SEARCH · PubMed Health

Results for “Perception”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 289 records · Page 16Linked to original sources

PubMedDate not supplied

Underconstrained perception: a theoretical approach to the nature and function of verbal hallucinations.

We do not see the world as it is. Perception forms a subjective image of the world in a language that has proven to be adaptive to our interaction with the external world. Perception is mainly determined by current needs of the organism and goals of behavior. Sensory processing itself does not culminate in perception and is not essential for perception, since perception derives from representations of internal symbols and their features. The current stimulation of sensory organs does, however, constrain our perception. Perception might be less constrained by the external world in cases of (1) increased attention, (2) decreased sensory stimulation, or (3) facilitated formation of cortical associations between representations of expectations and internal symbols. Hallucinations are perceptions that are underconstrained by external sensory stimulation. Verbal hallucinations that allow the patient to infer about his self-image might constitute the core psychopathology in a subset of schizophrenia. Commenting and discussing voices might be perceived under the pressure of increased attention to environmental factors that relate to the patient's social fears and wishes. Secondarily, delusions about the possession of thoughts and disorders of self-experience may develop.

Association↗

PubMed1990

Duplex perception: a comparison of monosyllables and slamming doors.

Duplex perception has been interpreted as revealing distinct systems for general auditory perception and speech perception. The systems yield distinct experiences of the same acoustic signal, the one conforming to the acoustic structure itself and the other to its source in vocal-tract activity. However, this interpretation has not been tested by examining whether duplex perception can be obtained for nonspeech sounds that are not plausibly perceived by a specialized system. In five experiments, we replicate some of the phenomena associated with duplex perception of speech using the sound of a slamming door. Similarities between subjects' responses to syllables and door sounds are striking enough to suggest that some conclusions in the speech literature should be tempered that (a) duplex perception is special to sounds for which there are perceptual modules and (b) duplex perception occurs because distinct systems have rendered different percepts of the same acoustic signal.

Adult↗

PubMed2003

Signal strength determines the nature of the relationship between perception and working memory.

Neurophysiological and behavioral studies have shown that perception and memory share neural substrates and functional properties. But are perception and the active working memory of a stimulus one and the same? To address this question in the spatial domain, we compared the percept and the working memory of the position of a target stimulus embedded within a surround of moving dots. Motion in a particular direction after the target's offset biased the memory of target location in the same direction. However, motion simultaneous with a high-contrast, perceptually strong target biased the percept of target location in the opposite direction. Thus, perception and working memory can be modified by motion in qualitatively different ways. Manipulations to strengthen the memory trace had no effect on the direction of the memory bias, indicating that memory signal strength can never equal that of the percept of a strong stimulus. However, the percept of a weak stimulus was biased in the direction of motion. Thus, although perception and working memory are not inherently different, they can differ behaviorally depending on the strength of the perceptual signal. Understanding how a changing surround biases neural representations in general, and postsensory processes in particular, can help one understand past reports of spatial mislocalization.

Computer Simulation↗

PubMed2005

Investigating spiritual care perceptions and practice patterns in Hong Kong nurses: results of a cluster analysis.

AIM: Nurses' spiritual care perceptions and practices are explored by identifying profiles of nurses studying in a part-time baccalaureate course in a local Hong Kong university. Relationships between nurses' spiritual care perceptions and their practices are explored. RESEARCH METHOD: Hundred and ninety three nurses completed a structured questionnaire. OUTCOME MEASURES: Spiritual care perceptions and practices. RESULTS: Two-step cluster analysis yielded three clusters. Clusters A, B, and C consisted of 15.0% (n = 29), 44.6% (n = 86), and 40.4% (n = 78), respectively. Cluster A nurses were characterized by relatively negative spiritual care perceptions and practices. Cluster C nurses reported positive perceptions, but negative practices; they mainly chose 'uncertain' for most items on both scales. Cluster B was a large group of nurses holding both positive spiritual care perceptions and practices. Significant differences towards spiritual care were found among clusters. Nurses' perceptions were significant positively correlated with practices (r = 0.62). High positive correlations were found between the two scales (r = 0.83) for nurses in Cluster A, for nurses in Clusters B and C, low positive correlations (r = 0.37) were found. CONCLUSION: Three clusters of Hong Kong nurses were differentiated. They showed differences in the level of their spiritual care perceptions and practices. Despite their level of spiritual care perceptions, nurses seldom incorporated spiritual care practices into their daily nursing care, and the level of spiritual care awareness of some nurses was low. Findings may be used to improve support of nurses, to ensure sensitive spiritual care in their daily practices, and to enhance nursing curricula.

