectiveness and costs of intraoperative ultrasound (IUS) and completion angiography as adjuncts to CEA. Data on procedural mortality, morbidity, and costs were obtained from the English-language literature. The review included a total of 52 reports, encompassing more than 22,000 patients. The main components of costs were those of the monitoring interventions and the care of perioperative stroke. RESULTS: Mean perioperative outcome without completion imaging is approximately 96.7% of what it would be in the absence of perioperative stroke or death. IUS and completion angiography each result in approximately 2% improvement in expected outcome. Mean perioperative costs are 396.50 dollars for IUS, 721.30 dollars for no monitoring, and 840.90 dollars for completion angiography. Because IUS is significantly more effective at detecting technical errors that would likely result in perioperative stroke than no imaging and is significantly less costly than angiography, this strategy dominates the other two (i.e., it provides greater effectiveness at lower cost). CONCLUSION: Although surgical complications are uncommon, IUS substantially lowers the rate of perioperative stroke and mortality and thus is significantly more cost-effective than either completion angiography or no operative imaging.

Angiography↗

Migration and spatial assimilation among U.S. Latinos: classical versus segmented trajectories.

We used merged data from the Latino National Political Survey, the Panel Study of Income Dynamics, and the U.S. census to examine patterns and determinants of interneighborhood residential mobility between 1990 and 1995 for 2,074 U.S. residents of Mexican, Puerto Rican, and Cuban ethnicity. In several respects, our findings confirm the central tenets of spatial assimilation theory: Latino residential mobility into neighborhoods that are inhabited by greater percentages of non-Hispanic whites (i.e., Anglos) increases with human and financial capital and English-language use. However, these results also point to variations in the residential mobility process among Latinos that are broadly consistent with the segmented assimilation perspective on ethnic and immigrant incorporation. Net of controls, Puerto Ricans are less likely than Mexicans to move to neighborhoods with relatively large Anglo populations, and the generational and socioeconomic differences that are anticipated by the classical assimilation model emerge more strongly for Mexicans than for Puerto Ricans or Cubans. Among Puerto Ricans and Cubans, darker skin color inhibits mobility into Anglo neighborhoods.

Adult↗

Functional segregation within pars opercularis of the inferior frontal gyrus: evidence from fMRI studies of imitation and action observation.

Recent neuroimaging studies have suggested that the inferior frontal gyrus (IFG) is important for action observation and imitation. In order to further explore the role of IFG in action observation and imitation, we pooled data from seven functional magnetic resonance imaging studies involving observation and imitation of simple finger movements performed in our laboratory. For imitation we found two peaks of activation in the pars opercularis, one in its dorsal sector and the other in its ventral sector. The dorsal sector of the pars opercularis was also activated during action observation, whereas the ventral sector was not. In addition, the pars triangularis was activated during action observation but not during imitation. This large dataset suggests a functional parcellation of the IFG that we discuss in terms of human mirror areas and the computational motor control architecture of internal models.

Adult↗

The International Classification of Impairments, Disabilities and Handicaps (ICIDH)--results and problems.

In 1980, the World Health Organization (WHO) published the International Classification of Impairments, Disabilities and Handicaps (ICIDH). Although these three concepts of impairment, of disability, and especially of handicap have been criticized for many reasons, the ICIDH has given rise to extensive research and other activities world-wide, resulting in more than a thousand publications. The ICIDH has been translated into numerous languages. The classification itself, developed for trial purposes, shows the large variety for the items of each basic term. Practical experience, however, has shown that the ICIDH cannot be applied without problems. This is especially true for the handicap concept.

Persons with Disabilities↗

Web based 3-D medical image visualization on the PC.

With the recent advance of Web and its associated technologies, information sharing on distribute computing environments has gained a great amount of attention from many researchers in many application areas, such as medicine, engineering, and business. One basic requirement of distributed medical consultation systems is that geographically dispersed, disparate participants are allowed to exchange information readily with each other. Such software also needs to be supported on a broad range of computer platforms to increase the softwares accessibility. In this paper, the development of world-wide-web based medical consultation system for radiology imaging is addressed to provide platform independence and greater accessibility. The system supports sharing of 3-dimensional objects. We use VRML (Virtual Reality Modeling Language), which is the defacto standard in 3-D modeling on the Web. 3-D objects are reconstructed from CT or MRI volume data using a VRML format, which can be viewed and manipulated easily in Web-browsers with a VRML plug-in. A Marching cubes method is used in the transformation of scanned volume data sets to polygonal surfaces of VRML. A decimation algorithm is adopted to reduce the number of meshes in the resulting VRML file. 3-D volume data are often very large in size, hence loading the data on PC level computers requires a significant reduction of the size of the data, while minimizing the loss of the original shape information. This is also important to decrease network delays. A prototype system has been implemented (http://cybernet5.snu.ac.kr/-cyber/mrivrml .html), and several sessions of experiments are carried out.

Algorithms↗

Condition-dependent functional connectivity: syntax networks in bilinguals.

