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PubMed1981

[Disorders of lysosomal enzyme activity in rats with experimental radiation sickness].

The studies undertaken were aimed at detecting the biological effects of radioactive radiation on rat's organism, through studying the activity of lysosomal enzymes in both blood plasma and some organs. The contemporary studies suggest that lysosomes play an important role in the occurrence and course of postradiation disease. The obtained results suggest the multidirectional gamma-rays effects on lysosomal enzymes response in serum, leucocytes, liver lysosomes and in liver, kidneys, lungs, heart. Increased activity of acid phosphatase, beta-glucuronidase and beta-acetyl-glucosaminase in the tissues of irradiated animals indicates that gamma rays labiliza the lysosomal membrane. The range of changes indicates a selective nature of this phenomenon. Kidneys, lungs and liver appeared the most ray--sensitive organs. The activity of acid phosphatase was found to be most increased in blood serum and leucocytes. The activity of all the examined enzymes in liver lysosomes was decreased. Acid phosphatase exhibited the greatest activity increases. Lysosomal responses, as one of the radiobiological effects of postradiation disease are indicative of the degree of destructive or regenerative changes in the organism.

Acetylglucosaminidase↗
PubMedDate not supplied

[Health status of persons with acute radiation sickness caused by Chernobyl AES accident].

After Chernobyl accident 75 survivors with acute radiation syndrome (ARS) have been under observation in the Clinic of the Institute of Biophysics. Years after accident serious problems occurred in the individuals, who suffered from late effects from radiation injuries (late radiation ulcers and radiation cataracts). One patient suffered on hypernephroma, one-kidney cyst. Observed somatic diseases are gastrointestinal diseases, different neurological diseases and syndromes and upper pulmonary tract diseases. Hemopoiesis system condition was characterised by the development of transient moderate cytopenia (light and moderate degree of ARS patients) as well as the periodical increase of blood cell counts above standard indices (severe degree of ARS patients).

Acute Disease↗