Adult↗

PubMed2003

Accuracy of sleep perceptions among insomnia sufferers and normal sleepers.

OBJECTIVE: To examine the distribution, consistency, and correlates of sleep time perceptions in primary insomnia sufferers and normal sleepers across settings (laboratory and home). METHODS: Fifty-two middle-aged and older insomnia sufferers and 49 matched normal sleepers underwent multiple nights of laboratory and home polysomnography (PSG) and provided concurrent subjective estimates of their sleep. Descriptive statistics, cluster analyses, and inferential tests were used to examine the nature of sleep time perceptions, identify subgroups with distinctive patterns such as perceptions, and explore factors that may contribute to these subgroups' distinctive sleep perceptions. RESULTS: Consistent with previous studies, the insomnia sufferers, as a group, showed a greater tendency to underestimate the time they slept than did the normal sleepers, but the accuracy of sleep time perceptions varied widely within each sample. Correlational analyses showed that study participants in each sample showed a moderate level of consistency in how accurately they estimated sleep time across nights. Subsequent cluster analyses conducted to identify subgroups with distinctive patterns of sleep time perceptions yielded four subgroups within the insomnia sample and three subgroups within the normal sleeper sample. Although the sleep setting significantly affected sleep perceptions for one insomnia subgroup, both laboratory and home objective-subjective sleep comparisons provided similar impressions regarding the relative accuracy of each subgroup's nocturnal sleep/wake perceptions. Finally, varying patterns of subgroup differences were noted across several common psychometric measures. CONCLUSIONS: The underestimation of sleep time is not a generic characteristic that separates all insomnia sufferers from normal sleepers. Sleep setting, personality traits, and perhaps constitutional factors appear to influence perceptions of sleep and wake time duration.

Analysis of Variance↗

PubMed2001

Schizophrenic outpatient perceptions of psychiatric treatment and psychotic symptomatology: an investigation using structural equation modeling.

Schizophrenic patient perceptions of treatment have clinical value and deserve detailed psychiatric investigation. The present study sought a model indicating statistically estimated cause-effect relationships of perceptions and psychotic symptomatology of outpatients with schizophrenia by applying a method of structural equation modeling. The perceptions included in this model were patient satisfaction with treatment, perceptions of their treating psychiatrists, and patient-role perception. Scores of Positive and Negative Syndrome Scale and poor insight measures were added to the model as possible influential factors. The constructed model revealed that the poor insight exerted a major influence on the patient-role perception that had small effects on the reliable therapist perception and the satisfaction. It was also shown that satisfaction was chiefly determined by the reliable therapist perception that was formed in the treatment relationship, rather independently of the other construct. These findings were valuable in terms of their implications for understanding the makeup of the perceptions and the strategy for interventions to improve them.

Adult↗

PubMed2003

Consumers' sensory and nutritional perceptions of three types of milk.

OBJECTIVE: To identify consumer perceptions of whole milk, reduced-fat milk and soy milk, and to investigate demographic influences on perceptions and types of milk consumption. DESIGN AND SETTING: Questionnaires covering nutritional and sensory perceptions of three types of milk. SUBJECTS: Three hundred and sixty-one randomly selected shoppers in Melbourne, Australia. RESULTS: Generally, respondents held positive perceptions about milk. Milk was considered as having good sensory properties, providing a good source of nutrients, and being a convenient and safe product. However, despite these findings, misperceptions and unawareness about the nutrient content of milk were prevalent. Negative perceptions were most common for whole milk and were mostly related to its perceived high fat, cholesterol and energy contents. Soy milk received lower ratings on sensory quality and convenience than dairy milk. There were few sociodemographic differences in consumers' perceptions. Although reduced-fat milk consumption was more frequent among elderly people and type of milk consumption was related to parenthood, no other significant effects of demographic variables were found on the consumption of specific milk types. CONCLUSION: Although positive perceptions were common, negative perceptions and misperceptions appear to be prevalent, presenting a challenge for nutrition education. Sociodemographic factors were not shown to be important predictors of perceptions and type of milk consumption.

Adolescent↗

PubMed2005

Perceptions of temperature, moisture and comfort in clothing during environmental transients.

