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[Combined action of vibration and ionizing radiation on the body].

The effect of vibration on the development and outcome of radiation injury was studied and the efficacy of pharmacochemical and local protection was measured. The biological effect of the combined exposure was estimated by radiobiological and hematological methods. The animals were exposed to vibration with a frequency of 70, 700, 1500 Hz (during single and repeated exposures) and irradiation with X-rays, gamma-rays and protons at different doses. Vibration may exert a significant effect on the development and outcome of radiation injury of animals. The effect was that this factor was capable either of increasing or decreasing responses of the animal body to ionizing radiation. The direction and level of changes depended on the pattern and force of stimulation, time and sequence of action of factors, etc. The lymph tissue showed high sensitivity to vibration. The findings indicate that vibration may both enhance and diminish the efficacy of antiradiation pharmacochemical drugs.

Animals↗
PubMed1978

Protective effect of a mixture of radioprotective substances (AET and mexamine) on the haemopoietic stem cells of mice.

A protective effect of a combined application of radioprotectors (AET -i.p., mexamine -s.c.) was studied in experiments on mice. Duration of the protective effect on the haemopoietic stem cells and on the survival of mice after a lethal exposure to X-ray radiation lasted for 5 hours after the injection. DRF calculated from a change of LD 50/30 reached the maximum (1.53) within 30 min after the injection, and was equal to 1.17 within an interval of 5 hrs. The protection of haemopoiesis, as expressed by DRF calculated from an equieffective exposure for 2 ESC, reached the maximum within a 60 min interval after the injection (DRF=3.4). D0 calculated from the CFU survival curves of endogenous haemopoietic tissue colonies (ESC) was, within a 120 min interval, almost three times higher (310 R) than in the control group (110 R). After the injection of radioprotectors a greater number of haemopoietic CFU survives at an exposure of 100-400 R than after mere irradiation. The postirradiation decrease in the weight of small intestine was smaller in protected animals than in the controls. The role of a decrease of the radiation damage to the haemopoietic stem cells in the total protective effect of the radioprotectors used is discussed.

Animals↗