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Female sexual dysfunction related to depression and antidepressant medications.

Major depression is frequently associated with sexual dysfunction (over 70% of patients), and the antidepressant medications used to treat the illness may exacerbate pre-existing sexual dysfunction, or induce sexual dysfunction not present on diagnosis. In women, sex hormones that change across the life cycle, menstrual cycle, and diurnally have direct effects on sexual functioning, and indirect effects via modulation of neurotransmitter systems. These complex neuroendocrine effects lead to the sexual dysfunction seen with antidepressants. Strategies to manage these effects have had some success. They include switching to antidepressants with minimal sexual side effects, addition of hormones and/or antidotes, and lowering the dose of medication. Emerging data on the pathophysiology of sexual function and dysfunction, and new treatment options may lead to improved quality of life for women diagnosed with depression.

Antidepressive Agents↗

Female sexual dysfunction: definitions, causes, and treatment.

Only recently has there been some focus on female sexual function. Due to increasing knowledge regarding male sexual dysfunction and increasing focus on women's health care issues, female sexual dysfunction and its relationship to quality of life is slowly attracting the attention of health care professionals and women in general. Health care professionals in urologic, gynecologic, and family practice offices and clinics are in key roles to identify females experiencing sexual dysfunction. Sexual identity is shaped throughout our life. It depends on religious and cultural beliefs and is strongly related to early sexual experiences.

Female↗

[Female sexual dysfunction as adverse effect of pharmacological treatment].

This review describes female sexual dysfunction (FSD) as an adverse effect to pharmacological treatment. FSD covers libido, arousal, orgasm, and pain problems. The existing knowledge of the influence of medication upon female sexual function is very sparse. Treatment with SSRIs and other antidepressants may cause decreased libido and organism problems. Antipsychotic treatment often causes libido, lubrication, and orgasm problems. Spironolactone may cause decreased libido and impaired lubrication. Whether antihypertensives, H2-receptor antagonists and sex hormones have sexual adverse effects has not been clarified properly. Some drugs, such as bupropion and sildenafil, may enhance the sexual function, but further studies have to be carried out. The need for further research on the topic is stressed.

Antidepressive Agents↗

[Sexual dysfunction in torture victims].

Sexual dysfunction is seen in up to 51% of torture victims. The torture victim seldom reports anything about having been tortured but often consults the health care system because of a somatic problem which may seem unrelated to torture. Therefore, it is important that doctors are aware of the possible correlation. Symptoms and findings may be both physical and psychical. The torture may be both sexual and non-sexual as well as physical and non-physical. Social, cultural and individual factors also influence the development of sexual dysfunction in a torture victim. The factors that cause sexual dysfunction and the identification of any direct causal relations are discussed. There are indications that sexual torture has a greater impact on the development of sexual dysfunction than other types of torture and it seems that sexual dysfunction is a result of many factors.

Female↗

Sexual side effects of SSRI medications: potential treatment strategies for SSRI-induced female sexual dysfunction.

Depression often coexists with sexual dysfunction, and the medical treatment of depression can further worsen sexual symptoms or cause de novo sexual dysfunction in a person who did not experience it prior to treatment. There are many drugs that can adversely affect sexual response. Among antidepressants, this effect is commonly observed with selective serotonin-reuptake inhibitors (SSRI). Various strategies for the treatment of SSRI-related sexual dysfunction have been studied, including: awaiting spontaneous remission of sexual dysfunction; reducing the dose of medication; taking a "drug holiday"; adding another drug to help reverse sexual symptoms; changing antidepressants; or initially starting with a different antidepressant that is known to have fewer or no sexual side effects. Overall, it is important to address sexual health when caring for a patient--to improve drug compliance and the patient's well being.

Antidepressive Agents, Second-Generation↗