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PubMed1988

Salmonella infections.

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Acquired Immunodeficiency Syndrome↗
PubMed2005

The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection.

Salmonella enterica is a gram-negative intracellular pathogen that can cause a variety of diseases ranging from gastroenteritis to typhoid fever. The Typhimurium serotype causes gastroenteritis in humans; however, infection of mice results in an enteric fever that resembles human typhoid fever and has been used as a model for typhoid fever. The present study examined the role of the chemokine CCL2 in the control of Salmonella infection. Upon infection with salmonellae, mucosal expression of CCL2 is rapidly up-regulated, followed by systemic expression in the spleen. CCL2(-/-) mice became moribund earlier and had a higher rate of mortality compared to wild-type C57BL/6 mice. Moreover, CCL2(-/-) mice had significantly higher levels of bacteria in the liver compared to wild-type controls. Mucosal and serum interleukin-6 and tumor necrosis factor alpha levels were elevated in CCL2(-/-) mice compared to wild-type mice. In vitro analysis demonstrated that CCL2(-/-) macrophages infected with salmonellae resulted in dysregulated cytokine production compared to macrophages derived from wild-type mice. These data are the first to directly demonstrate CCL2 as a critical factor for immune responses and survival following S. enterica infection.

Animals↗
PubMed1989

[A trial with attenuated live Salmonella typhimurium vaccine for protection against an experimental Salmonella infection in pigeons].

A live, attenuated Salmonella typhimurium vaccine, available on the market, was administered to six pigeons. The strain of vaccine could not be identified in the droppings of pigeons up to ten days after administration. The pigeons as well as controls were experimentally infected with a Salmonella typhimurium var. copenhagen pigeon strain four weeks after vaccination. Differences in excretion of the var. copenhagen strain and in the appearance of diarrhoea and polyuria between the vaccinated and non-vaccinated pigeons were not detected.

Animals↗
PubMed1990

[Immunologic memory in the course of udder immunization for the protection of calves against Salmonella infections].

Cows were vaccinated once or twice intracisternally in order to protect calves against salmonella infections. The amount of antibodies measured in the colostrum of re-vaccinated and not re-vaccinated cows indicated that a sensitive immunological memory has been provoked by this vaccination technique. This immunological memory showed a distinct synchronism with the state of pregnancy in order to provide a maximum amount of antibodies in the colostrum.

Animals↗