This paper introduces a method to study the variation of brain functional connectivity networks with respect to experimental conditions in fMRI data. It is related to the psychophysiological interaction technique introduced by Friston et al. and extends to networks of correlation modulation (CM networks). Extended networks containing several dozens of nodes are determined in which the links correspond to consistent correlation modulation across subjects. In addition, we assess inter-subject variability and determine networks in which the condition-dependent functional interactions can be explained by a subject-dependent variable. We applied the technique to data from a study on syntactical production in bilinguals and analysed functional interactions differentially across tasks (word reading or sentence production) and across languages. We find an extended network of consistent functional interaction modulation across tasks, whereas the network comparing languages shows fewer links. Interestingly, there is evidence for a specific network in which the differences in functional interaction across subjects can be explained by differences in the subjects' syntactical proficiency. Specifically, we find that regions, including ones that have previously been shown to be involved in syntax and in language production, such as the left inferior frontal gyrus, putamen, insula, precentral gyrus, as well as the supplementary motor area, are more functionally linked during sentence production in the second, compared with the first, language in syntactically more proficient bilinguals than in syntactically less proficient ones. Our approach extends conventional activation analyses to the notion of networks, emphasizing functional interactions between regions independently of whether or not they are activated. On the one hand, it gives rise to testable hypotheses and allows an interpretation of the results in terms of the previous literature, and on the other hand, it provides a basis for studying the structure of functional interactions as a whole, and hence represents a further step towards the notion of large-scale networks in functional imaging.

Brain↗

Community-based participatory research in the California Health Interview Survey.

INTRODUCTION: The California Health Interview Survey, the largest state health survey in the United States, uses community-based participatory research principles to develop each cycle. Other large-scale health surveys rarely include participatory research approaches. Every 2 years, the California Health Interview Survey generates state and local population-based data on health insurance coverage, access to health care, chronic disease prevalence and management, health behaviors and disease prevention, and other health issues in California. The survey is used for policy and program development, advocacy, and research. METHODS: The development of the California Health Interview Survey involves more than 145 people from more than 60 state and local policymaking bodies, public health agencies, advocacy groups, research organizations, and health care organizations. They participate as volunteers in an advisory board, on technical advisory committees, and in work groups that interact with California Health Interview Survey research staff in an accountable advisory process that shapes survey topics, measures, and sample design and determines languages selected for translation. Survey results and data are provided to the communities involved in the survey. RESULTS: California Health Interview Survey data have been widely used by local, state, and national public health leaders, policymakers, advocates, and researchers to improve access to health insurance and health care services and to develop and target prevention programs for obesity and chronic illnesses. CONCLUSION: The California Health Interview Survey participatory research model has been an effective approach to planning and implementing a health survey and should be considered by developers of other large health surveys.

California↗

The HL7 Clinical Document Architecture.

Many people know of Health Level 7 (HL7) as an organization that creates health care messaging standards. Health Level 7 is also developing standards for the representation of clinical documents (such as discharge summaries and progress notes). These document standards make up the HL7 Clinical Document Architecture (CDA). The HL7 CDA Framework, release 1.0, became an ANSI-approved HL7 standard in November 2000. This article presents the approach and objectives of the CDA, along with a technical overview of the standard. The CDA is a document markup standard that specifies the structure and semantics of clinical documents. A CDA document is a defined and complete information object that can include text, images, sounds, and other multimedia content. The document can be sent inside an HL7 message and can exist independently, outside a transferring message. The first release of the standard has attempted to fill an important gap by addressing common and largely narrative clinical notes. It deliberately leaves out certain advanced and complex semantics, both to foster broad implementation and to give time for these complex semantics to be fleshed out within HL7. Being a part of the emerging HL7 version 3 family of standards, the CDA derives its semantic content from the shared HL7 Reference Information Model and is implemented in Extensible Markup Language. The HL7 mission is to develop standards that enable semantic interoperability across all platforms. The HL7 version 3 family of standards, including the CDA, are moving us closer to the realization of this vision.

Computer Communication Networks↗

Treating skin disease: self-management behaviors of Latino farmworkers.

Latino migrant and seasonal farmworkers experience high rates of skin disease that result from their working and living conditions. Knowledge of the ways farmworkers treat skin disease symptoms will provide a foundation for developing culturally appropriate health education, improving the delivery of health services, and improving occupational health policy for agricultural workers. The purpose of this paper is to describe skin disease self-management practices among Latino migrant and seasonal farmworkers in North Carolina. This analysis uses a qualitative design based on in-depth interviews with 30 Latino farmworkers (six females, 24 males). Computer assisted, systematic procedures are used to analyze the verbatim transcripts of these interviews. Participants shared a consistent set of health self-management actions in treating skin disease. These actions were within the domains of self-care and medical care. A model of skin disease self-management among Latino farmworkers includes the self-care actions of hygiene, use of home remedies and use of over-the-counter remedies, with farmworkers often combining different domains of self-care. While farmworkers acknowledge the benefits of medical care, they are also mindful of barriers to its use, including cost, transportation and language. The large percentage of farmworkers who experience skin problems indicates that health outreach workers who serve this population need to provide education on preventing and treating skin problems, and they need to recommend to farmworkers appropriate over-the-counter medicines for the treatment of these skin problems. Appropriate medical care for treating skin problems that are dangerous and reduce farmworkers' quality-of-life needs to be made available to this population.

Adolescent↗