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Towards Efficient and Wide-Scope Metal-Catalyzed Alkyl-Alkyl Cross-Coupling Reactions.

The simplest organic fragment, C(sp(3))-C(sp(3)), is unfortunately the most difficult to prepare by metal-catalyzed cross-coupling reactions (shown schematically) in the presence of functional groups. Recent advances show, however, that alkane moieties can be built within functionalized molecules by a careful choice of catalysts and conditions.

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