A study has been carried out to investigate the psychophysical mechanisms of the perception of temperature and moisture sensations in clothing during environmental transients. A series of wear trials was conducted to measure the psychological perception of thermal and moisture sensations and the simultaneous temperature and humidity at the skin surface, fabric surface and in the clothing under simulated moderate rain conditions. Jumpers made from wool and acrylic fibres were used in the trial. Analysis has been carried out to study the relationship between psychological perceptions of temperature and moisture and the objectively measured skin and fabric temperatures and relative humidity in clothing microclimate. The perception of warmth seems to follow Fechner's law and Stevens' power law, having positive relationships with the skin temperature and fabric temperatures. The perception of dampness appears to follow Fechner's law more closely than Stevens' power law with a negative relationship with skin temperature, and is nonlinearly and positively correlated with relative humidity in clothing microclimate. The perception of comfort is positively related to the perception of warmth and negatively to the perception of dampness. This perception of comfort is positively related to the skin temperature, which appears to follow both Fechner's law and Stevens' law, also non-linearly and negatively related to relative humidity in clothing microclimate.

Adult↗

PubMed2002

Perceptions of diabetes among patients in an urban health care system.

OBJECTIVES: A major problem facing health care providers today is adherence to treatment regimens by patients. Adherence is of even greater significance for patients with diabetes, who shoulder a great deal of responsibility in their disease management. Perceptions of diabetes have been found to play a major role in adherence. The effects of race and socioeconomic status on the disease perceptions remain unclear. This exploratory study encompassed two themes: (1) assessing perceptions of diabetes among African American and white American adults with diabetes who were patients in 1994 in a large, Midwestern, urban health care system and (2) examining the psychometric properties of the measurement instruments used to study perceptions. DESIGN: A stratified random sampling scheme (by race and socioeconomic status (SES)) was used. Diabetes perceptions were measured using three scales from the Meaning of Illness Questionnaire assessing the impact, loss, and stress associated with diabetes. Perceptions of physician efficacy were also measured. The study population consisted of 50 (68% response rate) African American and white American patients aged 18-65 years. RESULTS: No differences in SES were found between the African American and white American participants (p = 0.44). However, the African Americans in the study indicated a greater sense of loss associated with diabetes than the white Americans in the study (p < 0.05). In the combined racial group, the reliability coefficients, as measured by Cronbach's alpha, were 0.76, 0.78, 0.68, and 0.68 for the Impact, Loss, Stress, and Perceptions of Physician Efficacy scales, respectively. However, the results of within-racial-group analyses tell a different story. The Impact scale fitted the African American and white American subgroups, although there was some item variation by racial group. The Loss scale did not fit the white American subgroup, and the Stress and Perceptions of Physician Efficacy scales did not fit the African American subgroup. CONCLUSION: Perceptions of diabetes may vary by race, even when controlling for SES. Health professionals are in a unique position to develop diabetes management programs to help patients understand more about their diabetes, and thus to reduce some of the negative outcomes of diabetes by promoting adherence to recommended treatment regimens. In addition, overall measures of reliability may mask the instability of scales within specific study groups.

Adolescent↗

PubMed2002

Perceptions of schizophrenia in multi-cultural Britain.

OBJECTIVES: The importance of perceptions of mental health problems from the perspectives of different ethnic populations is especially pertinent within a society such as Britain, which is culturally diverse, but employs a classification of psychopathology which is based upon western models. This study aimed to investigate differences in the lay perceptions of mental health problems, particularly schizophrenia, across different ethnic populations living in Britain. Further it aimed to look at the influence ethnic background had in relation to other variables such as age, gender, religion and contact with people with mental health problems. DESIGN: 190 participants from five broad ethnic groups (Afro-Caribbean, Bangladeshi, Indian, Sub-Saharan African and White British) reported their perceptions of schizophrenia symptoms using the Perceptions of Mental Health Problems Questionnaire. RESULTS: Differences were found across ethnic groups in participants' perceptions of schizophrenia symptoms. Differences were consistently shown across the specific symptoms of hallucinatory behaviour, suspiciousness, unusual thought content and alogia. In particular, in comparison with the white British group, Bangladeshi participants were less likely to view suspiciousness or hallucinatory behaviour as indicative of mental health problems, and the Afro-Caribbean participants were less likely to view unusual thought content as a symptom. As expected, differences in perceptions were also associated with religion, education, gender and contact with people with mental health problems. However, ethnicity was the best predictor of perceptions of schizophrenia symptoms. CONCLUSION: Ethnicity was found to be an important factor in influencing perceptions of schizophrenia. The specific differences found across ethnic groups are useful in beginning to understand more fully public perceptions of mental health problems in Britain today. The findings raise interesting discussion in relation to ethnic and cultural factors in planning services for people from ethnic minorities, and considering in more detail issues concerning diagnosis and engagement.

