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At least 289 records · Page 16Linked to original sources
PubMed2006

[Air pollution and cardiovascular and cerebrovascular disease: Epidemiologic data].

Recent convergent data suggest that air pollution affects the risk of acute atherothrombotic events including both myocardial infarction and ischemic stroke. The principal epidemiologic studies begun in the 1990s first examined the respiratory effects of atmospheric pollution and then focused on how pollution peaks affected cardiovascular risk. These studies used data from large metropolitan areas in North America and Asia as well as several large European cities to demonstrate the clear existence of a relation between air pollution and cardio- and cerebrovascular mortality. They also observed an increase in hospital admissions for myocardial infarctions and cerebrovascular accidents on days with high air pollution levels. The pollutants involved have not yet been clearly designated, but it appears that fine suspended particulate matter (PM2.5) and gaseous pollutants such as ozone appear to contribute strongly to these harmful effects. A complete analysis of these data shows the need for a thorough evaluation of the cardio- and cerebrovascular risks associated with air pollution, especially in French metropolitan areas. Precise identification of those at high risk from specific pollutants is essential to improve targeting of prevention strategies.

Air Pollutants↗
PubMed2003

Epidemiologic data on Asperger disorder.

In 1944, Asperger described a syndrome that was subsequently given his name, although there is evidence from earlier European literature that clinical descriptions matching this disorder were available in the 1920s. Asperger's work was largely ignored until the seminal article by Wing, however, which led to a resurgence of interest in this diagnostic concept. Asperger disorder (AD) was only introduced as a separate diagnostic category in the latest revisions of ICD-10 and DSM-IV. Epidemiologic research on this disorder has only started in recent years and therefore data are still scarce on the prevalence of this syndrome. This article reviews available epidemiologic surveys that have shed light on the prevalence of AD.

Adolescent↗
PubMed2000

Risk of giardiasis from consumption of wilderness water in North America: a systematic review of epidemiologic data.

OBJECTIVES: A meta-analytic study was conducted to test the hypothesis that consumption of water from North American backcountry sources poses a statistically significant risk for acquisition of giardiasis. METHODS: The biomedical literature was surveyed by accessing Medline, and identified studies were supplemented with references in current reviews, published dissertations, and prior communications with state health departments. Studies were classified by methodologic design and subjected to predetermined inclusion criteria. Odds ratios with 95% confidence intervals, chi-squares, and P-values for epidemiologic surveys were either computed from raw data or abstracted directly from the included studies. RESULTS: Of 104 articles identified in the initial screening, nine met the inclusion criteria. Neither of two case reports met the criteria of the Centers for Disease Control and Prevention (CDC) for waterborne disease outbreak. Two prospective studies were identified, but neither showed a significant association. Of four case-control studies providing data, three reported an odds ratio of greater than one. CONCLUSIONS: Published reports of confirmed giardiasis among outdoor recreationalists clearly demonstrate a high incidence among this population. However, the evidence for an association between drinking backcountry water and acquiring giardiasis is minimal. Education efforts aimed at outdoor recreationalists should place more emphasis on handwashing than on water purification. Further studies should attempt to separate the specific risk factor of drinking water from backcountry sources from other behaviors among this group that may contribute to the risk.

Animals↗
PubMed1998

Availability of epidemiologic data for chemicals known to cause cancer in animals: an update.

Between 1972 and 1996, the International Agency for Research on Cancer (IARC) identified 282 chemicals as having experimental evidence "sufficient" to conclude that the chemicals cause cancer in animals. Of the 282 IARC animal carcinogens, 7% (20) also had "sufficient" evidence from epidemiology studies. "Limited" human evidence was available for 5% (13) of the 282 IARC animal carcinogens. A 1996 IARC international compendium of cancer studies indicated that epidemiologic studies of chemicals determined by IARC to cause cancer in both humans and animals were considerably more common than studies of chemicals determined to cause cancer in animals but for which human data were inadequate or limited. Of the 1,101 studies reported to IARC by investigators, the IARC animal carcinogens, with the most ongoing studies were asbestos (50 studies) and benzene (26 studies). Both chemicals have sufficient evidence of carcinogenicity from studies of humans. There were epidemiologic studies ongoing for 65% (13/20) of the chemicals for which evidence of carcinogenicity was sufficient in both animals and humans. Epidemiologic studies were reported to IARC for 12% (30/247) of the IARC animal carcinogens for which human data were inadequate or for which no human data were available. Two factors appear critical in determining whether an IARC animal carcinogen becomes the subject of an epidemiologic study: the likelihood of overcoming methodological obstacles to carrying out successful epidemiologic studies, and the economic and/or regulatory interest in the chemical.

Animals↗
PubMed1987

Diabetes, hyperglycaemia, hyperinsulinaemia and atherosclerosis: epidemiological data.

Beside arterial hypertension, hypercholesterolaemia and smoking habits, diabetes is considered as a risk factor of coronary heart disease (CHD). However, the role of impaired glucose tolerance (IGT) has not been demonstrated in the different epidemiological studies in the world which are summarized here; hyperinsulinaemia was also suspected and its independent role--investigated in only three prospective surveys--was demonstrated. The recent data of the Paris Prospective Study, where normoglycaemic, IGT and diabetic patients were analysed together, show that hyperinsulinaemia may be the first and genuine marker of the carbohydrate metabolism disturbance connected to the clinical manifestations of atherosclerosis.

Adult↗
PubMedDate not supplied

Some epidemiological data on oral clefts in the northern Netherlands, 1981-1988.

Cleft lip with or without cleft palate [CL(P)] has a high prevalence [corrected] in the northern Netherlands. Several epidemiological parameters for oral clefts, including both CL(P) and cleft palate (CP), were analysed and compared with the literature. Except for the high prevalence at birth of isolated CL(P) no major differences in the pattern of occurrence described elsewhere were found. So far, descriptive epidemiological studies have not given any insight into the aetiology of this high CL(P) prevalence [corrected] in the Northern Netherlands. Therefore, case control studies on possible risk factors have been initiated.

Abortion, Induced↗
PubMed2005

[Cardiac consequences of subclinical dysthyroidism. Experimental, clinical, and epidemiologic data].

KEY POINTS: Although the cardiovascular consequences of clinical or "overt" dysthyroidism are well known and treatment relatively well established, subclinical dysthyroidism remains a controversial topic, both regarding its cardiovascular effects and the best methods for its management. Subclinical hyperthyroidism is frequent among the elderly, usually associated with multinodular goiter. Although several epidemiologic studies have demonstrated that subclinical hyperthyroidism is associated with an increased risk of atrial fibrillation and high cardiovascular mortality, solid practical data on which management can be based are not currently available. The risks related to subclinical hypothyroidism appear essentially vascular but a conclusive assessment must await further epidemiologic surveys.

Cardiovascular Diseases↗