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At least 289 records · Page 16Linked to original sources
PubMed1979

[Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].

After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in experiments with N-methyl-N-nitrosobenzylamines substituted with a methyl group at the phenyl moiety. Both chronic treatment and single doses induced tumors of the esophagus and the pharynx.

Animals↗
PubMed1988

Carcinogenic effect of N-nitrosotriethylurea in single administration to female rats.

N-Nitrosotriethylurea (NTEU) was administered once into the stomach or intravenously to outbred female rats. The rats given NTEU by oral administration developed malignant tumours of the mammary gland, uterus and liver. The rats exposed to NTEU by i.v. administration developed tumours of the mammary gland and ovaries. NTEU accelerated the appearance of tumours which are normally characteristic of the rat stock used (tumours of the pituitary, thyroid, adrenal cortex, fibroadenoma of the mammary gland, endometrial polyps.

Animals↗
PubMed1975

Djungarian hamster-a suitable tool for cancer research and cytogenetic studies.

The Djungarian hamster, bred under usual laboratory conditions, developed different spontaneous neoplasms, most often mammary and skin cancers. Some mammary tumors were serially transplanted to noninbred animals. This hamster was susceptible to some chemical carcinogens and oncogenic viruses but resistant to others. It had comparatively few chromosomes (2n equal to 28), most of which could be recognized even in conventionally stained preparations. The chromosome-breaking effect of gamma-rays, chemical carcinogens, and viruses was studied with primary cultures of cells. Several transformed cell lines were developed. Karyotype abnormalities were generally not seen in primary and induced neoplasms. This hamster is a new suitable tool for cancer research and cytogenetic studies.

Animals↗