Adolescent↗

PubMed1996

A taxonomy for lay risk perceptions of dentistry.

OBJECTIVE: This paper aims to develop and organize a set of variables that can be used to: (1) test the widely held but unproven assumption that lay risk perceptions can adversely affect dental care, (2) investigate the possible influence of lay risk perceptions on dental care and (3) permit the evaluation of risk communication strategies in dentistry. METHODS: We reviewed the literature regarding risk perception and risk communication in health care and technology. We then selected a set of variables that could be measured in a study of the general public and organized these in a taxonomy to suggest likely relationships among the variables. RESULTS: The central relationship of the proposed taxonomy is between a lay person's perception of dental risk and a set of measurable outcomes that could affect that person's dental care. The taxonomy lists three possible influences on the lay person's risk perception: attributes of the individual, attributes of the dental procedure or technology perceived as risky, and attributes of the dental practice. CONCLUSIONS: Systematic testing of the proposed variables should demonstrate whether lay risk perceptions substantially influence dental care, and if so, which factors most strongly influence risk perceptions. A model of lay risk perceptions of dentistry then could be developed and strategies could be devised to minimize the detriment, if any, to dental care from risk perception.

Attitude to Health↗

PubMed2000

Understanding the effects of nurses, patients' hospital rooms, and patients' perception of control on the perceived quality of a hospital.

Service marketing researchers suggest that the physical environment, the people, and the process strongly affect consumers' judgements when they evaluate services. Previous research has rarely applied this general framework to help identify specific hospital variables that affect the perceived quality of a hospital. This article presents a proposed model and empirical evidence that is based upon this general framework. That is, this article reports the results of a study which found that the physical environment (i.e., patients' perception of their hospital rooms) and people (i.e., patients' perception of nurses) affected patients' perception of hospital quality. The process (i.e., patients' perception of control over the process) did not directly affect their perception of hospital quality. However, patients' perception of control over the process and their perception of their hospital rooms affected their perception of their nurses. Consequently, this research suggests that the general framework identified by service marketing researchers can be applied to help understand how patients develop their perception of hospital quality.

Health Services Research↗

PubMed2000

Perception of respiratory sensation assessed by means of histamine challenge and threshold loading tests.

BACKGROUND: Some asthmatic patients perceive the severity of their disease rather poorly. These patients may not receive optimal therapy because of underpresentation of their respiratory symptoms. It is therefore important to identify these patients. The present study evaluates a new threshold loading device for measuring the perception of respiratory sensation. This method for measuring the perception of respiratory sensation may be a viable alternative to the bronchial provocation test. The aim of the present study was to investigate whether the assessment of the perception of respiratory sensation based on a threshold loading test (inspiratory and expiratory) identifies the same subjects as poor perceivers as compared to assessment by histamine bronchial provocation test. METHOD: In 36 subjects, the perception of respiratory sensation through a threshold loading device was compared to the perception of respiratory sensation during a histamine provocation test. Each test was performed with scoring of the magnitude of the respiratory sensation on a visual analog scale (VAS). The magnitude of the stimulus intensity was indicated by the percentage of decrease in FEV(1) during the histamine challenge test and by the percentage of the subject's maximum mouth pressure (percent maximal inspiratory pressure and percent maximal expiratory pressure) during the threshold loading test. The relationship between VAS values and the stimulus intensity was analyzed by determining the linear regression coefficient between the two parameters. RESULTS: No relationship was found between the perception of the sensation induced by the histamine challenge and that during breathing through a threshold loading device for both inspiration (Rs = 0.15; p = 0.40) and expiration (Rs = 0.13; p = 0.47). We did find a significant relation between the perception of respiratory sensation during the inspiratory and expiratory threshold loading test (Rs = 0.67; p = 0. 0001). Furthermore, we defined a subgroup of patients of special interest: those with low symptoms of breathlessness and high bronchial responsiveness. Compared to the inspiratory and expiratory threshold loading test, the histamine challenge test identified more patients in the special interest group as poorest perceivers. CONCLUSION: The measurement of perception by means of a threshold loading device and a histamine provocation test did not identify the same subjects as poor perceivers, probably because we did not measure the patient's perceptiveness for exactly the same stimuli. In the population with relatively more severe asthma and very low symptoms of breathlessness, the histamine-induced bronchoconstriction test identified more patients as poorest perceivers compared to the threshold loading test.

