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At least 289 records · Page 16Linked to original sources
PubMed1996

Association between Wegener's granulomatosis and Staphylococcus aureus infection?

Two patients are presented with Wegener's granulomatosis (WG) and lower respiratory tract infections with Staphyloccus aureus (SA). It is posulated that there is a relationship between the infection and the induction or relapse of the disease. We suggest that bronchoalveolar lavages should be performed in cases of suspected WG to identify SA-infections. The co-existence of WG and SA support the reported beneficial effects of sulfamethoxazole/trimethoprim, but needs further evaluation in patients with and without SA-infection of the airways.

Anti-Bacterial Agents↗
PubMed1991

Intrathecal vancomycin in the treatment of Ommaya reservoir infection by Staphylococcus epidermidis.

Ommaya reservoirs are frequently used in the treatment of patients with meningeal involvement by malignant diseases. The reported infectious complications range between 5-50%. We describe a 35-year-old male patient with Staphylococcus epidermidis infection of an Ommaya reservoir in whom intravenous antibiotics and removal of the reservoir failed to eradicate the organism. The patient was treated successfully by intrathecal injections of vancomycin. Patients with Ommaya reservoir related infections that persist in spite of shunt removal may derive a therapeutic benefit from the intrathecal administration of appropriate antibiotics.

Adult↗
PubMed1988

Functional activity of neutrophils from bovine mammary glands infected with Staphylococcus aureus.

To test the effect of Staphylococcus aureus infection on mammary neutrophil function, intramammary neutrophils from S. aureus-infected quarters (n = 8), from adjacent uninfected quarters (n = 8) of S. aureus-infected cows, and from quarters (n = 8) of uninfected cows were collected and incubated with S. aureus in vitro. Mean percent neutrophils phagocytizing, number S. aureus per neutrophil, and log10 viable phagocytized S. aureus/ml were: 53.2, 6.4, and 4.72. Differences in function of neutrophils collected from infected and uninfected quarters were not statistically significant. Results indicate that function of neutrophils from S. aureus-infected quarters is similar to function of neutrophils from uninfected quarters.

Animals↗
PubMed1994

Coagulase-positive Staphylococcus intramammary infections in primiparous dairy cows.

Objectives were to determine the prevalence of coagulase-positive staphylococcal IMI in primiparous cows at first parturition, to contrast the differences in coagulase-positive staphylococcal IMI in primiparous cows at parturition in herds with high and low prevalences of coagulase-positive staphylococcal IMI in the lactating herd, and to determine the percentage of primiparous cows having persistent coagulase-positive staphylococcal IMI. Milk samples were collected aseptically from cows at the start and end of the study, at dry-off, and at parturition. Herds (n = 18) were split evenly into two categories: high (> 10%) or low (< 5%) prevalence of coagulase-positive staphylococcal IMI. At the start, the mean prevalence of coagulase-positive staphylococcal IMI in high prevalence herds was 30%, ranging from 13 to 65%, and in low prevalence herds was 2%, ranging from 0 to 5%. Overall the prevalence of coagulase-positive staphylococcal IMI in primiparous cows at parturition was 8.1% (67 of 828), ranging from 0 to 27%. Although primiparous cows from high prevalence herds had a higher prevalence of coagulase-positive staphylococcal IMI (9.2%; 40 of 436) at parturition than did primiparous cows from low herds (6.9%; 27 of 392), the difference was not significant. Of primiparous cows with coagulase-positive staphylococcal IMI at parturition, 43% had coagulase-positive staphylococcal IMI at least 2 mo after parturition. Primiparous cows with coagulase-positive staphylococcal IMI at parturition may represent significant reservoirs of infection to uninfected herdmates.

Animals↗
PubMed2001

The many faces of Staphylococcus aureus infection. Recognizing and managing its life-threatening manifestations.

Serious infections caused by S aureus, particularly those associated with bloodstream infection, are rapidly increasing in frequency, likely as a result of the proliferation of invasive procedures, the increasing severity of illness of hospitalized patients, suboptimal adherence to infection control practices, selection of resistant strains by antibiotic use, high rates of injecting drug use, and diabetes mellitus. In many cases, being aware of the clinical manifestations and treatment of S aureus can help to decrease the incidence of these infections and promote better care for patients who have been--or could be--exposed to the pathogen.

Anti-Bacterial Agents↗
PubMed1999

Surgical patients with methicillin resistant staphylococcus aureus infection: an analysis of outcome using P-POSSUM.

The significance of MRSA infection in surgical patients was studied using the P-POSSUM scoring system. All surgical patients undergoing operation between 1/10/96 and 30/09/97 were prospectively scored using P-POSSUM. A subset of these patients with MRSA infection was analysed using P-POSSUM predicted mortality. Physiological and operative severity scores were compared with non-MRSA surgical patients and length of hospital stay with P-POSSUM matched non-MRSA controls. Thirty of the 1,132 patients were MRSA positive and of these five died, giving a P-POSSUM observed/expected deaths ratio of 1.7 (not significant; 95% CI -0.24 to 0.10). The P-POSSUM physiology score of 30 MRSA positive patients, compared with the non-MRSA group (n = 1102), was significantly more severe (20.9 v/s 17.4; 95% CI 1.09 to 5.95) as was the operative severity score (15.6 v/s 9.2; 95% CI 4.40 to 8.42). The length of stay for surviving MRSA positive patients was significantly longer than P-POSSUM matched controls. MRSA infection in surgical patients does not increase mortality. However, patients who contract MRSA infection are more debilitated and have undergone a greater surgical insult.

Adult↗
PubMed2000

Risk factors for methicillin resistant and sensitive Staphylococcus aureus infection in a Brazilian university hospital.

Two hundred three isolates of S. aureus were collected from 140 patients during a 1 year period in our hospital in Minas Gerais, Brazil. Of these patients, 102 acquired the infection in the hospital (nosocomial) and are the subject of this report. Fifty-seven patients had Methicillin-sensitive S. aureus (MSSA) strains identified, and 45 had Methicillin-resistant S. aureus (MRSA) strains. The most common sites of clinical infections by S. aureus were bloodstream (bacteremia), surgical/skin wounds and lung (pneumonia). The patients with MRSA infections were most likely to be in the surgical and clinical wards, but those with MSSA infections were most likely to be in the neonatal and emergency units. By univariate analysis, we found several factors associated with an increased risk of MRSA infections: age, mean preinfections and total duration of hospital stay, use of 3 or more antimicrobials, presence of 3 or more indwelling devices (mainly vascular and urinary catheters). Colonization (67.6% x 27.8%; p<0.05) and multicolonization (89% x 11.0%; p<0.05) were more associated with MRSA infection. Of the total of 203 isolates, 110 MRSA were found to be multiresistant, with 106 showing resistance to 5 or more antibiotics, compared to 15/93 (16%) of the MSSA isolates. The most serious cases and higher colonization rates of MRSA occurred in elderly patients. The presence of nosocomial MRSA is a serious medical problem which requires continued attention to care in the overuse of antibiotics and indwelling devices in hospitals.

Adolescent↗