Adolescent↗

PubMed2005

Temporal perception in velo-cardio-facial syndrome.

Temporal perception abilities refer to timing mechanisms used in daily life, such as the ability to reproduce and judge time, previously associated with the basal ganglia and the cerebellum, respectively. In individuals affected by velo-cardio-facial (VCFS), both the basal ganglia and the cerebellum have been shown to be particularly vulnerable to abnormal brain development, though related temporal perception abilities have yet to be investigated. In this study, our goal was to characterize time perception and reproduction abilities in individuals with VCFS. Compared to controls, we hypothesized that individuals with VCFS would be less accurate and show more variability when reproducing a fixed-interval series of auditory beeps; furthermore, we predicted that they would show a higher perceptive acuity threshold when discriminating between subtle time differences. Forty-two subjects with VCFS and 35 matched controls participated in temporal perception evaluations. In the reproduction of time finger-tapping task, subjects were asked to press a button in cadence with a series of fixed interval beeps, and then to hold the same tempo when the beeps stopped. Overall, the VCFS group showed less accuracy and more variability in reproduction ability when compared to controls. In the second experiment, subjects were tested on auditory and visual time perception tasks. Subjects were presented with a fixed interval stimulus and a stimulus of varying duration, and were asked to determine the longer of the two. The VCFS group required a greater discrepancy between tones to accurately discriminate the two stimuli. The results point to an alteration in temporal perception associated with VCFS. Implications of altered temporal perception abilities and their relationship to the VCFS phenotype are discussed.

Acoustic Stimulation↗

PubMed2005

Optic-flow-based perception of two-dimensional trajectories and the effects of a single landmark.

Human observers can detect their heading direction on a short time scale on the basis of optic flow. We investigated the visual perception and reconstruction of visually travelled two-dimensional (2-D) trajectories from optic flow, with and without a landmark. As in our previous study, seated, stationary subjects wore a head-mounted display in which optic-flow stimuli were shown that simulated various manoeuvres: linear or curvilinear 2-D trajectories over a horizontal plane, with observer orientation either fixed in space, fixed relative to the path, or changing relative to both. Afterwards, they reproduced the perceived manoeuvre with a model vehicle, whose position and orientation were recorded. Previous results had suggested that our stimuli can induce illusory percepts when translation and yaw are unyoked. We tested that hypothesis and investigated how perception of the travelled trajectory depends on the amount of yaw and the average path-relative orientation. Using a structured visual environment instead of only dots, or making available additional extra-retinal information, can improve perception of ambiguous optic-flow stimuli. We investigated the amount of necessary structuring, specifically the effect of additional visual and/or extra-retinal information provided by a single landmark in conditions where illusory percepts occur. While yaw was perceived correctly, the travelled path was less accurately perceived, but still adequately when the simulated orientation was fixed in space or relative to the trajectory. When the amount of yaw was not equal to the rotation of the path, or in the opposite direction, subjects still perceived orientation as fixed relative to the trajectory. This caused trajectory misperception because yaw was wrongly attributed to a rotation of the path: path perception is governed by the amount of yaw in the manoeuvre. Trajectory misperception also occurs when orientation is fixed relative to a curvilinear path, but not tangential to it. A single landmark could improve perception. Our results confirm and extend previous findings that, for unambiguous perception of ego-motion from optic flow, additional information is required in many cases, which can take the form of fairly minimal, visual information.

Adult↗

PubMed2000

Visual contributions to human self-motion perception during horizontal body rotation.

It is still an enigma how human subjects combine visual and vestibular inputs for their self-motion perception. Visual cues have the benefit of high spatial resolution but entail the danger of self motion illusions. We performed psychophysical experiments (verbal estimates as well as pointer indications of perceived self-motion in space) in normal subjects (Ns) and patients with loss of vestibular function (Ps). Subjects were presented with horizontal sinusoidal rotations of an optokinetic pattern (OKP) alone (visual stimulus; 0.025-3.2 Hz; displacement amplitude, 8 degrees) or in combinations with rotations of a Bárány chair (vestibular stimulus; 0.025-0.4 Hz; +/- 8 degrees). We found that specific instructions to the subjects created different perceptual states in which their self-motion perception essentially reflected three processing steps during pure visual stimulation: i) When Ns were primed by a procedure based on induced motion and then they estimated perceived self-rotation upon pure optokinetic stimulation (circular vection, CV), the CV has a gain close to unity up to frequencies of almost 0.8 Hz, followed by a sharp decrease at higher frequencies (i.e., characteristics resembling those of the optokinetic reflex, OKR, and of smooth pursuit, SP). ii) When Ns were instructed to "stare through" the optokinetic pattern, CV was absent at high frequency, but increasingly developed as frequency was decreased below 0.1 Hz. iii) When Ns "looked at" the optokinetic pattern (accurately tracked it with their eyes) CV was usually absent, even at low frequency. CV in Ps showed similar dynamics as in Ns in condition i), independently of the instruction. During vestibular stimulation, self-motion perception in Ns fell from a maximum at 0.4 Hz to zero at 0.025 Hz. When vestibular stimulation was combined with visual stimulation while Ns "stared through" OKP, perception at low frequencies became modulated in magnitude. When Ns "looked" at OKP, this modulation was reduced, apart from the synergistic stimulus combination (OKP stationary) where magnitude was similar as during "staring". The obtained gain and phase curves of the perception were incompatible with linear systems prediction. We therefore describe the present findings by a non-linear dynamic model in which the visual input is processed in three steps: i) It shows dynamics similar to those of OKR and SP; ii) it is shaped to complement the vestibular dynamics and is fused with a vestibular signal by linear summation; and iii) it can be suppressed by a visual-vestibular conflict mechanism when the visual scene is moving in space. Finally, an important element of the model is a velocity threshold of about 1.2 degrees/s which is instrumental in maintaining perceptual stability and in explaining the observed dynamics of perception. We conclude from the experimental and theoretical evidence that self-motion perception normally is related to the visual scene as a reference, while the vestibular input is used to check the kinematic state of the scene; if the scene appears to move, the visual signal becomes suppressed and perception is based on the vestibular cue.

Adult↗

PubMed1997

The characteristics of interaction between color and motion perception in primary open angle glaucoma.

PURPOSE: To investigate the characteristics of interaction between color and motion perception in primary open angle glaucoma (POAG) and measure motion perception of B, G and R cones, thus find a more sensitive method to diagnose the visual nerve damage in POAG. METHODS: Motion perceptions of B, G and R cones were isolated by blue, green and red vertical line stimulus displayed on the yellow, purple and blue background respectively, then measured the displacement threshold and flicking threshold of motion perception from each cones in POAG, and compared it with the age-match normals. RESULTS: The displacement threshold and flicking threshold of motion perception from B, G and R cones were all damaged in POAG compared with the normals, and the motion perception of G and B cones was deficits more obviously than the R cones. CONCLUSION: These findings support the suggestion that color provides an input to human motion perception. Magnocellular and parvocellular pathway may be significantly damaged in POAG, which indicates, that the combination of Motion Perception and color testing may reveal preclinical visual nerve damage in early POAG.

Adult↗

PubMed1996

The prediction of Alzheimer disease. The role of patient and informant perceptions of cognitive deficits.

OBJECTIVE: To determine whether the perceptions of patients' cognitive deficits by either the patient or an informant could predict who would develop Alzheimer disease (AD) in a group of 120 memory-impaired patients without dementia. METHODS: At entry into the study, patients were assessed by several measures that included neuropsychological tests and the Cambridge Mental Disorders of the Elderly Examination Interview Schedule. The latter schedule asks patients and their informants about their perceptions of cognitive deficits in the patients. After 2 years, patients underwent a diagnostic workup for AD: 29 had developed probable AD, whereas the other 91 did not develop dementia. We used logistic regression analyses to examine the predictive accuracy of patients' and informants' perceptions of deficits at entry into the study. RESULTS: Informants' perceptions, not patients' perceptions, contributed significantly to the prediction of AD. The best prediction of AD was obtained by the regression model that included both informants' perceptions and 2 neuropsychological tests. CONCLUSIONS: These results demonstrate the clinical use of including informant perceptions about patients' cognitive deficits in the diagnostic assessment of AD. They also indicate that patients' perceptions of their own deficits are not predictive of AD, but are related to depressive affect.

Aged↗